JP5102221B2 - 過分極カルボン酸塩の製造方法 - Google Patents

過分極カルボン酸塩の製造方法 Download PDF

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Publication number
JP5102221B2
JP5102221B2 JP2008545523A JP2008545523A JP5102221B2 JP 5102221 B2 JP5102221 B2 JP 5102221B2 JP 2008545523 A JP2008545523 A JP 2008545523A JP 2008545523 A JP2008545523 A JP 2008545523A JP 5102221 B2 JP5102221 B2 JP 5102221B2
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Japan
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composition
carboxylate
polarization
paramagnetic metal
carboxylic acid
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JP2008545523A
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Japanese (ja)
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JP2009519329A5 (https=
JP2009519329A (ja
Inventor
サニング，ミッケル
グラム，カール・アンドレアス
Original Assignee
ジーイー・ヘルスケア・アクスイェ・セルスカプ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2008545523A 2005-12-16 2006-12-15 過分極カルボン酸塩の製造方法 Expired - Fee Related JP5102221B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20055983 2005-12-16
NO20055983 2005-12-16
PCT/NO2006/000481 WO2007069909A2 (en) 2005-12-16 2006-12-15 Method to produce hyperpolarised carboxylates of organic amines

Publications (3)

Publication Number Publication Date
JP2009519329A JP2009519329A (ja) 2009-05-14
JP2009519329A5 JP2009519329A5 (https=) 2010-01-14
JP5102221B2 true JP5102221B2 (ja) 2012-12-19

Family

ID=38163350

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008545523A Expired - Fee Related JP5102221B2 (ja) 2005-12-16 2006-12-15 過分極カルボン酸塩の製造方法

Country Status (7)

Country Link
US (1) US9272056B2 (https=)
EP (1) EP1962912B1 (https=)
JP (1) JP5102221B2 (https=)
CN (1) CN101378784B (https=)
ES (1) ES2393750T3 (https=)
PL (1) PL1962912T3 (https=)
WO (1) WO2007069909A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009531422A (ja) * 2006-03-29 2009-09-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ 過分極カルボン酸塩及びスルホン酸塩の製造方法
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
JP2010534498A (ja) * 2007-07-26 2010-11-11 ジーイー・ヘルスケア・ユーケイ・リミテッド 方法及び該方法で使用するためのイメージング媒体
CN101854956B (zh) * 2007-08-27 2013-01-23 通用电气健康护理有限公司 包含超极化13c-醋酸盐的成像介质及其应用
EP2902041A1 (en) * 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US20110038804A1 (en) * 2007-12-21 2011-02-17 Anna Gisselsson Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used
JP2011514313A (ja) * 2008-02-04 2011-05-06 ジーイー・ヘルスケア・リミテッド 過分極アミノ酸及びアミノスルホン酸の製造方法
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
SG179067A1 (en) * 2009-09-10 2012-04-27 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
WO2013053839A1 (en) * 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012024A1 (en) * 1990-02-12 1991-08-22 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in mri
GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6958244B2 (en) * 2002-04-12 2005-10-25 Bruker Biospin Corp. Low-conductivity buffers for magnetic resonance measurements
NO20023357D0 (no) 2002-04-19 2002-07-11 Amersham Health As Blanding
US7351402B2 (en) 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
PL1805186T3 (pl) 2004-07-30 2015-10-30 Ge Healthcare As Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej
WO2006011809A1 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
KR101249634B1 (ko) * 2004-11-19 2013-04-01 지이 헬스케어 에이에스 과분극화 13ｃ-피루베이트를 사용한 심장 영상화 방법
JP5475995B2 (ja) 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法

Also Published As

Publication number Publication date
US20080292551A1 (en) 2008-11-27
WO2007069909A3 (en) 2007-10-18
PL1962912T3 (pl) 2013-03-29
CN101378784A (zh) 2009-03-04
EP1962912A2 (en) 2008-09-03
US9272056B2 (en) 2016-03-01
EP1962912B1 (en) 2012-09-26
WO2007069909A2 (en) 2007-06-21
CN101378784B (zh) 2013-06-12
ES2393750T3 (es) 2012-12-27
JP2009519329A (ja) 2009-05-14

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