CN1857347A - Compound yam's horn soft capsule for Chinese medicine and its preparing method - Google Patents
Compound yam's horn soft capsule for Chinese medicine and its preparing method Download PDFInfo
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- CN1857347A CN1857347A CNA2006100728601A CN200610072860A CN1857347A CN 1857347 A CN1857347 A CN 1857347A CN A2006100728601 A CNA2006100728601 A CN A2006100728601A CN 200610072860 A CN200610072860 A CN 200610072860A CN 1857347 A CN1857347 A CN 1857347A
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- caprae seu
- seu ovis
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Abstract
The present invention belongs to the field of medicine technology, and is one kind of compound ram's horn soft and its preparation process. The compound ram's horn soft is used in treating hemicrania, vascular headache and neuralgia.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of migraine that is used for, vascular headache also can be used for neuralgic compound Chinese medicinal preparation and preparation method thereof.
Background technology:
Headache is one of common symptom of Neurology Department, the pathogeny complexity that has.Generally except that headache due to the organic disease, belong to function of nervous system's headache, the clinical obvious cause that can not find, and treatment difficulty comparatively more.Especially see with migraine and tension headache more, along with the fierceness of social competition in recent years, the quickening of rhythm, the sickness rate of headache has the trend that increases year by year, yet causes that the cause of disease of headache is more, especially migrainous pathogenesis complexity, though it is various to be used for clinical types of drugs, but these medicines mostly are the Western medicine analgesics, and are often big because of DeGrain or side effect, late result difference etc. and limited.Motherland's medical science is thought due to the many genus of the headache endogenous wind blood deficiency, and compound cavel capsule adopts QINGYANGJIAO, blood-activating analgesics such as compatibility Rhizoma Chuanxiong, Radix Aconiti have that suppressing the hyperactive liver dispels the wind, the effect of promoting blood circulation and stopping pain, verify through the pharmacology, but microcirculation improvement, the cerebral blood flow increasing amount suppresses thromboxane A and the concentration that increases prostacyclin, alleviates the outer edema of brain, can act on and a plurality of links such as relevant blood vessel and neurogenic inflammation of having a headache, therefore various headaches all be had significant curative effect.
The compound cavel soft capsule was granule originally, and specification is every bag of 8g, and volume is taken inconvenience more greatly, make soft capsule into after finished product single dose volume reduce.Simultaneously it possesses solid preparation again and is easy to carry advantages such as storage.
Summary of the invention:
The invention provides a kind of migraine that is used for, vascular headache also can be used for neuralgic compound Chinese medicinal preparation and preparation method thereof.
Compound Chinese medicinal preparation provided by the invention, it is characterized in that, calculate according to composition by weight, make by the raw material of Chinese medicine and the adjuvant of following weight parts: 987 parts on Cornu Caprae seu Ovis, 329 parts of Rhizoma Chuanxiongs, 329 parts of the Radixs Angelicae Dahuricae, 247 parts of Radix Aconiti Preparatas, soybean oil 400-500 part, Cera Flava 10-15 part, lecithin 5-12 part
Pharmaceutical preparation provided by the invention is soft capsule.
Pharmaceutical preparation provided by the invention, its preparation method is: with above-mentioned four Chinese medicine material, get 987 parts of Cornu Caprae seu Ovis pound sheets, decoct with water secondary, amount of water is 2～8 times of amounts, each 3 hours, collecting decoction, filter, filtrate is concentrated into 197ml, adds ethanol 985ml, stir, left standstill 24 hours, and got supernatant, standby.329 parts of all the other Rhizoma Chuanxiongs, 329 parts of the Radixs Angelicae Dahuricae, 247 part of three flavor of Radix Aconiti Preparata pulverizing medicinal materials become coarse powder, according to the percolation under fluid extract and the fluid extract item.(appendix I0 of Chinese Pharmacopoeia version in 2000), make solvent with 70% ethanol, collect percolate 6335ml, percolate and Cornu Caprae seu Ovis supernatant merge, decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (80～85 ℃), drying under reduced pressure is ground into fine powder, sieves, mixing, add 430 parts of soybean oils, 12.5 parts in Cera Flava, 7.5 parts in lecithin, mix homogeneously, compacting soft capsule.Soft capsule shell provided by the invention has gelatin, plasticizer, water three to constitute, and its ratio is dry gelatin: dried plasticizer: water=1: 0.4～0.6: 1.Wherein plasticizer has glycerol, Macrogol 200, PEG400, propylene glycol, sorbitol, Oleum Ricini, acetylation monoglyceride, phthalic acid esters etc.
The specific embodiment:
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment:
The preparation method of soft capsule of the present invention:
Cornu Caprae seu Ovis 987g Rhizoma Chuanxiong 329g
Radix Angelicae Dahuricae 329g Radix Aconiti Preparata 247g
Soybean oil 430g Cera Flava 12.5g lecithin 7.5g
Gelatin 150g glycerol 70g water 150g
Make 1000
Preparation method: with above-mentioned four Chinese medicine material, get Cornu Caprae seu Ovis pound sheet 987g, decoct with water secondary, each 3 hours, amount of water was respectively 6 times of amounts, 4 times of amounts, collecting decoction filters, and filtrate is concentrated into 197ml, adds ethanol 985ml, stir, left standstill 24 hours, get supernatant, standby.All the other Rhizoma Chuanxiong 329g, Radix Angelicae Dahuricae 329g, Radix Aconiti Preparata 247g three flavor pulverizing medicinal materials become coarse powder, according to the percolation under fluid extract and the fluid extract item.(appendix I0 of Chinese Pharmacopoeia version in 2000) makes solvent with 70% ethanol, collects percolate 6335ml, percolate and Cornu Caprae seu Ovis supernatant merge, and decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (80～85 ℃), drying under reduced pressure, be ground into fine powder, sieve, mixing, add soybean oil 430g, Cera Flava 12.5g, lecithin 7.5g, mix homogeneously, compacting soft capsule, make 1000 (every dress 0.70g), drying, packing, promptly.
Claims (4)
1, a kind of migraine that is used for, vascular headache, also can be used for neuralgic compound Chinese medicinal preparation, it is characterized in that: calculate according to composition by weight, make by the raw material of Chinese medicine and the adjuvant of following weight parts: 987 parts on Cornu Caprae seu Ovis, 329 parts of Rhizoma Chuanxiongs, 329 parts of the Radixs Angelicae Dahuricae, 247 parts of Radix Aconiti Preparatas, soybean oil 400-500 part, Cera Flava 10-15 part, lecithin 5-12 part.
2, according to the compound Chinese medicinal preparation of claim 1, be soft capsule, it is characterized in that: 987 parts on Cornu Caprae seu Ovis, 329 parts of Rhizoma Chuanxiongs, 329 parts of the Radixs Angelicae Dahuricae, 247 parts of Radix Aconiti Preparatas, soybean oil 400-500 part, Cera Flava 10-15 part, lecithin 5-12 part are prepared from.
3, the preparation method of the compound Chinese medicinal preparation of claim 1 is characterized in that: with above-mentioned four Chinese medicine material, get 987 parts of Cornu Caprae seu Ovis pound sheets, decoct with water secondary, amount of water is 2～8 times of amounts, each 3 hours, collecting decoction, filter, filtrate is concentrated into 197ml, adds ethanol 985ml, stir, left standstill 24 hours, and got supernatant, standby.329 parts of all the other Rhizoma Chuanxiongs, 329 parts of the Radixs Angelicae Dahuricae, 247 part of three flavor of Radix Aconiti Preparata pulverizing medicinal materials become coarse powder, according to the percolation under fluid extract and the fluid extract item.(appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 70% ethanol, collect percolate 6335ml, percolate and Cornu Caprae seu Ovis supernatant merge, decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (80～85 ℃), drying under reduced pressure is ground into fine powder, sieves, mixing, add 430 parts of soybean oils, 12.5 parts in Cera Flava, 7.5 parts in lecithin, mix homogeneously, compacting soft capsule.
4, according to the preparation method of the described compound Chinese medicinal preparation of claim 3, it is characterized in that:, get Cornu Caprae seu Ovis pound sheet 987g with above-mentioned four Chinese medicine material, decoct with water secondary, amount of water is 2～8 times of amounts, each 3 hours, collecting decoction, filter, filtrate is concentrated into 197ml, adds ethanol 985ml, stir, left standstill 24 hours, and got supernatant, standby.All the other Rhizoma Chuanxiong 329g, Radix Angelicae Dahuricae 329g, Radix Aconiti Preparata 247g three flavor pulverizing medicinal materials become coarse powder, according to the percolation under fluid extract and the fluid extract item.(appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 70% ethanol, collect percolate 6335ml, percolate and Cornu Caprae seu Ovis supernatant merge, decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (80～85 ℃), drying under reduced pressure is ground into fine powder, sieves, mixing, add soybean oil 430g, Cera Flava 12.5g, lecithin 7.5g, mix homogeneously, compacting soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100728601A CN1857347A (en) | 2006-04-13 | 2006-04-13 | Compound yam's horn soft capsule for Chinese medicine and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100728601A CN1857347A (en) | 2006-04-13 | 2006-04-13 | Compound yam's horn soft capsule for Chinese medicine and its preparing method |
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| Publication Number | Publication Date |
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| CN1857347A true CN1857347A (en) | 2006-11-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006100728601A Pending CN1857347A (en) | 2006-04-13 | 2006-04-13 | Compound yam's horn soft capsule for Chinese medicine and its preparing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366832B (en) * | 2008-08-31 | 2012-03-28 | 赤峰丹龙药业有限公司 | Method for preparing compound cavel capsule |
-
2006
- 2006-04-13 CN CNA2006100728601A patent/CN1857347A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366832B (en) * | 2008-08-31 | 2012-03-28 | 赤峰丹龙药业有限公司 | Method for preparing compound cavel capsule |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |