ES2393750T3 - Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas - Google Patents

Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas Download PDF

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Publication number
ES2393750T3
ES2393750T3 ES06835724T ES06835724T ES2393750T3 ES 2393750 T3 ES2393750 T3 ES 2393750T3 ES 06835724 T ES06835724 T ES 06835724T ES 06835724 T ES06835724 T ES 06835724T ES 2393750 T3 ES2393750 T3 ES 2393750T3
Authority
ES
Spain
Prior art keywords
carboxylate
composition
polarization
hyperpolarized
dnp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06835724T
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English (en)
Spanish (es)
Inventor
Mikkel Thaning
Karl Andreas Gram
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Application granted granted Critical
Publication of ES2393750T3 publication Critical patent/ES2393750T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES06835724T 2005-12-16 2006-12-15 Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas Active ES2393750T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20055983 2005-12-16
NO20055983 2005-12-16
PCT/NO2006/000481 WO2007069909A2 (en) 2005-12-16 2006-12-15 Method to produce hyperpolarised carboxylates of organic amines

Publications (1)

Publication Number Publication Date
ES2393750T3 true ES2393750T3 (es) 2012-12-27

Family

ID=38163350

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06835724T Active ES2393750T3 (es) 2005-12-16 2006-12-15 Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas

Country Status (7)

Country Link
US (1) US9272056B2 (https=)
EP (1) EP1962912B1 (https=)
JP (1) JP5102221B2 (https=)
CN (1) CN101378784B (https=)
ES (1) ES2393750T3 (https=)
PL (1) PL1962912T3 (https=)
WO (1) WO2007069909A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009531422A (ja) * 2006-03-29 2009-09-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ 過分極カルボン酸塩及びスルホン酸塩の製造方法
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
JP2010534498A (ja) * 2007-07-26 2010-11-11 ジーイー・ヘルスケア・ユーケイ・リミテッド 方法及び該方法で使用するためのイメージング媒体
CN101854956B (zh) * 2007-08-27 2013-01-23 通用电气健康护理有限公司 包含超极化13c-醋酸盐的成像介质及其应用
EP2902041A1 (en) * 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US20110038804A1 (en) * 2007-12-21 2011-02-17 Anna Gisselsson Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used
JP2011514313A (ja) * 2008-02-04 2011-05-06 ジーイー・ヘルスケア・リミテッド 過分極アミノ酸及びアミノスルホン酸の製造方法
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
SG179067A1 (en) * 2009-09-10 2012-04-27 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
WO2013053839A1 (en) * 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012024A1 (en) * 1990-02-12 1991-08-22 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in mri
GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6958244B2 (en) * 2002-04-12 2005-10-25 Bruker Biospin Corp. Low-conductivity buffers for magnetic resonance measurements
NO20023357D0 (no) 2002-04-19 2002-07-11 Amersham Health As Blanding
US7351402B2 (en) 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
PL1805186T3 (pl) 2004-07-30 2015-10-30 Ge Healthcare As Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej
WO2006011809A1 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
KR101249634B1 (ko) * 2004-11-19 2013-04-01 지이 헬스케어 에이에스 과분극화 13ｃ-피루베이트를 사용한 심장 영상화 방법
JP5475995B2 (ja) 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法

Also Published As

Publication number Publication date
US20080292551A1 (en) 2008-11-27
WO2007069909A3 (en) 2007-10-18
PL1962912T3 (pl) 2013-03-29
JP5102221B2 (ja) 2012-12-19
CN101378784A (zh) 2009-03-04
EP1962912A2 (en) 2008-09-03
US9272056B2 (en) 2016-03-01
EP1962912B1 (en) 2012-09-26
WO2007069909A2 (en) 2007-06-21
CN101378784B (zh) 2013-06-12
JP2009519329A (ja) 2009-05-14

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