CN101297826B - Compound Bupleurum injection for curing common cold of dog and preparation thereof - Google Patents
Compound Bupleurum injection for curing common cold of dog and preparation thereof Download PDFInfo
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- CN101297826B CN101297826B CN2008100528958A CN200810052895A CN101297826B CN 101297826 B CN101297826 B CN 101297826B CN 2008100528958 A CN2008100528958 A CN 2008100528958A CN 200810052895 A CN200810052895 A CN 200810052895A CN 101297826 B CN101297826 B CN 101297826B
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Abstract
The invention discloses a compound bupleurum injection for the treatment for canine influenza and a preparation method thereof, which aims at providing the compound bupleurum injection that can control the canine secondary infection at the same time of treating the canine influenza, have rapid onset of action, reduce the canine suffering and accelerate the canine healing speed, and the preparation method that has simple technology and easy realization. Each 100l of the injection contains: bupleurum extract liquid which is prepared by 50 to 200kg of bupleurum, 1 to 10kg of lincomycin hydrochloride, 0.05 to 1kg of chlorpheniramine, 0.2kg of sodium sulfite, 0.01kg of EDTA-2Na, 0.5kg of Tween-80 and the rest of water for injection. The injection of the invention adopts a compound preparation which combines the traditional Chinese medicine and the western medicine, the bupleurum and the chlorpheniramine can control the clinical symptoms caused by canine influenza and reduce the suffering caused by the canine influenza, the lincomycin hydrochloride can control the bacterial infection, the three are combined together for the usage, thus having rapid onset of action for the canine influenza and controlling the canine secondary infection, significantly ease the clinical symptoms caused by the canine influenza, treat both manifestation and root cause of disease and accelerate the caninerecovery.
Description
Technical field
The present invention relates to a kind of compound bupleuri injection that is used for the treatment of dog class flu and preparation method thereof.
Background technology
Cold of dog is a kind of commonly encountered diseases of dog, is by climate change, and passive protective physical fitness descends, is affected by the cold or factor such as wind heat causes that main clinic symptoms is heating, and symptoms such as fear of cold is afraid of cold, cough can cause that the dog resistance significantly reduces, and cause the antibacterial secondary infection.Cold of dog be dog common a kind of disease, especially weather sharply change or cold season pilosity.
Treat cold of dog at present, generally all take symptomatic treatment in the majority, all can only control the clinical symptoms that cold of dog causes as injection of Radix Bupleuri, lincomycin hydrochloride injection, chlorphenamine injection etc., and ignored because the secondary bacterial infection that cold of dog causes, and cause treatment to be failed, treatment time is longer, and provisions dog fan brings many inconvenience, and brings inconvenience in the treatment for the house pet doctor.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provides a kind of and can control the secondary infection of dog in the treatment cold of dog, and instant effect reduces the painful of dog and accelerates the compound bupleuri injection of the recovery from illness speed of dog.
It is simple that another object of the present invention provides a kind of technology, and the above-mentioned dog of realizing is easily used the preparation method of compound bupleuri injection.
The present invention is achieved through the following technical solutions:
A kind of compound bupleuri injection that is used for the treatment of dog class flu, it is characterized in that, consisting of of every 100L injection: the Radix Bupleuri extracting solution that makes by 50～200kg Radix Bupleuri, lincomycin hydrochloride 1～10kg, chlorphenamine 0.05～1kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg, the water for injection of surplus.
The preferable content of each component is in wherein every 100L injection: the Radix Bupleuri extracting solution that is made by 80～150kg Radix Bupleuri, lincomycin hydrochloride 2～8kg, chlorphenamine 0.08～0.8kg sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg, the water for injection of surplus.
The optimum content of each component is in every 100L injection: by the Radix Bupleuri extracting solution that 100kg Radix Bupleuri makes, lincomycin hydrochloride 6kg, chlorphenamine 0.2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg, the water for injection of surplus.
A kind of above-mentioned compound bupleuri injection preparation that is used for the treatment of dog class flu is characterized in that, comprises the steps:
(1) takes by weighing Radix Bupleuri 50～200kg and put into purified water 200～800L, obtain distillate 100～200L, again the distillate post bake is distilled to 80L with adding thermal distillation;
(2) add lincomycin hydrochloride 1～10kg, chlorphenamine 0.05～1kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg in the 80L distillate that above-mentioned second distillation is obtained, tween 80 0.5kg, be stirred to whole dissolvings, add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid is clear and bright after, promptly make the compound bupleuri injection that the present invention is used for the treatment of dog class flu.
Wherein the preferable consumption of each component is: Radix Bupleuri 80～150kg, lincomycin hydrochloride 2～8kg, chlorphenamine 0.08～0.8kg sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg.
Optimum amount is: Radix Bupleuri 100kg, lincomycin hydrochloride 6kg, chlorphenamine 0.2kg sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg.
The present invention has following technique effect:
The present invention is for adopting the compound preparation of Integrative Chinese-Western, Radix Bupleuri and chlorphenamine, lincomycin hydrochloride unite use, adopt multi-efficiency, multi-faceted treatment cold of dog is controlled the secondary infection of dog simultaneously, and the recovery from illness speed of quickening dog.The clinical symptoms that Radix Bupleuri and chlorphenamine control cold of dog cause, and treatment targetedly, alleviate the misery that dog causes because of flu, the lincomycin hydrochloride control of bacterial infection, the three share, by the treatment cold of dog fast of determining to the reasonable compatibility of each component and consumption, reduce the medication number of times, reduce secondary infection and misery that dog brings because of flu, control the Secondary cases bacterial infection simultaneously, treating both the principal and secondary aspects of a disease, effectively also the treatment disease of safety.
The preparation method technology of the compound bupleuri injection that is used for the treatment of dog class flu of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) takes by weighing Radix Bupleuri 50kg and put into purified water 200L, obtain distillate 100L, again the distillate post bake is distilled to 80L with adding thermal distillation;
(2) in the 80L distillate that above-mentioned post bake distillation obtains, add lincomycin hydrochloride 10kg, chlorphenamine 1kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg, be stirred to whole dissolvings, add water for injection again to 100L, stir, keep 15-20min, after treating that medicinal liquid is clear and bright, promptly make the compound bupleuri injection that the present invention is used for the treatment of dog class flu.
Embodiment 2
(1) takes by weighing Radix Bupleuri 200kg and put into purified water 800L, obtain distillate 200L, again the distillate post bake is distilled to 80L with adding thermal distillation;
(2) adding lincomycin hydrochloride 1kg, chlorphenamine 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg are stirred to whole dissolvings in the 80L distillate that above-mentioned post bake distillation obtains, add water for injection again to 100L, stir, keep 15-20min, after treating that medicinal liquid is clear and bright, promptly make the compound bupleuri injection that the present invention is used for the treatment of dog class flu.
Embodiment 3
(1) takes by weighing Radix Bupleuri 80kg and put into purified water 300L, obtain distillate 150L, distillate is reheated be distilled to 80L again with adding thermal distillation;
(2) adding lincomycin hydrochloride 8kg, chlorphenamine 0.8kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg are stirred to whole dissolvings in the 80L distillate that above-mentioned post bake distillation obtains, add water for injection again to 100L, stir, keep 15-20min, after treating that medicinal liquid is clear and bright, promptly make the compound bupleuri injection that the present invention is used for the treatment of dog class flu.
Embodiment 4
(1) takes by weighing Radix Bupleuri 150kg and put into purified water 500L, obtain distillate 200L, distillate is reheated be distilled to 80L again with adding thermal distillation;
(2) adding lincomycin hydrochloride 2kg, chlorphenamine 0.08kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg are stirred to whole dissolvings in the 80L distillate that above-mentioned post bake distillation obtains, add water for injection again to 100L, stir, keep 15-20min, after treating that medicinal liquid is clear and bright, promptly make the compound bupleuri injection that the present invention is used for the treatment of dog class flu.
Embodiment 5
(1) takes by weighing Radix Bupleuri 120kg and put into purified water 450L, obtain distillate 200L, distillate is reheated be distilled to 80L again with adding thermal distillation;
(2) adding lincomycin hydrochloride 5kg, chlorphenamine 0.3kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg are stirred to whole dissolvings in the 80L distillate that above-mentioned post bake distillation obtains, add water for injection again to 100L, stir, keep 15-20min, after treating that medicinal liquid is clear and bright, promptly make the compound bupleuri injection that the present invention is used for the treatment of dog class flu.
Embodiment 6
(1) takes by weighing Radix Bupleuri 100kg and put into purified water 300L, obtain distillate 200L, distillate is reheated be distilled to 80L again with adding thermal distillation;
(2) adding lincomycin hydrochloride 6kg, chlorphenamine 0.2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg are stirred to whole dissolvings in the 80L distillate that above-mentioned post bake distillation obtains, add water for injection again to 100L, stir, keep 15-20min, after treating that medicinal liquid is clear and bright, promptly make the compound bupleuri injection that the present invention is used for the treatment of dog class flu.
Clinical trial:
1. laboratory animal:
Only 100 of the ill dogs of picked at random,
2. experiment medicine
The compound bupleuri injection our unit development that is used for the treatment of dog class flu of the embodiment of the invention 6;
Injection of Radix Bupleuri (1ml is equivalent to the 1g crude drug in whole) our unit's prepared in laboratory;
6% lincomycin hydrochloride injection our unit prepared in laboratory.
3. experimental technique:
Suffer from dog with 100 and be divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with injection of Radix Bupleuri: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 4 days.
The C group is treated usage with 6% lincomycin hydrochloride injection: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 4 days.
The D group is treated usage with the compound bupleuri injection that is used for the treatment of dog class flu of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, dog health situation of change suffered from record, and treat and add up therapeutic effect after 5 days, wherein:
Invalid: as after referring to 5 days, to suffer from the dog symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 5 days, suffer from the dog symptom and change, the effect before symptom is better than treating.
Cure: after referring to 5 days, transference cure is suffered from dog and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 5 days, suffer from dog and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from dog and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, compound bupleuri injection for treating group, injection of Radix Bupleuri treatment group and lincomycin hydrochloride injection group and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | Symptom pig's head number is arranged during end |
| A | Matched group | 25 | 0 | 0 | 25 |
| B | The injection of Radix Bupleuri treatment | 7 | 18 | 15 | 10 |
| C | The treatment of 6% lincomycin hydrochloride injection | 18 | 7 | 3 | 22 |
| D | The compound bupleuri injection for treating | 2 | 23 | 21 | 4 |
Claims (6)
1. one kind is used for the treatment of the compound bupleuri injection that the dog class is caught a cold, it is characterized in that, consisting of of every 100L injection: the Radix Bupleuri extracting solution 80L that makes by 50～200kg Radix Bupleuri, lincomycin hydrochloride 1～10kg, chlorphenamine 0.05～1kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg, the water for injection of surplus.
2. the compound bupleuri injection that is used for the treatment of dog class flu according to claim 1, it is characterized in that, consisting of of every 100L injection: the Radix Bupleuri extracting solution 80L that makes by 80～150kg Radix Bupleuri, lincomycin hydrochloride 2～8kg, chlorphenamine 0.08～0.8kg sodium sulfite 0.2kg, EDTA-2Na0.01kg, tween 80 0.5kg, the water for injection of surplus.
3. the compound bupleuri injection that is used for the treatment of dog class flu according to claim 1, it is characterized in that, consisting of of every 100L injection: the Radix Bupleuri extracting solution 80L that makes by 100kg Radix Bupleuri, lincomycin hydrochloride 6kg, chlorphenamine 0.2kg sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg, the water for injection of surplus.
4. the described preparation method that is used for the treatment of the compound bupleuri injection of dog class flu of claim 1 is characterized in that, comprises the steps:
(1) takes by weighing Radix Bupleuri 50～200kg and put into purified water 200～800L, add thermal distillation and obtain distillate 100～200L, again the distillate post bake is distilled to 80L;
(2) in the 80L distillate that above-mentioned second distillation obtains, add lincomycin hydrochloride 1～10kg, chlorphenamine 0.05～1kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg, be stirred to whole dissolvings, add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid is clear and bright after, promptly make the compound bupleuri injection that is used for the treatment of dog class flu of the present invention.
5. the preparation method that is used for the treatment of the compound bupleuri injection of dog class flu according to claim 4 is characterized in that described Radix Bupleuri 80～150kg, lincomycin hydrochloride 2～8kg, chlorphenamine 0.08～0.8kg sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg.
6. the preparation method that is used for the treatment of the compound bupleuri injection of dog class flu according to claim 4 is characterized in that described Radix Bupleuri 100kg, lincomycin hydrochloride 6kg, chlorphenamine 0.2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, tween 80 0.5kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100528958A CN101297826B (en) | 2008-04-25 | 2008-04-25 | Compound Bupleurum injection for curing common cold of dog and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100528958A CN101297826B (en) | 2008-04-25 | 2008-04-25 | Compound Bupleurum injection for curing common cold of dog and preparation thereof |
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| Publication Number | Publication Date |
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| CN101297826A CN101297826A (en) | 2008-11-05 |
| CN101297826B true CN101297826B (en) | 2010-11-03 |
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| CN102872174B (en) * | 2012-10-26 | 2014-04-16 | 郑州百瑞动物药业有限公司 | Method for preparing bupleurum injection |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1115245A (en) * | 1994-07-16 | 1996-01-24 | 曹青春 | Anti-cold inhalation and its prepn. method |
| CN1557408A (en) * | 2004-01-14 | 2004-12-29 | 上海方大药业股份有限公司 | Medicinal composition for treating common and infectious cold |
| CN1232679C (en) * | 2003-05-16 | 2005-12-21 | 上海交通大学 | Preparation of potassium hexatitanate whiskers |
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2008
- 2008-04-25 CN CN2008100528958A patent/CN101297826B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1115245A (en) * | 1994-07-16 | 1996-01-24 | 曹青春 | Anti-cold inhalation and its prepn. method |
| CN1232679C (en) * | 2003-05-16 | 2005-12-21 | 上海交通大学 | Preparation of potassium hexatitanate whiskers |
| CN1557408A (en) * | 2004-01-14 | 2004-12-29 | 上海方大药业股份有限公司 | Medicinal composition for treating common and infectious cold |
Non-Patent Citations (2)
| Title |
|---|
| 张霄岳,常树春,毕研更.牛黄抗感灵的制备及临床应用.中国药师.2000,3(06),373-374. * |
| 李金环.犬瘟热及其防治.邯郸农业高等专科学校学报.2000,17(01),26-28. * |
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