CN103239525B - Blood activating and lipid lowering medicinal liquor and preparation method thereof - Google Patents
Blood activating and lipid lowering medicinal liquor and preparation method thereof Download PDFInfo
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- CN103239525B CN103239525B CN201310192099.5A CN201310192099A CN103239525B CN 103239525 B CN103239525 B CN 103239525B CN 201310192099 A CN201310192099 A CN 201310192099A CN 103239525 B CN103239525 B CN 103239525B
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Abstract
The invention discloses a blood activating and lipid lowering medicinal liquor. The medicinal liquor comprises the following active pharmaceutical ingredients in parts by weight: 60-120 parts of salvia miltiorrhiza, 60-120 parts of panax pseudo-ginseng, 120-240 parts of crataegus, 120-240 parts of folium ginkgo, 60-120 parts of prepared fleece flower root, 60-120 parts of radix puerariae, 60-120 parts of semen cassiae, 60-120 parts of spina date seed and 60-120 parts of semen platycladi. The preparation method comprises steps of: mixing the active pharmaceutical ingredients according to a ratio, then crushing to form particles, adding white spirit of 45 degrees-50 degrees, then adding brown sugar, sealing, soaking for 40-50 days, pouring the supernatant, standing for 18-30 hours, and filtering so as to obtain the medicinal liquor. The medicinal liquor has blood activating and lipid lowering functions and an obvious effect, is suitable for hyperlipemia symptoms, can also be used for preventing and treating cardiovascular and cerebrovascular diseases, and is convenient to use and easy to accept.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Traditional Chinese medicinal liquor with blood activating and fat reducing effect and preparation method thereof.
Background technology
Hyperlipemia is one of common disease of middle-aged and elderly people, and wherein increasing of serum total cholesterol and triacylglycerol and low-density lipoprotein cholesterol is the key factor that has caused shape atherosclerotic heart disease.Lipid-lowering therapy is to prevention and stop generation and the development of hyperlipidemia patient coronary artery pathological changes to have positive effect.
Summary of the invention
The object of this invention is to provide a kind of blood activating and fat reducing medicated wine, described medicated wine has feature evident in efficacy, easy to use.
For achieving the above object, the technical solution used in the present invention is:
A kind of blood activating and fat reducing medicated wine, the crude drug that comprises following weight portion meter, 60 ~ 120 parts of Radix Salviae Miltiorrhizaes, 60 ~ 120 parts of Radix Notoginseng, 120 ~ 240 parts of Fructus Crataegis, 120 ~ 240 parts of Folium Ginkgos, 60 ~ 120 parts of Radix Polygoni Multiflori Preparata, 60 ~ 120 parts of Radix Puerariaes, 60 ~ 120 parts of Semen Cassiaes, 60 ~ 120 parts of Semen Ziziphi Spinosaes, 60 ~ 120 parts of Semen Platycladi.
As preferred technical scheme, the present invention includes the crude drug of following weight portion meter, 90 parts of Radix Salviae Miltiorrhizaes, 90 parts of Radix Notoginseng, 180 parts of Fructus Crataegis, 180 parts of Folium Ginkgos, 90 parts of Radix Polygoni Multiflori Preparata, 90 parts of Radix Puerariaes, 90 parts of Semen Cassiaes, 90 parts of Semen Ziziphi Spinosaes, 90 parts of Semen Platycladi.
Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling in side, the relieving restlessness that clears away heart-fire, improves heart blood supply; The hemostasis of Radix Notoginseng dissipating blood stasis, subduing swelling and relieving pain; Hawthorn digesting spleen invigorating, circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing; Folium Ginkgo blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, changes turbid blood fat reducing; Radix Puerariae removing toxic substances is brought down a fever, promoting the production of body fluid to quench thirst, dredge the meridian passage, alcoholic intoxication; Radix Polygoni Multiflori invigorating the liver and kidney, benefiting essence-blood, changes turbid blood fat reducing; Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation, the Semen Ziziphi Spinosae tonifying liver that nourishes heart, mind tranquilizing and the heart calming; Semen Platycladi tranquilizing by nourishing the heart, loosening bowel to relieve constipation.All medicines are harmonious, and can play blood circulation promoting and blood stasis dispelling, the effect that blood fat reducingization is turbid.
According to above-mentioned formula, can make wine according to the conventional method of this area.
As preferred technical scheme, a kind of method of preparing blood activating and fat reducing medicated wine provided by the invention, to be ground into granule after crude drug Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Crataegi, Folium Ginkgo, Radix Polygoni Multiflori Preparata, Radix Puerariae, Semen Cassiae, Semen Ziziphi Spinosae and Semen Platycladi are mixed in proportion, add the Chinese liquor of 45 °-50 °, then add brown sugar, sealing, soak 40-50 days, incline and supernatant, standing 18-30h, after filtration and get final product.
Preferably the addition of Chinese liquor is that every 1kg crude drug adds the Chinese liquor 3000-4000ml of 45 °-50 °.Preferably the addition of brown sugar is that every 1kg crude drug adds brown sugar 100-200g.
After adding brown sugar, sealing is soaked 45 days; Incline and after supernatant, standing 24h.
Medicated wine of the present invention is brownish red transparency liquid, and gas is fragrant, the micro-sweetness of taste, micro-hardship.Using method is: after lunch, supper, drink each 25ml, every day 2 times.
China's traditional medicine thinks that hyperlipemia is due to stagnation of turbid phlegm in middle-JIAO, qi depression to blood stasis, and stagnation of liver-QI with deficiency of the spleen, caused by liver and kidney deficiency causes, the treatment medication of need to suiting the medicine to the illness just can obtain good effect.We be take Chinese medical theory as foundation, select the Radix Salviae Miltiorrhizae with remarkable blood circulation invigorating efficacies as monarch; Radix Notoginseng, Folium Ginkgo promoting blood circulation to remove obstruction in the collateral, changing turbid blood fat reducing is minister; Hawthorn digesting spleen invigorating, circulation of qi promoting dissipating blood stasis, Radix Puerariae dredge the meridian passage, alcoholic intoxication, Semen Cassiae clearing away heat to improve acuity of vision, Radix Polygoni Multiflori invigorating the liver and kidney, benefiting essence-blood is assistant; Semen Ziziphi Spinosae, the Semen Platycladi tonifying liver that nourishes heart, the intestine moistening of calming the nerves is for making.Each medicine share, and can play blood circulation promoting and blood stasis dispelling, and blood fat reducingization is turbid, spleen invigorating QI invigorating, liver and kidney tonifying, the effect of tranquilizing by nourishing the heart.In side, add brown sugar not only can improve the mouthfeel of medicinal liquid, and in brown sugar, contain multiple beneficial in the trace element of human body.Chinese liquor is as a part for medicine, can promoting blood circulation, and row medicine gesture, existing effect of invigorating blood circulation, can promote again metabolism in vivo of medicine running, but excessive concentration is because mouthfeel is too peppery and easily fascinating, the too low proposition of effective ingredient and the stability of medicine of can having influence on again of concentration.Through a large amount of experiments, result shows that the Chinese liquor of 45-50 degree can have good mouthfeel and more satisfactory stability simultaneously.The time of soaking directly can have influence on the proposition of effective ingredient, the effective ingredient of too short medicine of time proposes not exclusively, overlong time can increase the cost of making, through a large amount of experimental results show that, the soak time of medicine with 40 days to 50 days better, various effective ingredient all can obtain the proposition in limit.Standing main purpose is in order to make the particulate matter precipitation in medicinal liquid, so that overanxious, make medicinal liquid limpid, also change the mouthfeel while drinking simultaneously.
Below with the present invention, to treat the clinical observation experiment of hyperlipemia.
One, case selection
MethodsThe cases enrolled is totally 180 examples, all meets the diagnostic criteria of hyperlipemia, and Diagnostic Value of Fasting Serum T-CHOL (TC) >=6.0mmol/L or triglyceride (TG) >=1.69mmol/L, be divided into two groups at random by patient, each 90 examples for the treatment of group and matched group.
Treatment group man 40 examples, female's 50 examples, 36 years old ~ 68 years old age is flat, all (56.5 ± 8.8) year, body weight 55kg ~ 92kg, average (66.8 ± 10.6) kg; High TC mass formed by blood stasis 6 examples, high TG mass formed by blood stasis 24, combined hyperlipidemia 50 examples, high/low density hyperlipoproteinemia 10 examples; Severity extent: slight (symptom integral <10 divides) 20 examples, moderate (10≤symptom integral <19 divides) 60 examples, severe (symptom integral >=19 minute) 10 examples.
Matched group man 36 examples, female's 54 examples, 28 years old ~ 68 years old age, average (52.6 ± 9.2) year, body weight 60kg ~ 93.5kg, average (67 ± 10.2) kg; High TC mass formed by blood stasis 10 examples, high TG mass formed by blood stasis 34 examples, combined hyperlipidemia 46 examples; Severity extent: slight 28 examples, moderate 47 examples, severe 15 examples.Two groups of data comparing differences without significance (
p>0.05), there is comparability.
Two, Therapeutic Method
Treatment group: take blood activating and fat reducing wine of the present invention, each 25ml, every day 2 times, respectively at drinking after lunch, supper.
Matched group: take YUEJIANCAOYOU WAN, each 1.5g, every day 2 times.
Be 60 days two groups of courses for the treatment of, do not add with any interference blood lipid metabolism medicine during test of cure.
Three, observation index:
Press < < dyslipidemia control suggestion > > adnexa and method of quality control and measure TC, TG, HDL-C, low-density lipoprotein cholesterol (LDL-C), Apolipoprotein A1 (apoAl), apolipoprotein B100 (apoBl00).
Four, curative effect judging standard
Clinic control: blood lipid level detects and recovers normal.Effective: blood lipid level detects and reaches following any one person: TC decline >=20%, TG decline >=40%, HDL-C rising 0.26mmol/L, and TC-HDL-C/HDL-C declines >=20%; Effective: blood lipid level detects and to reach following any one person: TC >=10% ~ <20% that declines, TG >=20% ~ <40% that declines, HDL-C rising >=0.104mmol/L ~ <0.26mmol/L, TC-HDL-C/HDL-C >=10% ~ <20% that declines; Invalid: lipids detection is not improved or improves and do not reach effective standard person.
Four, result
the comparison of two groups of patient's blood fat reducing total effectses
| Group | Number of cases | Clinic control | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 90 | 28 | 26 | 18 | 18 | 80.0% * |
| Matched group | 90 | 18 | 12 | 15 | 45 | 50.0% |
Note: * and matched group comparison
p<0.01
Five, conclusion
Through observation and comparison, take blood activating and fat reducing wine person lipid-lowering effect and be obviously better than matched group, show to take the effect that blood activating and fat reducing wine can play Antilipemic health.
Blood activating and fat reducing medicated wine of the present invention has the effect of blood activating and fat reducing, and effect is remarkable, is applicable to hyperlipemia, also can be used for prevention and treatment cardiovascular and cerebrovascular disease, uses easy to usely, is more easily accepted.
The specific embodiment
Embodiment 1
60 grams of Radix Salviae Miltiorrhizaes, 60 grams of Radix Notoginseng, 120 grams of Fructus Crataegis, 120 grams of Folium Ginkgos, 60 grams of Radix Polygoni Multiflori Preparata, 60 grams of Radix Puerariaes, 60 grams of Semen Cassiaes, 60 grams of Semen Ziziphi Spinosaes, 60 grams of Semen Platycladi.
Raw material is picked up to most impurity, after being mixed in proportion, Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Crataegi, Folium Ginkgo, Radix Polygoni Multiflori Preparata, Radix Puerariae, Semen Cassiae, Semen Ziziphi Spinosae and Semen Platycladi be ground into granule, the 1980ml Chinese liquor that adds 45 °, add again 66 grams of brown sugar, sealing, soaks 40 days, inclines and supernatant, standing 18h, after filtration and get final product.
Embodiment 2
120 grams of Radix Salviae Miltiorrhizaes, 120 grams of Radix Notoginseng, 240 grams of Fructus Crataegis, 240 grams of Folium Ginkgos, 120 grams of Radix Polygoni Multiflori Preparata, 120 grams of Radix Puerariaes, 120 grams of Semen Cassiaes, 120 grams of Semen Ziziphi Spinosaes, 120 grams of Semen Platycladi.
Raw material is picked up to most impurity, after being mixed in proportion, Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Crataegi, Folium Ginkgo, Radix Polygoni Multiflori Preparata, Radix Puerariae, Semen Cassiae, Semen Ziziphi Spinosae and Semen Platycladi be ground into granule, the Chinese liquor 5280ml that adds 50 °, add again brown sugar 264g, sealing, soaks 50 days, inclines and supernatant, standing 30h, after filtration and get final product.
Embodiment 3
90 grams of Radix Salviae Miltiorrhizaes, 90 grams of Radix Notoginseng, 180 grams of Fructus Crataegis, 180 grams of Folium Ginkgos, 90 grams of Radix Polygoni Multiflori Preparata, 90 grams of Radix Puerariaes, 90 grams of Semen Cassiaes, 90 grams of Semen Ziziphi Spinosaes, 90 grams of Semen Platycladi.
Raw material is picked up to most impurity, after being mixed in proportion, Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Crataegi, Folium Ginkgo, Radix Polygoni Multiflori Preparata, Radix Puerariae, Semen Cassiae, Semen Ziziphi Spinosae and Semen Platycladi be ground into granule, the Chinese liquor 3500ml that adds 45 °, add again brown sugar 150g, sealing, soaks 45 days, inclines and supernatant, standing 24h, after filtration and get final product.
Embodiment 4
80 grams of Radix Salviae Miltiorrhizaes, 100 grams of Radix Notoginseng, 200 grams of Fructus Crataegis, 150 grams of Folium Ginkgos, 70 grams of Radix Polygoni Multiflori Preparata, 90 grams of Radix Puerariaes, 110 grams of Semen Cassiaes, 80 grams of Semen Ziziphi Spinosaes, 100 grams of Semen Platycladi.
Raw material is picked up to most impurity, after being mixed in proportion, Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Crataegi, Folium Ginkgo, Radix Polygoni Multiflori Preparata, Radix Puerariae, Semen Cassiae, Semen Ziziphi Spinosae and Semen Platycladi be ground into granule, the Chinese liquor 3000ml that adds 48 °, add again brown sugar 180g, sealing, soaks 48 days, inclines and supernatant, standing 28h, after filtration and get final product.
Embodiment 5
100 grams of Radix Salviae Miltiorrhizaes, 70 grams of Radix Notoginseng, 160 grams of Fructus Crataegis, 220 grams of Folium Ginkgos, 100 grams of Radix Polygoni Multiflori Preparata, 80 grams of Radix Puerariaes, 90 grams of Semen Cassiaes, 80 grams of Semen Ziziphi Spinosaes, 70 grams of Semen Platycladi.
Raw material is picked up to most impurity, after being mixed in proportion, Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Crataegi, Folium Ginkgo, Radix Polygoni Multiflori Preparata, Radix Puerariae, Semen Cassiae, Semen Ziziphi Spinosae and Semen Platycladi be ground into granule, the Chinese liquor 3500ml that adds 50 °, add again brown sugar 150g, sealing, soaks 45 days, inclines and supernatant, standing 24h, after filtration and get final product.
Claims (7)
1. a blood activating and fat reducing medicated wine, it is characterized in that: the crude drug by following weight portion meter is made 60 ~ 120 parts of Radix Salviae Miltiorrhizaes, 60 ~ 120 parts of Radix Notoginseng, 120 ~ 240 parts of Fructus Crataegis, 120 ~ 240 parts of Folium Ginkgos, 60 ~ 120 parts of Radix Polygoni Multiflori Preparata, 60 ~ 120 parts of Radix Puerariaes, 60 ~ 120 parts of Semen Cassiaes, 60 ~ 120 parts of Semen Ziziphi Spinosaes, 60 ~ 120 parts of Semen Platycladi.
2. medicated wine according to claim 1, it is characterized in that: the crude drug by following weight portion meter is made 90 parts of Radix Salviae Miltiorrhizaes, 90 parts of Radix Notoginseng, 180 parts of Fructus Crataegis, 180 parts of Folium Ginkgos, 90 parts of Radix Polygoni Multiflori Preparata, 90 parts of Radix Puerariaes, 90 parts of Semen Cassiaes, 90 parts of Semen Ziziphi Spinosaes, 90 parts of Semen Platycladi.
3. prepare the method for medicated wine as claimed in claim 1 or 2, it is characterized in that: after crude drug Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Crataegi, Folium Ginkgo, Radix Polygoni Multiflori Preparata, Radix Puerariae, Semen Cassiae, Semen Ziziphi Spinosae and Semen Platycladi are mixed in proportion, be ground into granule, the Chinese liquor that adds 45 °-50 °, add again brown sugar, sealing, soaks 40-50 days, inclines and supernatant, standing 18-30h, after filtration and get final product.
4. method according to claim 3, is characterized in that: the addition of Chinese liquor is that every 1kg crude drug adds the Chinese liquor 3000-4000ml of 45 °-50 °.
5. method according to claim 3, is characterized in that: the addition of brown sugar is that every 1kg crude drug adds brown sugar 100-200g.
6. method according to claim 3, is characterized in that: after adding brown sugar, sealing is soaked 45 days.
7. method according to claim 3, is characterized in that: incline and after supernatant, standing 24h.
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| CN1785284B (en) * | 2004-12-10 | 2012-04-18 | 天津天士力制药股份有限公司 | Medicinal composition containing flowery knotwood root |
| CN1325088C (en) * | 2005-03-14 | 2007-07-11 | 张广东 | Oral administration liquor for reducing blood fat |
| KR100974545B1 (en) * | 2008-06-30 | 2010-08-11 | 한국 한의학 연구원 | Compositions and functional food for prevention and treatment of obesity |
| CN101721507B (en) * | 2008-10-14 | 2012-09-05 | 北京因科瑞斯医药科技有限公司 | Composition for relieving and treating fatty livers and preparation method thereof |
| CN101433699A (en) * | 2008-12-19 | 2009-05-20 | 吕夫杰 | Granular formulation for treating hypertension and hyperlipemia, and preparation method thereof |
| CN101428132B (en) * | 2008-12-19 | 2010-12-01 | 肖永雪 | Chinese medicinal composition for treating hyperlipemia and preparation thereof |
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