CN105194083B - A kind of strengthen immunity and anti-radiation medicine composite and preparation method thereof - Google Patents
A kind of strengthen immunity and anti-radiation medicine composite and preparation method thereof Download PDFInfo
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- CN105194083B CN105194083B CN201510603949.5A CN201510603949A CN105194083B CN 105194083 B CN105194083 B CN 105194083B CN 201510603949 A CN201510603949 A CN 201510603949A CN 105194083 B CN105194083 B CN 105194083B
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Abstract
The present invention relates to a kind of strengthen immunity and anti-radiation medicine composites and preparation method thereof, belong to the field of Chinese medicines.It is made from the following raw materials in parts by weight: 20-40 parts of ginseng, 20-40 parts of wilsonii, 15-25 parts of fructus lycii, 15-25 parts of root of kirilow rhodiola.The present invention has tonifying middle-Jiao and Qi, the effect of strong liver kidney, benefiting essence-blood, can be improved or improve raying crowd immunity of organisms and anti-radiation, anti-aging ability, and the harm of various radiation can be prevented, also can be used as the adjuvant radiotherapy pharmaceutical preparation of tumor patient.
Description
Technical field
The invention belongs to the field of Chinese medicines, a kind of strengthen immunity and anti-radiation medicine composite and its preparation are referred in particular to
Method.
Background technique
As people's living standard improves, work rhythm is accelerated, daily all facing to various electronic equipments, as hand is mechanical, electrical
The various ionising radiations such as brain and electromagnetic radiation constitute new threat to the living environment of people: the electricity issued such as computer monitor
Magnetic radiation long term can endocrine to women and Reproductive Performance generate adverse effect, electromagnetic radiation induced leukemia of children
Possibility also increasingly causes concern etc..Furthermore pressure is big in terms of Working Life, and living irregular etc. causes people to locate for a long time
In sub-health state, it is low body immunity occur, immunocyte decline, resistance difference easy catching a cold, whole body fatiguability out of strength etc.
Symptom.
The various product fish mesh for adjusting immunity currently on the market mix, such as ginseng royal jelly, American Ginseng piece, these
Many drawbacks such as product is single there is acting on, and effect is not significant, expensive, and side effect is obvious.
In addition, traditional extracting method such as infusion process, water extraction, organic solvent extractionprocess etc., time-consuming, toxicity are big, are lost
Greatly, at high cost, inflammable and explosive, there are the shortcomings such as environmental pollution is serious, to solve the above problems, the present invention is using high electricity
It presses impulse electric field rapidly extracting technology (high-voltage pulsed electric field, HPEF), it is generally acknowledged using its
Domestic and international state-of-the-art cell membrane disruption technology applies electric field in the cell membrane surface of medicinal material, eventually leads to cell membrane and generate machine
Tool, irreversible electroporation, flows out cellular component, is a kind of novel to complete the extraction to medicinal material effective component
Energy conservation, sterilizing and substance extracting method efficiently, environmentally friendly.
The basic principle of ultra high pressure extraction (ultra-high pressure extraction technology, UHPE)
It is under normal temperature conditions, to apply the hydrostatic pressure of 100~1000MPa, pressure maintaining rapid removal pressure after a certain period of time to material liquid
Power, and then complete entire extraction process.Solvent may penetrate into inside solid material under super-pressure effect, make effective in raw material
Ingredient dissolves in a solvent, keeps certain time under a predetermined, rapid release, In after so that effective component is reached dissolution equilibrium
Under the action of intraor extracellular osmotic pressure difference, cellular content and Extraction solvent is promoted to come into full contact with, effective component can expand rapidly
It is scattered in the Extraction solvent around tissue, with traditional solvent extraction, circumfluence distillation, ultrasonic extraction, microwave loss mechanisms, super
The methods of supercritical fluid extraction method is compared, and ultra high pressure extraction technology is with quick, efficient, extraction time is short, effective component is extracted
The advantages that change of effective component structure, loss and physiological activity caused by rate height and avoidable fuel factor reduce, simultaneously because
Ultra high pressure extraction is carried out in closed environment, is volatilized without solvent, not will cause environmental pollution.But high pressure can make albumen
Qualitative change, enzyme inactivation, microorganism are dead, change polysaccharide solution rheological properties, physicochemical properties, without destroying small molecule
The molecular structure of substance, so ultra high pressure extraction is more suitble to extract for some small-molecule active substances in medicinal material.
Ginseng (Panax.Ginseng C.A.Meyer) derives from the drying root and rhizome of Araliaceae ginseng, first recorded in " mind
Agriculture book on Chinese herbal medicine warp ", Li Shizhen (1518-1593 A.D.) meaning " is gained the name " because root is similar to people, has thousands of years medicinal histories as invigorant.It has been observed that people
Contain saponins, flavonoids, alkaloid, sterols, lignanoid, ginseng essential oil, amino acid, polypeptide, panaxan etc. in ginseng
Multiple types ingredient, wherein ginsenoside and polysaccharide are its main components, and are considered as its main active.Ginseng exists
It is listed in Chinese medicine " top grade ", ginseng is sweet in flavor, slight bitter, warm-natured, has and reinforces vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, promote the production of body fluid, pacifying
The effect of refreshing is the pride of the important crude drug of one of Chinese traditional medicine and Chinese national culture.Such as Shennong's Herbal cloud:
" main tonifying five zang organs, soothe the nerves determine soul, and stop palpitate with fear removes pathogenic factor, improving eyesight, happy intelligence development, long term usage make light of one's life by commiting suicide macrobiosis "." detailed outline ": it " controls
All asthenic symptoms of male woman, generate heat spontaneous perspiration, the dizzy fortune head, regurgitation and emesis, rash malaria, sliding to rush down protracted dysentery, and frequent urination leaching drips, overstrain internal injury,
Apoplexy heatstroke, phlegm numbness are spitted blood, blood of coughing, lower blood, blood strangury, metrorrhagia, postpartum all diseases before tire " ginseng is kind reinforces vital energy, have to whole body good
Good strong effect, energy " Hui Yangqi goes empty heresy in a moment in hanging down absolutely ", to control the first key medicine of consumptive disease internal injury.Pharmacological research shows
Ginseng is in antitumor, antifatigue, anti-aging, antidepression, anti-arrhythmia, inhibition Apoptosis, hypoglycemic, improvement study note
Recall, enhancing sexual function and immune function etc. it is effective in cure, especially in antiradiation drug research also more and more by
To widely paying close attention to.The radiation resistance of ginseng, which is mainly manifested in, there is protection to make hemopoietic system, immune system, inhereditary material
With, and radicals scavenging, inhibition can be obviously promoted or block the peroxidatic reaction of lipid caused by free radical, improve body antioxygen
Change ability.
Wilsonii also known as slender acanthopanax ginseng, sting bent stick, are Araliaceae wilsonii (Acanthopanax senticosus
Harm root and rhizome), contain lignanoid, triterpene, cumarin, flavones, polysaccharide and other multiple active components.Compendium of Material Medica claims to pierce
Five add as " this is through top grade ", energy " tonifying middle-Jiao and Qi, hard muscles and bones, Qiang Yizhi, long term usage are made light of one's life by commiting suicide resistance to old ".With strengthen the body resistance to consolidate the constitution, kidney tonifying it is strong
The effect of spleen, intelligence promoting and tranquilization.Wilsonii, which has, promotees sexual gland, antifatigue and prevent amnesia isoreactivity, is medically referred to as " suitable
Answer original " sample drug.Especially contained various saccharides and eleutheroside are the agent of ideal interferon (CFN) Stimulation effect, can be improved
IFN is horizontal in human body, enhances body immunity.In recent years, domestic and foreign scholars are by a large amount of research and experiment, it was demonstrated that wilsonii
It can promote the antibody tormation of experimental rabbit and cavy；Radix Et Caulis Acanthopanacis Senticosi polysaccharide can enhance mice spleen secretion IgM and IgG；Radix Et Caulis Acanthopanacis Senticosi polysaccharide and
Its glycoside is ideal interferon Stimulation effect agent, can improve internal Interferon level, strengthen immunity.
Fructus lycii (Lycium barbarum L.) is the traditional rare Chinese herbal medicine in China, and main active is fructus lycii
Polysaccharide, total sugar amount are 46.5%, contain 19 kinds of amino acid (including 8 kinds of essential amino acids), total amount 9.14%, while also sending out
Now contain tarine (taurine), be the plant containing taurine ingredient that is uniquely reported, content up to 0.205%~
0.689%, additionally constituents containing alkaloids.It is multinomial with immunological regulation, hypoglycemic, reducing blood lipid, anti-aging, antifatigue etc.
Biological function, can nourishing the liver, kidney tonifying, moistening lung.Nearest pharmacology and clinical research shows that polysaccharides can enhance immunity of organism function
Can, and promote the hematopoiesis function of marrow.Polysaccharides is short of money to Rat Testis tissue damage caused by effect of low dose radiation
Anti- effect and the influence to injury recovery, the radiation of the worker radiated for Long Term Contact and the tumor patient for receiving radiotherapy
The adjuvant treatment of protection and damage provides the theoretical foundation of science.
Root of kirilow rhodiola is Crassulaceae Sedum (Rhodiola L.) herbaceos perennial, is mainly distributed on the happiness in the Northern Hemisphere
The refined mountain area of horse traction, the Asia northwestward and North America, are grown in the high and cold, dry of 1600~4000m of height above sea level, anoxic, intensive ultraviolet
The big area of irradiation, day and night temperature, has extremely strong adaptive capacity to environment and vitality.Contain benzene alkyl glycoside, flavonoids, perfume (or spice)
The ingredients such as legumin class, volatile oil, wherein benzene alkyl glycoside and flavone compound are a kind of main activity in root of kirilow rhodiola medicinal material
Substance.Recent study proves that Rhodida plant has the effect of promoting blood circulation and hemostasis, clearing lung and relieving cough.Clinically for treat hemoptysis,
The diseases such as hemoptysis, pneumonia cough and women leukorrhea.In recent years, the pharmacological research about rhodiola medicinal plant is concentrated mainly on anti-
Anoxia functions, radiation resistance, antifatigue effect, immunological regulation, remove the side such as free radical and hepatoprotective effect at antioxidation
Face.
Summary of the invention
The present invention provides a kind of strengthen immunity and anti-radiation medicine composite and preparation method thereof, passes through and adjusts people's
The whole body, help the five internal organs adjust immune function of human body.
Drug dosage of each component of the present invention is also to carry out largely groping to summarize to obtain through inventor, and dosage of each component is following
All have good therapeutic effect in weight range:
20-40 parts of ginseng, 20-40 parts of wilsonii, 15-25 parts of fructus lycii, 15-25 parts of root of kirilow rhodiola.
Preferably；
25-35 parts of ginseng, 25-35 parts of wilsonii, 18-22 parts of fructus lycii, 18-22 parts of root of kirilow rhodiola.
Preferably；
30 parts of ginseng, 30 parts of wilsonii, 20 parts of fructus lycii, 20 parts of root of kirilow rhodiola.
Drug of the present invention can be prepared into any conventional formulation using the conventional method of Chinese materia medica preparation.Preferred medicine of the present invention
Object active component the preparation method is as follows: the following steps are included:
(1) qualified medicine materical crude slice is weighed according to the parts by weight of bulk pharmaceutical chemicals；
(2) above-mentioned qualified medicine materical crude slice Chinese medicine crushed, cross 80 meshes, take three ginseng, wilsonii, fructus lycii medicinal powders
Add 20-30 times to measure water, the citric acid of 0.31mol/L be added, impregnates in 24 hours postposition high-voltage pulse electric field quick-speed extraction apparatus,
Adjusting electric field strength is 20kV/cm, 6000~10000Hz of pulse frequency, and 60 DEG C of Extracting temperature, extracting solution filtering obtains filtrate I；
It takes root of kirilow rhodiola medicinal powder to be fitted into sealing bag, sets in normal-temperature superhigh pressure extractor, 40~60 times of 70%~80% second of amount are added
Alcohol drains bubble, sealing, and by pressure rise to 250Mpa, fast pressure relief after 3~5min of pressure maintaining obtains extracting solution, centrifuging and taking supernatant
Filtrate II is obtained after liquid filtering；
(3) merging filtrate I and filtrate II, after mixing, it is 1.15- that relative density is surveyed when being concentrated under reduced pressure into 60 DEG C
1.25 liquid extract；
Or: filtrate I is merged with filtrate II, is filtered after mixing, filtrate decompression is dry, 0.06MPa, 60 DEG C -80 DEG C,
It crushes, crosses 80 meshes and obtain fine powder.
Various customary adjuvants required when preparing different dosage forms can be added in the active component of drug of the present invention, be made corresponding
Dosage form, such as capsule, tablet, oral solution, granule, effervescent tablet, medicinal tea or vina.
Ginseng in drug of the present invention, wilsonii containing water-soluble height polysaccharide component, and are main in fructus lycii
Ingredient is to adjust immune function, anti-radiation and anti-tumor activity main active substances.Rhodioside contained by root of kirilow rhodiola and Huang
Ketone compounds are its pharmacological active substances, have the characteristics that it is fat-soluble, thermo-responsive, oxidizable, therefore in the extraction work of this prescription
In skill, having used high-voltage pulse electric field rapidly extracting technology (HPEF) and ultra high pressure extraction (UHPE) respectively, both are novel
Extracting method carry out the effective component extraction process of medicinal material can at low temperature, avoid the inactivation of effective component.Due to super
The high pressure that high pressure extraction method is applied can make the macromoleculars space structure such as polysaccharide, albumen change and lead to active decline,
Therefore it by ginseng, wilsonii, fructus lycii and root of kirilow rhodiola adaptation to local conditions is extracted with two methods more effective.
The present invention has the effect of tonifying middle-Jiao and Qi, strong liver kidney, benefiting essence-blood, and the body that can be improved or improve raying crowd is exempted from
Epidemic disease power and anti-radiation, anti-aging ability, and the harm of various radiation can be prevented, it also can be used as the adjuvant radiotherapy of tumor patient
Pharmaceutical preparation.
Specific embodiment
The preparation of the oral solution of the present invention of embodiment 1
Ginseng 20g, wilsonii 20g, fructus lycii 15g, root of kirilow rhodiola 15g,
(1) qualified medicine materical crude slice is weighed according to the parts by weight of bulk pharmaceutical chemicals；
(2) above-mentioned qualified medicine materical crude slice Chinese medicine crushed, cross 80 meshes, take three ginseng, wilsonii, fructus lycii medicinal powders
Add 20 volumes to measure water again, the citric acid of 0.31mol/L is added, impregnates 24 hours postposition high-voltage pulse electric field quick-speed extraction apparatus
In, adjusting electric field strength is 20kV/cm, pulse frequency 6000Hz, and 60 DEG C of Extracting temperature, extracting solution filtering obtains filtrate I；It takes red
Red-spotted stonecrop medicinal powder is fitted into sealing bag, is set in normal-temperature superhigh pressure extractor, and 40 times of 70% ethyl alcohol of amount are added, drain bubble, envelope
Mouthful, by pressure rise to 250Mpa, fast pressure relief after pressure maintaining 3min obtains extracting solution, after centrifuging and taking supernatant liquid filtering filtrate II；
(3) merging filtrate I and filtrate II, after mixing, it is 1.15- that relative density is surveyed when being concentrated under reduced pressure into 60 DEG C
1.25 liquid extract；The liquid extract and common sweetener, acid, preservative, fruit juice, essence, water etc. are proportionally mixed
It closes, filling after 200 mesh net filtrations, capping is labelled, the product of external packaging using 121 DEG C of sterilizing 20min after cooling.
The preparation of the oral solution of the present invention of embodiment 2
Ginseng 30g, wilsonii 30g, fructus lycii 20g, root of kirilow rhodiola 20g；
(1) qualified medicine materical crude slice is weighed according to the parts by weight of bulk pharmaceutical chemicals；
(2) above-mentioned qualified medicine materical crude slice Chinese medicine crushed, cross 80 meshes, take three ginseng, wilsonii, fructus lycii medicinal powders
Add 25 volumes to measure water again, the citric acid of 0.31mol/L is added, impregnates 24 hours postposition high-voltage pulse electric field quick-speed extraction apparatus
In, adjusting electric field strength is 20kV/cm, pulse frequency 8000Hz, and 60 DEG C of Extracting temperature, extracting solution filtering obtains filtrate I；It takes red
Red-spotted stonecrop medicinal powder is fitted into sealing bag, is set in normal-temperature superhigh pressure extractor, and 50 times of 75% ethyl alcohol of amount are added, drain bubble, envelope
Mouthful, by pressure rise to 250Mpa, fast pressure relief after pressure maintaining 4min obtains extracting solution, after centrifuging and taking supernatant liquid filtering filtrate II；
(3) merging filtrate I and filtrate II, after mixing, it is 1.15- that relative density is surveyed when being concentrated under reduced pressure into 60 DEG C
1.25 liquid extract；The liquid extract and common sweetener, acid, preservative, fruit juice, essence, water etc. are proportionally mixed
It closes, filling after 200 mesh net filtrations, capping is labelled, the product of external packaging using 121 DEG C of sterilizing 20min after cooling.
The preparation of the oral solution of the present invention of embodiment 3
Ginseng 40g, wilsonii 40g, fructus lycii 25g, root of kirilow rhodiola 25g；
(1) qualified medicine materical crude slice is weighed according to the parts by weight of bulk pharmaceutical chemicals；
(2) above-mentioned qualified medicine materical crude slice Chinese medicine crushed, cross 80 meshes, take three ginseng, wilsonii, fructus lycii medicinal powders
Add 30 volumes to measure water again, the citric acid of 0.31mol/L is added, impregnates 24 hours postposition high-voltage pulse electric field quick-speed extraction apparatus
In, adjusting electric field strength is 20kV/cm, pulse frequency 10000Hz, and 60 DEG C of Extracting temperature, extracting solution filtering obtains filtrate I；It takes red
Red-spotted stonecrop medicinal powder is fitted into sealing bag, is set in normal-temperature superhigh pressure extractor, and 60 times of 80% ethyl alcohol of amount are added, drain bubble, envelope
Mouthful, by pressure rise to 250Mpa, fast pressure relief after pressure maintaining 5min obtains extracting solution, after centrifuging and taking supernatant liquid filtering filtrate II；
(3) merging filtrate I and filtrate II, after mixing, it is 1.15- that relative density is surveyed when being concentrated under reduced pressure into 60 DEG C
1.25 liquid extract；The liquid extract and common sweetener, acid, preservative, fruit juice, essence, water etc. are proportionally mixed
It closes, filling after 200 mesh net filtrations, capping is labelled, the product of external packaging using 121 DEG C of sterilizing 20min after cooling.
The preparation of the capsule of the present invention of embodiment 4
Ginseng 25g, wilsonii 25g, fructus lycii 18g, root of kirilow rhodiola 18g；
(1) qualified medicine materical crude slice is weighed according to the parts by weight of bulk pharmaceutical chemicals；
(2) above-mentioned qualified medicine materical crude slice Chinese medicine crushed, cross 80 meshes, take three ginseng, wilsonii, fructus lycii medicinal powders
Add 20 volumes to measure water again, the citric acid of 0.31mol/L is added, impregnates 24 hours postposition high-voltage pulse electric field quick-speed extraction apparatus
In, adjusting electric field strength is 20kV/cm, pulse frequency 6000Hz, and 60 DEG C of Extracting temperature, extracting solution filtering obtains filtrate I；It takes red
Red-spotted stonecrop medicinal powder is fitted into sealing bag, is set in normal-temperature superhigh pressure extractor, and 40 times of 70% ethyl alcohol of amount are added, drain bubble, envelope
Mouthful, by pressure rise to 250Mpa, fast pressure relief after pressure maintaining 3min obtains extracting solution, after centrifuging and taking supernatant liquid filtering filtrate II；
(3) filtrate I is merged with filtrate II, is filtered after mixing, filtrate decompression is dry, 0.06MPa, 60 DEG C, powder
It is broken, it crosses 80 meshes and obtains fine powder, the dextrin of same 80 mesh of mistake is set into three-dimensional mixer mixing 15min with the fine powder, fills capsule,
Polishing, packet inner packing, outer packing examine qualification to get product capsule.
The preparation of the capsule of the present invention of embodiment 5
Ginseng 30g, wilsonii 30g, fructus lycii 20g, root of kirilow rhodiola 20g；
(1) qualified medicine materical crude slice is weighed according to the parts by weight of bulk pharmaceutical chemicals；
(2) above-mentioned qualified medicine materical crude slice Chinese medicine crushed, cross 80 meshes, take three ginseng, wilsonii, fructus lycii medicinal powders
Add 25 volumes to measure water again, the citric acid of 0.31mol/L is added, impregnates 24 hours postposition high-voltage pulse electric field quick-speed extraction apparatus
In, adjusting electric field strength is 20kV/cm, pulse frequency 8000Hz, and 60 DEG C of Extracting temperature, extracting solution filtering obtains filtrate I；It takes red
Red-spotted stonecrop medicinal powder is fitted into sealing bag, is set in normal-temperature superhigh pressure extractor, and 50 times of 75% ethyl alcohol of amount are added, drain bubble, envelope
Mouthful, by pressure rise to 250Mpa, fast pressure relief after pressure maintaining 4min obtains extracting solution, after centrifuging and taking supernatant liquid filtering filtrate II；
(3) filtrate I is merged with filtrate II, is filtered after mixing, filtrate decompression is dry, 0.06MPa, 70 DEG C, powder
It is broken, it crosses 80 meshes and obtains fine powder, the dextrin of same 80 mesh of mistake is set into three-dimensional mixer mixing 15min with the fine powder, fills capsule,
Polishing, packet inner packing, outer packing examine qualification to get product capsule.
The preparation of the capsule of the present invention of embodiment 6
Ginseng 35g, wilsonii 35g, fructus lycii 22g, root of kirilow rhodiola 22g；
(1) qualified medicine materical crude slice is weighed according to the parts by weight of bulk pharmaceutical chemicals；
(2) above-mentioned qualified medicine materical crude slice Chinese medicine crushed, cross 80 meshes, take three ginseng, wilsonii, fructus lycii medicinal powders
Add 30 volumes to measure water again, the citric acid of 0.31mol/L is added, impregnates 24 hours postposition high-voltage pulse electric field quick-speed extraction apparatus
In, adjusting electric field strength is 20kV/cm, pulse frequency 10000Hz, and 60 DEG C of Extracting temperature, extracting solution filtering obtains filtrate I；It takes red
Red-spotted stonecrop medicinal powder is fitted into sealing bag, is set in normal-temperature superhigh pressure extractor, and 60 times of 80% ethyl alcohol of amount are added, drain bubble, envelope
Mouthful, by pressure rise to 250Mpa, fast pressure relief after pressure maintaining 5min obtains extracting solution, after centrifuging and taking supernatant liquid filtering filtrate II；
(3) filtrate I is merged with filtrate II, is filtered after mixing, filtrate decompression is dry, 0.06MPa, 80 DEG C, powder
It is broken, it crosses 80 meshes and obtains fine powder, the dextrin of same 80 mesh of mistake is set into three-dimensional mixer mixing 15min with the fine powder, fills capsule,
Polishing, packet inner packing, outer packing examine qualification to get product capsule.
Effect of the invention is further illustrated by pharmacodynamic experiment below.
1. the present invention studies mouse immune regulating effect
1.1 test materials: healthy regular grade Kunming mouse, half male and half female, weight 18-22g are mentioned by Jilin University's animal center
For oral solution prepared by embodiment 1-3；
1.2 test methods and grouping
Mouse is randomly divided into five groups, every group 12: blank control group, model group, administration group (give respectively embodiment 1,2,
3).Administration group: intraperitoneal injection 100mg/kg cyclophosphamide causes hypoimmunity model, 1 time/d, for three days on end, gives within the 4th day
Each group fills corresponding embodiment 1,2,3, and stomach-filling volume is 0.4ml/, continuous to fill 30 days；Model group: intracavitary administration 100mg/kg
Cyclophosphamide causes hypoimmunity model, 1 time/d, for three days on end, fills physiological saline 0.4ml/ only to mouse within the 4th day, continuous to fill
30 days；Blank control group: without any processing in experiment process.Test carries out the 30th day, after being discontinued 1 day, carries out ConA induction
Mouse lymphocyte transformation experiment, mouse carbonic clearance experiment, serum hemolysin experiment and NK cytoactive detection.
1.3 drug dose
Dosage presses the conversion of 70kg adult's body surface area, and crude drug amount 21g/d calculates mouse equivalent dose and is
2.73g/kgbw, using 10 times of equivalent amounts as dosage, that is, 27.3g/kgbw of mouse.
1.4 statistical analysis
Experimental data is analyzed with SPSS17.0 statistical software, the comparison between two groups of means is examined using LSD, multiple groups
Between compare between mean using one-way analysis of variance (One-way ANOVA), each group of data withx± s is indicated, as P < 0.05
When think that difference is statistically significant.
2 test results
The 2.1 embodiment 1-3 are to the dirty body ratio of mouse immune organ and ConA the mouse lymphocyte conversion induced
It influences, is shown in Table 1:
Table 1 (N=12)
Note*P<0.05,**P < 0.01 compared with blank control group,△P<0.05,△△P < 0.01, compared with model group
The mouse of embodiment 1-3 group it can be seen from the table, for the dirty body ratio of spleen/thymus gland compared with model group, difference is non-
In the mouse lymphocyte conversion capability experiment of Chang Xianzhu, ConA induction, 2,3 groups of embodiment of mouse group mouse lymphocyte increases
Ability is grown compared with model group, and the difference with highly significant, the method can significantly improve mouse cell immune functions for prompt.
Influence of the 2.2 embodiment 1-3 to mouse carbon particle clearance and serum hemolysin, is shown in Table 2:
Table 3 (N=12)
Note*P<0.05,**P < 0.01 compared with blank control group,△P<0.05,△△P < 0.01, compared with model group
The mouse carbon particle clearance of embodiment 1-3 group and serum hemolysin value and model group phase it can be seen from the table
Than difference has statistical significance, and 2 groups of differences of embodiment have very significant meaning, show that the present invention can significantly improve and exempt from
The humoral immune function and monocytes/macrophages of the low mouse of epidemic disease swallow carbon particle clearance function.
The 2.3 embodiment 1-3 are shown in Table 3 to the active influence of NK cells in mice:
Table 3 (N=12)
The NK cells in mice activity of embodiment 1-3 group is compared with model group it can be seen from the table, and difference is extremely significant, table
The bright present invention can significantly improve the NK cell activity of hypoimmunity mice.
As above-mentioned experiment 2.1-2.3 it is found that by ginseng composite strengthen immunity and anti-radiation mouth obtained by embodiment 1-3
Liquid is taken with immunological enhancement, wherein 2 groups of embodiment of oral solution is to adjusting the effect of mouse immune ability most in the present invention
It is good.
Claims (3)
1. the preparation method of a kind of strengthen immunity and anti-radiation medicine composite, including the following steps:
(1) qualified medicine materical crude slice is weighed according to the parts by weight of bulk pharmaceutical chemicals:
20-40 parts of ginseng, 20-40 parts of wilsonii, 15-25 parts of fructus lycii, 15-25 parts of root of kirilow rhodiola；
It is characterized by:
(2) above-mentioned qualified medicine materical crude slice Chinese medicine crushed, cross 80 meshes, three ginseng, wilsonii, fructus lycii medicinal powders is taken to add 20-
30 times of amount water, are added the citric acid of 0.31mol/L, impregnate in 24 hours postposition high-voltage pulse electric field quick-speed extraction apparatus, adjust
Electric field strength is 20kV/cm, 6000~10000Hz of pulse frequency, and 60 DEG C of Extracting temperature, extracting solution filtering obtains filtrate I；It takes red
Red-spotted stonecrop medicinal powder is fitted into sealing bag, is set in normal-temperature superhigh pressure extractor, and 40~60 times of 70%~80% ethyl alcohol of amount, row is added
Bubble to the greatest extent, sealing, by pressure rise to 250Mpa, fast pressure relief after 3~5min of pressure maintaining obtains extracting solution, centrifuging and taking supernatant mistake
Filtrate II is obtained after filter；
(3) merging filtrate I and filtrate II, after mixing, it is 1.15-1.25's that relative density is surveyed when being concentrated under reduced pressure into 60 DEG C
Liquid extract；
Or: filtrate I is merged with filtrate II, is filtered after mixing, filtrate decompression is dry, 0.06MPa, 60 DEG C -80 DEG C, powder
It is broken, it crosses 80 meshes and obtains fine powder.
2. the preparation method of a kind of strengthen immunity as described in claim 1 and anti-radiation medicine composite, feature exist
In: it is made from the following raw materials in parts by weight:
25-35 parts of ginseng, 25-35 parts of wilsonii, 18-22 parts of fructus lycii, 18-22 parts of root of kirilow rhodiola.
3. the preparation method of a kind of strengthen immunity as claimed in claim 1 or 2 and anti-radiation medicine composite, feature
It is: is made from the following raw materials in parts by weight:
30 parts of ginseng, 30 parts of wilsonii, 20 parts of fructus lycii, 20 parts of root of kirilow rhodiola.
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| CN106236927A (en) * | 2016-08-02 | 2016-12-21 | 姚传明 | A kind of Chinese medicine composition with enhancing immunity and antifatigue effect and preparation method thereof and purposes |
| CN107412460A (en) * | 2017-05-24 | 2017-12-01 | 厦门中美康泰生物技术有限公司 | Radioresistance active compound and its production technology |
| CN108244031B (en) * | 2017-12-15 | 2020-08-28 | 中国水产科学研究院东海水产研究所 | Method for improving non-specific immunity of mice with low immunity model |
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