CN101366832B - Method for preparing compound cavel capsule - Google Patents
Method for preparing compound cavel capsule Download PDFInfo
- Publication number
- CN101366832B CN101366832B CN2008100130955A CN200810013095A CN101366832B CN 101366832 B CN101366832 B CN 101366832B CN 2008100130955 A CN2008100130955 A CN 2008100130955A CN 200810013095 A CN200810013095 A CN 200810013095A CN 101366832 B CN101366832 B CN 101366832B
- Authority
- CN
- China
- Prior art keywords
- hours
- ethanol
- concentrated
- capsule
- caprae seu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for preparing a compound cavel capsule, which comprises the following steps: the whole cavel is cleaned and is steamed and boiled for sixteen hours by a globe digester, the decoction is performed for three times and the mixture is filtered to obtain the decoction liquid, filtrate is concentrated into thick paste; szechuan lovage rhizome, angelica dahurica, processed radix aconiti are ground into coarse powder, 70 percent ethanol is taken as a solvent, and the dynamic reverse current extraction is performed; the extracting solution is added into the cavel paste, is stirred, is kept stand and is filtered, the filtrate is concentrated into hot stream extract, proper amount of starch is added into the hot stream extract be stirred, the mixture is dried and ground into fine powder and is filled into a capsule; therefore, the product is obtained. The preparation method ensures that the effective components of the medicine are extracted completely; the cavel does not use pang slice, thereby greatly improving the efficiency; in addition, the method is convenient to realize the mass production under the continuous GMP condition. The medicine has the functions of soothing liver and relieving pain and is used for treating migraine, vascular headache, tension headache and neuralgia.
Description
Technical field the present invention relates to a kind of preparation method of Chinese medicine, is a kind of have suppressing the hyperactive liver, analgesia specifically, is used for migraine, vascular headache, and tension headache also can be used for the method for preparing of neuralgic medicine.
Background technology compound cavel capsule primary raw material is a Cornu Caprae seu Ovis, and Cornu Caprae seu Ovis has the rich in natural resources advantage as Inner Mongol special product, and steady quality.At present along with the improving constantly of living standards of the people, the quickening of rhythm of life, the work competition is relatively fiercer, causes migraine, vascular headache, tension headache patient more.Through market survey, the medicine of the treatment migraine of determined curative effect etc. and few as compound cavel capsule so in the market, so have brilliant market developing prospect.
The former method for distilling of compound cavel capsule be Cornu Caprae seu Ovis pound sheet or make smooth with a file broken, the decocte with water secondary, filtrating is condensed into thick paste.Cornu Caprae seu Ovis is a cutin, and matter is hard, also is not fit to cut at present the machinery of Cornu Caprae seu Ovis, and the pound sheet is generally used manual work, time-consuming, effort, and efficient is very low, is not suitable for large-scale production under the seriality GMP condition, and its effective ingredient retention rate is lower; Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Aconiti Preparata three flavors are ground into coarse powder, according to the percolation under fluid extract and the extractum item, make solvent with ethanol, carry out percolation behind the dipping, and this method extraction time is longer, and is big with quantity of solvent.
Summary of the invention the object of the present invention is to provide a kind of method for preparing of compound cavel capsule, and this method makes the effective ingredient retention rate height of medicine and is convenient to large-scale production under the seriality GMP condition.
The method for preparing of this medicine is as follows:
1, soaks into raw material: will pass through selection, wash Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the Radix Aconiti Preparata cut and feed intake, and place in the container, and prepare against countercurrent extraction with 70% ethanol infiltration 48 hours by prescription;
2, countercurrent extraction: the medical material that above-mentioned infiltration is good, carry out contrary carrying with the countercurrent extraction unit, at first in extraction pot, add 70% ethanol to liquid outlet lower edge before the driving; Open the feeding machine charging,, open and extract the unit motor when expecting when reaching extraction pot; Reductor is controlled at lowest speed extracts, when medical material through extraction pot when slag-drip opening is slagged tap, open spinner flowmeter; Flow speed control was at 1-1.5Kg/ minute; Regulate storage tank valve on all, make each jar advance to annotate ethanol speed and be consistent, adverse current is carried ethanol liquid and in automatic pump is squeezed into receiver, was left standstill 8 hours;
3, the extraction of Cornu Caprae seu Ovis: by recipe quantity requirement weighting raw materials Cornu Caprae seu Ovis, be placed in the rotary drum and cleaned 48 hours, the flush away blood stains, in the rustless steel rotary spherical digester of packing into then, decocte with water three times, the decocting that adds 6 times of amounts for the first time boiled 16 hours; The decocting that adds for the second time 6 times of amounts boiled 16 hours; The decocting that adds 6 times of amounts for the third time boiled 16 hours; Steam pressure is controlled at 0.2-0.25MPa, and extracting solution is got supernatant and begun to concentrate after filtration is left standstill 8 hours, and steam pressure is controlled at 0.05-0.15MPa when concentrating, and temperature 75-85 ℃, being concentrated into relative density is 1.14-1.18 (45 ℃);
4, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Aconiti Preparata countercurrent extraction liquid are added in the Cornu Caprae seu Ovis cream: the ethanol liquid of above-mentioned countercurrent extraction is joined in the Alcohol-settling tank, add the load weighted Cornu Caprae seu Ovis hot-fluid extractum in concentrated back again, the limit edged stirs; After treating the dissolving evenly of Cornu Caprae seu Ovis cream; Left standstill 24 hours, and extracted the ethanol supernatant that leaves standstill, reclaim concentrated; Thickening temperature is 45--50 ℃, and steam pressure is 0.05-0.15Mpa; When being concentrated into relative density to 1.27-1.31 (80 ℃), receive cream; Stir after adding starch, in the stainless steel disc of packing into, thickness is that 2-3cm carries out drying under reduced pressure; Temperature is 70--90 ℃, and steam pressure is 0.04-0.08MPa, and dried cream is pulverized; The dry extract that crushes is mixed, and mix homogeneously carries out capsule charge and promptly gets product.
The invention has the advantages that: 1, this method is to be made up of the new technique that Continuous Countercurrent Extraction, rustless steel rotary spherical digester extract; The Continuous Countercurrent Extraction unit is a kind of brand-new dynamic extraction equipment that active ingredient in the crude drug is leached; Continuous flow upstream technology is that medical material is from going up most a jar automatic ration input; Solvent is then injected by next jar slowly, promotes down at power set, and opposite continuous flow upstream leaching process is moved towards in leachate and medical material formation.Utilize Continuous Countercurrent Extraction unit Concentraton gradient big, have relative velocity motion between the solvent medical material, diffusion boundary layer is thin and upgrade fast principle, has accelerated leaching velocity, and this method is than percolation, makes the more complete of extracts active ingredients in the medical material, and is not destroyed.Continuous flow upstream leachate volume is little, reduces investment outlay, and treating capacity was little when back operation concentrated, and improves work efficiency, and is energy-conservation, also saves solvent cost.
2, package unit belongs to closed system, and both suitable volatility organic solvent leaches, and also being fit to water is solvent extraction, clean health, and reinforced and deslagging is all accomplished automatically, and is easy to operate.Can internal components be extracted out during cleaning and thoroughly carry out GMP compatible.
3, the principal agent Cornu Caprae seu Ovis in these article prescriptions need not the pound sheet, adopts the rustless steel rotary spherical digester that whole Cornu Caprae seu Ovis is carried out steaming and decocting, shortens man-hour greatly, increases work efficiency; Make the more complete of extracts active ingredients in the Cornu Caprae seu Ovis.4, the said method operating process is simple, is convenient to large-scale production under the seriality GMP condition.
Table 1 manufacture method of the present invention and technology is the paste-forming rate comparison sheet before changing
Visible by table 1; Each batch of paste-forming rate of this method Cornu Caprae seu Ovis all increases; And by the drug standard YBZ07612005 of State Food and Drug Administration check, the nitrogen content of compound cavel capsule increases than technology before changing, and this explanation is more complete with the Cornu Caprae seu Ovis that rotary spherical digester extracts; The medicine active ingredient that same this method for preparing of prescription is extracted is high, good drug efficacy.The alcoholic solution of using when said extracted liquid is Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Aconiti Preparata countercurrent extraction, the extracting solution comparison is practiced thrift solvent according to reducing 1/20, reduces cost.
Compound cavel capsule Pharmacodynamic test of active extract result with this method production:
1, the sedation of compound cavel capsule
1.1 influence to the mice autonomic activities:
Get 100 of healthy mices, be divided into 5 groups at random, 20 every group, male and female half and half.Irritate stomach compound cavel capsule 1.0,2.5,5.0g/kg, chlorpromazine 5mg/kg respectively, once a day, successive administration three days, matched group gives with the volume normal saline.After the last administration 40 minutes, mice is put into photoelectricity activity inventory appearance successively, write down 10 minutes movable number of times of mice.The result sees table 2
Table 2 compound cavel capsule is to the influence of mice autonomic activities
Annotate: compare with normal saline: * P 0.05, * * P < 0.01
Table 2 shows compound cavel capsule 2.5g/kg, and 5.0g/kg and chlorpromazine seemingly all can obviously resist mice autonomic activities number of times.
1.2 the sub-threshold dose pentobarbital sodium is caused the influence that mice is sleeping:
Get 100 of healthy mices, be divided into 5 groups at random, 20 every group, male and female half and half.Medication is with 1.1.40 minutes difference lumbar injection pentobarbital sodium 25mg/kg after the last administration, with the index of sleeping more than the righting reflex loss 1min, the sleeping number of the interior mice of observed and recorded 15min calculates and respectively organizes sleeping rate and with X 2 test sleeping rate between group is carried out significance test.Result such as table 3.
Table 3 compound cavel capsule causes the influence that mice is sleeping to the sub-threshold dose pentobarbital sodium
Annotate: compare with normal saline: * P 0.05, * * P < 0.01
Table 3 result shows that compound cavel capsule and pentobarbital sodium have synergism, and sedation is obvious.
2, the analgesic activity of compound cavel capsule:
2.1 electricity irritation is caused the influence of mice pain:
Mouse tail is coated with conducting resinl after removing sebum with 75% ethanol; The part is the constant stimulus electrode again, carries out square wave stimulation (voltage 10V, frequency 1Hz with pharmacology physiology is many with appearance; The wide 10ms of ripple); Continued stimulus 3 times, each 5min at interval all shouts for three times, responder such as abnormal movement is qualified mice.During experiment 100 of qualified mices are divided into 5 groups at random by body weight, sex, 20 every group, male and female half and half; Irritate stomach compound cavel capsule 1.0,2.5,5.0g/kg, indometacin 50mg/kg respectively; The normal saline group gives with the volume normal saline, once a day, and successive administration three days.In the last administration after 40 minutes, repetitive nerve stimulation, stimulus parameter is the same.Double nonresponder representes that analgesic effect is arranged.Analgesia number according to each group calculates the analgesia rate.The result sees table 4.
Table 4 compound cavel capsule causes the influence of mice pain to electricity irritation
Annotate: compare with normal saline: * P 0.05, * * P < 0.01
Table 4 result shows compound cavel capsule 2.5g/kg, and 50mg/kg has stronger analgesic activity to the mice pain that electricity irritation causes.
2.2 Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction:
50 of mices are divided into 5 groups at random, and 10 every group, male and female half and half, medication is with 2.1.Only inject 0.6% acetic acid 0.2ml/ in 40 minutes pneumoretroperitoneums of last administration, mouse writhing reaction times in the observed and recorded 30min, detailed results is seen table 5.
Table 5 compound cavel capsule Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction
Annotate: compare with normal saline: * * P < 0.01
Table 5 is the result show, compound cavel capsule 5.0g/kg and indometacin 50mg/kg irritate stomach and give all can significantly reduce acetic acid induced mice writhing response number of times, with normal saline group comparing difference highly significant.
3, compound cavel capsule improves periphery and meninges microcirculation
3.1 to the microcirculatory influence of mouse ear
Mice pentobarbital sodium 40mg/kg intraperitoneal injection of anesthesia; Gently draw with the light towel of adhesive plaster and to remove the auricle hair; With being fixed on the object stage after the auricle flattening; Drip a little liquid paraffin again on ear surface, intravenously administrable is observed the variation of vascular venous administration front and back, same position color, VPV and blood capillary opening amount (point of intersect of the capillary network counting) with magnifier (40 times) printing opacity after 30 minutes.Its influence to the point of intersect of the capillary network number sees table 6 for details.
Table 6 compound cavel capsule is to the influence of the open number of Mice Auricle blood capillary
Annotate: compare * P < 0.05 before and after the self administration
Table 6 is the result show, the blood vessel color reddens after the administration, the caliber chap, and blood flow obviously quickens, and the open quantity showed increased of blood capillary has the obvious auricular microcirculation effect that improves.
3.2 influence to rabbit pia mater encephali microcirculation disturbance:
5 pentobarbital sodium 45mg/kg anesthesia of rabbit back row skull windowing carefully exposes pia mater encephali and the microcirculatory situation of change of pia mater encephali before and after high voltage mercury lamp throws following 40 times of magnifieres observation intravenously administrable.The result shows, 5 rabbit auricular veins are injected respectively behind the 10% high molecular dextran 10ml/kg and VPV all to be occurred in about 15 minutes and significantly slow down microcirculation disturbance such as small thrombosis.Fluidised form was not seen change after vein injected normal saline 2ml/kg; And about 5 minutes fluidised forms are promptly significantly improved after injecting compound cavel capsule 0.1g/kg; Become line grain stream by grain stream, even return to normal linear flow, flow velocity is obviously accelerated; The number of hits of capillary network also obviously increases, and blood vessel darker in color redness becomes cerise in the visual field.The above results shows that compound cavel capsule improves significantly to the microcirculation disturbance tool of rabbit meninges.
Pharmacodynamic test of active extract result shows: compound cavel capsule has sedation preferably, obviously reduces mice autonomic activities number of times, significantly increases the sleeping rate that the sub-threshold dose pentobarbital sodium causes mice; This medical instrument has stronger analgesic activity, can resist the pain reaction of electricity irritation induced mice, reduces acetic acid and causes the writhing response number of times of mice.Compound cavel capsule also has the periphery of improvement and meninges microcirculation in addition, increases Mice Auricle portion point of intersect of the capillary network number, accelerates VPV, improves the Leptomeningeal microcirculation disturbance of rabbit that high molecular dextran causes.Above-mentioned test is that compound cavel capsule clinical treatment migraine, angioneurotic headache, tension headache and nervous headache provide certain experimental basis.
The specific embodiment
Embodiment 1: the method for preparing of this medicine as follows:
1, soaks into raw material: will pass through selection, wash Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the Radix Aconiti Preparata cut and feed intake, and be transported on the operating board, and place in the square groove, and prepare against countercurrent extraction with 70% ethanol infiltration 48 hours with elevator by prescription;
2, countercurrent extraction: the medical material that above-mentioned infiltration is good, carry out contrary carrying with the countercurrent extraction unit, at first in three groups of extraction pot, add 70% ethanol to liquid outlet lower edge before the driving; Open the feeding machine charging, open this unit motor when reaching extraction pot when expecting; Reductor is controlled at lowest speed extracts, when medical material through three groups of extraction pot when slag-drip opening is slagged tap, open spinner flowmeter; Flow speed control was at 1-1.5Kg/ minute; Regulate storage tank valve on all, make each jar advance to annotate ethanol speed and be consistent, adverse current is carried ethanol liquid and in automatic pump is squeezed into receiver, was left standstill 8 hours;
3, the extraction of Cornu Caprae seu Ovis: by recipe quantity requirement weighting raw materials Cornu Caprae seu Ovis, be placed in the rotary drum and cleaned 48 hours, the flush away blood stains, in the rustless steel rotary spherical digester of packing into then, decocte with water three times, the decocting that adds 6 times of amounts for the first time boiled 16 hours; The decocting that adds for the second time 6 times of amounts boiled 16 hours; The decocting that adds 6 times of amounts for the third time boiled 16 hours; Steam pressure is controlled at 0.2-0.25MPa, and extracting solution is got supernatant and begun to concentrate after filtration is left standstill 8 hours, and steam pressure is controlled at 0.05-0.15MPa when concentrating, and temperature 75-85 ℃, measures when being concentrated into relative density and being 1.14-1.18,45 ℃;
4, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Aconiti Preparata countercurrent extraction liquid are added in the Cornu Caprae seu Ovis cream: the ethanol liquid of above-mentioned countercurrent extraction is joined in the Alcohol-settling tank, add the load weighted Cornu Caprae seu Ovis hot-fluid extractum in concentrated back again, the limit edged stirs; After treating the dissolving evenly of Cornu Caprae seu Ovis cream; Left standstill 24 hours, and extracted the ethanol supernatant that leaves standstill, reclaim concentrated; Thickening temperature is 45--50 ℃, and steam pressure is 0.05-0.15Mpa; When being concentrated into relative density to 1.27-1.31 (80 ℃ of mensuration of temperature), receive cream; Stir after adding starch, in the stainless steel disc of packing into, thickness is that 2-3cm carries out drying under reduced pressure; Temperature is 70--90 ℃, and steam pressure is 0.04-0.08MPa, and dried cream is pulverized; The dry extract that crushes is mixed, and mix homogeneously carries out capsule charge and promptly gets product.
Claims (1)
1. the method for preparing of a compound cavel capsule, it is characterized in that: it is made up of following steps:
(1) soaks into raw material: will pass through selection, wash Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the Radix Aconiti Preparata cut and feed intake, and place in the container, and prepare against countercurrent extraction with 70% ethanol infiltration 48 hours by prescription;
(2) countercurrent extraction: the medical material that above-mentioned infiltration is good, carry out contrary carrying with the countercurrent extraction unit, at first in extraction pot, add 70% ethanol to liquid outlet lower edge before the driving; Open the feeding machine charging,, open and extract the unit motor when expecting when reaching extraction pot; Reductor is controlled at lowest speed extracts, when medical material through extraction pot when slag-drip opening is slagged tap, open spinner flowmeter; Flow speed control was at 1-1.5Kg/ minute; Regulate storage tank valve on all, make each jar advance to annotate ethanol speed and be consistent, adverse current is carried ethanol liquid and in automatic pump is squeezed into receiver, was left standstill 8 hours;
(3) extraction of Cornu Caprae seu Ovis: by prescription weighting raw materials Cornu Caprae seu Ovis, be placed in the rotary drum and cleaned 48 hours, the flush away blood stains, in the rustless steel rotary spherical digester of packing into then, decocte with water three times, the decocting that adds 6 times of amounts for the first time boiled 16 hours; The decocting that adds for the second time 6 times of amounts boiled 16 hours; The decocting that adds 6 times of amounts for the third time boiled 16 hours; Steam pressure is controlled at 0.2-0.25MPa, and extracting solution is got supernatant and begun to concentrate after filtration is left standstill 8 hours, and steam pressure is controlled at 0.05-0.15MPa when concentrating, and temperature 75-85 ℃, being concentrated into and surveying relative density at 45 ℃ is 1.14-1.18;
(4) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Aconiti Preparata countercurrent extraction liquid are added in the Cornu Caprae seu Ovis cream: the ethanol liquid of above-mentioned countercurrent extraction is joined in the Alcohol-settling tank, add the load weighted Cornu Caprae seu Ovis hot-fluid extractum in concentrated back again, the limit edged stirs; After treating the dissolving evenly of Cornu Caprae seu Ovis cream; Left standstill 24 hours, and extracted the ethanol supernatant that leaves standstill, reclaim concentrated; Thickening temperature is 45-50 ℃, and steam pressure is 0.05-0.15Mpa; Be concentrated into when surveying relative density to 1.27-1.31 for 80 ℃, receive cream; Stir after adding starch, in the stainless steel disc of packing into, thickness is that 2-3cm carries out drying under reduced pressure; Temperature is 70-90 ℃, and steam pressure is 0.04-0.08MPa, and dried cream is pulverized; The dry extract that crushes is mixed, and mix homogeneously carries out capsule charge and promptly gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100130955A CN101366832B (en) | 2008-08-31 | 2008-08-31 | Method for preparing compound cavel capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100130955A CN101366832B (en) | 2008-08-31 | 2008-08-31 | Method for preparing compound cavel capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101366832A CN101366832A (en) | 2009-02-18 |
| CN101366832B true CN101366832B (en) | 2012-03-28 |
Family
ID=40410924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100130955A Active CN101366832B (en) | 2008-08-31 | 2008-08-31 | Method for preparing compound cavel capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101366832B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857347A (en) * | 2006-04-13 | 2006-11-08 | 贵州信邦制药股份有限公司 | Compound yam's horn soft capsule for Chinese medicine and its preparing method |
-
2008
- 2008-08-31 CN CN2008100130955A patent/CN101366832B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857347A (en) * | 2006-04-13 | 2006-11-08 | 贵州信邦制药股份有限公司 | Compound yam's horn soft capsule for Chinese medicine and its preparing method |
Non-Patent Citations (1)
| Title |
|---|
| 刘伟等."复方羊角胶囊治疗头痛100例临床疗效观察".《陕西中医学院学报》.2002,第25卷(第4期),21-23. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101366832A (en) | 2009-02-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102827750A (en) | Maca health care liquor for improving organism immunity and sexuality | |
| CN105194083B (en) | A kind of strengthen immunity and anti-radiation medicine composite and preparation method thereof | |
| US10772932B2 (en) | Medicament for use in treating cardiovascular and cerebrovascular diseases | |
| CN102631424A (en) | Compound traditional Chinese medicinal extract with anti-hair loss function and preparation method and applications thereof | |
| CN106244371A (en) | A kind of blood sugar lowering Rhizoma Polygonati grape health care wine and production technology thereof | |
| CN102703271A (en) | Formula of grape medicinal liquor and preparation method thereof | |
| CN102283913B (en) | Radix aconiti carmichaeli extract and application thereof | |
| CN104666643B (en) | A kind of compound snow chrysanthemum product and its preparation method and application | |
| CN108066501B (en) | Agilawood extract with blood sugar reducing effect and application thereof | |
| CN103462855B (en) | Cosmetic containing American ginseng and longan and preparation method thereof | |
| CN108434191A (en) | A kind of composition and preparation method thereof with effects of losing weight and lowering blood sugar and blood lipid | |
| CN101693866A (en) | Antler blood wine and processing method thereof | |
| CN101366832B (en) | Method for preparing compound cavel capsule | |
| CN103584095B (en) | Treat hypertensive health beverages and preparation method thereof | |
| CN101138399A (en) | Schisandra chinensis and honey composition and method of making the same | |
| CN105725209A (en) | Dendrobium officinale granules and preparation method thereof | |
| CN108403542A (en) | One kind is compacted massage oil and preparation method thereof | |
| CN101612353B (en) | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases and method for preparing same | |
| CN103937650B (en) | A kind of aweto health-care wine and manufacture method thereof | |
| CN103525640B (en) | Energy-keeping yang-tonifying wine | |
| CN112168848A (en) | Preparation method and application of salicornia herbacea blood sugar reducing component | |
| CN102119952A (en) | Ultrasonic extraction preparation method of Chinese traditional medicine preparation for treating lumbago due to kidney deficiency | |
| CN102120000B (en) | Composition of effective parts of traditional Chinese medicine preparation for resisting Coxsackie virus B and preparation method thereof | |
| CN108853464A (en) | A kind of preparation method of ginkgo-leaf oral liquor | |
| KR20130074120A (en) | Ginseng prosapogenin high concentration containing ginseng flower preparation using sonication and process for thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: JINGFUKANG PHARMACEUTICAL GROUP CHIFENG DANLONG PH Free format text: FORMER NAME: CHIFENG DANLONG PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 024000, No. eight, Spark Road, Hongshan District, Hongshan District, the Inner Mongolia Autonomous Region, Chifeng Patentee after: JINGFUKANG PHARMACEUTICAL GROUP CHIFENG DANLONG PHARMACEUTICAL CO., LTD. Address before: 024000, No. eight, Spark Road, Hongshan District, Hongshan District, the Inner Mongolia Autonomous Region, Chifeng Patentee before: Chifeng Danlong Pharmaceutical Co., Ltd. |