CN101271076A - Control method for integrated nuclear magnetic resonance spectrometer data communication - Google Patents
Control method for integrated nuclear magnetic resonance spectrometer data communication Download PDFInfo
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- CN101271076A CN101271076A CNA2008100364318A CN200810036431A CN101271076A CN 101271076 A CN101271076 A CN 101271076A CN A2008100364318 A CNA2008100364318 A CN A2008100364318A CN 200810036431 A CN200810036431 A CN 200810036431A CN 101271076 A CN101271076 A CN 101271076A
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- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
Abstract
The invention specifically relates to a control method of the data exchange of an integrated nuclear magnetic resonance spectrometer, and the method adopts a large-scale programmable logic device FPGA aiming at the nuclear magnetic resonance and real-time needs of an imaging test thereof as well as each function module of the spectrometer, comprising a digital frequency source, a digital receiver, a gradient waveform generator and a pulse sequence generator, etc. The interior of the FPGA is constructed with an independent FIFO (or a dual port RAM), the data of the initial part of the sequence is firstly written into the FIFO according to the needs of the different pulse sequences, the data in each FIFO is carried out the real-time reading and is output and the corresponding function is further realized under the control of the pulse sequence generator. The control method has the advantage that one ARM chip is used as a CPU of the whole system, which is coordinated with the FPGA to work by a single bus, at the same time, all the function modules are controlled, then the whole nuclear magnetic resonance spectrometer system is concentrated on a single plate, the hardware of the system is not dependent on a PC machine, thus having more portable and smaller table type nuclear magnetic resonance spectrometer and having high integration level and saving development cost.
Description
Technical field
The present invention relates to the nuclear magnetic resonance technique field, be specifically related to a kind of based on control method embedded system (such as ARM), that be used for integrated veneer nuclear magnetic resonance spectrometer exchanges data.
Background technology
NMR system mainly is made up of spectrometer, magnet, radio-frequency (RF) power amplification, gradient power amplifier, coil and other accessory constituents.Spectrometer wherein then is the core component of total system, the co-ordination between each parts of control system.Divide according to function, spectrometer is made up of digitization frequencies source, digital receiver, gradient waveform generator and pulse-series generator module again.According to the needs of nuclear magnetic resonance and image-forming principle thereof, very high to the real-time control requirement of each module, in order to guarantee to obtain better experiment results, generally require the control accuracy of pulse train to reach tens nanosecond orders.
Nuclear magnetic resonance (NMR) method is one of important detection means of a kind of amalyzing substances structure.Along with the expansion of its application and deeply, the nuclear magnetic resonance spectrometer technology is development and perfect constantly also.Conventional commercialization spectrometer function is powerful, but the spectrometer complex structure, bulky, cost an arm and a leg, therefore limited NMR The Application of Technology scope.Under many application scenarios, such as carrying out core analysis in the open air, often more need a kind of simple in structure, volume is small and exquisite, low price, integrated level height, even integrated NMR spectrometer that can the divorced from computer independent operating.According to the document introduction, the design of present nuclear magnetic resonance spectrometer generally is all to use with a slice static memory (SRAM) independently at each functional module, needs according to nuclear magnetic resonance and imaging experiment thereof, at first that pulse train is required whole control datas in real time download among the SRAM of respective modules, then under the control of pulse-series generator, also export by the data that the FPGA on each module reads among the corresponding SRAM in real time, to reach the pulse train purpose of control in real time.The SRAM that more than relates to is general, and employing is external, and capacity required is bigger.When the pulse train data exceeded memory capacity, the method had just run into problem, may must redesign spectrometer owing to hardware constraints.
Summary of the invention
The objective of the invention is at above-mentioned the deficiencies in the prior art part, a kind of control method that is used for the integral nuclear magnetic resonance spectrometer exchanges data is provided, this method needs at the real-time of nuclear magnetic resonance and imaging experiment thereof, adopted large-scale programmable logic device (PLD) FPGA, at each spectrometer function module, comprise the digitization frequencies source, digital receiver, gradient waveform generator and pulse-series generator etc., all make up an independently push-up storage FIFO (or two-port RAM) in FPGA inside, needs according to different pulse trains, initial partial data with sequence writes FIFO earlier, under the control of pulse-series generator, the data and the output of reading in real time among each FIFO realize corresponding function, when data among the FIFO reduced to a certain degree, FIFO notified microprocessor to write subsequently data automatically.The present invention is enough fast as long as microprocessor is filled in the speed of data fifo, guarantees that FIFO is not in full dummy status, promptly is fully feasible, and to the storage depth of FIFO high request too not.
Realization of the present invention is finished by following technical scheme:
A kind of control method that is used for the integral nuclear magnetic resonance spectrometer exchanges data, described spectrometer comprises the digitization frequencies source module, the digital receiver module, the gradient waveform generator module, the pulse-series generator module, and field programmable gate array (FPGA) and microprocessor, it is characterized in that at the digitization frequencies source module, the digital receiver module, the gradient waveform generator module, and pulse train control module, exchanges data between each functional module and the microprocessor, all make up at least one separate storer in FPGA inside, the input/output port of described storer is respectively under the control of microprocessor and pulse-series generator, operate simultaneously and do not interfere with each other, to guarantee the real-time requirement of pulse train.
What described storer adopted is push-up storage FIFO or dual-ported memory.
Needs according to different IPs magnetic resonance and imaging pulse sequence thereof, the initial partial data of each functional module that earlier will be relevant with sequence writes corresponding FIFO, under the control of pulse-series generator, the data and the output of reading in real time among each FIFO realize corresponding function, when data among the FIFO reduced to a certain degree, FIFO notice microprocessor automatically filled in this module pulse train data subsequently immediately.
Use the CPU of microprocessor, coordinate to connect described digitization frequencies source module, digital receiver module, gradient waveform generator module simultaneously under the control at described FPGA as described spectrometer system, and the pulse train control module.
That described microprocessor is selected is embedded microprocessor chip ARM, can select digital signal processor (DSP) or other microprocessors equally.
Described pulse train control module, priority sequential requirement by the pulse sequence, being used for the frequency output of real-time control figure frequency source module and directions X, Y direction, the Z direction gradient of gradient waveform generator module exports, and the real-time data acquisition of digital receiver module.
Be connected with address bus by data between described FPGA and the ARM, described ARM connects a dynamic RAM SDRAM, is used for the microprocessor internal memory and provides pulse train data and configuration information to each functional module.
Advantage of the present invention is, use the CPU of a slice ARM chip as total system, having only under the prerequisite of unified bus, with the FPGA co-ordination, controlled the digitization frequencies source module simultaneously, the digital receiver module, the gradient waveform generator module, and the pulse train control module, and satisfy the needs of pulse train faster, thus whole nuclear magnetic resoance spectrum instrument system is focused on the veneer, system hardware does not all rely on PC, make desk-top nuclear magnetic resonance spectrometer more portable, small and exquisite, the integrated level height is saved cost of development.
Description of drawings
Accompanying drawing 1 is general frame synoptic diagram of the present invention;
Accompanying drawing 2 is the design frame chart of programmable logic controller (PLC) spare FPGA of the present invention.
Embodiment
Feature of the present invention and other correlated characteristic are described in further detail by embodiment below in conjunction with accompanying drawing, so that technician's of the same trade understanding:
Shown in Fig. 1-2, symbol is represented respectively among the figure: microcontroller ARM, programmable logic device (PLD) FPGA, dynamic storage SDARM, push-up storage FIFO.
Embodiment:
Be the single board system of present embodiment as shown in fig. 1, comprised digitization frequencies source part, digital receiver part, gradient waveform generator part, pulse train control module and remote computer control module.
The logical design block diagram of present embodiment programmable logic device (PLD) FPGA as shown in Figure 2, wherein to each spectrometer function module, comprise the digitization frequencies source, digital receiver, gradient waveform generator (three tunnel) and pulse-series generator etc., all make up an independently push-up storage FIFO (or two-port RAM) in FPGA inside, needs according to different pulse trains, initial partial data with sequence writes FIFO earlier, under the control of pulse-series generator, the data and the output of reading in real time among each FIFO realize corresponding function, when data among the FIFO reduce to a certain degree (such as half-full state), the automatic notice of FIFO meeting microprocessor is filled in pulse train data subsequently immediately.Like this, enough fast as long as microprocessor is filled in the speed of data fifo, guarantee that FIFO is not in full dummy status, promptly present design is feasible fully, and to the storage depth of FIFO high request too not.
The pulse-series generator module that marks off is used for control figure frequency source DDS, directions X gradient, Y direction gradient, Z direction gradient, these five control sections of receiver, each control section and then connection output circuit separately, ARM is connected with address bus by data with FPGA, and the SDRAM that links to each other with ARM is used to provide to the Wave data of each module and configuration information.
Below ARM, FPGA are how co-ordination realizes each functions of modules in the explanation present embodiment:
Digitizing magnetic resonance frequency source is made up of Direct Digital Frequency Synthesizers DDS, microcontroller ARM, Digital Logic interface FPGA, wherein, Direct Digital Frequency Synthesizers is responsible for producing radiofrequency signal, FPGA is then as the control circuit on the plate, and mark an internal storage as FIFO in FPGA inside, the temporary transient required pulse waveform data of store M RI sequence.ARM is responsible for carrying out communication with remote computer, extraneous more new data can be sent among the ARM and stores among the SDRAM by netting twine, ARM receives update instruction, just all configuration informations are at first write the buffer register of DDS by FPGA, when receiving the pulse that produces by pulse-series generator, automatically upgrade DDS, guaranteed the synchronous of DDS frequency, amplitude, phase place renewal and pulse train like this.
Digital receiver is a kind of direct radio frequency sampling digital receiver that is used for nuclear magnetic resonance spectrum and imaging thereof, mainly by putting before the radio frequency, frequency overlapped-resistable filter, analog to digital converter, commercial digital frequency conversion process chip DDC chip, digital logic device FPGA etc. partly form, and whole digital receiver is connected with extraneous PC by ARM.Low noise programmable amplifier VGA provides suitable amplification and gain control to faint nuclear magnetic signal as pre-amplifier.The outer noise of frequency overlapped-resistable filter filtering sampling bandwidth prevents the noise aliasing.High-speed ADC is responsible for the magnetic resonance signal after amplifying is quantized.Fpga chip then is the processing core of this digital receiver, translation interface and storage path (data that the FIFO storage receives) to image data is provided, and realizes the data-interface program control to DDC.The DDC effect is the magnetic resonance signal of high frequency is carried out Digital Down Convert, filtering and rate transition processing, and by the data after the parallel port output processing.
Pulse-series generator is used to produce the required various pulse trains of magnetic resonance imaging experiment as one of core component of spectrometer, and its function mainly is to control the co-ordination of parts such as receiver in the spectrometer system, frequency source, gradient waveform generator in real time.The function of the pulse-series generator part of native system is mainly in the inner realization of FPGA, produce pulse train and need one group of incident and corresponding time-delay, this unit stores into the incident and the delay time of whole pulse train correspondence among the SDRAM in advance, call over data storage among the SDRAM in FIFO by the FPGA gradation in the pulse train implementation, trigger by timer control, realize the logic control of pulse train.Because pre-depositing of data fully by FPGA control, avoided computing machine to participate in the execution of pulse train in the process, time control accuracy and degree of stability have been guaranteed.
The gradient waveform generator mainly is made up of digital logic device FPGA, DAC device and amplifier except ARM.ARM serves as the heart effect of system, and before the system works, ARM receives Wave data by netting twine from extraneous PC, and is kept among the SDRAM.FPGA is responsible for the Digital Logic interface of entire device, after receiving outside trigger pip, FPGA just reads Wave data and is transferred to DAC on the plate and is converted to analog quantity output from FIFO, when data among the FIFO reduce to a certain degree, just resume studies from the SDRAM relaying automatically and get Wave data, output current is by the output of operational amplifier driving voltage difference form, drive gradient amplifier then, in gradient coil, produce three orthogonal linear gradient fields, to satisfy the demand of magnetic resonance imaging.
Can not produce conflict each other with the fifo structure of using in the upper module because of having little time on the time, because the data between FPGA and the output circuit are provided with speed, the time demand that depends on the execution of magnetic resonance and imaging pulse sequence thereof, though the precedence of output data is set and accuracy requirement is set higher to each module, but the speed that pulse train itself is carried out, compare with the time of ARM reference-to storage will be slowly many.FPGA can constantly give each functional module output circuit transmission data like this, when the data of being stored among the FIFO reduce to certain full scale sign, just automatically from SDRAM reading of data in FIFO, when the FIFO priority mistiming of two functional modules seldom reaches half-full sign, whom processor transmit data according to time order and function decision elder generation to, because transmission speed is fast, can't influence FIFO and transmit data to output circuit, does not have delay on the time.Like this under single microprocessor control, this Design Mode of FIFO cleverly can allow each functional module work alone simultaneously, can also reach the desired real-time of nuclear magnetic resonance spectrometer, than before many plates realize the method for spectrometer all functions all having unique advantages from aspects such as mentality of designing, spectrometer costs.
Claims (7)
1. control method that is used for the integral nuclear magnetic resonance spectrometer exchanges data, described spectrometer comprises the digitization frequencies source module, the digital receiver module, the gradient waveform generator module, the pulse-series generator module, and field programmable gate array (FPGA) and microprocessor, it is characterized in that at the digitization frequencies source module, the digital receiver module, the gradient waveform generator module, and pulse train control module, exchanges data between each functional module and the microprocessor, all make up at least one separate storer in FPGA inside, the input and output port of described storer is respectively under the control of microprocessor and pulse-series generator, operate simultaneously and do not interfere with each other, to guarantee the real-time requirement of pulse train.
2. a kind of control method that is used for the integral nuclear magnetic resonance spectrometer exchanges data according to claim 1, what it is characterized in that described storer employing is push-up storage FIFO or dual-ported memory.
3. a kind of control method that is used for the integral nuclear magnetic resonance spectrometer exchanges data according to claim 1, it is characterized in that needs according to different IPs magnetic resonance and imaging pulse sequence thereof, the initial partial data of each functional module that earlier will be relevant with sequence writes corresponding FIFO, under the control of pulse-series generator, the data and the output of reading in real time among each FIFO realize corresponding function, when data among the FIFO reduced to a certain degree, FIFO notice microprocessor automatically filled in this module pulse train data subsequently immediately.
4. a kind of control method that is used for the integral nuclear magnetic resonance spectrometer exchanges data according to claim 1, it is characterized in that using the CPU of microprocessor as described spectrometer system, coordinate under the control at described FPGA, connect described digitization frequencies source module, digital receiver module, gradient waveform generator module simultaneously, and the pulse train control module.
5. a kind of control method that is used for the integral nuclear magnetic resonance spectrometer exchanges data according to claim 4, what it is characterized in that described microprocessor selection is embedded microprocessor chip ARM or digital signal processor (DSP).
6. a kind of control method that is used for the integral nuclear magnetic resonance spectrometer exchanges data according to claim 1, it is characterized in that described pulse train control module, priority sequential requirement by the pulse sequence, being used for the frequency output of real-time control figure frequency source module and directions X, Y direction, the Z direction gradient of gradient waveform generator module exports, and the real-time data acquisition of digital receiver module.
7. a kind of control method that is used for the exchanges data of integral nuclear magnetic resonance spectrometer according to claim 1, it is characterized in that being connected with address bus by data between described FPGA and the ARM, described ARM connects a dynamic RAM SDRAM, is used for the microprocessor internal memory and provides pulse train data and configuration information to each functional module.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100364318A CN101271076B (en) | 2008-04-22 | 2008-04-22 | Control method for integrated nuclear magnetic resonance spectrometer data communication |
| PCT/CN2009/071381 WO2009129735A1 (en) | 2008-04-22 | 2009-04-21 | Control method for data exchange of integrative magnetic resonance spectrometer and integrative magnetic resonance spectrometer device |
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| CN2008100364318A CN101271076B (en) | 2008-04-22 | 2008-04-22 | Control method for integrated nuclear magnetic resonance spectrometer data communication |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009129735A1 (en) * | 2008-04-22 | 2009-10-29 | 华东师范大学 | Control method for data exchange of integrative magnetic resonance spectrometer and integrative magnetic resonance spectrometer device |
| CN102156270A (en) * | 2011-03-07 | 2011-08-17 | 华东师范大学 | Method for correcting magnetic field gradient delay of magnetic resonance imaging system |
| CN101493698B (en) * | 2009-02-27 | 2012-01-25 | 株洲南车时代电气股份有限公司 | Frequency signal generating method and circuit based on CAN bus |
| CN102435968A (en) * | 2011-10-26 | 2012-05-02 | 华东师范大学 | Pulse sequence generator having independent channel delay function |
| CN102957643A (en) * | 2011-08-26 | 2013-03-06 | 上海创远仪器技术股份有限公司 | Method and device for triggering and capturing broadband signals |
| CN102103196B (en) * | 2009-12-18 | 2013-03-06 | 东软飞利浦医疗设备系统有限责任公司 | System and method for generating magnetic resonance gradient waveform with adjustable digital pre-emphasis |
| CN103349550A (en) * | 2013-07-04 | 2013-10-16 | 华东师范大学 | Method and device for integrating magnetic resonance imaging scanning and compressive sensing reconstruction |
| CN103885015A (en) * | 2012-12-19 | 2014-06-25 | 西门子(深圳)磁共振有限公司 | Method for carrying out gradient delay compensation on magnetic resonance scanning sequence, device thereof and system thereof |
| CN105662415A (en) * | 2016-03-03 | 2016-06-15 | 哈尔滨医科大学 | Multi-nucleus magnetic resonance imaging system |
| CN107638178A (en) * | 2016-07-22 | 2018-01-30 | 西门子(深圳)磁共振有限公司 | The control system and control panel of a kind of magnetic resonance imaging system |
| CN111521963A (en) * | 2020-05-06 | 2020-08-11 | 电子科技大学 | Method for automatically adapting and outputting gradient waveform rate and magnetic resonance system |
| CN112379317A (en) * | 2020-06-15 | 2021-02-19 | 武汉中科牛津波谱技术有限公司 | Nuclear magnetic resonance pulse sequence controller |
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| CN110347084B (en) * | 2019-07-15 | 2024-04-12 | 散裂中子源科学中心 | CSNS engineering spectrometer control device and signal processing method of control device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6486668B1 (en) * | 2000-11-20 | 2002-11-26 | Ge Medical Systems Global Technology Company, Llc | Preparatory pulse sequence for suppression of artifacts in MR images |
| JP2002186595A (en) * | 2000-12-22 | 2002-07-02 | Toshiba Corp | Magnetic resonance diagnosing apparatus and storage medium |
| CN1284002C (en) * | 2003-08-27 | 2006-11-08 | 华东师范大学 | Nuclear magnetic resonance pulse sequency generator |
| CN1831552B (en) * | 2006-04-20 | 2010-05-12 | 华东师范大学 | Integral nuclear magnetic resonance spectrometer control stage bused on USB bus |
| CN101271076B (en) * | 2008-04-22 | 2010-09-01 | 华东师范大学 | Control method for integrated nuclear magnetic resonance spectrometer data communication |
-
2008
- 2008-04-22 CN CN2008100364318A patent/CN101271076B/en not_active Expired - Fee Related
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2009
- 2009-04-21 WO PCT/CN2009/071381 patent/WO2009129735A1/en active Application Filing
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| WO2009129735A1 (en) * | 2008-04-22 | 2009-10-29 | 华东师范大学 | Control method for data exchange of integrative magnetic resonance spectrometer and integrative magnetic resonance spectrometer device |
| CN101493698B (en) * | 2009-02-27 | 2012-01-25 | 株洲南车时代电气股份有限公司 | Frequency signal generating method and circuit based on CAN bus |
| CN102103196B (en) * | 2009-12-18 | 2013-03-06 | 东软飞利浦医疗设备系统有限责任公司 | System and method for generating magnetic resonance gradient waveform with adjustable digital pre-emphasis |
| CN102156270A (en) * | 2011-03-07 | 2011-08-17 | 华东师范大学 | Method for correcting magnetic field gradient delay of magnetic resonance imaging system |
| CN102957643B (en) * | 2011-08-26 | 2015-10-21 | 上海创远仪器技术股份有限公司 | A kind of triggering catching method of broadband signal and device |
| CN102957643A (en) * | 2011-08-26 | 2013-03-06 | 上海创远仪器技术股份有限公司 | Method and device for triggering and capturing broadband signals |
| CN102435968A (en) * | 2011-10-26 | 2012-05-02 | 华东师范大学 | Pulse sequence generator having independent channel delay function |
| CN103885015A (en) * | 2012-12-19 | 2014-06-25 | 西门子(深圳)磁共振有限公司 | Method for carrying out gradient delay compensation on magnetic resonance scanning sequence, device thereof and system thereof |
| CN103885015B (en) * | 2012-12-19 | 2016-10-05 | 西门子(深圳)磁共振有限公司 | Carry out the methods, devices and systems of gradient delay compensation to magnetic resonance imaging sequence |
| CN103349550A (en) * | 2013-07-04 | 2013-10-16 | 华东师范大学 | Method and device for integrating magnetic resonance imaging scanning and compressive sensing reconstruction |
| CN105662415A (en) * | 2016-03-03 | 2016-06-15 | 哈尔滨医科大学 | Multi-nucleus magnetic resonance imaging system |
| CN107638178A (en) * | 2016-07-22 | 2018-01-30 | 西门子(深圳)磁共振有限公司 | The control system and control panel of a kind of magnetic resonance imaging system |
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| CN111521963A (en) * | 2020-05-06 | 2020-08-11 | 电子科技大学 | Method for automatically adapting and outputting gradient waveform rate and magnetic resonance system |
| CN112379317A (en) * | 2020-06-15 | 2021-02-19 | 武汉中科牛津波谱技术有限公司 | Nuclear magnetic resonance pulse sequence controller |
| CN112379317B (en) * | 2020-06-15 | 2021-05-18 | 武汉中科牛津波谱技术有限公司 | Nuclear magnetic resonance pulse sequence controller |
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| Publication number | Publication date |
|---|---|
| WO2009129735A1 (en) | 2009-10-29 |
| CN101271076B (en) | 2010-09-01 |
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