CN101314016A - Compound andrographis paniculata injection for treating pig hyperpyrexia and preparation method thereof - Google Patents
Compound andrographis paniculata injection for treating pig hyperpyrexia and preparation method thereof Download PDFInfo
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- CN101314016A CN101314016A CNA2008100538841A CN200810053884A CN101314016A CN 101314016 A CN101314016 A CN 101314016A CN A2008100538841 A CNA2008100538841 A CN A2008100538841A CN 200810053884 A CN200810053884 A CN 200810053884A CN 101314016 A CN101314016 A CN 101314016A
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Abstract
The invention discloses compound creat injection used for treating hyperpyrexia of a pig and a preparation method thereof, aiming to provide the compound creat injection for treating the hyperpyrexia of the pig with small side effect and the preparation method thereof with the advantages of simple technique and easy realization. Each 100 liters of the injection is prepared by the following raw materials: 50 to 150 kilograms of creat, 0.5 to 5 kilograms of zedoary turmeric oil, 50 to 150 kilograms of Chinese thorowax, 30 to 80 kilograms of garlic, 0.5 kilograms of tween-80, 0.9 kilograms of sodium chloride, 100 kilograms of 95 percent ethanol, the balance being injection water. The compound creat injection is formed by the creat and three traditional Chinese medicines including the Chinese thorowax , the zedoary turmeric oil and the garlic, has the efficacies of antivirus, antibacteria, fever reduction and improvement of the immunity of an organism through reasonable determination of the content of various compositions, strengthens intrinsic phagocytic function, is effective to drug-resistant pathogen of western medicines and the hyperpyrexia of the pig, and relieves the stress reaction of the pig. Simultaneously, the product is traditional Chinese medicine preparation, has small side effect, does not aggravate the burden of the liver and the kidney, and can effectively treat an illness.
Description
Technical field
The present invention relates to a kind of compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia and preparation method thereof.
Background technology
Pig hyperpyrexia is to reveal existing a kind of disease, the main cause that causes this kind disease is mixed infections such as antibacterial, virus, the bacterial virus that causes infection has a variety of, have plenty of a kind of, have plenty of several MOI, mainly show as disease pig fever, hyperpyrexia, skin rubefaction turns blue, and sick pig passive protective physical fitness is extremely low, lassitude, inappetence, the mortality rate of sick pig is high.
At present, there is not the specific drug of treatment pig hyperpyrexia, some antibiotic medicines treatments of many clinically employings, but therapeutic effect is not good, and owing to cause that the cause of disease of infection can not be definite, often treatment failure brings very big loss to pig industry.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, a kind of treatment pig hyperpyrexia to be provided, improving Abwehrkraft des Koepers, the compound andrographis paniculata injection that side effect is little.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned animal compound CHUANXINLIAN ZHUSHEYE that realizes.
The present invention is achieved through the following technical solutions:
A kind of compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia, it is characterized in that, every 100L injection is made by following raw material: Herba Andrographis 50～150kg, Oleum Curcumae 0.5～5kg, Radix Bupleuri 50～150kg, Bulbus Allii 30～80kg, tween 80 0.5kg, sodium chloride 0.9kg, 95% ethanol 100kg, the water for injection of surplus.
A kind of above-mentioned preparation method that is used for the treatment of the compound andrographis paniculata injection of pig hyperpyrexia is characterized in that, comprises the steps:
(1) takes by weighing the water that Herba Andrographis 50～150kg puts into 8 times of Herba Andrographis weight and decoct, keep boiling 90 minutes, filter; Medicinal residues after filtering are added the water of 6 times of Herba Andrographis weight, and secondary decocts, and keeps boiling 90 minutes, filters.Merge twice decocting liquid, be concentrated into 50L, add the ethanol of 100kg 95%, after stirring, precipitate 24 hours, afterwards, filter, collect filtrate, remove impurity, as tannic acid, unnecessary polysaccharide, and easy sedimentary material etc.Reclaim the ethanol in the filtrate, do not have the alcohol flavor to filtrate, the filtrate that will reclaim again behind the ethanol is concentrated into 30L, with the maintenance drug level.Wherein, employed water is preferably purified water during decoction.By this operating procedure, obtain the high concentration Herba Andrographis medicinal liquid of injection, and remove impurity, guarantee injection.
(2) with Radix Bupleuri 50～150kg, Bulbus Allii 30～80kg pulverizes to improve contact area.With the flowing steam distillation, collect distillate 300L afterwards.Because the boiling point of volatile oil is lower than water, but in still-process, water can not be controlled evaporation, in order to improve drug level, removes unnecessary water, so with this method of redistillation.The distillate that obtains is carried out second distillation, collect the distillate 100L of second distillation, the distillate of the second distillation that obtains is distilled for the third time, collect distillatory for the third time distillate 50L, with tween 80 0.5kg, sodium chloride 0.9kg joins in the above-mentioned distillate for the third time and is stirred to whole dissolvings again.By this step, obtain the distillate of volatile oil, and keep drug level.
(3) the prepared solution of combining step 1 and step 2 adds Oleum Curcumae 0.5～5kg, stirs, add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the present invention after clear and bright.
The preferable content of each raw material is when wherein preparing every 100L injection: Herba Andrographis 80～120kg, Oleum Curcumae 1～3kg, Radix Bupleuri 70～120kg, Bulbus Allii 40～70kg, tween 80 0.5kg, sodium chloride 0.9kg, 95% ethanol 100kg, the water for injection of surplus.
The optimum content of each raw material is when wherein preparing every 100L injection: Herba Andrographis 100kg, Oleum Curcumae 2kg, Radix Bupleuri 100kg, Bulbus Allii 50kg, tween 80 0.5kg, sodium chloride 0.9kg, 95% ethanol 100kg, the water for injection of surplus.
The present invention has following technique effect:
The compound preparation of the present invention for adopting Herba Andrographis and Radix Bupleuri, Oleum Curcumae, three kinds of Chinese medicine composition of Bulbus Allii to form.Herba Andrographis has the effect of heat-clearing and toxic substances removing, can strengthen the phagocytic function of body and bring down a fever, inflammation-diminishing function, various bacteria is infected effectively.Radix Bupleuri has effects for removing toxic heat, and has certain antiviral, liver-protecting efficacy, is used for that domestic animal is analgesic brings down a fever.Oleum Curcumae has powerful antiviral efficacy, and Bulbus Allii has has inhibition and killing action to multiple coccus, bacillus, fungus, virus.Four by reasonable formula, and to rationally the determining of each constituent content, has the effect of antiviral, antibacterium, analgesic, human body immunity improving power.Cause of disease and clinical symptoms to causing pig hyperpyrexia have therapeutical effect, and alleviate the stress of pig.Energy human body immunity improving power, and strengthen intrinsic phagocytic function.Has the function of protecting the liver.Simultaneously, this product is a Chinese medicine preparation, and side effect is little, and it is effective that Western medicine is produced chemical sproof cause of disease, do not increase the weight of the burden to liver, kidney, can effectively treat disease.
The preparation method that is used for the treatment of the compound andrographis paniculata injection of pig hyperpyrexia of the present invention can combine volatile oil injection and the water soluble preparation in the general Chinese medicine extraction liquid.And technology is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) takes by weighing Herba Andrographis 50kg and put into the 400kg purified water and decoct, keep boiling 90 minutes, filter.Medicinal residues after filtering are added the purified water of 300kg, and secondary decocts, and keeps boiling 90 minutes, filters.The decocting liquid that merges twice is concentrated into 50L, adds the ethanol of 100kg 95%, after stirring, precipitates 24 hours, filters, and collects filtrate.Reclaim the ethanol in the filtrate, do not have the alcohol flavor to filtrate, the filtrate that will reclaim again behind the ethanol is concentrated into 30L.
(2) with Radix Bupleuri 150kg, Bulbus Allii 80kg, after the pulverizing,, collect distillate 300L with the flowing steam distillation, the distillate that obtains is carried out second distillation, collect the distillate 100L of second distillation, the distillate of the second distillation that obtains is distilled for the third time, collect distillatory for the third time distillate 50L, with tween 80 0.5kg, sodium chloride 0.9kg joins in the above-mentioned distillate for the third time and is stirred to whole dissolvings again.
(3) the prepared solution of combining step 1 and step 2 adds Oleum Curcumae 0.5kg, stirs, add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the present invention after clear and bright.
Embodiment 2
(1) takes by weighing Herba Andrographis 150kg and put into the 1200kg purified water and decoct, keep boiling 90 minutes, filter.Medicinal residues after filtering are added the purified water of 900kg, and secondary decocts, and keeps boiling 90 minutes, filters.Merge twice decocting liquid, be concentrated into 50L, add the ethanol of 100kg95%, after stirring, precipitate 24 hours, filter.Collect filtrate, reclaim the ethanol in the filtrate, do not have the alcohol flavor to filtrate, the filtrate that will reclaim again behind the ethanol is concentrated into 30L.
(2) with Radix Bupleuri 50kg, Bulbus Allii 30kg, after the pulverizing,, collect distillate 300L with the flowing steam distillation, the distillate that obtains is carried out second distillation, collect the distillate 100L of second distillation, the distillate of the second distillation that obtains is distilled for the third time, collect distillatory for the third time distillate 50L, with tween 80 0.5kg, sodium chloride 0.9kg joins in the above-mentioned distillate for the third time and is stirred to whole dissolvings again.
(3) the prepared solution of combining step 1 and step 2 adds Oleum Curcumae 5kg, stirs, and adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the present invention after clear and bright.
Embodiment 3
(1) takes by weighing Herba Andrographis 80kg and put into the 640kg purified water and decoct, keep boiling 90 minutes, filter.Medicinal residues after filtering are added the 480kg purified water, and secondary decocts, and keeps boiling 90 minutes, filters.Merge twice decocting liquid, be concentrated into 50L, add the ethanol of 100kg 95%, after stirring, precipitate 24 hours, filter.Collect filtrate, reclaim the ethanol in the filtrate, do not have the alcohol flavor to filtrate, the filtrate that will reclaim again behind the ethanol is concentrated into 30L.
(2) with Radix Bupleuri 120kg, Bulbus Allii 70kg, after the pulverizing,, collect distillate 300L with the flowing steam distillation, the distillate that obtains is carried out second distillation, collect the distillate 100L of second distillation, the distillate of the second distillation that obtains is distilled for the third time, collect distillatory for the third time distillate 50L, with tween 80 0.5kg, sodium chloride 0.9kg joins in the above-mentioned distillate for the third time and is stirred to whole dissolvings again.
(3) the prepared solution of combining step 1 and step 2 adds Oleum Curcumae 1kg, stirs, and adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the present invention after clear and bright.
Embodiment 4
(1) take by weighing Herba Andrographis 120kg and put into the 960kg purified water and decoct, keep boiling 90 minutes, filter, the medicinal residues after filtering are added the purified water of 720kg, secondary decocts, and keeps boiling 90 minutes, filters.Merge twice decocting liquid, be concentrated into 50L, add the ethanol of 100kg 95%, after stirring, precipitate 24 hours, filter.Collect filtrate, reclaim the ethanol in the filtrate, do not have the alcohol flavor to filtrate, the filtrate that will reclaim again behind the ethanol is concentrated into 30L.
(2) with Radix Bupleuri 70kg, Bulbus Allii 40kg, after the pulverizing,, collect distillate 300L with the flowing steam distillation, the distillate that obtains is carried out second distillation, collect the distillate 100L of second distillation, the distillate of the second distillation that obtains is distilled for the third time, collect distillatory for the third time distillate 50L, with tween 80 0.5kg, sodium chloride 0.9kg joins in the above-mentioned distillate for the third time and is stirred to whole dissolvings again.
(3) the prepared solution of combining step 1 and step 2 adds Oleum Curcumae 3kg, stirs, and adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the present invention after clear and bright.
Embodiment 5
(1) takes by weighing Herba Andrographis 90kg and put into the 720kg purified water and decoct, keep boiling 90 minutes, filter.Medicinal residues after filtering are added the 540kg purified water, and secondary decocts, and keeps boiling 90 minutes, filters.Merge twice decocting liquid, be concentrated into 50L, add the ethanol of 100kg 95%, after stirring, precipitate 24 hours, filter.Collect filtrate, reclaim the ethanol in the filtrate, do not have the alcohol flavor to filtrate, the filtrate that will reclaim again behind the ethanol is concentrated into 30L.
(2) with Radix Bupleuri 90kg, Bulbus Allii 45kg, after the pulverizing,, collect distillate 300L with the flowing steam distillation, the distillate that obtains is carried out second distillation, collect the distillate 100L of second distillation, the distillate of the second distillation that obtains is distilled for the third time, collect distillatory for the third time distillate 50L, with tween 80 0.5kg, sodium chloride 0.9kg joins in the above-mentioned distillate for the third time and is stirred to whole dissolvings again.
(3) the prepared solution of combining step 1 and step 2 adds Oleum Curcumae 2.5kg, stirs, add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the present invention after clear and bright.
Embodiment 6
(1) takes by weighing Herba Andrographis 100kg and put into the 800kg purified water and decoct, keep boiling 90 minutes, filter.Medicinal residues after filtering are added the 600kg purified water, and secondary decocts, and keeps boiling 90 minutes, filters.Merge twice decocting liquid, be concentrated into 50L, add the ethanol of 100kg 95%, after stirring, precipitate 24 hours, filter.Collect filtrate, reclaim the ethanol in the filtrate, do not have the alcohol flavor to filtrate, the filtrate that will reclaim again behind the ethanol is concentrated into 30L.
(2) with Radix Bupleuri 100kg, Bulbus Allii 50kg, after the pulverizing,, collect distillate 300L with the flowing steam distillation, the distillate that obtains is carried out second distillation, collect the distillate 100L of second distillation, the distillate of the second distillation that obtains is distilled for the third time, collect distillatory for the third time distillate 50L, with tween 80 0.5kg, sodium chloride 0.9kg joins in the above-mentioned distillate for the third time and is stirred to whole dissolvings again.
(3) the prepared solution of combining step 1 and step 2 adds Oleum Curcumae 2kg, stirs, and adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the present invention after clear and bright.
Clinical trial:
1. laboratory animal:
100 of the ill one-tenth of picked at random pigs.
2. experiment medicine:
The compound andrographis paniculata injection our unit development that is used for the treatment of pig hyperpyrexia of the embodiment of the invention 6 preparations;
CHUANXINLIAN ZHUSHEYE (1ml is equivalent to crude drug in whole 1g) our unit's prepared in laboratory;
2% Oleum Curcumae injection our unit prepared in laboratory.
3. experimental technique:
Suffer from pig with 100 and be divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with CHUANXINLIAN ZHUSHEYE (1ml is equivalent to crude drug in whole 1g): intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 5 days.
The C group is treated usage with 2% Oleum Curcumae injection: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 5 days.
The D group is treated usage with the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 5 days.
After the treatment beginning, every day, record trouble poultry health situation of change distributed, and treat after the 10th day and add up therapeutic effect, wherein:
Invalid: as after referring to 10 days, to suffer from the poultry symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 10 days, suffer from the poultry symptom and change, the effect before symptom is better than treating.
Cure: after referring to 10 days, transference cure is suffered from poultry and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 10 days, suffer from poultry and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from poultry and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the compound andrographis paniculata injection treatment group that is used for the treatment of pig hyperpyrexia of the embodiment of the invention 6 preparations, CHUANXINLIAN ZHUSHEYE (1ml is equivalent to crude drug in whole 1g) treatment group and 2% Oleum Curcumae injection peace injection group and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | Symptom pig's head number is arranged during end | A dead number | The relative weight gain rate % |
| A | Matched group | 25 | 0 | 0 | 3 | 22 | 0 |
| B | CHUANXINLIAN ZHUSHEYE | 18 | 7 | 2 | 5 | 18 | 10 |
| C | 2% Oleum Curcumae injection | 19 | 6 | 3 | 4 | 18 | 8 |
| D | Embodiment 6 is used for the treatment of the compound andrographis paniculata injection of pig hyperpyrexia | 5 | 20 | 18 | 5 | 2 | 70.0 |
Claims (6)
1, a kind of compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia, it is characterized in that, every 100L injection is made by following raw material: Herba Andrographis 50～150kg, Oleum Curcumae 0.5～5kg, Radix Bupleuri 50～150kg, Bulbus Allii 30～80kg, tween 80 0.5kg, sodium chloride 0.9kg, 95% ethanol 100kg, the water for injection of surplus.
2, the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia according to claim 1, it is characterized in that, every 100L injection is made by following raw material: Herba Andrographis 80～120kg, Oleum Curcumae 1～3kg, Radix Bupleuri 70～120kg, Bulbus Allii 40～70kg, tween 80 0.5kg, sodium chloride 0.9kg, 95% ethanol 100kg, the water for injection of surplus.
3, the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia according to claim 1, it is characterized in that, every 100L injection is made by following raw material: Herba Andrographis 100kg, Oleum Curcumae 2kg, Radix Bupleuri 100kg, Bulbus Allii 50kg, tween 80 0.5kg, sodium chloride 0.9kg, 95% ethanol 100kg, the water for injection of surplus.
4, the described preparation method that is used for the treatment of the compound andrographis paniculata injection of pig hyperpyrexia of a kind of claim 1 is characterized in that, comprises the steps:
(1) takes by weighing the water that Herba Andrographis 50～150kg puts into 8 times of Herba Andrographis weight and decoct, keep boiling 90 minutes, filter; Medicinal residues after filtering are added the water of 6 times of Herba Andrographis weight, and secondary decocts, and keeps boiling 90 minutes, filters; Merge twice decocting liquid, be concentrated into 50L, add the ethanol of 100kg 95%, after stirring, precipitate 24 hours, filter, collect filtrate; Reclaim the ethanol in the filtrate, do not have the alcohol flavor to filtrate, the filtrate that will reclaim again behind the ethanol is concentrated into 30L;
(2) with Radix Bupleuri 50～150kg, Bulbus Allii 30～80kg, after the pulverizing,, collect distillate 300L with the flowing steam distillation, the distillate that obtains is carried out second distillation, collect the distillate 100L of second distillation, the distillate of the second distillation that obtains is distilled for the third time, collect distillatory for the third time distillate 50L, with tween 80 0.5kg, sodium chloride 0.9kg joins in the above-mentioned distillate for the third time and is stirred to whole dissolvings again;
(3) the prepared solution of combining step 1 and step 2 adds Oleum Curcumae 0.5～5kg, stirs, add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes the compound andrographis paniculata injection that is used for the treatment of pig hyperpyrexia of the present invention after clear and bright.
5, the preparation method that is used for the treatment of the compound andrographis paniculata injection of pig hyperpyrexia according to claim 4, it is characterized in that, every 100L injection is made by following raw material: Herba Andrographis 80～120kg, Oleum Curcumae 1～3kg, Radix Bupleuri 70～120kg, Bulbus Allii 40～70kg, tween 80 0.5kg, sodium chloride 0.9kg, 95% ethanol 100kg, the water for injection of surplus.
6, the preparation method that is used for the treatment of the compound andrographis paniculata of pig hyperpyrexia according to claim 4, it is characterized in that, every 100L injection is made by following raw material: Herba Andrographis 100kg, Oleum Curcumae 2kg, Radix Bupleuri 100kg, Bulbus Allii 50kg, tween 80 0.5kg, sodium chloride 0.9kg, 95% ethanol 100kg, the water for injection of surplus.
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| CN2008100538841A CN101314016B (en) | 2008-07-18 | 2008-07-18 | Compound andrographis paniculata injection for treating pig hyperpyrexia and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698193A (en) * | 2012-05-31 | 2012-10-03 | 四川金瑞克动物药业有限公司 | Chinese medicinal injection for preventing and controlling pig exogenous febrile diseases and preparation method thereof |
| CN102755590A (en) * | 2012-07-31 | 2012-10-31 | 河南光泰动物药业有限公司 | Veterinary medicine for enhancing porcine growth performance and preparation method thereof |
| CN104688827A (en) * | 2015-03-23 | 2015-06-10 | 伟达（湖南）科技有限公司 | Sterilizing and detoxicating poultry medicine and preparation method thereof |
| CN109331111A (en) * | 2018-12-10 | 2019-02-15 | 河南农业大学 | A kind of compound creat formulation and preparation method thereof for treating livestock and poultry warm heat disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN1546082A (en) * | 2003-12-05 | 2004-11-17 | 祁克宗 | Green chiretta injection for treating gastrointestinal disease of animal |
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2008
- 2008-07-18 CN CN2008100538841A patent/CN101314016B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698193A (en) * | 2012-05-31 | 2012-10-03 | 四川金瑞克动物药业有限公司 | Chinese medicinal injection for preventing and controlling pig exogenous febrile diseases and preparation method thereof |
| CN102755590A (en) * | 2012-07-31 | 2012-10-31 | 河南光泰动物药业有限公司 | Veterinary medicine for enhancing porcine growth performance and preparation method thereof |
| CN104688827A (en) * | 2015-03-23 | 2015-06-10 | 伟达（湖南）科技有限公司 | Sterilizing and detoxicating poultry medicine and preparation method thereof |
| CN109331111A (en) * | 2018-12-10 | 2019-02-15 | 河南农业大学 | A kind of compound creat formulation and preparation method thereof for treating livestock and poultry warm heat disease |
| CN109331111B (en) * | 2018-12-10 | 2021-09-28 | 河南农业大学 | Compound andrographis paniculata preparation for treating livestock and poultry epidemic febrile disease and preparation method thereof |
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| CN101314016B (en) | 2010-11-03 |
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