CN101366884A - 一种降血脂、降血糖复方制剂的制备工艺 - Google Patents
一种降血脂、降血糖复方制剂的制备工艺 Download PDFInfo
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Abstract
本发明公开一种降血脂、降血糖复方制剂的制备工艺，取人参灭菌，干燥，粉碎得人参粉，备用；将苍术、山楂、泽泻加水冷浸，煎煮，减压浓缩成浓缩液；加乙醇醇沉取上清液，减压回收乙醇，得精制浸膏，加入人参粉和绞股蓝总甙粉，混合，干燥、粉碎，加入乙醇，制软材，干燥造粒，装胶囊。本发明具有制备步骤科学，工艺参数合理，原料有效成分损失小，产量高、质量稳定、成本低。
Description
技术领域
本发明提供一种降低血脂、降血糖复方制剂的制备工艺，属于中医制药技术领域。
背景技术
本发明涉及的“降血脂、降血糖复方制剂”是由苍术10-20份、山楂10-20份、泽泻5-10份、人参1-5份、绞股蓝总甙0.25-2份组成的复方制剂，该复合制剂现有的制备方法简单的粉碎成粉混匀制成胶囊，工艺参数还不够科学，原料有效成分不能得到最大限度的提取，因此，也影响了其使用效果。
发明内容
本发明公开一种降低血脂、降血糖复方制剂的制备工艺，具有工艺参数合理，原料有效成分损失小，生物利用度高的特点。
本发明的制备工艺如下：
1、取人参1-5份，捡去杂质，洗净，80-200℃灭菌5-60min，干燥，粉碎，过40-200目筛，得人参粉，备用；
2、苍术10-20份、山楂10-20份、泽泻5-10份加水冷浸0.5-2小时，煎煮2～4次，每次0.5～2小时，煎液滤过，合并滤液，减压浓缩至相对密度为1-1.30(波美计，30-80℃)，放出，得浓缩液；
3、在步骤2的浓缩液中加乙醇到含醇量10％-95％，静置12小时，取上清液，沉淀用10％-95％乙醇洗二次，溶液并入上清液，上清液减压回收乙醇，得精制浸膏；
4、取步骤3的精制浸膏，加入步骤1的人参粉和0.25-2份绞股蓝总甙粉，混合，在60℃以下减压干燥、粉碎，过40-200目筛，得药粉，加入其10％-30％药粉重量的0％-95％浓度的乙醇，混匀消毒，制软材，过12-18目筛制粒，在60℃以下干燥2-3小时，装胶囊。
功效成分含量：每100g含总皂甙(以人参皂甙Re计)4.5g，总黄酮(以芦丁计)131.5mg。
用法用量：3次/日；0.8～1.2g/次。
本发明的积极效果在于：制备步骤科学，工艺参数合理，原料有效成分损失小，产量高、质量稳定、成本低。
具体实施方式
通过以下实施例进一步举例描述本发明，并不以任何方式限制本发明，在不背离本发明的技术解决方案的前提下，对本发明所作的本领域普通技术人员容易实现的任何改动或改变都将落入本发明的权利要求范围之内。
实施例1
1、取人参30kg，捡去杂质，洗净，置卧式灭菌柜中200℃灭菌60min，取出，干燥，粉碎，过40-200目筛，得人参粉，备用。
2、苍术160kg、山楂160kg、泽泻75kg加水冷浸0.5-2小时，煎煮2次，每次1小时，煎液滤过，合并滤液，减压浓缩至相对密度为1-1.30(波美计，30-80℃)，放出，得浓缩液。
3、在相对密度为1-1.30(波美计，30-80℃)的浓缩液中加乙醇至含醇量75％，静置12小时，取上清液，沉淀用85％乙醇洗二次，溶液并入上清液，上清液减压回收乙醇，得精制浸膏。
4、取精制浸膏，加入步骤1的人参粉和11kg绞股蓝总甙粉，混合，在60℃以下减压干燥、粉碎，过40-200目筛，得药粉，加入30％药粉重量的65％浓度的乙醇，混匀消毒，制软材，过12-18目筛制粒，在60℃以下干燥2-3小时，装胶囊。每100g含总皂甙(以人参皂甙Re计)4.5g，总黄酮(以芦丁计)142.5mg
实施例2
1、取人参1kg，捡去杂质，洗净，置卧式灭菌柜中180℃，灭菌10min，取出，干燥，粉碎，过40-200目筛，得人参粉，备用。
2、苍术10kg、山楂15kg、泽泻5kg加水冷浸0.5-2小时，煎煮4次，每次1小时，煎液滤过，合并滤液，减压浓缩至相对密度为1-1.30(波美计，30-80℃)，放出，得浓缩液。
3、在相对密度为1-1.30(波美计，30-80℃)的浓缩液中加乙醇至含醇量50％，静置12小时，取上清液，沉淀用75％乙醇洗二次，溶液并入上清液，上清液减压回收乙醇，得精制浸膏。
4、取精制浸膏，加入人参粉、1kg绞股蓝总甙粉，混合，在60℃以下减压干燥、粉碎，过40-200目筛，得药粉，加入20％药粉重量的95％浓度的乙醇，混匀消毒，制软材，过12-18目筛制粒，在60℃以下干燥2-3小时，装胶囊。每100g含总皂甙(以人参皂甙Re计)4.9g，总黄酮(以芦丁计)139.5mg。
实施例3
1、取人参5kg，捡去杂质，洗净，置卧式灭菌柜中200℃，灭菌60min，取出，干燥，粉碎，过40-200目筛，得人参粉，备用。
2、苍术20kg、山楂10kg、泽泻10kg加水冷浸2小时，煎煮3次，每次1小时，煎液滤过，合并滤液，减压浓缩至相对密度为1-1.30(波美计，30-80℃)，放出，得浓缩液。
3、在相对密度为1-1.30(波美计，30-80℃)的浓缩液中加乙醇至含醇量85％，静置12小时，取上清液，沉淀用75％乙醇洗二次，溶液并入上清液，上清液减压回收乙醇，得精制浸膏。
4、取精制浸膏，加入人参粉、2kg绞股蓝总甙粉，混合，在60℃以下减压干燥、粉碎，过40-200目筛，得药粉，加入15％药粉重量的水，混匀消毒，制软材，过12-18目筛制粒，在60℃以下干燥2-3小时，装胶囊。每100g含总皂甙(以人参皂甙Re计)4.5g，总黄酮(以芦丁计)131.5mg。
Claims (1)
1.一种降血脂、降血糖复方制剂的制备工艺，其特征在于包括以下步骤：
1)取人参1-5份，于80-200℃灭菌5-60分钟，干燥，粉碎，过40-200目筛；
2)苍术10-20份、山楂10-20份、泽泻5-10份加水冷浸0.5-2小时，煎煮2～4次，每次0.5～2小时，煎液滤过，合并滤液，减压浓缩至相对密度为1-1.30(波美计，30-80℃)，得浓缩液；
3)在步骤2的浓缩液中加乙醇到含醇量10％-95％，静置12小时，取上清液，将沉淀用10％-95％乙醇洗二次，溶液并入上清液，将上清液减压蒸馏，得精制浸膏；
4)取步骤3的精制浸膏，加入步骤1的人参粉和0.25-2份绞股蓝总甙粉，混合，在60℃以下减压干燥、粉碎，过40-200目筛，得药粉，加入其10％-30％药粉重量的0％-95％浓度的乙醇，混匀过12-18目筛制粒，在60℃以下干燥2-3小时，装胶囊。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810051221A CN101366884B (zh) | 2008-09-26 | 2008-09-26 | 一种降血脂、降血糖复方制剂的制备工艺 |
| PCT/CN2009/001065 WO2011011905A1 (zh) | 2008-09-26 | 2009-09-22 | 一种降血脂、降血糖复方制剂的制备工艺 |
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| CN200810051221A CN101366884B (zh) | 2008-09-26 | 2008-09-26 | 一种降血脂、降血糖复方制剂的制备工艺 |
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| CN101366884A true CN101366884A (zh) | 2009-02-18 |
| CN101366884B CN101366884B (zh) | 2010-05-12 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010037256A1 (zh) * | 2008-09-26 | 2010-04-08 | Wang Maoxiang | 降低血脂和血糖的组合物 |
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| CN102526264B (zh) * | 2012-01-04 | 2013-09-18 | 山东省中医药研究院 | 一种具有降血脂功效的中药制剂及其制备方法 |
| CN102600228B (zh) * | 2012-04-10 | 2013-06-12 | 湖南麓山天然植物制药有限公司 | 一种绞股蓝总苷颗粒中绞股蓝总苷的制备方法 |
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| CN1255149C (zh) * | 2004-08-09 | 2006-05-10 | 广东庆发药业有限公司 | 一种药物组合物 |
| CN100484408C (zh) * | 2006-11-24 | 2009-05-06 | 朱迅 | 一种降脂健身茶及其制作方法 |
| CN101366882B (zh) * | 2008-09-26 | 2010-04-21 | 茂祥集团吉林制药有限公司 | 一种具有降低血脂血糖功能的复方制剂 |
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| WO2010037256A1 (zh) * | 2008-09-26 | 2010-04-08 | Wang Maoxiang | 降低血脂和血糖的组合物 |
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