CN101421256A - 蛋白酪氨酸磷酸酶的噻二唑烷酮抑制剂 - Google Patents

蛋白酪氨酸磷酸酶的噻二唑烷酮抑制剂 Download PDF

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Publication number
CN101421256A
CN101421256A CNA2007800120054A CN200780012005A CN101421256A CN 101421256 A CN101421256 A CN 101421256A CN A2007800120054 A CNA2007800120054 A CN A2007800120054A CN 200780012005 A CN200780012005 A CN 200780012005A CN 101421256 A CN101421256 A CN 101421256A
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hydroxy
thiadiazolidin
phenyl
trioxo
substituted
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Chinese (zh)
Inventor
A·诺伊贝特
D·巴恩斯
郭英信
中岛胜正
G·R·贝伯恩尼茨
G·M·科波拉
L·克尔曼
M·H·塞拉诺-武
T·施塔姆斯
S·W·托皮欧
T·R·维达那达
J·R·韦尔林
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Novartis AG
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Novartis AG
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Publication of CN101421256A publication Critical patent/CN101421256A/zh
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
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  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
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  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CNA2007800120054A 2006-03-31 2007-03-29 蛋白酪氨酸磷酸酶的噻二唑烷酮抑制剂 Pending CN101421256A (zh)

Applications Claiming Priority (2)

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US78850206P 2006-03-31 2006-03-31
US60/788,502 2006-03-31

Publications (1)

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CN101421256A true CN101421256A (zh) 2009-04-29

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CNA2007800120054A Pending CN101421256A (zh) 2006-03-31 2007-03-29 蛋白酪氨酸磷酸酶的噻二唑烷酮抑制剂

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US (1) US8084448B2 (enExample)
EP (1) EP2038267A2 (enExample)
JP (1) JP2009532379A (enExample)
KR (1) KR20080110882A (enExample)
CN (1) CN101421256A (enExample)
AU (1) AU2007233251A1 (enExample)
BR (1) BRPI0710182A2 (enExample)
CA (1) CA2647472A1 (enExample)
MX (1) MX2008012598A (enExample)
RU (1) RU2008143053A (enExample)
WO (1) WO2007115058A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102659539A (zh) * 2012-05-15 2012-09-12 北京化工大学 一种由α,β-不饱和酰氯制备二氢查尔酮类化合物的方法
CN102884047A (zh) * 2009-12-04 2013-01-16 大正制药株式会社 2-吡啶酮化合物
CN116283467A (zh) * 2023-01-18 2023-06-23 四川大学 一种合成二芳基烷基甲烷的方法
CN117658947A (zh) * 2022-09-06 2024-03-08 杭州中美华东制药有限公司 蛋白酪氨酸磷酸酶抑制作用的5-(取代芳基)-1,2,5-噻二唑啉-3-酮类化合物
CN119220146A (zh) * 2024-10-24 2024-12-31 山东三佳聚合高分子材料有限公司 一种新型隔热保温涂料
WO2025077572A1 (zh) * 2023-10-13 2025-04-17 华东师范大学 一种用于前药给药系统的可裂解连接体化合物及其制备和应用

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UA94921C2 (en) 2005-12-08 2011-06-25 Новартис Аг 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as ptp-as inhibitors
AU2006321903A1 (en) * 2005-12-08 2007-06-14 Novartis Ag. 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPASE)
US20080293782A1 (en) * 2005-12-08 2008-11-27 David Barnes 1,1,3-Trioxo-1,2,5-Thiadiazolidines and Their Use as Ptp-Ases Inhibitors
UA94724C2 (en) * 2005-12-08 2011-06-10 Новартис Аг Thiadiazolidinone derivatives as antidiabetic agents
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
CA2813639A1 (en) 2010-10-08 2012-04-12 Mochida Pharmaceutical Co. Ltd. Cyclic amide derivative
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2703393A4 (en) * 2011-04-28 2014-09-24 Mochida Pharm Co Ltd CYCLIC AMIDE DERIVATIVE
CA2834465A1 (en) * 2011-04-28 2012-11-01 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9216988B2 (en) * 2011-12-22 2015-12-22 Genentech, Inc. Benzyl sulfonamide derivatives as RORc modulators
CN104955824B (zh) 2012-11-20 2017-09-22 豪夫迈·罗氏有限公司 作为含t790m的egfr突变体的抑制剂的氨基嘧啶化合物
US10550091B2 (en) 2016-03-25 2020-02-04 St. Jude Children's Research Hospital 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
AU2019200683B2 (en) * 2018-02-01 2024-05-30 The University Of Sydney Anti-cancer compounds
RS63915B1 (sr) * 2018-03-27 2023-02-28 Neuropore Therapies Inc Jedinjenja kao modulatori tlr2 signalizacije
KR20250133466A (ko) * 2018-06-21 2025-09-05 칼리코 라이프 사이언시스 엘엘씨 단백질 타이로신 포스파타아제 억제제 및 그의 사용 방법
WO2020035019A1 (zh) 2018-08-17 2020-02-20 浙江海正药业股份有限公司 吲唑胺类衍生物及其制备方法和其在医药上的用途
PH12021552194A1 (en) * 2019-03-14 2022-08-22 Abbvie Inc Protein tyrosine phosphatase inhibitors and methods of use thereof
IL313028A (en) * 2021-11-23 2024-07-01 Kumquat Biosciences Inc Hetero-atom containing compounds and uses thereof
IL314650A (en) * 2022-02-02 2024-09-01 Nerio Therapeutics Inc Protein tyrosine phosphatase inhibitors and uses thereof
EP4508050A1 (en) * 2022-04-14 2025-02-19 Nerio Therapeutics, Inc. Protein tyrosine phosphatase inhibitors and uses thereof
EP4522594A1 (en) * 2022-05-13 2025-03-19 Ness Therapeutics, Inc. Ptpn2 inhibitors
AR131413A1 (es) * 2022-12-21 2025-03-19 Bristol Myers Squibb Co Inhibidores de la proteína tirosina fosfatasa, composiciones y métodos de uso

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JP2000511883A (ja) * 1996-04-19 2000-09-12 ノボ ノルディスク アクティーゼルスカブ ホスホチロシン認識ユニットを有する分子のモジュレーター
NZ535545A (en) * 2002-04-03 2007-06-29 Novartis Ag 5-substituted 1,1-dioxo-1,2,5-thiazolidine-3-one derivatives as PTPase 1B inhibitors
GB0225986D0 (en) 2002-11-07 2002-12-11 Astrazeneca Ab Chemical compounds
GB0227813D0 (en) * 2002-11-29 2003-01-08 Astrazeneca Ab Chemical compounds
ATE432074T1 (de) * 2002-12-30 2009-06-15 Vertex Pharma Sulfhydantoine als phosphatisostere zur verwendung als phosphatasehemmer bei der behandlung von krebs und autoimmunerkrankungen
UA94921C2 (en) * 2005-12-08 2011-06-25 Новартис Аг 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as ptp-as inhibitors
US20080293782A1 (en) * 2005-12-08 2008-11-27 David Barnes 1,1,3-Trioxo-1,2,5-Thiadiazolidines and Their Use as Ptp-Ases Inhibitors
AU2006321903A1 (en) * 2005-12-08 2007-06-14 Novartis Ag. 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPASE)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102884047A (zh) * 2009-12-04 2013-01-16 大正制药株式会社 2-吡啶酮化合物
CN102884047B (zh) * 2009-12-04 2015-11-25 日产化学工业株式会社 2-吡啶酮化合物
CN102659539A (zh) * 2012-05-15 2012-09-12 北京化工大学 一种由α,β-不饱和酰氯制备二氢查尔酮类化合物的方法
CN117658947A (zh) * 2022-09-06 2024-03-08 杭州中美华东制药有限公司 蛋白酪氨酸磷酸酶抑制作用的5-(取代芳基)-1,2,5-噻二唑啉-3-酮类化合物
CN116283467A (zh) * 2023-01-18 2023-06-23 四川大学 一种合成二芳基烷基甲烷的方法
CN116283467B (zh) * 2023-01-18 2024-06-11 四川大学 一种合成二芳基烷基甲烷的方法
WO2025077572A1 (zh) * 2023-10-13 2025-04-17 华东师范大学 一种用于前药给药系统的可裂解连接体化合物及其制备和应用
CN119220146A (zh) * 2024-10-24 2024-12-31 山东三佳聚合高分子材料有限公司 一种新型隔热保温涂料

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Publication number Publication date
US8084448B2 (en) 2011-12-27
KR20080110882A (ko) 2008-12-19
WO2007115058A3 (en) 2008-03-20
BRPI0710182A2 (pt) 2012-08-07
WO2007115058A2 (en) 2007-10-11
US20090181928A1 (en) 2009-07-16
RU2008143053A (ru) 2010-05-10
CA2647472A1 (en) 2007-10-11
AU2007233251A1 (en) 2007-10-11
MX2008012598A (es) 2008-10-10
JP2009532379A (ja) 2009-09-10
EP2038267A2 (en) 2009-03-25

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Application publication date: 20090429