CN105434777A - Preparation method of traditional Chinese medicine vinum - Google Patents

Preparation method of traditional Chinese medicine vinum Download PDF

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Publication number
CN105434777A
CN105434777A CN201510945255.XA CN201510945255A CN105434777A CN 105434777 A CN105434777 A CN 105434777A CN 201510945255 A CN201510945255 A CN 201510945255A CN 105434777 A CN105434777 A CN 105434777A
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China
Prior art keywords
parts
fructus
radix
raw material
preparation
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CN201510945255.XA
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Chinese (zh)
Inventor
耿炤
周美娟
周青罡
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SHANGHAI ZHONGCHUANG MEDICINE SCIENCE CO Ltd
Jiangxi Huiren Pharmaceutical Co Ltd
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SHANGHAI ZHONGCHUANG MEDICINE SCIENCE CO Ltd
Jiangxi Huiren Pharmaceutical Co Ltd
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Publication of CN105434777A publication Critical patent/CN105434777A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention relates to a traditional Chinese medicine vinum prepared from the following traditional Chinese medicines as raw material medicines: herba epimedii, semen trigonellae, fructus rosae laevigatae, prepared rehmannia root, semen psoraleae, common cnidium fruit, radix polygonum multiflorum preparata, herba cistanche, Chinese wolfberry, semen cuscutae, fructus schisandrae chinensis, raspberry, radix astragali, red ginseng, white atractylodes rhizome, Chinese yam, poria cocos, angelica sinensis, ligusticum wallichii, common fennel fruit, plantain seed, and honey-fried licorice root. A certain content of an ethanol solvent is adopted for solvent-process extraction to prepare a product conforming to vinum specifications, wherein the product can be medicated wine and health-care wine, and has the effect of promoting recovery of sexual capacity functions and the strengthening effect.

Description

A kind of preparation method of Chinese medicine tincture
Technical field:
The invention belongs to medical and health field, be specifically related to a kind of preparation method and its usage of Chinese medicine tincture.
Background technology:
Wine is one of daily beverage, has extensive and long use history at all times, and creates the spirits culture differed from one another.
Ethanol (ethanol) is the principal character composition of wine, and be a kind of colourless, inflammable, volatile liquid, proportion about 0.8, has sweet-smelling abnormal smells from the patient.Concentration of alcohol in wine is generally volumetric concentration: medicated beer is about 3%-5%, and yellow wine is about 10%-15%, and wine is about 10%-25%, and health promoting wine is about 15%-40%, liquor with high degree more than 40%, as Chinese liquor (as strong, colourless liquor distilled from sorghum), brandy can reach 65%.Production process wine base concentration can be higher.
A small amount of or responsible drinking is good for health." guide of drinking ": " heat that wine can give human body certain also has certain nutritive value.The aminoacid, vitamin etc. that contain human body needs as wine plant nutrient, and contained resveratrol has antioxidant activity.Low alcohol consumption is of value to cardiovascular system, and light moderate drinker is alcohol user and heavy drinker more not, and the danger of its coronary heart disease is low.Responsible drinking can make small artery vasodilation, blood circulation promoting.Responsible drinking contributes to inspiring enthusiasm, and relaxes worried and nervous psychology, improves delight of life.Appropriate wine energy gastric acid secretion, appetite stimulator, improves digestion power.The raw material of health promoting wine because using containing food and medicament dual-purpose or state approval, and there is the effects such as tonification body-building, vital energy regualting and blood circulation-promoting, immunity moderation, resisting fatigue." also have during Chinese Traditional Medicine is clinical wine can " priming is up " effect.
International ethanol policy center ICAP, World Health Organization's Worldwide collaboration are pointed out: every day is the limit that male drinks safely be no more than 20g, and women is no more than 10g.According to: ethanol amount=capacity for liquor × alcoholic strength × 0.8, limit of drinking every day (upper limit) is amounted to medicated beer and is about 500ml-830ml, and yellow wine is about 160ml-250ml, wine is about 100ml-250ml, 40 ° of Chinese liquor are about 60ml, and 50 ° of Chinese liquor are about 50ml, and 65 ° of Chinese liquor are about 38ml.
According to the pertinent regulations of " Chinese Pharmacopoeia " medicated wine, the prepared slices of Chinese crude drugs producing medicated wine used should carry out suitable pulverizing; Prepared by available infusion process, percolation or other proper method; Appropriate sugar or Mel seasoning can be added; Preparation medicated wine must leave standstill clarification, be sub-packed in clean container after filtration; The concentration of Spirit and consumption, dipping temperature and time, percolation speed all should be investigated.
Therefore, for being suitable for the crowd and custom is drunk, if its Ethanol intake amount can be controlled, add health-care components or medical material for himself health states or morbid state simultaneously, can design and both meet its alcohol drinking patterns, health promoting wine or the medicated wine of health care or therapeutical effect can be played again.
Summary of the invention:
The present invention is directed to and be suitable for the crowd of drinking, a kind of medicated wine is provided, comprise its raw material, method for making and improving the application in physical function state or tcm clinical practice symptom.
The invention provides a kind of Chinese medicine tincture, the described medicated wine raw material of Chinese medicine medicine of following weight proportion is prepared from: Herba Epimedii 3-9 part, Semen Trigonellae 3-9 part, Fructus Rosae Laevigatae 3-9 part, Radix Rehmanniae Preparata 3-9 part, Fructus Psoraleae 1-4 part, Fructus Cnidii 1-4 part, Radix Polygoni Multiflori Preparata 2-8 part, Herba Cistanches 1-6 part, Fructus Lycii 2-7 part, Semen Cuscutae 2-7 part, Fructus Schisandrae Chinensis 1-6 part, Fructus Rubi 1-6 part, Radix Astragali 2-8 part, Radix Ginseng Rubra 0.5-3 part, Rhizoma Atractylodis Macrocephalae 0.5-3 part, Rhizoma Dioscoreae 1-6 part, Poria 0.5-5 part, Radix Angelicae Sinensis 1-6 part, Rhizoma Chuanxiong 0.5-4 part, Fructus Foeniculi 0.5-3 part, Semen Plantaginis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part.
Preferably, the medicated wine of the present invention raw material of Chinese medicine medicine of following weight proportion is prepared from: Herba Epimedii 6.7 parts, Semen Trigonellae 6.6 parts, Fructus Rosae Laevigatae 6.7 parts, Radix Rehmanniae Preparata 6.6 parts, Fructus Psoraleae 2.0 parts, Fructus Cnidii 2.0 parts, Radix Polygoni Multiflori Preparata 5.2 parts, Herba Cistanches 3.3 parts, Fructus Lycii 4.6 parts, Semen Cuscutae 4.6 parts, Fructus Schisandrae Chinensis 2.5 parts, Fructus Rubi 2.3 parts, the Radix Astragali 3.6 parts, Radix Ginseng Rubra 1.4 parts, the Rhizoma Atractylodis Macrocephalae 1.0 parts, Rhizoma Dioscoreae 3.3 parts, 2.1 parts, Poria, Radix Angelicae Sinensis 3.3 parts, Rhizoma Chuanxiong 2.0 parts, Fructus Foeniculi 1.0 parts, Semen Plantaginis 1.2 parts, Radix Glycyrrhizae Preparata 1.0 parts.
The present invention also provides the preparation method of medicated wine of the present invention, described method, step is as follows: raw material Extraction solvent extracts, then through conventional filtration, recycling design, precipitation, concentrated obtain concentrated extracting solution, then be adjusted to the finished product containing amount of alcohol 5%-75% with ethanol.Preferably, described method, step is as follows: raw material carries out extract by solvents through the Extraction solvent containing 10%-95% (v/v) ethanol, extracting solution after filtration, leave standstill, refilter, obtain active constituents of medicine, add adjuvant, make alcohol content be 5%-75% (v/v) through allotment.
Described Extraction solvent comprises the Spirit in corn source.Described extracting mode is selected from: immersion, percolation, backflow, ultrasonic power.
Described extracting method can adopt the ultrasound wave of certain frequency to carry out assisted extraction as enhancements, preferably as adopted 40kHz soak extraction.
Another is preferred, described extracting method, and step is as follows: the broken or shredding by all raw materials, and with 55%-65% soaking in Chinese liquor, 55%-65% Chinese liquor, distilled water adjustment amount, to the finished product 1000ml containing amount of alcohol 20%-50%, leave standstill, and filter, fill and get final product.
The function of Chinese medicine tincture of the present invention cures mainly and comprises warming and recuperating the kidney-YANG, controlling nocturnal emission with astringent drugs QI invigorating, strengthening the body resistance, be afraid of cold for the impotence and seminal emission caused by kidney yang virtual loss, vital essence deficiency, waist and leg ache, lassitude, nocturia, fear of cold, menorrhagia, clear and thin leucorrhea etc.; It is 30-65g that every consumption per day amounts to raw material.
The function of Chinese medicine tincture of the present invention is for improving tolerance, alleviating physical fatigue; It is 5-30g that every consumption per day amounts to raw material.
Chinese medicine of the present invention selects up-to-standard Chinese crude drug as extraction raw material, need before extraction to be broken into Semen Glycines size, the different size such as most coarse powder, coarse powder, middle powder, or be the silk lamellar of 0.1mm-20mm to blade class width, be preferably wherein tiny kind of subclass be coarse powder, the silk sheet of tubers to be Semen Glycines size and blade class be wide 10 ± 5mm.
Medicated wine provided by the invention, be to drink crowd's objective reality according to custom, it has objective demand to health care or treatment, and these two objective realities propose.Through to Ethanol intake quantitative limitation, the research of raw material and method for making, and compliance test result, medicated wine of the present invention has and meets specific crowd and realize specific health care or therapeutical effect.
Accompanying drawing illustrates:
The stripping curve of Fig. 1-2 0KHz different time effective ingredient
The stripping curve of Fig. 2-40KHz different time effective ingredient
The stripping curve of Fig. 3-60KHz different time effective ingredient
Fig. 4-HPLC characteristic spectrum of the present invention
Fig. 5-comparative sample HPLC characteristic spectrum
Detailed description of the invention:
Further illustrate the present invention by the following examples, but not as limitation of the present invention.Those skilled in the relevant art further can implement on the basis of content of the present invention and embodiment.
Embodiment 1
(every part is 14.2g decoction pieces to get Herba Epimedii 6.7 parts, lower same), Semen Trigonellae 6.6 parts, Fructus Rosae Laevigatae 6.7 parts, Radix Rehmanniae Preparata 6.6 parts, Fructus Psoraleae 2.0 parts, Fructus Cnidii 2.0 parts, Radix Polygoni Multiflori Preparata 5.2 parts, Herba Cistanches 3.3 parts, Fructus Lycii 4.6 parts, Semen Cuscutae 4.6 parts, Fructus Schisandrae Chinensis 2.5 parts, Fructus Rubi 2.3 parts, the Radix Astragali 3.6 parts, Radix Ginseng Rubra 1.4 parts, the Rhizoma Atractylodis Macrocephalae 1.0 parts, Rhizoma Dioscoreae 3.3 parts, 2.1 parts, Poria, Radix Angelicae Sinensis 3.3 parts, Rhizoma Chuanxiong 2.0 parts, Fructus Foeniculi 1.0 parts, Semen Plantaginis 1.2 parts, Radix Glycyrrhizae Preparata 1.0 parts, be ground into most coarse powder, add 55% ethanol (55 °) Chinese liquor of above-mentioned raw material weight 3 times amount volume respectively, stir in immersion process, soak 40 days under room temperature, 200 orders filter, high speed centrifuge is adopted to carry out centrifugal, it is appropriate that centrifugal liquid adds Mel, with the Chinese liquor containing 55% ethanol, distilled water adjustment alcohol content to 20% or 40%, adjustment total amount is to 1000ml, leave standstill, filter, obtain.Gradation is drunk, and every consumption per day is no more than 120ml or 60ml.
Embodiment 2
Form and pretreatment with embodiment 1 raw material and weight proportion, after soaked overnight, adopt percolation to collect 800ml, 200 orders filter, and adopt high speed centrifuge to carry out centrifugal, it is appropriate that centrifugal liquid adds Mel, with Chinese liquor, distilled water adjustment alcohol content to 40% containing 55% ethanol, adjustment total amount, to 1000ml, leaves standstill, filter, to obtain final product.Gradation is drunk, and every consumption per day is no more than 60ml.
Embodiment 3
With embodiment 1 raw material and weight proportion composition, Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi are ground into coarse powder, 70% ethanol as solvent, stain carries out percolation in 48 hours, collect percolation 1500ml, reclaim ethanol and be evaporated to the clear paste that relative degree is 1.10 ~ 1.15 (60 DEG C), filter, filtrate is for subsequent use; Red ginseng powder is broken into coarse powder, uses 20% ethanol as solvent, flood after 8 hours, heating and refluxing extraction secondary, each 2 hours, united extraction, filter, filtrate recycling ethanol, is concentrated into the clear paste that relative density is 1.05 ~ 1.10 (60 DEG C), for subsequent use; Ten Six-elements such as all the other Fructus Rubies, above-mentioned Radix Ginseng Rubra medicinal residues, decoct with water secondary, each 2 hours, merge, filter, filtrate is concentrated into the clear paste that relative density is 1.16 ~ 1.20 (60 DEG C), adding ethanol makes alcohol content be 65%, leaves standstill 48 hours, gets supernatant and reclaims ethanol, be concentrated into the clear paste that relative density is 1.10 ~ 1.15 (60 DEG C), add the extracting solution such as above-mentioned Fructus Cnidii and Radix Ginseng Rubra alcohol extract, mixing, it is appropriate to add Mel, with 65% Chinese liquor, distilled water adjustment amount to the finished product 1000ml containing amount of alcohol 40%, leave standstill, filter, to obtain final product.Every consumption per day is no more than 60ml.Be afraid of cold for the impotence and seminal emission caused by kidney yang virtual loss, vital essence deficiency, waist and leg ache, lassitude, nocturia, fear of cold, menorrhagia, clear and thin leucorrhea etc., and the crowd with alcohol drinking patterns.
Embodiment 4
With embodiment 1 raw material and weight proportion composition, be ground into coarse powder, add the Spirit 3.5 times of 22% and 55% concentration ethanol, airtight, put respectively in the ultrasonic extractor of different capacity (20,40,60kHz) and extract, sample every 20min, fluid infusion simultaneously, terminate after 3 hours, test by above characteristic spectrum method, carry out the comparison of peak area with epimedin, icariin, psoralen, isopsoralen, schisandrin, precious icariin I, osthole for object.Characteristic spectrum method and chromatographic condition: chromatographic column: PhenomenexGeminiC185 μm, 4.6 × 250mm; 254nm, mobile phase: A acetonitrile; B water, gradient elution:
That compares the results are shown in accompanying drawing 1-accompanying drawing 3.
According to the investigation to the different capacity time period, the ultrasound condition determined is 40kHz, 35 ± 5 DEG C, 60min.Example 1 same materials and weight proportion, be ground into most coarse powder, supersound extraction is carried out by the condition determined above, the Spirit 2.5 adding alcohol content 55% doubly carries out supersound extraction, and the volume medicinal liquid of leaching equivalent weight after extracting, through centrifugal (5000r/min), be adjusted to containing amount of alcohol 40% with extraction wine, distilled water, proper honey, leave standstill, filter, to obtain final product.
Adopt HPLC characteristic spectrum (mobile phase: A acetonitrile; B water, gradient elution) this embodiment sample of relative analysis and " Chinese Pharmacopoeia " version in 2015 the 1050th page of quadrat sampling product that exist together, through ethanol dilution post analysis.
The results are shown in accompanying drawing 4 inventive samples HPLC characteristic spectrum, Fig. 5 comparative sample HPLC characteristic spectrum.Known, this sample room similarity is very high, but preparation method is simple, efficient.
Prove the effect of medicated wine with irritability sexual function of rats decline kidney-yang deficiency model, Testing index comprises the impact on rat sexual behaviour, gonadal hormone, sexual organ.The impact of rat sexual behaviour mainly comprises: ride incubation period, ejaculation latency, ejaculation interval, ride total degree etc.The impact of gonadal hormone mainly comprises: the detection of testosterone concentration, Folliculogenesis hormone (FSH), luteotropic hormone (LH).The impact of sexual organ mainly comprises: testis proportion, prostate proportion, seminal vesicle proportion, epididymis proportion.
Test method:
The preparation of Ovariectomized Female Rats: get female rats 200, after 4% chloral hydrate intraperitoneal anesthesia (1ml/100g), makes abdominal part median incision, aseptically enters abdominal cavity, complete excision bilateral ovaries.Postoperative continuous intramuscular injection penicillin infection 3 days, 50,000 U/, every day 1 time.Postoperative all animals are raised at identical conditions (room temperature 19 DEG C ~ 24 DEG C, relative humidity about 40%) normal diet, freely drink water.
The preparation of heat Mus: female Mus castration after 2 weeks for mating test.Test first 48 hours subcutaneous injection 20 μ g estradiol benzoates, test first 4 hours subcutaneous injection 500 μ g Progesterone and promote the sexual maturity, use in order to mating test.
The screening of male rat sexuality: be placed in separately by male rat in Mus transparent plastic cage tool, keep quite, use safety supervisory video recording system is recorded a video, and is dimmed to by light and can observes and record a video.After 10 minutes, 1 female rats of oestrusing is put down gently in male mouse cage, photograph the copulation activity of rat in 90 minutes immediately.The male rat of amixia record is rejected.
To suffer from a deficiency of the kidney the preparation of male rat: 168 male rats with sexuality are divided into 12 groups at random, are respectively model group, Chinese liquor group, high low dosage SJ1 group, high low dosage SJ2 group, high low dosage SJ3 group, high low dosage SJ4 group, high low dosage SJ5 group.Each group of rat all adopts chronic unpredictable stimulation, makes rat be in stress state for a long time, and preparation stress caused kidney of rats virtual model.Modeling group carries out modeling by the following method: 1. frozen water swimming: rat is put into cold water bucket, 15min/ time.2. water is prohibited: cut off the water supply 8:00 from morning 8:00 next day, totally 24 hours.3. fasting: jejunitas to 8:00 next day from morning 8:00, totally 24 hours.4. heat stress: warmer be transferred to about 40 degrees Celsius constant, rat is put into warmer, after 15 minutes take out.5. light and shade is put upside down: 8:00, rat is put into homemade camera bellows from morning, and evening, 8:00 took out, after rat is placed in independent laboratory, and all night illumination, terminates to 8:00 the next morning.6. tail is pressed from both sides: be clipped in large mousetrap tail and be about 1cm place apart from root of the tail, each lasting 1 minute, 3 times altogether.7. moist bedding and padding: make rat be placed in wet environment and continue 24 hours (moist bedding and padding by every 100g bedding and padding add water 200ml).8. shock by electricity each 5 minutes, 3 times altogether.9. each 20 minutes are fettered.Random arrangement gave a kind and stimulated alternately stimulation in rats 21 days every day, occurred being no more than 3 times with a kind of stimulation, and discontinuous appearance, make it can not predict the stimulation given.
Sexology is observed: administration, after the 4th week, is observed rat copulation situation with method 3, photographed the mating behavior of rat in 40 minutes.The following parameter of playback video record: 1. ride incubation period: male and female Mus rides the required time the 1st time with cage to male Mus; 2. total degree is ridden: male and female Mus occurs riding the total degree of behavior with Mus male after cage; 3. movable Mus number is ridden: the male mouse number having the behavior of riding; 4. ejaculation activity Mus number: the male mouse number having ejaculation behavior; 5. ejaculation latency; 6. ejaculate interval.(note: male Mus ride each time might not with insertion) above parameter in order to evaluate rat libido, the toggle speed that property is waken up, the height of erection function.
Sexual organ detects: sexual behaviour is observed and terminated next day, and rat is taken body weight, and with the amobarbital anesthetized rat of 3%, row abdominal aortic blood, and centrifuging and taking serum is that-80 DEG C of refrigerators are for subsequent use immediately; Take out testis again, epididymis, prostate and seminal vesicle, weigh and record, the corresponding index of computational organ.
The detection of gonadal hormone: get 1ml serum, carries out the detection of testosterone, flitropin, lutropin in fully automatic electric chemiluminescence immunoassay system.
Medication: male rat stress start administration after 21 days, test medicine group rat gastric infusion every day 1 time, gavage high dose Chinese liquor respectively, high low dosage (be equivalent to people's consumption per day respectively and amount to material quantity 62g and 30g) test specimen, blank group and model group rats gavage every day give isometric(al) distilled water, gavage amount is 6ml/kg, successive administration 4 weeks.
Result shows, the recovery of medicated wine of the present invention to experimental sexual function has significant facilitation.Under low dosage, there is strong effect.In conjunction with raw material prescription and applied analysis, the present invention is used for kidney yang virtual loss, the impotence and seminal emission caused by vital essence deficiency, waist and leg ache, lassitude, nocturia, fear of cold are afraid of cold, menorrhagia, clear and thin leucorrhea etc., and the crowd with alcohol drinking patterns.Tolerance, alleviating physical fatigue can be improved under low dosage condition, and there is alcohol drinking patterns crowd.

Claims (10)

1. a Chinese medicine tincture, it is characterized in that, the described medicated wine raw material of Chinese medicine medicine of following weight proportion is prepared from: Herba Epimedii 3-9 part, Semen Trigonellae 3-9 part, Fructus Rosae Laevigatae 3-9 part, Radix Rehmanniae Preparata 3-9 part, Fructus Psoraleae 1-4 part, Fructus Cnidii 1-4 part, Radix Polygoni Multiflori Preparata 2-8 part, Herba Cistanches 1-6 part, Fructus Lycii 2-7 part, Semen Cuscutae 2-7 part, Fructus Schisandrae Chinensis 1-6 part, Fructus Rubi 1-6 part, Radix Astragali 2-8 part, Radix Ginseng Rubra 0.5-3 part, Rhizoma Atractylodis Macrocephalae 0.5-3 part, Rhizoma Dioscoreae 1-6 part, Poria 0.5-5 part, Radix Angelicae Sinensis 1-6 part, Rhizoma Chuanxiong 0.5-4 part, Fructus Foeniculi 0.5-3 part, Semen Plantaginis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part.
2. medicated wine according to claim 1, it is characterized in that: the raw material of Chinese medicine medicine of the following weight proportion of described medicated wine is prepared from: Herba Epimedii 6.7 parts, Semen Trigonellae 6.6 parts, Fructus Rosae Laevigatae 6.7 parts, Radix Rehmanniae Preparata 6.6 parts, Fructus Psoraleae 2.0 parts, Fructus Cnidii 2.0 parts, Radix Polygoni Multiflori Preparata 5.2 parts, Herba Cistanches 3.3 parts, Fructus Lycii 4.6 parts, Semen Cuscutae 4.6 parts, Fructus Schisandrae Chinensis 2.5 parts, Fructus Rubi 2.3 parts, the Radix Astragali 3.6 parts, Radix Ginseng Rubra 1.4 parts, the Rhizoma Atractylodis Macrocephalae 1.0 parts, Rhizoma Dioscoreae 3.3 parts, 2.1 parts, Poria, Radix Angelicae Sinensis 3.3 parts, Rhizoma Chuanxiong 2.0 parts, Fructus Foeniculi 1.0 parts, Semen Plantaginis 1.2 parts, Radix Glycyrrhizae Preparata 1.0 parts.
3. the preparation method of medicated wine according to claim 1, it is characterized in that, step is as follows: raw material Extraction solvent extracts, then through conventional filtration, recycling design, precipitation, concentrated obtain concentrated extracting solution, then be adjusted to the finished product containing amount of alcohol 5%-75% with ethanol.
4. preparation method according to claim 3, it is characterized in that, step is as follows: raw material carries out extract by solvents through the Extraction solvent containing 10%-95% (v/v) ethanol, extracting solution after filtration, leave standstill, refilter, obtain active constituents of medicine, add adjuvant, make alcohol content be 5%-75% (v/v) through allotment.
5. preparation method according to claim 3, is characterized in that: described Extraction solvent comprises the Spirit in corn source.
6. preparation method according to claim 3, is characterized in that: described extracting mode is selected from: immersion, percolation, backflow, ultrasonic power.
7. preparation method according to claim 3, is characterized in that: described extracting method can adopt the ultrasound wave of certain frequency to carry out assisted extraction as enhancements, preferably as adopted 40kHz soak extraction.
8. preparation method according to claim 3, it is characterized in that: described extracting method, step is as follows: the broken or shredding by all raw materials, with 55%-65% soaking in Chinese liquor, 55%-65% Chinese liquor, distilled water adjustment amount are to the finished product 1000ml containing amount of alcohol 20%-50%, leave standstill, filter, fill and get final product.
9. medicated wine according to claim 1, it is characterized in that: the function of described medicine wine cures mainly and comprises warming and recuperating the kidney-YANG, controlling nocturnal emission with astringent drugs QI invigorating, strengthening the body resistance, be afraid of cold for the impotence and seminal emission caused by kidney yang virtual loss, vital essence deficiency, waist and leg ache, lassitude, nocturia, fear of cold, menorrhagia, clear and thin leucorrhea etc.; It is 30-65g that every consumption per day amounts to raw material.
10. medicated wine according to claim 1, is characterized in that: the function of described health promoting wine is for improving tolerance, alleviating physical fatigue; It is 5-30g that every consumption per day amounts to raw material.
CN201510945255.XA 2015-12-17 2015-12-17 Preparation method of traditional Chinese medicine vinum Pending CN105434777A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105920269A (en) * 2016-06-01 2016-09-07 高乐君 Health-care medicinal liquor for females
CN108117961A (en) * 2018-01-26 2018-06-05 贵州理工学院 A kind of minuent health preserving wine and preparation method thereof
CN113274448A (en) * 2021-02-05 2021-08-20 老君堂生物科技有限公司 Pure traditional Chinese medicine kidney tonifying preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
国家药典委员会: "《中华人民共和国药典：2010年版：第三增补本》", 30 November 2014, 中国医药科技出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105920269A (en) * 2016-06-01 2016-09-07 高乐君 Health-care medicinal liquor for females
CN108117961A (en) * 2018-01-26 2018-06-05 贵州理工学院 A kind of minuent health preserving wine and preparation method thereof
CN113274448A (en) * 2021-02-05 2021-08-20 老君堂生物科技有限公司 Pure traditional Chinese medicine kidney tonifying preparation

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