CN101284058A - 一种解酒剂及其制备方法 - Google Patents
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Abstract
本发明公开了一种解酒剂及其制备方法。元宝枫叶经醇提、浓缩、大孔树脂吸附、洗脱、浓缩、干燥、粉碎后制得元宝枫叶提取物。枳椇子经醇提、浓缩、干燥、粉碎后制得枳椇子提取物。将元宝枫叶提取物、枳椇子提取物、葛根粉、山楂粉和VB6混合均匀，即为本发明解酒剂的活性组份。再以常规方法制成口服剂型，即为所需的解酒剂产品。本发明采用药食同源的植物进行组配，含量准确、均衡、没有毒性，可以非常方便的长期食用。具有醒酒，清热解毒、保护肝脏，增强体内微循环的功效，同时可减轻酒后头痛、头晕感觉。能明显降低血液中过高的血脂浓度，可用于动脉硬化、血栓、冠心病等疾病的预防和辅助治疗。
Description
技术领域
本发明属于保健品制备技术领域，具体涉及一种解酒剂及其制备方法。
背景技术
人类饮酒已经有上千年的历史，特别在我国自古就有“无酒不成席”的说法。科学研究表明，适量饮酒能够舒筋活血，对人体有益。但酒精会麻醉神经，酒喝多了会使人神志不清，引起肠胃不适和呕吐，加重肝脏负担，使人性情暴躁、疲劳、多痰、食欲不振和燥热等症状。市场上的解酒剂产品有很多种，虽然也能起到一定的解酒作用，但大多不能长期服用，同时也缺乏对心脑血管疾病的预防和保健作用。
发明内容
本发明的目的在于针对现有技术的不足，提供一种效果显著、由纯植物配制而成的解酒剂。
本发明的目的还在于提供一种制备所述解酒剂的方法。
本发明的解酒剂选择元宝枫、枳椇子、葛根和山楂进行组配，通过他们的协同作用，达到醒酒、清热解毒、保护肝脏和增强体内微循环的功效。其中，元宝枫(Acer Truncatum Bunge)是槭树科槭属(Acer)落叶乔木，因翅果形状酷似中国古代“金锭”而得名。元宝枫叶中富含黄酮、强心甙、单宁、维生素、微量元素、氨基酸等，具有预防和治冠心病，心绞痛、血液循环障碍性疾病及抗病毒，消炎利胆，消除人体自由基等功效。
枳椇子为鼠李科(Rhamnaceae)拐枣属(Hovenia Thunb.)植物枳椇子的干燥成熟种子。在我国枳椇子分布广、资源丰富。枳椇子作为传统中药材应用历史悠久，已被卫生部药品标准收载。属养阴，生津，润燥，止渴，凉血类药物。其功效主要为清热利尿、止渴除烦、解酒毒。用于热病烦渴、呃逆、二便不利、酒精中毒。
葛根为豆科(Leguminasae)属植物葛[PuerariaLobata(Wild.)Ohwi]的根，是一种常用传统中药，是药、食两用的天然植物资源。葛根主要含：葛根素、大豆黄酮、大豆黄酮甙、β谷甾醇等，具有清凉下火，开胃下食，利尿解酒、生津止渴，抗菌解毒的特效，能降低胆固醇和血粘度，抑制血小板聚集，改善微循环的作用；另外葛根含有人体需要的十多种氨基酸和十多种微量元素，其中硒元素含量较高，具有一定的防癌抗癌之功效。
山楂(Crataegus pinnatifide Bunge)为蔷薇科(Rosaceae)山楂属植物山里红的干燥成熟果实；全国各地均有栽培，为药食同源植物。山楂含多种维生素、酒石酸、柠檬酸、山楂酸、苹果酸等，还含有黄酮类、内酯、糖类、蛋白质、脂肪和钙、磷、铁等矿物质；山楂具有消积化滞、收敛止痢、活血化淤等功效。近年来临床常以生山楂用于高血压、冠心病及高脂血症的治疗。
本发明解酒剂的组份用量是经过发明人大量摸索总结得到的，各组份用量在下述重量份范围内都具有较好地效果：
一种解酒剂，其特征在于它的活性成分由下述重量份的原料制成：元宝枫叶10～55份、枳椇子4～30份、葛根2～18份、山楂2～15份和VB61～8份。
将本发明解酒剂的活性组份进一步加入常规辅料，以常规方法制成口服剂型，例如胶囊剂、片剂、冲剂等。
本发明解酒剂的制备方法，包括以下步骤：
1、按所述重量份称取各原料备用；
2、元宝枫叶经醇提、浓缩、大孔树脂吸附、洗脱、浓缩、干燥、粉碎后制得元宝枫叶提取物；
3、枳椇子经醇提、浓缩、干燥、粉碎后制得枳椇子提取物；
4、将葛根、山楂分别粉碎，过200目筛；
5、将元宝枫叶提取物、枳椇子提取物、葛根粉、山楂粉和VB6混合均匀，即为本发明解酒剂的活性组份；
6、进一步加入常规辅料，以常规方法制成口服剂型，例如胶囊剂、片剂、颗粒剂等。
与现有技术相比本发明具有以下优点：
1、本发明解酒剂采用药食同源的植物进行组配，含量准确、均衡、没有毒性，不破坏药理功能，可以非常方便的长期食用；
2、具有醒酒，清热解毒、保护肝脏，增强体内微循环的功效，同时可减轻酒后头痛、头晕感觉；
3、能明显降低血液中过高的血脂浓度，缓解因高血脂引起的高血压、心脑血管疾病及血液循环障碍等疾病，可用于动脉硬化、血栓、冠心病等疾病的预防和辅助治疗。
具体实施方式：
下面结合实施例对本发明作进一步地详细说明，但它们并不是对本发明内容的限定。
实施例1
制备解酒剂，称取元宝枫叶80kg、枳椇子10kg、葛根6kg、山楂5kg和VB6 2kg备用。
将干燥的元宝枫叶粗碎后用720kg含量为50％的乙醇溶液，在温度为60℃下浸提2小时，取浸提液，过滤得滤液A。剩余残渣用400Kg含量为50％的乙醇溶液在温度60℃时再浸提1小时，过滤得滤液B，合并滤液A和B，蒸发回收乙醇。取溶剂油和上述回收乙醇后的水相按1∶1进行萃取2次，萃取后的水相采用大孔树脂充分吸附。将未吸附的水相用去离子水洗去，再用50％的乙醇将吸附物洗脱，收集洗脱液。洗脱液常压蒸发回收乙醇，再减压浓缩至膏状。将膏状物取出进行真空干燥，干燥后的产品经粉碎，过200目分筛，得元宝枫叶提取物。将枳椇子粉碎后用75kg含量为50％的乙醇溶液，在温度为70℃下浸提2小时，过滤得滤液A。剩余枳椇子残渣用50kg含量为50％的乙醇溶液在温度90℃下再浸提1小时，过滤得滤液B。合并滤液A和B，蒸发回收乙醇，进一步浓缩至膏状，将膏状物取出进行真空干燥，干燥后的产品经粉碎，过200目分筛，即得枳椇子提取物。将已切成小块并干燥的葛根加入粉碎机进行粉碎，并通过200目分筛，制得葛根粉。将干燥，无霉烂、颜色正常的山楂加入粉碎机进行粉碎，并通过200目分筛，制成山楂粉。将元宝枫叶提取物、枳椇子提取物、葛根粉、山楂粉和VB6混合均匀。经胶囊灌装机灌装而制得解酒胶囊。每粒胶囊净重0.25g，总黄酮含量不低于20mg。
实施例2
重复实施例1，有以下不同点：称取元宝枫叶100kg、枳椇子50kg、葛根30kg、山楂25kg和VB6 8kg备用。
制备解酒剂，将干燥的元宝枫叶粗碎后用1000kg含量为70％的乙醇溶液，在温度为80℃下浸提4小时，取浸提液，过滤得滤液A。剩余残渣用600Kg含量为70％的乙醇溶液在温度80℃时再浸提2小时，过滤得滤液B，合并滤液A和B，蒸发回收乙醇。取溶剂油和上述回收乙醇后的水相按1∶1进行萃取2次，萃取后的水相采用大孔树脂充分吸附。将未吸附的水相用去离子水洗去，再用80％的乙醇将吸附物洗脱，收集洗脱液。洗脱液常压蒸发回收乙醇，再减压浓缩至膏状。将膏状物取出进行真空干燥，干燥后的产品经粉碎，过200目分筛，得元宝枫叶提取物。将枳椇子粉碎后用300kg含量为50％的乙醇溶液，在温度为90℃下浸提2小时，过滤得滤液A。剩余枳椇子残渣用200kg含量为50％的乙醇溶液在温度90℃下再浸提1小时，过滤得滤液B。合并滤液A和B，蒸发回收乙醇，进一步浓缩至膏状，将膏状物取出进行真空干燥，干燥后的产品经粉碎，过200目分筛，即得枳椇子提取物。将已切成小块并干燥的葛根加入粉碎机进行粉碎，并通过200目分筛，制得葛根粉。将干燥，无霉烂、颜色正常的山楂加入粉碎机进行粉碎，并通过200目分筛，制成山楂粉。将元宝枫叶提取物、枳椇子提取物、葛根粉、山楂粉和VB6混合均匀。经胶囊灌装机灌装而制得解酒胶囊。每粒胶囊净重0.25g，总黄酮含量不低于20mg。
实施例3
重复实施例1，有以下不同点：称取元宝枫叶40kg、枳椇子60kg、葛根10kg、山楂12kg和VB6 5kg备用。
制备解酒剂，将干燥的元宝枫叶粗碎后用600kg含量为80％的乙醇溶液，在温度为80℃下浸提3小时，取浸提液，过滤得滤液A。剩余残渣用300Kg含量为80％的乙醇溶液在温度80℃时再浸提2小时，过滤得滤液B，合并滤液A和B，蒸发回收乙醇。取溶剂油和上述回收乙醇后的水相按1∶1进行萃取2次，萃取后的水相采用大孔树脂充分吸附。将未吸附的水相用去离子水洗去，再用80％的乙醇将吸附物洗脱，收集洗脱液。洗脱液常压蒸发回收乙醇，再减压浓缩至膏状。将膏状物取出进行真空干燥，干燥后的产品经粉碎，过200目分筛，得元宝枫叶提取物。将枳椇子粉碎后用480kg含量为70％的乙醇溶液，在温度为70℃下浸提4小时，过滤得滤液A。剩余枳椇子残渣用300kg含量为70％的乙醇溶液在温度70℃下再浸提2小时，过滤得滤液B。合并滤液A和B，蒸发回收乙醇，进一步浓缩至膏状，将膏状物取出进行真空干燥，干燥后的产品经粉碎，过200目分筛，即得枳椇子提取物。将已切成小块并干燥的葛根加入粉碎机进行粉碎，并通过200目分筛，制得葛根粉。将干燥，无霉烂、颜色正常的山楂加入粉碎机进行粉碎，并通过200目分筛，制成山楂粉。将元宝枫叶提取物、枳椇子提取物、葛根粉、山楂粉和VB6混合均匀。经胶囊灌装机灌装而制得解酒胶囊。每粒胶囊净重0.25g，总黄酮含量不低于20mg。
实施例4
重复实施例1，有以下不同点：选取表面光滑、无霉烂、无破损的葛根用水洗去泥土、沙子等杂质，无需除去表皮。将洗净的葛根块与水按比例1∶3加入碎解机中碎解。碎解机的筛网孔径选取2毫米规格即可。再将90～100目的钢丝筛置于一个干净的池子，在筛内铺上纱布，把浆末盛于纱布上，注入清水，充分搅动，使淀粉随水漏入池内，反复加水，直至淀粉与粉渣分离干净。将淀粉浆用离心机分离，离心机转速为每分钟1000转，离心10分钟即得湿淀粉。湿淀粉在60℃烘干就得到葛根粉。
实施例5
重复实施例1，有以下不同点：添加碳酸钙、可溶性淀粉，与本发明活性成分混合，在≤60℃下烘干后，加入1％硬脂酸镁，混匀，通过压片机压制成片，制得元宝枫解酒片。每粒净重0.20g，总黄酮含量不低于12mg。
实施例6
重复实施例1，有以下不同点：添加1％葡萄糖粉末，与本发明活性成分混合均匀。经灌装机按每袋1.0g灌装而制得解酒冲剂，每袋总黄酮含量不低于60mg。用200～300mL开水冲泡溶解饮用。
Claims (4)
1、一种解酒剂，其特征在于它的活性成分由下述重量份的原料制成：元宝枫叶10～55份、枳椇子4～30份、葛根2～18份、山楂2～15份和VB61～8份。
2、根据权利要求1所述的解酒剂，其特征在于：所述解酒剂的活性组份中进一步加入常规辅料，以常规方法制成口服剂型。
3、根据权利要求2所述的解酒剂，其特征在于：所述的口服剂型为胶囊剂、片剂或冲剂。
4、一种制备权利要求1所述解酒剂的方法，包括以下步骤：
(1)按所述重量份称取各原料备用；
(2)元宝枫叶经醇提、浓缩、大孔树脂吸附、洗脱、浓缩、干燥、粉碎后制得元宝枫叶提取物；
(3)枳椇子经醇提、浓缩、干燥、粉碎后制得枳椇子提取物；
(4)将葛根、山楂分别粉碎，过200目筛；
(5)将元宝枫叶提取物、枳椇子提取物、葛根粉、山楂粉和VB6混合均匀，即为本发明解酒剂的活性组份；
(6)进一步加入常规辅料，以常规方法制成口服剂型。
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349609A (zh) * | 2011-10-27 | 2012-02-15 | 安徽野岭饮料食品有限公司 | 一种亮菌复方解酒饮料 |
| CN102626227A (zh) * | 2012-04-23 | 2012-08-08 | 昆明海之灵生物科技开发有限公司 | 元宝枫黄酮和神经酸软胶囊及其制备方法 |
| CN104105496A (zh) * | 2012-02-10 | 2014-10-15 | 雀巢产品技术援助有限公司 | 山楂和葛及它们对心血管疾病的作用 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349609A (zh) * | 2011-10-27 | 2012-02-15 | 安徽野岭饮料食品有限公司 | 一种亮菌复方解酒饮料 |
| CN104105496A (zh) * | 2012-02-10 | 2014-10-15 | 雀巢产品技术援助有限公司 | 山楂和葛及它们对心血管疾病的作用 |
| CN102626227A (zh) * | 2012-04-23 | 2012-08-08 | 昆明海之灵生物科技开发有限公司 | 元宝枫黄酮和神经酸软胶囊及其制备方法 |
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