CN101378784B - 产生有机胺的超极化羧酸盐的方法 - Google Patents

产生有机胺的超极化羧酸盐的方法 Download PDF

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Publication number
CN101378784B
CN101378784B CN2006800464616A CN200680046461A CN101378784B CN 101378784 B CN101378784 B CN 101378784B CN 2006800464616 A CN2006800464616 A CN 2006800464616A CN 200680046461 A CN200680046461 A CN 200680046461A CN 101378784 B CN101378784 B CN 101378784B
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China
Prior art keywords
carboxylate
compositions
amino
compound
organic amine
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Expired - Fee Related
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CN2006800464616A
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English (en)
Chinese (zh)
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CN101378784A (zh
Inventor
M·萨宁
K·A·格拉姆
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GE Healthcare AS
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GE Healthcare AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN2006800464616A 2005-12-16 2006-12-15 产生有机胺的超极化羧酸盐的方法 Expired - Fee Related CN101378784B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20055983 2005-12-16
NO20055983 2005-12-16
PCT/NO2006/000481 WO2007069909A2 (en) 2005-12-16 2006-12-15 Method to produce hyperpolarised carboxylates of organic amines

Publications (2)

Publication Number Publication Date
CN101378784A CN101378784A (zh) 2009-03-04
CN101378784B true CN101378784B (zh) 2013-06-12

Family

ID=38163350

Family Applications (1)

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CN2006800464616A Expired - Fee Related CN101378784B (zh) 2005-12-16 2006-12-15 产生有机胺的超极化羧酸盐的方法

Country Status (7)

Country Link
US (1) US9272056B2 (https=)
EP (1) EP1962912B1 (https=)
JP (1) JP5102221B2 (https=)
CN (1) CN101378784B (https=)
ES (1) ES2393750T3 (https=)
PL (1) PL1962912T3 (https=)
WO (1) WO2007069909A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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US20100233096A1 (en) * 2006-03-29 2010-09-16 Lerche Mathilde H Method to produce hyperpolarised carboxylates and sulphonates
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
PL2180902T3 (pl) * 2007-08-27 2012-07-31 Ge Healthcare Ltd Ośrodek obrazujący zawierający hiperpolaryzowany ¹³C-octan oraz jego zastosowanie
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US20110038804A1 (en) * 2007-12-21 2011-02-17 Anna Gisselsson Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used
JP2011514313A (ja) * 2008-02-04 2011-05-06 ジーイー・ヘルスケア・リミテッド 過分極アミノ酸及びアミノスルホン酸の製造方法
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
US8968703B2 (en) * 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
JP5758982B2 (ja) 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 過分極基質の製造方法およびｍｒｉのための方法
WO2013053839A1 (en) * 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법

Citations (2)

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GB2252245A (en) * 1990-11-12 1992-08-05 Instrumentarium Corp Diagnostic composition and apparatus for use in magnetic resonance imaging
CN1285044A (zh) * 1998-01-05 2001-02-21 耐克麦德英梅金公司 磁共振研究方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3175940B2 (ja) * 1990-02-12 2001-06-11 ニコムド イノベーション アーベー トリアリールメチルラジカルおよび磁気共鳴造影法における不活性炭素フリーラジカルの用途
US5728370A (en) 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US6958244B2 (en) * 2002-04-12 2005-10-25 Bruker Biospin Corp. Low-conductivity buffers for magnetic resonance measurements
NO20023357D0 (no) 2002-04-19 2002-07-11 Amersham Health As Blanding
US7351402B2 (en) 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
NZ552898A (en) * 2004-07-30 2011-02-25 Ge Healthcare As Method of producing a composition, composition and its use
ES2545377T3 (es) 2004-07-30 2015-09-10 Ge Healthcare As Radicales y su uso como agentes paramagnéticos en un proceso de polarización nuclear dinámica
WO2006054903A2 (en) * 2004-11-19 2006-05-26 Ge Healthcare As Method of cardiac imaging with the use of hyperpolarized 13 c-pyruvate
JP5475995B2 (ja) * 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2252245A (en) * 1990-11-12 1992-08-05 Instrumentarium Corp Diagnostic composition and apparatus for use in magnetic resonance imaging
CN1285044A (zh) * 1998-01-05 2001-02-21 耐克麦德英梅金公司 磁共振研究方法

Also Published As

Publication number Publication date
US20080292551A1 (en) 2008-11-27
JP5102221B2 (ja) 2012-12-19
ES2393750T3 (es) 2012-12-27
EP1962912B1 (en) 2012-09-26
EP1962912A2 (en) 2008-09-03
JP2009519329A (ja) 2009-05-14
PL1962912T3 (pl) 2013-03-29
US9272056B2 (en) 2016-03-01
CN101378784A (zh) 2009-03-04
WO2007069909A2 (en) 2007-06-21
WO2007069909A3 (en) 2007-10-18

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