CN101355967A - 用α-7烟碱受体抗体治疗炎性疾病 - Google Patents

用α-7烟碱受体抗体治疗炎性疾病 Download PDF

Info

Publication number
CN101355967A
CN101355967A CNA2006800503150A CN200680050315A CN101355967A CN 101355967 A CN101355967 A CN 101355967A CN A2006800503150 A CNA2006800503150 A CN A2006800503150A CN 200680050315 A CN200680050315 A CN 200680050315A CN 101355967 A CN101355967 A CN 101355967A
Authority
CN
China
Prior art keywords
seq
antibody
fragment
antigen
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800503150A
Other languages
English (en)
Chinese (zh)
Inventor
杨立宏
K·J·特雷西
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Feinstein Institutes for Medical Research
Original Assignee
Feinstein Institutes for Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38007280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101355967(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Feinstein Institutes for Medical Research filed Critical Feinstein Institutes for Medical Research
Publication of CN101355967A publication Critical patent/CN101355967A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04Amoebicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04LTRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L12/00Data switching networks
    • H04L12/02Details
    • H04L12/16Arrangements for providing special services to substations
    • H04L12/18Arrangements for providing special services to substations for broadcast or conference, e.g. multicast
    • H04L12/1813Arrangements for providing special services to substations for broadcast or conference, e.g. multicast for computer conferences, e.g. chat rooms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04LTRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L51/00User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail
    • H04L51/04Real-time or near real-time messaging, e.g. instant messaging [IM]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Signal Processing (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Otolaryngology (AREA)
  • Reproductive Health (AREA)
  • General Engineering & Computer Science (AREA)
CNA2006800503150A 2005-11-15 2006-11-15 用α-7烟碱受体抗体治疗炎性疾病 Pending CN101355967A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73704505P 2005-11-15 2005-11-15
US60/737,045 2005-11-15

Publications (1)

Publication Number Publication Date
CN101355967A true CN101355967A (zh) 2009-01-28

Family

ID=38007280

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800503150A Pending CN101355967A (zh) 2005-11-15 2006-11-15 用α-7烟碱受体抗体治疗炎性疾病

Country Status (7)

Country Link
US (2) US8316104B2 (https=)
EP (1) EP1957107A2 (https=)
JP (1) JP5303279B2 (https=)
CN (1) CN101355967A (https=)
AU (1) AU2006315420B2 (https=)
CA (1) CA2629545A1 (https=)
WO (1) WO2007059203A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103262529A (zh) * 2010-05-12 2013-08-21 布鲁珍视网络有限公司 实时多媒体通讯中媒体流可伸缩复合的系统和方法
CN110151762A (zh) * 2019-05-19 2019-08-23 青海大学 一种噻虫啉的新用途
CN111432883A (zh) * 2017-08-15 2020-07-17 安蒂多特疗法公司 新型烟碱结合抗体
CN121041449A (zh) * 2025-07-31 2025-12-02 中国人民解放军军事科学院军事医学研究院 乙酰胆碱受体激动剂在治疗脑膜炎中的应用

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050149364A1 (en) * 2000-10-06 2005-07-07 Ombrellaro Mark P. Multifunction telemedicine software with integrated electronic medical record
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US7599989B2 (en) * 2005-01-24 2009-10-06 Microsoft Corporation System and method for gathering and reporting screen resolutions of attendees of a collaboration session
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
RU2432362C2 (ru) 2005-11-30 2011-10-27 Эбботт Лэборетриз Моноклональные антитела и их применения
PL2289909T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał
US20070268294A1 (en) * 2006-05-16 2007-11-22 Stephen Troy Eagen Apparatus and method for topology navigation and change awareness
US20070294404A1 (en) * 2006-06-15 2007-12-20 International Business Machines Corporation Method and system for authorization and access control delegation in an on demand grid environment
US20080065999A1 (en) * 2006-09-13 2008-03-13 Majors Kenneth D Conferencing system with document access
US8418069B2 (en) * 2006-09-29 2013-04-09 International Business Machines Corporation Spinning off chat threads
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US9195996B1 (en) 2006-12-27 2015-11-24 Qurio Holdings, Inc. System and method for classification of communication sessions in a social network
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
US8339991B2 (en) 2007-03-01 2012-12-25 Meraki, Inc. Node self-configuration and operation in a wireless network
US9274847B2 (en) * 2007-05-04 2016-03-01 Microsoft Technology Licensing, Llc Resource management platform
US8782527B2 (en) * 2007-06-27 2014-07-15 Microsoft Corp. Collaborative phone-based file exchange
SA08290475B1 (ar) * 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
US7822841B2 (en) * 2007-10-30 2010-10-26 Modern Grids, Inc. Method and system for hosting multiple, customized computing clusters
EP2056563B1 (en) * 2007-11-05 2012-09-26 Alcatel Lucent Peer-to-peer network
US9117211B2 (en) * 2008-07-24 2015-08-25 International Business Machines Corporation System and method for correlating questions and answers in an instant messaging environment
US8655950B2 (en) * 2008-08-06 2014-02-18 International Business Machines Corporation Contextual awareness in real time collaborative activity alerts
US8838532B2 (en) * 2008-12-24 2014-09-16 At&T Intellectual Property I, L.P. Collaborative self-service contact architecture with automatic blog content mapping capability
GB2469501B (en) * 2009-04-16 2012-01-04 Appshare Ltd Method and system for network-based collaboration
US9390156B2 (en) * 2009-06-29 2016-07-12 International Business Machines Corporation Distributed directory environment using clustered LDAP servers
US20110142221A1 (en) * 2009-12-15 2011-06-16 At&T Intellectual Property I, L.P. System and method for automated group calling service based on key words
US8508575B2 (en) * 2010-03-31 2013-08-13 Sony Corporation Television system, television set and method for operating a television system
ES2684475T3 (es) 2010-04-15 2018-10-03 Abbvie Inc. Proteínas que se unen a beta amiloide
US9081633B2 (en) 2010-05-24 2015-07-14 Microsoft Technology Licensing, Llc Remote application connection sharing
WO2012002853A1 (en) * 2010-06-29 2012-01-05 Telefonaktiebolaget Lm Ericsson (Publ) A method and an apparatus for evaluating network performance
US8558868B2 (en) * 2010-07-01 2013-10-15 Cisco Technology, Inc. Conference participant visualization
CN103298833B (zh) 2010-08-14 2015-12-16 Abbvie公司 β淀粉样蛋白结合蛋白
US9124757B2 (en) 2010-10-04 2015-09-01 Blue Jeans Networks, Inc. Systems and methods for error resilient scheme for low latency H.264 video coding
US8380845B2 (en) 2010-10-08 2013-02-19 Microsoft Corporation Providing a monitoring service in a cloud-based computing environment
US9015281B2 (en) * 2010-10-08 2015-04-21 Brian Lee Moffat Private data sharing system
US8843632B2 (en) 2010-10-11 2014-09-23 Microsoft Corporation Allocation of resources between web services in a composite service
US8959219B2 (en) 2010-10-18 2015-02-17 Microsoft Technology Licensing, Llc Dynamic rerouting of service requests between service endpoints for web services in a composite service
US8874787B2 (en) 2010-10-20 2014-10-28 Microsoft Corporation Optimized consumption of third-party web services in a composite service
US9300705B2 (en) 2011-05-11 2016-03-29 Blue Jeans Network Methods and systems for interfacing heterogeneous endpoints and web-based media sources in a video conference
US9369673B2 (en) 2011-05-11 2016-06-14 Blue Jeans Network Methods and systems for using a mobile device to join a video conference endpoint into a video conference
US9159037B2 (en) * 2011-06-14 2015-10-13 Genesys Telecommunications Laboratories, Inc. Context aware interaction
US9195971B2 (en) * 2011-07-12 2015-11-24 Salesforce.Com, Inc. Method and system for planning a meeting in a cloud computing environment
EP2555141A1 (en) * 2011-08-03 2013-02-06 Alcatel Lucent A method, a system, a server, a control element, a computer program and a computer program product for operating a power grid having decentralized control elements
US20130080513A1 (en) * 2011-09-28 2013-03-28 Jeremy Debate Multi-party communication sessions via broadcast notification network
US20130097244A1 (en) 2011-09-30 2013-04-18 Clearone Communications, Inc. Unified communications bridging architecture
DE102011117777B3 (de) * 2011-11-01 2013-01-31 Markus Lehnert System und Verfahren zur Bestimmung eines bevorzugten Kommunikationskanal
US9124646B2 (en) 2012-02-16 2015-09-01 Blackberry Limited Method and system for obtaining availability status for multiple SIP users
JP6102575B2 (ja) * 2013-07-02 2017-03-29 富士通株式会社 性能測定方法、性能測定プログラム及び性能測定装置
US9392079B2 (en) 2013-07-19 2016-07-12 International Business Machines Corporation Directory service discovery and/or learning
US20150077509A1 (en) 2013-07-29 2015-03-19 ClearOne Inc. System for a Virtual Multipoint Control Unit for Unified Communications
US20170034235A1 (en) * 2015-07-27 2017-02-02 Browan Communications Inc. Electronic device, communication system and method for transmitting/receiving audio and video data
US10771508B2 (en) 2016-01-19 2020-09-08 Nadejda Sarmova Systems and methods for establishing a virtual shared experience for media playback
US9800931B1 (en) * 2016-06-08 2017-10-24 Cisco Technology, Inc. Adaptive screen layout for video conferencing
US9712570B1 (en) 2016-09-28 2017-07-18 Atlassian Pty Ltd Dynamic adaptation to increased SFU load by disabling video streams
EP4309374A1 (en) 2021-04-19 2024-01-24 Meta Platforms Technologies, Llc Wrist-wearable device for automatically switching between video and other calling modes based on sensor data at the wrist-wearable device, head-worn wearable devices for use therewith and for coordinated video capturing with the wrist-wearable device, and methods of use thereof
US11736605B2 (en) 2021-04-19 2023-08-22 Meta Platforms Technologies, Llc Coordinated video streaming and messaging using a wrist-wearable device and a head-worn wearable device, and methods of use thereof
CN120457144A (zh) * 2022-11-10 2025-08-08 巴斯德研究所 产生作为α7烟碱乙酰胆碱受体的沉默和正变构调节剂的抗体
US20260095365A1 (en) * 2024-09-27 2026-04-02 Juniper Networks, Inc. Performance monitoring of an application session based on coparticipants

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659078B1 (en) 1992-08-31 2003-01-15 University Of Florida Research Foundation, Inc. Anabaseine derivatives useful in the treatment of degenerative diseases of the nervous system
US5977144A (en) 1992-08-31 1999-11-02 University Of Florida Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines
JP3708962B2 (ja) 1994-08-24 2005-10-19 アストラゼネカ・アクチエボラーグ 治療に有用なスピロ−アザ二環式化合物
SE9600683D0 (sv) 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
US7266686B1 (en) * 1996-05-09 2007-09-04 Two-Way Media Llc Multicasting method and apparatus
FR2756826B1 (fr) 1996-12-05 1999-01-08 Adir Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6323000B2 (en) 1996-12-20 2001-11-27 Clark A. Briggs Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
NZ500645A (en) 1997-05-30 2001-06-29 Neurosearch As 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors
AR013184A1 (es) 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
JP2003512290A (ja) 1997-09-10 2003-04-02 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての8a−アザライド
US6484196B1 (en) * 1998-03-20 2002-11-19 Advanced Web Solutions Internet messaging system and method for use in computer networks
US6459682B1 (en) * 1998-04-07 2002-10-01 International Business Machines Corporation Architecture for supporting service level agreements in an IP network
EP1083889B1 (en) 1998-06-01 2003-12-10 Ortho-McNeil Pharmaceutical, Inc. Tetrahydronaphtalene compounds and their use for the treatment of neurodegenerative diseases
FR2786769B1 (fr) 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
FR2786770B1 (fr) 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
US6432975B1 (en) 1998-12-11 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
SE9900100D0 (sv) 1999-01-15 1999-01-15 Astra Ab New compounds
FR2790474B1 (fr) 1999-03-05 2001-04-06 Synthelabo Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique
GB2349055B (en) * 1999-04-16 2004-03-24 Mitel Corp Virtual meeting rooms with spatial audio
EP1177196B1 (en) 1999-05-04 2004-03-10 Neurosearch A/S Heteroaryl diazabicycloalkanes, their preparation and use
EP1269201A1 (en) 2000-03-29 2003-01-02 Synaptica Limited Alpha 7 nicotinic receptor screening assays
US6751404B1 (en) * 2000-04-13 2004-06-15 Forgent Networks, Inc. Method and apparatus for detecting processor congestion during audio and video decode
GB0010955D0 (en) 2000-05-05 2000-06-28 Novartis Ag Organic compounds
US6976066B1 (en) * 2000-05-22 2005-12-13 Microsoft Corporation Network and method for implementing network platform services for a computing device
US6610713B2 (en) 2000-05-23 2003-08-26 North Shore - Long Island Jewish Research Institute Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
JP2002007294A (ja) * 2000-06-22 2002-01-11 Canon Inc 画像配信システム及び方法並びに記憶媒体
ATE287888T1 (de) 2000-07-04 2005-02-15 Neurosearch As Aryl- und heteroaryldiazabicycloalkane, deren zubereitung und verwendung
JP4616971B2 (ja) 2000-07-18 2011-01-19 田辺三菱製薬株式会社 1−アザビシクロアルカン化合物およびその医薬用途
US20030037109A1 (en) * 2000-08-11 2003-02-20 Newman Harvey B. Virtual room videoconferencing system
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492386B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6479510B2 (en) 2000-08-18 2002-11-12 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6599916B2 (en) 2000-08-21 2003-07-29 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
US7158534B2 (en) * 2000-11-30 2007-01-02 Imajet Communications, Inc. Unified distributed architecture for a multi-point video conference and interactive broadcast systems
US6884807B2 (en) 2000-12-01 2005-04-26 Neurosearch, A/S 3-substituted quinuclidines and their use as nicotinic agonists
US20020086871A1 (en) 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
US7130883B2 (en) * 2000-12-29 2006-10-31 Webex Communications, Inc. Distributed network system architecture for collaborative computing
WO2002057275A1 (en) 2001-01-17 2002-07-25 University Of Kentucky Research Foundation Boron-containing nicotine analogs for use in the treatment of cns pathologies
US6479172B2 (en) 2001-01-26 2002-11-12 Xerox Corporation Electroluminescent (EL) devices
US20020133611A1 (en) * 2001-03-16 2002-09-19 Eddy Gorsuch System and method for facilitating real-time, multi-point communications over an electronic network
CA2341952A1 (en) 2001-03-23 2002-09-23 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases
US6569865B2 (en) 2001-06-01 2003-05-27 Astrazeneca Ab Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine
BR0212101A (pt) 2001-08-24 2004-08-24 Pharmacia & Up John Company 7-aza [2.2.1] biciclo-heptanos substituìdos com heteroarila para o tratamento de doenças
JP2005527472A (ja) 2001-09-12 2005-09-15 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 疾患治療のための置換された7−アザ[2.2.1]ビシクロヘプタン
HUP0402289A2 (hu) 2001-10-02 2005-02-28 Pharmacia & Upjohn Company Gyógyhatású azabiciklusos csoporttal helyettesített kondenzált heteroaril-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AU2002339810A1 (en) 2001-10-16 2003-04-28 Astrazeneca Ab Azabicyclic compounds for the treatment of fibromyalgia syndrome
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
US6951868B2 (en) 2001-11-09 2005-10-04 Pfizer Inc. Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease
KR100411251B1 (ko) * 2001-11-28 2003-12-18 한국전자통신연구원 제한조건을 만족하는 다중 경로 배정방법
DE10211415A1 (de) 2002-03-15 2003-09-25 Bayer Ag Bicyclische N-Biarylamide
US7238715B2 (en) 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
WO2004052365A2 (en) * 2002-12-06 2004-06-24 North Shore-Long Island Jewish Research Institute Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists
US7680920B2 (en) * 2003-03-24 2010-03-16 Netiq Corporation Methods, systems and computer program products for evaluating network performance using diagnostic rules identifying performance data to be collected
US7415527B2 (en) * 2003-06-13 2008-08-19 Satyam Computer Services Limited Of Mayfair Centre System and method for piecewise streaming of video using a dedicated overlay network
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103262529A (zh) * 2010-05-12 2013-08-21 布鲁珍视网络有限公司 实时多媒体通讯中媒体流可伸缩复合的系统和方法
CN103262529B (zh) * 2010-05-12 2017-11-17 布鲁珍视网络有限公司 实时多媒体通讯中媒体流可伸缩复合的系统和方法
CN111432883A (zh) * 2017-08-15 2020-07-17 安蒂多特疗法公司 新型烟碱结合抗体
CN111432883B (zh) * 2017-08-15 2024-10-01 安蒂多特疗法公司 新型烟碱结合抗体
CN110151762A (zh) * 2019-05-19 2019-08-23 青海大学 一种噻虫啉的新用途
CN121041449A (zh) * 2025-07-31 2025-12-02 中国人民解放军军事科学院军事医学研究院 乙酰胆碱受体激动剂在治疗脑膜炎中的应用

Also Published As

Publication number Publication date
US20070156813A1 (en) 2007-07-05
WO2007059203A3 (en) 2007-07-19
JP5303279B2 (ja) 2013-10-02
AU2006315420B2 (en) 2010-07-15
JP2009515982A (ja) 2009-04-16
WO2007059203A2 (en) 2007-05-24
US8316104B2 (en) 2012-11-20
CA2629545A1 (en) 2007-05-24
US8524866B2 (en) 2013-09-03
AU2006315420A1 (en) 2007-05-24
EP1957107A2 (en) 2008-08-20
US20090324588A1 (en) 2009-12-31

Similar Documents

Publication Publication Date Title
CN101355967A (zh) 用α-7烟碱受体抗体治疗炎性疾病
CN112424224B (zh) 抗白细胞介素-17a抗体、其药物组合物及其用途
CN110172098B (zh) 抗α-突触核蛋白的单克隆抗体及其应用
US7736638B2 (en) Interleukin-15 antagonist peptide
US20100256341A1 (en) Treatment of inflammation using alpha 7 receptor-binding cholinergic agonists
JP2008532936A (ja) インターロイキン−17f抗体及び他のil−17fシグナル伝達拮抗物質並びにそれらの使用
JPWO1998046644A1 (ja) 新規蛋白質及びその製造方法
KR20190134614A (ko) B7-h3 항체, 이의 항원-결합 단편 및 이의 의학적 용도
CN101952316B (zh) 用于治疗炎性关节障碍的钙黏着蛋白-11 ec1结构域拮抗剂
JP7497293B2 (ja) インターロイキン-31に対するペプチドワクチン
US20090136970A1 (en) Nogo receptor homologues and their use
KR20080059449A (ko) 치료용 약제
JP2003511007A (ja) サイトカインレセプター鎖
CN102089327A (zh) 抗PirB抗体
EP3016977B1 (en) Human anti-il-32 antibodies
CA2163350A1 (en) Opioid receptors: compositions and methods
CN114805572B (zh) 抗原结合蛋白及其应用
CA3239216A1 (en) Method of treating ulcerative colitis with anti-il23 specific antibody
JP4754143B2 (ja) ケモカインレセプター
AU2023383916A1 (en) Method of treating ulcerative colitis with anti-il23 specific antibody
CN119604529A (zh) 抗体、其抗原结合片段及其药物用途
CN114127110B (zh) 抗cgrp抗体及其应用
WO2025160964A1 (zh) 一种trpm3抗体、制备其的方法及应用
CA2452195A1 (en) Identification and characterization of multiple splice variants of the mu opioid receptor gene
US7273725B2 (en) Human and mammalian stem cell-derived neuron survival factors

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20090128