CN101312948B - 用于治疗炎症的lta4h的二芳基取代杂环抑制剂 - Google Patents

用于治疗炎症的lta4h的二芳基取代杂环抑制剂 Download PDF

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CN101312948B
CN101312948B CN200680043305.4A CN200680043305A CN101312948B CN 101312948 B CN101312948 B CN 101312948B CN 200680043305 A CN200680043305 A CN 200680043305A CN 101312948 B CN101312948 B CN 101312948B
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mmol
pyrrolidine
phenoxymethyl
compound
alkyl
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CN101312948A (zh
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J·辛格
V·桑达纳亚卡
M·格尼
P·于
L·比德尔
B·马马特
赵镭
R·K·米什拉
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Decode Genetics ehf
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CN200680043305.4A 2005-09-21 2006-06-23 用于治疗炎症的lta4h的二芳基取代杂环抑制剂 Expired - Fee Related CN101312948B (zh)

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US71901605P 2005-09-21 2005-09-21
US60/719,016 2005-09-21
PCT/US2006/024393 WO2007040682A1 (en) 2005-09-21 2006-06-23 Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation

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CN101312948A CN101312948A (zh) 2008-11-26
CN101312948B true CN101312948B (zh) 2015-01-14

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US (3) US20070078263A1 (enExample)
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JP (1) JP5133889B2 (enExample)
KR (1) KR101328306B1 (enExample)
CN (1) CN101312948B (enExample)
AU (1) AU2006297798B2 (enExample)
BR (1) BRPI0616187A2 (enExample)
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CA2634701C (en) * 2005-12-21 2014-07-29 Decode Genetics Ehf Biaryl substituted nitrogen containing heterocycle inhibitors of lta4h for treating inflammation
HUE031972T2 (en) * 2005-12-29 2017-08-28 Celtaxsys Inc Diamine derivatives as inhibitors of leukotriene a4 hydrolase
US8653115B2 (en) * 2006-06-13 2014-02-18 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents
WO2008019302A1 (en) * 2006-08-04 2008-02-14 Decode Genetics Ehf Pyrazolylphenyl and pyrrolylphenyl inhibitors of lta4h for treating inflammation
BRPI0813837A2 (pt) * 2007-07-27 2015-01-06 Hoffmann La Roche 2-azetidinametanoaminas e 2-pirrolidinametanoaminas como ligantes de taar
UY31443A1 (es) * 2007-10-31 2009-04-30 Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa
US20090312558A1 (en) * 2008-06-13 2009-12-17 Reliance Life Sciences Pvt. Ltd. Process for the preparation of arylcyclopropoane carboxylic carbonitriles, and compounds derived therefrom
WO2010045633A2 (en) * 2008-10-17 2010-04-22 National Jewish Health Measurement and analysis of leukotrienes
AU2010249041B2 (en) * 2009-05-14 2014-11-13 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase
WO2011011598A1 (en) 2009-07-24 2011-01-27 Decode Genetics Ehf Process for preparing 4- { (s) -2- (4-(4-chlorophenoxy) phenoxymethyl) pyrrolidin-1-yl) } butyric acid and salts thereof
CN102666490A (zh) 2009-12-25 2012-09-12 宇部兴产株式会社 氨基吡啶化合物
CN103338767B (zh) 2010-08-04 2018-06-22 弗吉尼亚大学专利基金会 治疗炎症性疾病的组合物和方法
CN103415513B (zh) 2011-03-14 2016-01-20 勃林格殷格翰国际有限公司 白三烯产物的苯并二氧杂环己烷抑制剂
EP2734516B1 (en) 2011-07-19 2015-06-17 Boehringer Ingelheim International GmbH Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
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