CN101300265A - 糖皮质激素硝酰氧基衍生物 - Google Patents

糖皮质激素硝酰氧基衍生物 Download PDF

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Publication number
CN101300265A
CN101300265A CNA2006800405622A CN200680040562A CN101300265A CN 101300265 A CN101300265 A CN 101300265A CN A2006800405622 A CNA2006800405622 A CN A2006800405622A CN 200680040562 A CN200680040562 A CN 200680040562A CN 101300265 A CN101300265 A CN 101300265A
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CN
China
Prior art keywords
formula
group
integer
ono
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800405622A
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English (en)
Chinese (zh)
Inventor
F·贝尼迪尼
E·翁吉尼
A·古格莱塔
D·帕洛普
M·普林斯普
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Nicox SA
Original Assignee
Ferrer Internacional SA
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37450883&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101300265(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferrer Internacional SA, Nicox SA filed Critical Ferrer Internacional SA
Publication of CN101300265A publication Critical patent/CN101300265A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
CNA2006800405622A 2005-09-02 2006-08-04 糖皮质激素硝酰氧基衍生物 Pending CN101300265A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05019155.0 2005-09-02
EP05019155 2005-09-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2011100265155A Division CN102134269A (zh) 2005-09-02 2006-08-04 糖皮质激素硝酰氧基衍生物

Publications (1)

Publication Number Publication Date
CN101300265A true CN101300265A (zh) 2008-11-05

Family

ID=37450883

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2006800405622A Pending CN101300265A (zh) 2005-09-02 2006-08-04 糖皮质激素硝酰氧基衍生物
CN2011100265155A Pending CN102134269A (zh) 2005-09-02 2006-08-04 糖皮质激素硝酰氧基衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011100265155A Pending CN102134269A (zh) 2005-09-02 2006-08-04 糖皮质激素硝酰氧基衍生物

Country Status (19)

Country Link
US (5) US20080221073A1 (enExample)
EP (1) EP1940863B1 (enExample)
JP (1) JP5216589B2 (enExample)
KR (1) KR20080039442A (enExample)
CN (2) CN101300265A (enExample)
AR (1) AR056868A1 (enExample)
AU (1) AU2006286838C1 (enExample)
BR (1) BRPI0614967A2 (enExample)
CA (1) CA2621117A1 (enExample)
ES (1) ES2393363T3 (enExample)
IL (2) IL189337A0 (enExample)
NO (1) NO20081614L (enExample)
NZ (1) NZ566128A (enExample)
RU (1) RU2415864C2 (enExample)
SG (1) SG158916A1 (enExample)
TW (1) TW200801031A (enExample)
UY (1) UY29779A1 (enExample)
WO (1) WO2007025632A2 (enExample)
ZA (1) ZA200801789B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102612522A (zh) * 2009-11-16 2012-07-25 菲尔若国际公司 制备(11β，16α)-9-氟-11-羟基-16,17-[1-甲基-亚乙基二氧基]-21-[1-氧代-[4-(硝基氧基甲基)苯甲酰氧基]]孕-1,4-二烯-3,20-二酮的方法
CN110382033A (zh) * 2016-10-14 2019-10-25 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
CN101652380A (zh) 2007-02-05 2010-02-17 尼科克斯公司 释放一氧化氮的类固醇
EP1964550A1 (en) * 2007-03-01 2008-09-03 NicOx S.A. Glucocorticoid-nitrooxyderivative compositions
ES2324007A1 (es) * 2007-10-25 2009-07-28 Ferrer Internacional, S.A. Una forma amorfa de un compuesto antiinflamatorio.
EP2318427B1 (en) * 2008-07-31 2013-10-23 Nicox S.A. Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
US20110130375A1 (en) * 2008-08-05 2011-06-02 Nicox S.A. New no-releasing steroids for the treatment of retina and macula lutea diseases
CA2731477A1 (en) * 2008-08-05 2010-02-11 Nicox S.A. New no releasing steroids derivatives
US8062653B2 (en) * 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
WO2010096320A2 (en) * 2009-02-18 2010-08-26 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
US9022788B2 (en) * 2009-10-17 2015-05-05 Gregory John Stahler System and method for cardiac defibrillation response simulation in health training mannequin
ES2362894B1 (es) 2009-11-16 2012-05-21 Ferrer Internacional S.A. Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.
US20230131943A1 (en) 2020-03-24 2023-04-27 Burnet Micheal W Anti-infective and anti-viral compounds and compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1201114A (en) 1980-02-15 1986-02-25 Gordon H. Phillipps Androstane carbothioates
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1311922B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102612522A (zh) * 2009-11-16 2012-07-25 菲尔若国际公司 制备(11β，16α)-9-氟-11-羟基-16,17-[1-甲基-亚乙基二氧基]-21-[1-氧代-[4-(硝基氧基甲基)苯甲酰氧基]]孕-1,4-二烯-3,20-二酮的方法
CN110382033A (zh) * 2016-10-14 2019-10-25 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制
CN110382033B (zh) * 2016-10-14 2022-04-15 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制

Also Published As

Publication number Publication date
US20090264393A1 (en) 2009-10-22
EP1940863A2 (en) 2008-07-09
EP1940863B1 (en) 2012-09-05
JP5216589B2 (ja) 2013-06-19
ES2393363T3 (es) 2012-12-20
ZA200801789B (en) 2008-12-31
SG158916A1 (en) 2010-02-26
AR056868A1 (es) 2007-10-31
NZ566128A (en) 2011-03-31
US20090264394A1 (en) 2009-10-22
WO2007025632A2 (en) 2007-03-08
RU2415864C2 (ru) 2011-04-10
CN102134269A (zh) 2011-07-27
US20090258849A1 (en) 2009-10-15
CA2621117A1 (en) 2007-03-08
WO2007025632A3 (en) 2007-04-19
AU2006286838B2 (en) 2012-03-29
US20080221073A1 (en) 2008-09-11
KR20080039442A (ko) 2008-05-07
JP2009506994A (ja) 2009-02-19
TW200801031A (en) 2008-01-01
AU2006286838C1 (en) 2013-05-02
UY29779A1 (es) 2006-12-29
IL189337A0 (en) 2008-06-05
RU2008111076A (ru) 2009-10-10
BRPI0614967A2 (pt) 2013-01-01
US20110294769A1 (en) 2011-12-01
AU2006286838A1 (en) 2007-03-08
NO20081614L (no) 2008-05-28
IL216516A0 (en) 2011-12-29

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