CN109331111A - A kind of compound creat formulation and preparation method thereof for treating livestock and poultry warm heat disease - Google Patents
A kind of compound creat formulation and preparation method thereof for treating livestock and poultry warm heat disease Download PDFInfo
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- CN109331111A CN109331111A CN201811503070.3A CN201811503070A CN109331111A CN 109331111 A CN109331111 A CN 109331111A CN 201811503070 A CN201811503070 A CN 201811503070A CN 109331111 A CN109331111 A CN 109331111A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Abstract
The present invention relates to livestock and poultry treatment technology fields, more particularly to a kind of compound creat formulation and preparation method thereof for treating livestock and poultry warm heat disease, including Herba Andrographitis extracting solution, 95% ethyl alcohol, alternanthera philoxeroides, peristrophe, polyoxyethylene sorbitan fatty acid ester (80), EDTA-4Na, matrine, carbasalate calcium, garlic extract, β-amylodextrin, Scutellaria discolor, discolored skullcap herb, red stalk grass roots, wild Fructus Momordicae charantiae, astragalus polyose, phlomis umbrosa.Compound creat formulation of the present invention antiviral ingredients containing there are many, antiviral effect is excellent, efficacy stability.Compound creat formulation of the present invention has effectively sheltered the bad smell of compound creat formulation, so that livestock and poultry are easier to take, therapeutic effect is substantially improved by selecting Suitable coatings material and art for coating.
Description
Technical field
The present invention relates to livestock and poultry treatment technology fields, and in particular to a kind of compound andrographis paniculata for treating livestock and poultry warm heat disease
Preparation and preparation method thereof.
Background technique
Warm heat disease is caused by exogenous disease warm disease and evil, as main feature and is had seasonal and different degrees of using thermal image weighting
Communicable one kind disease.The warm heat disease four seasons can occur, and be common disease, frequently-occurring disease clinically, be easy in animal population
The spread in china between group, or even extensive prevalence is caused, it brings about great losses to aquaculture.Modern viewpoint analysis, livestock and poultry temperature
Pyreticosis is as caused by a kind of filterability substance or virus, and the virus is i.e. dead rapidly at room temperature, but is stored in animal
Virus in tissue or in intestines and stomach content, activity can maintain the several months long.In recent years, with livestock and poultry warm heat disease disease incidence
It is in rising trend, the healthy and sustainable development of animal husbandry is seriously restrict, especially pig raising and poultry are influenced maximum.Example
Such as: pig transmissible warm heat disease in the piglet within 7-10 days ages the death rate it is very high, be the one of the major reasons of piglet death.
CN101966323A discloses a kind of for treating the compound andrographis paniculata injection of pig hyperpyrexia, every 100L injection
Composition are as follows: 3~7Kg of creat extract, 0.5~1.5Kg of oil of zedoary turmeric, 1.5~6Kg of gentamicin sulphate, Ofloxacin 1.5~
4.5Kg, 8~30Kg of analgin, carbamylcholine chloride 0.05Kg, anhydrous sodium hydrogensulfite 0.2Kg, EDTA-2Na
0.01Kg, Tween-80 1Kg, hydrochloric acid 0.5Kg, surplus are water for injection.
But the above-mentioned antiviral effect that exists in the prior art is not good enough, and contains gentamicin sulphate, Ofloxacin, An Nai
It is close to wait western medicine compositions, satisfied therapeutic effect is unable to reach to poultry warm heat disease.Therefore, it is necessary to develop a kind of antiviral effects
More preferably, to the higher pharmaceutical preparation of poultry warm heat disease cure rate.
Summary of the invention
The purpose of the present invention is to provide a kind of compound creat formulation for treating livestock and poultry warm heat disease, using compound preparation,
Selected raw material medicament, antiviral property is excellent, and therapeutic effect is significant.
Another object of the present invention is to provide a kind of preparation method of compound creat formulation for treating livestock and poultry warm heat disease, work
Skill is scientific and reasonable, simple and easy.
To achieve the above object, the present invention adopts the following technical solutions:
A kind of compound creat formulation for treating livestock and poultry warm heat disease, including following mass parts raw material: Herba Andrographitis extracting solution
100-240 parts, 150-500 parts of 95% ethyl alcohol, 30-45 parts of alternanthera philoxeroides, 21-30 parts of peristrophe, polyoxyethylene sorbitan
20-45 parts of Span (80), 10-15 parts of EDTA-4Na, 80-120 parts of matrine, 50-85 parts of carbasalate calcium,
65-90 parts of garlic extract, β -30-50 parts of amylodextrin, 25-40 parts of Scutellaria discolor, 18-26 parts of discolored skullcap herb, red stalk grass roots 15-
24 parts, 22-28 parts of wild Fructus Momordicae charantiae, 20-42 parts of astragalus polyose, 15-20 parts of phlomis umbrosa.
Wherein, the Herba Andrographitis extracting solution the preparation method comprises the following steps: being put into the boiling of 5 times of Herba Andrographitis quality after Herba Andrographitis is crushed
It is decocted 30 minutes in water, the boiling water that the filtered dregs of a decoction reuse 5 times of Herba Andrographitis dregs of a decoction quality is decocted 60 minutes；Merge twice
Filtrate after decoction, is concentrated into 50L, and 95% ethyl alcohol is added and stirs evenly, and alcohol precipitation 24 hours, filtrate was collected in filtering；Wherein decoct
Boiling with water is high purity water.
Preferably, each component mass parts are as follows: 130-200 parts of Herba Andrographitis extracting solution, 180-400 parts of 95% ethyl alcohol, hollow lotus
Sub- 32-41 parts of grass, 24-30 parts of peristrophe, 20-38 parts of polyoxyethylene sorbitan fatty acid ester (80), EDTA-4Na
11-15 parts, 90-110 parts of matrine, 60-85 parts of carbasalate calcium, 72-90 parts of garlic extract, β -35-50 parts of amylodextrin,
25-38 parts of Scutellaria discolor, 20-25 parts of discolored skullcap herb, 15-22 parts of red stalk grass roots, 22-26 parts of wild Fructus Momordicae charantiae, 20-35 parts of astragalus polyose,
15-19 parts of phlomis umbrosa.
Further, each component mass parts are preferred are as follows: 150-185 parts of Herba Andrographitis extracting solution, 200-380 parts of 95% ethyl alcohol,
32-37 parts of alternanthera philoxeroides, 24-28 parts of peristrophe, 20-30 parts of polyoxyethylene sorbitan fatty acid ester (80),
11-14 parts of EDTA-4Na, 100-110 parts of matrine, 75-85 parts of carbasalate calcium, 80-90 parts of garlic extract, β-gelatinized corn starch
40-50 parts smart, 25-33 parts of Scutellaria discolor, 21-24 parts of discolored skullcap herb, 17-21 parts of red stalk grass roots, 23-25 parts of wild Fructus Momordicae charantiae, Radix Astragali are more
It is 20-30 parts sugared, 16-18 parts of phlomis umbrosa.
Preferably, compound creat formulation of the present invention also includes odor mask, and the odor mask is by acrylic resin and xanthan
Glue composition, the acrylic resin is preferably Utech E100, and the odor mask dosage is compound creat formulation gross mass
20-35%, wherein acrylic resin and xanthan gum mass ratio are 1:2-1:3.5.
The present invention also provides a kind of preparation methods of compound creat formulation for treating livestock and poultry warm heat disease, including walk as follows
It is rapid:
SS1: 100-240 parts of Herba Andrographitis extracting solution, 150-500 parts of 95% ethyl alcohol, alternanthera philoxeroides 30-45 are weighed according to the ratio
Part, 21-30 parts of peristrophe, 20-45 parts of polyoxyethylene sorbitan fatty acid ester (80), 10-15 parts of EDTA-4Na,
80-120 parts of matrine, 50-85 parts of carbasalate calcium, 65-90 parts of garlic extract, β -30-50 parts of amylodextrin, Scutellaria discolor
25-40 parts, 18-26 parts of discolored skullcap herb, 15-24 parts of red stalk grass roots, 22-28 parts of wild Fructus Momordicae charantiae, 20-42 parts of astragalus polyose, phlomis umbrosa 15-20
Part；
SS2: alternanthera philoxeroides, peristrophe, Scutellaria discolor, discolored skullcap herb, red stalk grass roots, wild Fructus Momordicae charantiae, phlomis umbrosa is dry
After crush, distilled respectively using flowing steam, collect the distillate with the weight such as each traditional Chinese medicinal components of this step, mix each distillate and obtain
Material α；
SS3: being heated to 35-50 DEG C for Herba Andrographitis extracting solution, and matrine, garlic extract, astragalus polyose, card is then added
Bar woods calcium stirs 5-10min, and liquid to be mixed, which is cooled to room temperature, is added 95% ethyl alcohol and material α, is stirred until homogeneous to obtain material β；
SS4: polyoxyethylene sorbitan fatty acid ester (80), EDTA-4Na and β-amylodextrin are added into material β
It is stirred until homogeneous to obtain material γ；
SS5: acrylic resin and xanthan gum being added into material γ, use dispersion machine high-speed stirred 15-30min, stirring
Speed is 2000-3000r/min；
SS6: by system be cooled to room temperature to get.
Wherein, the Herba Andrographitis extracting solution the preparation method comprises the following steps: being put into the boiling of 5 times of Herba Andrographitis quality after Herba Andrographitis is crushed
It is decocted 30 minutes in water, the boiling water that the filtered dregs of a decoction reuse 5 times of Herba Andrographitis dregs of a decoction quality is decocted 60 minutes；Merge twice
Filtrate after decoction, is concentrated into 50L, and 95% ethyl alcohol is added and stirs evenly, and alcohol precipitation 24 hours, filtrate was collected in filtering；Wherein decoct
Boiling with water is high purity water.
Preferably, each component mass parts are as follows: 130-200 parts of Herba Andrographitis extracting solution, 180-400 parts of 95% ethyl alcohol, hollow lotus
Sub- 32-41 parts of grass, 24-30 parts of peristrophe, 20-38 parts of polyoxyethylene sorbitan fatty acid ester (80), EDTA-4Na
11-15 parts, 90-110 parts of matrine, 60-85 parts of carbasalate calcium, 72-90 parts of garlic extract, β -35-50 parts of amylodextrin,
25-38 parts of Scutellaria discolor, 20-25 parts of discolored skullcap herb, 15-22 parts of red stalk grass roots, 22-26 parts of wild Fructus Momordicae charantiae, 20-35 parts of astragalus polyose,
15-19 parts of phlomis umbrosa.
Further, each component mass parts are preferred are as follows: 150-185 parts of Herba Andrographitis extracting solution, 200-380 parts of 95% ethyl alcohol,
32-37 parts of alternanthera philoxeroides, 24-28 parts of peristrophe, 20-30 parts of polyoxyethylene sorbitan fatty acid ester (80),
11-14 parts of EDTA-4Na, 100-110 parts of matrine, 75-85 parts of carbasalate calcium, 80-90 parts of garlic extract, β-gelatinized corn starch
40-50 parts smart, 25-33 parts of Scutellaria discolor, 21-24 parts of discolored skullcap herb, 17-21 parts of red stalk grass roots, 23-25 parts of wild Fructus Momordicae charantiae, Radix Astragali are more
It is 20-30 parts sugared, 16-18 parts of phlomis umbrosa.
Preferably, compound creat formulation of the present invention also includes odor mask, and the odor mask is by acrylic resin and xanthan
Glue composition, the acrylic resin is preferably Utech E100, and the odor mask dosage is compound creat formulation gross mass
20-35%, wherein acrylic resin and xanthan gum mass ratio are 1:2-1:3.5.
Compound creat formulation of the present invention for powder or can be packed into capsule and obtain capsule or tabletted or ball is made
The product forms such as particle are made in agent, and the conventional preparation work of this field powder, capsule, tablet, pill, particle is used when production
Skill.
The beneficial effects of the present invention are: compound creat formulation of the present invention contains there are many antiviral ingredients, livestock and poultry are warmed
Sick Causative virus has good inhibition, killing effect, and by the specific selection to component in preparation and content, improves drug effect
Stability is responded well to treatment fast.Compound creat formulation of the present invention, which also passes through, selects Suitable coatings material and art for coating, effectively covers
The bad smell of compound creat formulation is covered, so that livestock and poultry are easier to take, therapeutic effect is substantially improved.
Specific embodiment
The present invention is further described with reference to embodiments:
Embodiment 1
A kind of compound creat formulation for treating livestock and poultry warm heat disease, including following mass parts raw material: Herba Andrographitis extracting solution 220
Part, 450 parts of 95% ethyl alcohol, 45 parts of alternanthera philoxeroides, 22 parts of peristrophe, polyoxyethylene sorbitan fatty acid ester (80)
40 parts, 10 parts of EDTA-4Na, 115 parts of matrine, 55 parts of carbasalate calcium, 70 parts of garlic extract, 33 parts of β-amylodextrin,
40 parts of Scutellaria discolor, 18 parts of discolored skullcap herb, red 23 parts of stalk grass roots, 28 parts of wild Fructus Momordicae charantiae, 40 parts of astragalus polyose, 20 parts of phlomis umbrosa, by propylene
The odor mask of acid resin and xanthan gum composition, the odor mask dosage is the 25% of compound creat formulation gross mass, wherein third
Olefin(e) acid resin and xanthan gum mass ratio are 1:2.
The Herba Andrographitis extracting solution the preparation method comprises the following steps: being put into after Herba Andrographitis is crushed in the boiling water of 5 times of Herba Andrographitis quality
It decocts 30 minutes, the boiling water that the filtered dregs of a decoction reuse 5 times of Herba Andrographitis dregs of a decoction quality is decocted 60 minutes；Merging decocts twice
Filtrate afterwards, is concentrated into 50L, and 95% ethyl alcohol is added and stirs evenly, and alcohol precipitation 24 hours, filtrate was collected in filtering；It wherein decocts and uses
Water is high purity water.
The compound creat formulation preparation method includes the following steps:
SS1: 220 parts of Herba Andrographitis extracting solution, 450 parts of 95% ethyl alcohol, 45 parts of alternanthera philoxeroides, Herba Peristrophes are weighed according to the ratio
Careless 22 parts, (80) 40 parts of polyoxyethylene sorbitan fatty acid ester, 10 parts of EDTA-4Na, 115 parts of matrine, Carbaspirin
55 parts of calcium, 70 parts of garlic extract, 33 parts of β-amylodextrin, 40 parts of Scutellaria discolor, 18 parts of discolored skullcap herb, red 23 parts of stalk grass roots, open country
28 parts of balsam pear, the odor mask 40 parts of astragalus polyose, 20 parts of phlomis umbrosa, be made of acrylic resin and xanthan gum, the odor mask is used
Amount is that the 25% of compound creat formulation gross mass, wherein acrylic resin and xanthan gum mass ratio are 1:2；
SS2: alternanthera philoxeroides, peristrophe, Scutellaria discolor, discolored skullcap herb, red stalk grass roots, wild Fructus Momordicae charantiae, phlomis umbrosa is dry
After crush, distilled respectively using flowing steam, collect the distillate with the weight such as each traditional Chinese medicinal components of this step, mix each distillate and obtain
Material α；
SS3: being heated to 45 DEG C for Herba Andrographitis extracting solution, and matrine, garlic extract, astragalus polyose, kappa is then added
Woods calcium stirs 10min, and liquid to be mixed, which is cooled to room temperature, is added 95% ethyl alcohol and material α, is stirred until homogeneous to obtain material β；
SS4: polyoxyethylene sorbitan fatty acid ester (80), EDTA-4Na and β-amylodextrin are added into material β
It is stirred until homogeneous to obtain material γ；
SS5: acrylic resin and xanthan gum are added into material γ, uses dispersion machine high-speed stirred 30min, mixing speed
For 3000r/min；
SS6: by system be cooled to room temperature to get.
Embodiment 2
A kind of compound creat formulation for treating livestock and poultry warm heat disease, including following mass parts raw material: Herba Andrographitis extracting solution 190
Part, 390 parts of 95% ethyl alcohol, 38 parts of alternanthera philoxeroides, 30 parts of peristrophe, polyoxyethylene sorbitan fatty acid ester (80)
35 parts, 15 parts of EDTA-4Na, 95 parts of matrine, 70 parts of carbasalate calcium, 76 parts of garlic extract, 37 parts of β-amylodextrin, purple
Carry on the back 35 parts of radix scutellariae, 20 parts of discolored skullcap herb, red 16 parts of stalk grass roots, 26 parts of wild Fructus Momordicae charantiae, 33 parts of astragalus polyose, 15 parts of phlomis umbrosa, by acrylic acid
The odor mask of resin and xanthan gum composition, the odor mask dosage are the 25% of compound creat formulation gross mass, wherein propylene
Acid resin and xanthan gum mass ratio are 1:2.
The Herba Andrographitis extracting solution the preparation method comprises the following steps: being put into after Herba Andrographitis is crushed in the boiling water of 5 times of Herba Andrographitis quality
It decocts 30 minutes, the boiling water that the filtered dregs of a decoction reuse 5 times of Herba Andrographitis dregs of a decoction quality is decocted 60 minutes；Merging decocts twice
Filtrate afterwards, is concentrated into 50L, and 95% ethyl alcohol is added and stirs evenly, and alcohol precipitation 24 hours, filtrate was collected in filtering；It wherein decocts and uses
Water is high purity water.
The compound creat formulation preparation method includes the following steps:
SS1: 190 parts of Herba Andrographitis extracting solution, 390 parts of 95% ethyl alcohol, 38 parts of alternanthera philoxeroides, Herba Peristrophes are weighed according to the ratio
Careless 30 parts, (80) 35 parts of polyoxyethylene sorbitan fatty acid ester, 15 parts of EDTA-4Na, 95 parts of matrine, carbasalate calcium
70 parts, 76 parts of garlic extract, 37 parts of β-amylodextrin, 35 parts of Scutellaria discolor, 20 parts of discolored skullcap herb, red 16 parts of stalk grass roots, wild hardship
26 parts of melon, the odor mask 33 parts of astragalus polyose, 15 parts of phlomis umbrosa, be made of acrylic resin and xanthan gum, the odor mask dosage
It is the 25% of compound creat formulation gross mass, wherein acrylic resin and xanthan gum mass ratio are 1:2；
SS2: alternanthera philoxeroides, peristrophe, Scutellaria discolor, discolored skullcap herb, red stalk grass roots, wild Fructus Momordicae charantiae, phlomis umbrosa is dry
After crush, distilled respectively using flowing steam, collect the distillate with the weight such as each traditional Chinese medicinal components of this step, mix each distillate and obtain
Material α；
SS3: being heated to 45 DEG C for Herba Andrographitis extracting solution, and matrine, garlic extract, astragalus polyose, kappa is then added
Woods calcium stirs 10min, and liquid to be mixed, which is cooled to room temperature, is added 95% ethyl alcohol and material α, is stirred until homogeneous to obtain material β；
SS4: polyoxyethylene sorbitan fatty acid ester (80), EDTA-4Na and β-amylodextrin are added into material β
It is stirred until homogeneous to obtain material γ；
SS5: acrylic resin and xanthan gum are added into material γ, uses dispersion machine high-speed stirred 30min, mixing speed
For 3000r/min；
SS6: by system be cooled to room temperature to get.
Embodiment 3
A kind of compound creat formulation for treating livestock and poultry warm heat disease, including following mass parts raw material: Herba Andrographitis extracting solution 170
Part, 350 parts of 95% ethyl alcohol, 34 parts of alternanthera philoxeroides, 25 parts of peristrophe, polyoxyethylene sorbitan fatty acid ester (80)
26 parts, 13 parts of EDTA-4Na, 110 parts of matrine, 80 parts of carbasalate calcium, 80 parts of garlic extract, 46 parts of β-amylodextrin,
30 parts of Scutellaria discolor, 22 parts of discolored skullcap herb, red 20 parts of stalk grass roots, 24 parts of wild Fructus Momordicae charantiae, 25 parts of astragalus polyose, 18 parts of phlomis umbrosa, by propylene
The odor mask of acid resin and xanthan gum composition, the odor mask dosage is the 25% of compound creat formulation gross mass, wherein third
Olefin(e) acid resin and xanthan gum mass ratio are 1:2.
The Herba Andrographitis extracting solution the preparation method comprises the following steps: being put into after Herba Andrographitis is crushed in the boiling water of 5 times of Herba Andrographitis quality
It decocts 30 minutes, the boiling water that the filtered dregs of a decoction reuse 5 times of Herba Andrographitis dregs of a decoction quality is decocted 60 minutes；Merging decocts twice
Filtrate afterwards, is concentrated into 50L, and 95% ethyl alcohol is added and stirs evenly, and alcohol precipitation 24 hours, filtrate was collected in filtering；It wherein decocts and uses
Water is high purity water.
The compound creat formulation preparation method includes the following steps:
SS1: 170 parts of Herba Andrographitis extracting solution, 350 parts of 95% ethyl alcohol, 34 parts of alternanthera philoxeroides, Herba Peristrophes are weighed according to the ratio
Careless 25 parts, (80) 26 parts of polyoxyethylene sorbitan fatty acid ester, 13 parts of EDTA-4Na, 110 parts of matrine, Carbaspirin
80 parts of calcium, 80 parts of garlic extract, 46 parts of β-amylodextrin, 30 parts of Scutellaria discolor, 22 parts of discolored skullcap herb, red 20 parts of stalk grass roots, open country
24 parts of balsam pear, the odor mask 25 parts of astragalus polyose, 18 parts of phlomis umbrosa, be made of acrylic resin and xanthan gum, the odor mask is used
Amount is that the 25% of compound creat formulation gross mass, wherein acrylic resin and xanthan gum mass ratio are 1:2；
SS2: alternanthera philoxeroides, peristrophe, Scutellaria discolor, discolored skullcap herb, red stalk grass roots, wild Fructus Momordicae charantiae, phlomis umbrosa is dry
After crush, distilled respectively using flowing steam, collect the distillate with the weight such as each traditional Chinese medicinal components of this step, mix each distillate and obtain
Material α；
SS3: being heated to 45 DEG C for Herba Andrographitis extracting solution, and matrine, garlic extract, astragalus polyose, kappa is then added
Woods calcium stirs 10min, and liquid to be mixed, which is cooled to room temperature, is added 95% ethyl alcohol and material α, is stirred until homogeneous to obtain material β；
SS4: polyoxyethylene sorbitan fatty acid ester (80), EDTA-4Na and β-amylodextrin are added into material β
It is stirred until homogeneous to obtain material γ；
SS5: acrylic resin and xanthan gum are added into material γ, uses dispersion machine high-speed stirred 30min, mixing speed
For 3000r/min；
SS6: by system be cooled to room temperature to get.
Comparative example 1
A kind of compound creat formulation, including following mass parts raw material: 280 parts of Herba Andrographitis extracting solution, 95% ethyl alcohol 550
Part, 10 parts of alternanthera philoxeroides, 10 parts of peristrophe, (80) 50 parts of polyoxyethylene sorbitan fatty acid ester, EDTA-4Na
5 parts, 50 parts of matrine, 100 parts of carbasalate calcium, 50 parts of garlic extract, 15 parts of β-amylodextrin, 10 parts of Scutellaria discolor, digging
45 parts of Auricled Hedyotis Herb, red 45 parts of stalk grass roots, 30 parts of wild Fructus Momordicae charantiae, 45 parts of astragalus polyose, 10 parts of phlomis umbrosa, by acrylic resin and xanthan gum group
At odor mask, the odor mask dosage is the 25% of compound creat formulation gross mass, wherein acrylic resin and xanthan gum
Mass ratio is 1:2.
1 preparation method of comparative example is same as Example 1.
Comparative example 2
A kind of compound creat formulation, preparation method is same as Example 1, and difference is in preparation without odor mask,
Other components and content are same as Example 1.
Livestock and poultry clinical test:
The sick pig 200 for suffering from warm heat disease, diseased chicken 200 are randomly selected, 8 groups of (A group, B group, C group, D group, E groups, F are divided into
Group, G group, H group), every group each 25/only.A group is not to be administered the blank control group for the treatment of, and B group uses Herba Andrographitis of the present invention
Extracting solution treatment, C group using CN101966323A embodiment 6 compound andrographis paniculata injection treat (C group only relates to controlling for sick pig
Treat), D, E, F group are treated using the embodiment of the present application 1-3 respectively, and G, H group are treated using the application comparative example 1-2 respectively.Wherein,
B, D, E, F, G, H group dosage are that pannage per ton is mixed into Herba Andrographitis extracting solution or compound creat formulation 10Kg, every Kg chicken feed
It is mixed into Herba Andrographitis extracting solution or compound creat formulation 5g.Observation statistics therapeutic effect after treatment 7 days.
Sick pig diseased chicken curative effect after table 1 is treated 7 days
As shown in Table 1, compound creat formulation of the present invention is to livestock and poultry warm heat disease compared to blank control group and using only wearing
The treatment of heart lotus extracting solution has significant curative effect advantage, equally can reach more compared with compound creat formulation in the prior art
Excellent therapeutic effect.From the comparison of D, E, F, G group it is found that influence of the instant component content to curative effect is more significant, using this
It invents preferred constituent content and prepares the available optimum therapeuticing effect of compound creat formulation, and general therapeutic pig warm heat disease system
Agent needs 15 days or so cure rates can be up to 85% or more, and 1-3 onset time of the embodiment of the present invention is short, it is only necessary to 7 days cure rates
Up to 84% or more, warm heat disease can be substantially reduced to loss caused by farm；By H group treatment results it is found that odor mask of the present invention
The bad smell that compound creat formulation itself can effectively be sheltered, makes livestock and poultry be easier to take drugs, and improves curative effect.
Above-described embodiment is the preferable implementation of the present invention, and in addition to this, the present invention can be realized with other modes,
Do not depart under the premise of present inventive concept it is any obviously replace it is within the scope of the present invention.
Claims (10)
1. a kind of compound creat formulation for treating livestock and poultry warm heat disease, which is characterized in that including following mass parts raw material: Herba Andrographitis
100-240 parts of extracting solution, 150-500 parts of 95% ethyl alcohol, 30-45 parts of alternanthera philoxeroides, 21-30 parts of peristrophe, polyoxy second
20-45 parts of alkene sorbitan fatty acid ester (80), EDTA-4Na10-15 parts, 80-120 parts of matrine, carbasalate calcium 50-
85 parts, 65-90 parts of garlic extract, β -30-50 parts of amylodextrin, 25-40 parts of Scutellaria discolor, 18-26 parts of discolored skullcap herb, red stalk grass
15-24 parts of root, 22-28 parts of wild Fructus Momordicae charantiae, 20-42 parts of astragalus polyose, 15-20 parts of phlomis umbrosa.
2. treating the compound creat formulation of livestock and poultry warm heat disease, the preparation of the Herba Andrographitis extracting solution according to claim 1
Method are as follows: be put into the boiling water of 5 times of Herba Andrographitis quality and decoct 30 minutes after crushing Herba Andrographitis, the filtered dregs of a decoction are reused
The boiling water of 5 times of Herba Andrographitis dregs of a decoction quality decocts 60 minutes；Merge the filtrate after decocting twice, is concentrated into 50L, 95% second is added
Alcohol stirs evenly, and alcohol precipitation 24 hours, filtrate was collected in filtering；Wherein decoction is high purity water with water.
3. the compound creat formulation for the treatment of livestock and poultry warm heat disease according to claim 1 or claim 2, each component mass parts are as follows: punching
130-200 parts of lotus extracting solution, 180-400 parts of 95% ethyl alcohol, 32-41 parts of alternanthera philoxeroides, 24-30 parts of peristrophe, polyoxy
20-38 parts of ethylene sorbitan fatty acid ester (80), EDTA-4Na11-15 parts, 90-110 parts of matrine, carbasalate calcium
60-85 parts, it is 72-90 parts of garlic extract, β -35-50 parts of amylodextrin, 25-38 parts of Scutellaria discolor, 20-25 parts of discolored skullcap herb, red
Obstruct grass roots 15-22 parts, 22-26 parts of wild Fructus Momordicae charantiae, 20-35 parts of astragalus polyose, 15-19 parts of phlomis umbrosa.
4. treating the compound creat formulation of livestock and poultry warm heat disease, each component mass parts are as follows: Herba Andrographitis proposes according to claim 3
Take 150-185 parts of liquid, 200-380 parts of 95% ethyl alcohol, 32-37 parts of alternanthera philoxeroides, 24-28 parts of peristrophe, polyoxyethylene
20-30 parts of sorbitan fatty acid ester (80), 11-14 parts of EDTA-4Na, 100-110 parts of matrine, carbasalate calcium 75-
85 parts, 80-90 parts of garlic extract, β -40-50 parts of amylodextrin, 25-33 parts of Scutellaria discolor, 21-24 parts of discolored skullcap herb, red stalk grass
17-21 parts of root, 23-25 parts of wild Fructus Momordicae charantiae, 20-30 parts of astragalus polyose, 16-18 parts of phlomis umbrosa.
It also include odor mask 5. treating the compound creat formulation of livestock and poultry warm heat disease according to claim 4, the taste masking
Agent is made of acrylic resin and xanthan gum, and the odor mask dosage is the 20-35% of compound creat formulation gross mass.
6. treating the compound creat formulation of livestock and poultry warm heat disease according to claim 5, the acrylic resin is preferably outstanding
Special surprise E100, wherein acrylic resin and xanthan gum mass ratio are 1:2-1:3.5.
7. a kind of preparation method for the compound creat formulation for treating livestock and poultry warm heat disease, which comprises the steps of:
SS1: weigh according to the ratio 100-240 parts of Herba Andrographitis extracting solution, 150-500 parts of 95% ethyl alcohol, 30-45 parts of alternanthera philoxeroides,
21-30 parts of peristrophe, 20-45 parts of polyoxyethylene sorbitan fatty acid ester (80), 10-15 parts of EDTA-4Na, kuh-seng
80-120 parts of alkali, 50-85 parts of carbasalate calcium, 65-90 parts of garlic extract, β -30-50 parts of amylodextrin, Scutellaria discolor 25-
40 parts, 18-26 parts of discolored skullcap herb, 15-24 parts of red stalk grass roots, 22-28 parts of wild Fructus Momordicae charantiae, 20-42 parts of astragalus polyose, 15-20 parts of phlomis umbrosa；
SS2: by powder after alternanthera philoxeroides, peristrophe, Scutellaria discolor, discolored skullcap herb, red stalk grass roots, wild Fructus Momordicae charantiae, phlomis umbrosa drying
It is broken, it is distilled respectively using flowing steam, collects the distillate with weights such as each traditional Chinese medicinal components of this step, mix each distillate and obtain material
α；
SS3: being heated to 35-50 DEG C for Herba Andrographitis extracting solution, and matrine, garlic extract, astragalus polyose, kappa is then added
Woods calcium stirs 5-10min, and liquid to be mixed, which is cooled to room temperature, is added 95% ethyl alcohol and material α, is stirred until homogeneous to obtain material β；
SS4: polyoxyethylene sorbitan fatty acid ester (80), EDTA-4Na and β-amylodextrin stirring are added into material β
Material γ is obtained to uniform；
SS5: acrylic resin and xanthan gum are added into material γ, uses dispersion machine high-speed stirred 15-30min, mixing speed
For 2000-3000r/min；
SS6: by system be cooled to room temperature to get.
8. treating the preparation method of the compound creat formulation of livestock and poultry warm heat disease according to claim 7, the Herba Andrographitis is mentioned
Decocting 30 minutes the preparation method comprises the following steps: being put into the boiling water of 5 times of Herba Andrographitis quality after Herba Andrographitis is crushed for liquid is taken, it will be filtered
The boiling water that the dregs of a decoction reuse 5 times of Herba Andrographitis dregs of a decoction quality decocts 60 minutes；Merge the filtrate after decocting twice, is concentrated into 50L, adds
Enter 95% ethyl alcohol to stir evenly, alcohol precipitation 24 hours, filtrate is collected in filtering；Wherein decoction is high purity water with water.
9. treating the preparation method of the compound creat formulation of livestock and poultry warm heat disease, the acrylic acid tree according to claim 8
The gross mass of rouge and xanthan gum is the 20-35% of compound creat formulation gross mass.
10. treating the preparation method of the compound creat formulation of livestock and poultry warm heat disease, the acrylic acid tree according to claim 9
Rouge is preferably Utech E100, and wherein acrylic resin and xanthan gum mass ratio are 1:2-1:3.5.
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