CN101313925A - Sanshi detoxication powder - Google Patents
Sanshi detoxication powder Download PDFInfo
- Publication number
- CN101313925A CN101313925A CNA2008100478681A CN200810047868A CN101313925A CN 101313925 A CN101313925 A CN 101313925A CN A2008100478681 A CNA2008100478681 A CN A2008100478681A CN 200810047868 A CN200810047868 A CN 200810047868A CN 101313925 A CN101313925 A CN 101313925A
- Authority
- CN
- China
- Prior art keywords
- radix cynanchi
- pulvis talci
- cynanchi atrati
- powder
- gypsum fibrosum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a three-stone alexipharmic pulverization for preventing and treating cloudy muscle disease of shrimps, which comprises the following materials in portion by weight: 15 to 40 portions of calcite, 5 to 15 portions of French chalk, 5 to 15 portions of plaster and 30 to 60 portions of cynanchum atratum. The three-stone alexipharmic pulverization has the characteristics of obvious effect and no toxic and side effect. The three-stone alexipharmic pulverization can be fed to shrimps remove various toxins as well as physical signs of muggy and poisonous moisture, etc. in the bodies of shrimp, thereby reducing rapidly the mortality rate of sick shrimps. In addition, the three-stone alexipharmic pulverization addresses symptoms as well as root causes and can remarkably improve the immunity of shrimp bodies.
Description
Technical field
The present invention relates to a kind of aquatic products medication, especially relate to a kind of Sanshi detoxication powder of preventing and treating the shrimp muscle nebulousurine.
Background technology
Shrimp muscle nebulousurine and mid intestinal gland nebulousurine are a kind of mortality rate height, the raiser are influenced big shrimps disease.Shrimp gets this after being ill, and its abdominal part adularescent speckle or whole abdominal part are all white, and abdominal part to tail muscles is a white, and the abnormality of moving about, and performance is uneasy, and the water surface of being everlasting is movable and break the water.This disease causes by shrimp bacteria infection, virus or to the uncomfortable institute of environment, at present for the shrimp muscle nebulousurine, mainly adopts chemical drugs such as TCCA (Trichloroisocyanuric acid) powder, BAIDUXIAO or antibiotic to prevent and treat.But these medicines are cured the symptoms, not the disease, even after sick shrimp is cured, and still residual poison of drug in the shrimp body, therefore the safety to food causes certain influence.
Though use Chinese herb prevention shrimp nebulousurine disease, there is not drug residue, mostly Chinese medicine preparation is folk prescription at present, and specific aim is relatively poor, so curative effect is not satisfactory.
Summary of the invention
The present invention mainly is that the medicine that solves tradition control shrimp muscle nebulousurine, mid intestinal gland nebulousurine is cured the symptoms, not the disease, and specific aim is relatively poor, and effect is not satisfactory, and technical problems such as poison of drug is residual are arranged in the shrimp body.
Above-mentioned technical problem of the present invention is mainly solved by following technical proposals: described Sanshi detoxication powder is mainly made by the proportioning raw materials of following weight portion: Mirabilitum crystallina 15-40 part, Pulvis Talci 5-15 part, Gypsum Fibrosum 5-15 part, Radix Cynanchi Atrati 30-60 part.
The optimum ratio of said components is: Mirabilitum crystallina 15-40 part, Pulvis Talci 5-15 part, Gypsum Fibrosum 5-15 part, Radix Cynanchi Atrati extract 10-20 part.
Wherein the preferred Radix Cynanchi Atrati of Radix Cynanchi Atrati extract is through supercritical CO
2Extraction obtains extract, and its yield is 33%
The best proportioning of said components is: 30 parts of Mirabilitum crystallinas, 10 parts of Pulvis Talci, 10 parts in Gypsum Fibrosum, 15 parts of Radix Cynanchi Atrati extracts.
Distinguish that according to the traditional Chinese medical science disease executes the improvement opinion, shrimp nebulousurine disease be the evil poison of seed shrimp diseases caused by exogenous pathogenic factor, in damp and hot disease is arranged.In component of the present invention, Mirabilitum crystallina (calcite) is cold in nature, has clearing away heat-fire, removes the effect of diarrhea of heat type key detumescence, is usually used in the calentura excessive thirst, diseases such as erysipelas scald.Pulvis Talci is cold in nature, is used for damp and hot watery diarrhea, external treatment eczema, eczema etc.Good physics, chemical characteristics such as chemical torpescence, covering power are good, softness, good luster, absorption affinity are strong.Radix Cynanchi Atrati is cold in nature, has clearing away heat and cooling blood, and the effect of skin ulcer is treated in detoxifcation, is usually used in pathogenic warmth and hinders battalion, ulcer sores, the disease such as do not close up of bursting.Gypsum Fibrosum is cold in nature, has the effect of detoxifcation, spasmolytic, antiinflammatory, can control hyperactivity of toxic heat, sends out diseases such as speckle dermexanthesis.
The present invention is by selected drug component, and reasonable compatibility is brought into play the synergism of each component, so had the effect of good heat-clearing and toxic substances removing, can remove various toxin in the shrimp body rapidly, eliminates signs such as it is damp and hot, noxious dampness.Test shows: bactericidal of the present invention, antiviral effect are remarkable, use the present invention, and shrimp muscle and mid intestinal gland nebulousurine disease are well controlled, and shrimp restores calm gradually, ingest and also recover normal.
Prepare above-mentioned Sanshi detoxication powder composition and can adopt following common process,, after the drying, above-mentioned medicinal powder is mixed, can obtain Sanshi detoxication powder by proportioning described in the compositions both with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum, Radix Cynanchi Atrati pulverize separately to 120 order.
In order to make drug effect of the present invention more remarkable, prepare above-mentioned Sanshi detoxication powder composition and can further adopt following method, this method may further comprise the steps: a. is with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum pulverize separately, crossing 120 mesh sieves, to obtain micropowder standby, to put into extraction kettle after the Radix Cynanchi Atrati pulverizing, with ethanol is entrainer, through supercritical CO
2Extraction obtains the Radix Cynanchi Atrati extract, and its optimum extraction condition is: the extraction time is 2.0h, and extraction temperature is 45 ℃, extracting pressure 25MPa; CO
2Flow is 10～20Kg/h; B. Pulvis Talci is put into the baking oven inner drying, by described proportioning Pulvis Talci is mixed with the Radix Cynanchi Atrati extract then, the spray-dried Radix Cynanchi Atrati-Pulvis Talci that obtains is gathered thing; C. Mirabilitum crystallina, Gypsum Fibrosum are put into drying in oven respectively, the Mirabilitum crystallina powder is taken out in dry back, Gypsum Fibrosum powder is poured in the mixer and mixed, stir and obtain the present composition after 30 minutes with Radix Cynanchi Atrati-Pulvis Talci collection thing.
In above-mentioned preparation method, Radix Cynanchi Atrati carries out supercritical CO
2After the extraction, its extract is about 33% of raw material weight.In order to utilize active substance in the Radix Cynanchi Atrati extract to greatest extent, the present invention adopts the Pulvis Talci in the component to fill collection to the Radix Cynanchi Atrati volatile oil in its rectifying column.Overcome traditional acquisition mode like this and adopted octadecyl Silicon stone (ODS) or inert material, the problem that resultant extract easily runs off in elution process as capturing material.In addition, utilize spray drying method to carry out drying, can guarantee the effective collection and the storage of extract the extract after gathering.
Certainly, also can add various adjuvants in the pharmaceutical composition of the present invention, as disintegrating agent, binding agent etc., the method for Chinese medicinal by routine prepares different dosage form.
It is remarkable that the present invention has drug effect, and use cost is low, and characteristics such as have no side effect.Can reduce disease shrimp mortality rate rapidly after the use, and treating both the principal and secondary aspects of a disease, can significantly strengthen shrimp body immunity, fully guaranteed raiser's economic interests.Because it is the present invention is a pure Chinese medicinal preparation, without any side effects simultaneously, can in the shrimp body, not form drug residue, therefore guaranteed the food quality of shrimp products.
The specific embodiment
Embodiment 1: with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum, Radix Cynanchi Atrati pulverize separately to 120 order, after the drying, get 30 parts in Mirabilitum crystallina powder, 10 parts of Pulvis Talci, 10 parts of Gypsum Fibrosum powders, 45 parts of mixing of Radix Cynanchi Atrati powder, can obtain the present composition.
Embodiment 2: with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum, Radix Cynanchi Atrati pulverize separately to 120 order, after the drying, get 15 parts in Mirabilitum crystallina powder, 15 parts of Pulvis Talci, 15 parts of Gypsum Fibrosum powders, 60 parts of mixing of Radix Cynanchi Atrati powder, can obtain the present composition.
Embodiment 3: with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum, Radix Cynanchi Atrati pulverize separately to 120 order, after the drying, get 40 parts in Mirabilitum crystallina powder, 5 parts of Pulvis Talci, 5 parts of Gypsum Fibrosum powders, 30 parts of mixing of Radix Cynanchi Atrati powder, can obtain the present composition.
Embodiment 4: with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum, Radix Cynanchi Atrati pulverize separately to 120 order, after the drying, get 25 parts in Mirabilitum crystallina powder, 10 parts of Pulvis Talci, 10 parts of Gypsum Fibrosum powders, 50 parts of mixing of Radix Cynanchi Atrati powder, can obtain the present composition.
Embodiment 5: with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum pulverize separately, it is standby that mistake 120 mesh sieves obtain micropowder, puts into extraction kettle after Radix Cynanchi Atrati is pulverized, and is entrainer with ethanol, through supercritical CO
2Extraction obtains the Radix Cynanchi Atrati extract; Pulvis Talci is put into the baking oven inner drying, get 10 parts of Pulvis Talci then and mix for 15 parts with the Radix Cynanchi Atrati extract, the spray-dried Radix Cynanchi Atrati-Pulvis Talci that obtains is gathered thing; C. Mirabilitum crystallina, Gypsum Fibrosum are put into drying in oven respectively, 30 parts in Mirabilitum crystallina powder is taken out in dry back, Gypsum Fibrosum powder is poured in the mixer for 10 parts and mixed, stir and obtain the present composition after 30 minutes with Radix Cynanchi Atrati-Pulvis Talci collection thing.
Embodiment 6: with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum pulverize separately, it is standby that mistake 120 mesh sieves obtain micropowder, puts into extraction kettle after Radix Cynanchi Atrati is pulverized, and is entrainer with ethanol, through supercritical CO
2Extraction obtains the Radix Cynanchi Atrati extract; Pulvis Talci is put into the baking oven inner drying, get 15 parts of Pulvis Talci then and mix for 20 parts with the Radix Cynanchi Atrati extract, the spray-dried Radix Cynanchi Atrati-Pulvis Talci that obtains is gathered thing; C. Mirabilitum crystallina, Gypsum Fibrosum are put into drying in oven respectively, 15 parts in Mirabilitum crystallina powder is taken out in dry back, Gypsum Fibrosum powder is poured in the mixer for 15 parts and mixed, stir and obtain the present composition after 30 minutes with Radix Cynanchi Atrati-Pulvis Talci collection thing.
Embodiment 7: with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum pulverize separately, it is standby that mistake 120 mesh sieves obtain micropowder, puts into extraction kettle after Radix Cynanchi Atrati is pulverized, and is entrainer with ethanol, through supercritical CO
2Extraction obtains the Radix Cynanchi Atrati extract; Pulvis Talci is put into the baking oven inner drying, get 5 parts of Pulvis Talci then and mix for 10 parts with the Radix Cynanchi Atrati extract, the spray-dried Radix Cynanchi Atrati-Pulvis Talci that obtains is gathered thing; C. Mirabilitum crystallina, Gypsum Fibrosum are put into drying in oven respectively, 40 parts in Mirabilitum crystallina powder is taken out in dry back, Gypsum Fibrosum powder is poured in the mixer for 5 parts and mixed, stir and obtain the present composition after 30 minutes with Radix Cynanchi Atrati-Pulvis Talci collection thing.
Embodiment 8: with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum pulverize separately, it is standby that mistake 120 mesh sieves obtain micropowder, puts into extraction kettle after Radix Cynanchi Atrati is pulverized, and is entrainer with ethanol, through supercritical CO
2Extraction obtains the Radix Cynanchi Atrati extract; Pulvis Talci is put into the baking oven inner drying, get 5 parts of Pulvis Talci then and mix for 12 parts with the Radix Cynanchi Atrati extract, the spray-dried Radix Cynanchi Atrati-Pulvis Talci that obtains is gathered thing; C. Mirabilitum crystallina, Gypsum Fibrosum are put into drying in oven respectively, 20 parts in Mirabilitum crystallina powder is taken out in dry back, Gypsum Fibrosum powder is poured in the mixer for 10 parts and mixed, stir and obtain the present composition after 30 minutes with Radix Cynanchi Atrati-Pulvis Talci collection thing.
Below further verify beneficial effect of the present invention by the curative effect of medication contrast test.
Selection has A, two mouthfuls of Penaeus vannamei shrimps of B pond of shrimp nebulousurine disease (muscle nebulousurine and mid intestinal gland nebulousurine), and A shrimp pool area is that 3 mu, shrimp quantity are 300,000 tails; B shrimp pond is 3.5 mu, and shrimp quantity is 350,000 tails.
The A pond is a test tank, and the embodiment of the invention 5 is made pharmaceutical composition, at six o'clock of every afternoon, evenly splashes in A shrimp pond logotype 2 days by the consumption of every mu/3000 gram present compositions.For oral administration simultaneously: by the ratio of feedstuff gross weight 1% with this pharmaceutical composition and the abundant mixing of shrimp feedstuff, one day nursing secondary, logotype 3 days.
The B pond is the contrast pond, and BAIDUXIAO (pharmaceutical Co. Ltd provides by the modern pelagic organism in Chengdu) is dissolved in the water, dilute 200 times after full pond evenly splash, at six o'clock of every afternoon, splash in the shrimp pond logotype 2 days by every mu/200 consumptions that restrain BAIDUXIAO.Simultaneously in the ratio of feedstuff gross weight 1% with Radix Isatidis powder and the abundant mixing of shrimp feedstuff, fed secondary, logotype 3 days in one day.Its therapeutic outcome is as shown in table 1:
Table 1: shrimp pond dispensing result of the test.
| The shrimp pond | A pond (test tank) | B pond (contrast pond) |
| Symptom | Trip pool phenomenon appears in shrimp, and sick shrimp has muscle nebulousurine and empty stomach symptom, and food ration obviously reduces, and ingest time prolongs. | Trip pool phenomenon appears in shrimp, and sick shrimp has muscle nebulousurine and empty stomach symptom, and food ration obviously reduces, and ingest time prolongs. |
| The dispensing situation | Pharmaceutical composition external of the present invention adds for oral administration. | The BAIDUXIAO external, Radix Isatidis is for oral administration. |
| The medication result | Nebulousurine disease is well controlled, ingests and recovers normal substantially, does not have to find to have the phenomenon on the dead shrimp and the shrimp trip pool. | Occur the dead shrimp of part at the bottom of the pool, the trip pool phenomenon of shrimp is alleviated to some extent, and appetite increases gradually, and ingest time also reduced to two hours by original similar three hours. |
| Mortality rate | 0.5% | 10% |
In the test, no matter pharmaceutical composition of the present invention adopts embodiment 5 still is other embodiment preparation, as long as its composition and content are all within the scope of the present invention, all has essentially identical curative effect.
Conclusion (of pressure testing): after test tank was used the present invention, sick shrimp symptom improved, and mortality rate is effectively controlled, and mortality rate only is 0.5%.Though the sick shrimp symptom in contrast pond makes moderate progress, mortality rate is higher, up to 10%.Subsequently, the observation that A, B pond were carried out month by a definite date shows that A pond shoal of shrimps grows fine, and recurs shrimp nebulousurine disease never again.Though B pond water body is through twice renewal and processing, water quality is better, but still large tracts of land breaks out shrimp nebulousurine disease once more, suffers heavy losses.
Claims (4)
1. Sanshi detoxication powder is characterized in that it is mainly made by the proportioning raw materials of following weight portion:
Mirabilitum crystallina 15-40 part, Pulvis Talci 5-15 part, Gypsum Fibrosum 5-15 part, Radix Cynanchi Atrati 30-60 part.
2. Sanshi detoxication powder composition according to claim 1 is characterized in that described component is: Mirabilitum crystallina 15-40 part, Pulvis Talci 5-15 part, Gypsum Fibrosum 5-15 part, Radix Cynanchi Atrati extract 10-20 part.
3. Sanshi detoxication powder composition according to claim 2 is characterized in that described component is: 30 parts of Mirabilitum crystallinas, 10 parts of Pulvis Talci, 10 parts in Gypsum Fibrosum, 15 parts of Radix Cynanchi Atrati extracts.
4. method for preparing the described Sanshi detoxication powder of claim 1 is characterized in that may further comprise the steps in this method:
A. with Mirabilitum crystallina, Pulvis Talci, Gypsum Fibrosum pulverize separately, it is standby that mistake 120 mesh sieves obtain micropowder, puts into extraction kettle after Radix Cynanchi Atrati is pulverized, and is entrainer with ethanol, through supercritical CO
2Extraction obtains the Radix Cynanchi Atrati extract;
B. Pulvis Talci is put into the baking oven inner drying, by described proportioning Pulvis Talci is mixed with the Radix Cynanchi Atrati extract then, the spray-dried Radix Cynanchi Atrati-Pulvis Talci that obtains is gathered thing;
C. Mirabilitum crystallina, Gypsum Fibrosum are put into drying in oven respectively, the Mirabilitum crystallina powder is taken out in dry back, Gypsum Fibrosum powder is poured in the mixer and mixed, stir and obtain the present composition after 30 minutes with Radix Cynanchi Atrati-Pulvis Talci collection thing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100478681A CN101313925B (en) | 2008-05-30 | 2008-05-30 | Sanshi detoxication powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100478681A CN101313925B (en) | 2008-05-30 | 2008-05-30 | Sanshi detoxication powder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101313925A true CN101313925A (en) | 2008-12-03 |
| CN101313925B CN101313925B (en) | 2011-02-23 |
Family
ID=40105169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100478681A Expired - Fee Related CN101313925B (en) | 2008-05-30 | 2008-05-30 | Sanshi detoxication powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101313925B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139028A (en) * | 2010-10-31 | 2011-08-03 | 仙桃市魏氏生物工程有限责任公司 | Zhengchangsheng medicinal composition |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1438330A (en) * | 2003-03-06 | 2003-08-27 | 中国科学院武汉病毒研究所 | Method for detecting Nuoda Virus mucleic-acid point cross-breeding of luoshi shrimp in natural pond |
| CN1977977B (en) * | 2005-12-08 | 2010-04-21 | 张艺蒙 | Gastro intestinal ultrasonic developer |
| CN1850203A (en) * | 2006-02-23 | 2006-10-25 | 贾曼红 | Chinese medicine preparation and ointment for treating scald and burn |
-
2008
- 2008-05-30 CN CN2008100478681A patent/CN101313925B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139028A (en) * | 2010-10-31 | 2011-08-03 | 仙桃市魏氏生物工程有限责任公司 | Zhengchangsheng medicinal composition |
| CN102139028B (en) * | 2010-10-31 | 2015-02-11 | 仙桃市魏氏生物工程有限责任公司 | Medicinal composition for preventing and controlling bowel disease of aquatic animal |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101313925B (en) | 2011-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101698024B (en) | Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof | |
| CN100428946C (en) | Medicine for preventing and controlling chicken infectious fabricius bursa disease | |
| CN102698123A (en) | Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof | |
| CN110559363A (en) | Traditional Chinese medicine compound fermented oral liquid for preventing and treating African swine fever and preparation process thereof | |
| CN105166544A (en) | Pig mixed feed and preparation method thereof | |
| CN104127758A (en) | Traditional Chinese medicinal composition having spleen invigorating and stomach nourishing efficacies, and preparation method and application thereof | |
| CN101297889B (en) | Chinese medicine preparation for treating foot-and-mouth disease and preparation method thereof | |
| CN101695529A (en) | Compound Chinese herbal medicinal preparation for preventing and controlling bacterial enteritis, black gill and red skin disease of freshwater fish | |
| CN101810716A (en) | Preparation method of Chinese pulsatilla root submicron powder at normal temperature | |
| CN106173450A (en) | Improve compound feed additive and the feedstuff of pigeon immunity | |
| CN101238851A (en) | Chinese medicinal composition for promoting growing and fattening of meat chicken and preparation thereof | |
| CN103784510A (en) | Chinese herbal medicine oral liquid for treating piglet diarrhea and production method thereof | |
| CN101313925B (en) | Sanshi detoxication powder | |
| CN104547186A (en) | Compound fermented type traditional Chinese medicine for preventing and treating fowl cholera and preparation method of compound fermented type traditional Chinese medicine | |
| CN104825753B (en) | A kind of Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow | |
| CN101297857B (en) | Chinese medicine preparation for treating recessive mastitis of cow and preparation method thereof | |
| CN102266521A (en) | Traditional Chinese medicine preparation for treating bacterial enteritis of sea fish, and preparation method thereof | |
| CN103393891B (en) | Antiviral compound traditional Chinese medicine for animals, and preparation method and use thereof | |
| CN101791386B (en) | Traditional Chinese veterinary medicine extract for promoting gastrointestinal peristalsis as well as preparation and preparation method thereof | |
| CN104706728A (en) | Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof | |
| CN104208653A (en) | Traditional Chinese medicine composition for treating piglet yellow-white dysentery and preparation method for same | |
| CN102886011A (en) | Traditional Chinese medicine for treating dyspepsia | |
| CN102526211A (en) | Composition of oral medicine for treating constipation and preparation technology | |
| CN103211988B (en) | Pharmaceutical composition for treating porcine infectious gastrointestinal inflammations | |
| CN101912449B (en) | Medicament for treating hepatitis and preparation technology thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110223 Termination date: 20150530 |
|
| EXPY | Termination of patent right or utility model |