Summary of the invention
The object of the invention provides a kind of blood fat reducing soft capsule health food and preparation method thereof.
Blood fat reducing soft capsule of the present invention is made with Notogineng Extract, ginkgo biloba p.e, DHA and EPA primary raw material.
The preparation method of blood fat reducing soft capsule of the present invention is, Notogineng Extract, ginkgo biloba p.e added in 60~80 ℃ the vegetable oil and dissolve, add DHA (22 charcoal acid), EPA (20 charcoal pentaene acid), soybean lecithin, beeswax, ethyl cellulose again, fully mix with helical mixer, cross colloid mill, the degassing, pelleting, typing is dry, row is coiled drying, select ball, polishing makes blood fat reducing soft capsule health food of the present invention;
Described Notogineng Extract preparation process is pseudo-ginseng to be selected remove impurity, after the cleaning, adds 5~20 times the ultrasonic extraction of 60%~90% ethanol 1~3 time, each 20~100min, extract 45 ℃~75 ℃ of temperature, ultrasonic power 80~150W, supersonic frequency 15~60kHz, merge extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, 6~12KGY
60The Co irradiation sterilization is preserved standby;
Described ginkgo biloba p.e preparation process is ginkgo leaf to be selected remove impurity, and after the cleaning, the water that adds 5~20 times extracts 1~3 time, each 20~100min extracts 45 ℃~95 ℃ of temperature, merges extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, extract a, filter residue added 5~20 times the ultrasonic extraction of 60%~90% ethanol 1~3 time, each 20~100min, extract 45 ℃~75 ℃ of temperature, ultrasonic power 80~150W, supersonic frequency 15~60kHz, merge extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, get extract b, extract a and extract b are mixed 6~12KGY
60The Co irradiation sterilization is preserved standby;
Described vegetable oil is any one in soybean oil, olive oil, peanut oil, siritch, walnut oil, the bay-oil;
Blood fat reducing soft capsule formula for a product of the present invention is, Notogineng Extract 10~100 weight portions, ginkgo biloba p.e 10~100 weight portions, DHA 1~50 weight portion, EPA 1~50 weight portion, beeswax 10~80 weight portions, soybean lecithin 10~50 weight portions, ethyl cellulose 5~50 weight portions, vegetable oil 500~1000 weight portions;
The main functional component of blood fat reducing soft capsule of the present invention is total saponin, flavones, DHA, EPA.
The present invention is a primary raw material with Notogineng Extract, ginkgo biloba p.e, DHA and EPA, makes by advanced technology technology, and prescription is reasonable, exact efficacy, and effect stability, main functional component is total saponin, flavones, DHA, EPA.Experimental study finds that product of the present invention has the health care of reducing blood lipid, also has effects such as hypotensive, anti-oxidant, antifatigue.The extracting method that the present invention adopts can more effectively be extracted pseudo-ginseng, effective component of ginkgo leaf, goes the rough essence of depositing, and greatly reduces dose, and has improved curative effect, because conventional extracting method.
The specific embodiment
The following examples help those skilled in the art more fully to understand the present invention, but do not limit the present invention in any way.
Embodiment 1
Pseudo-ginseng selected remove impurity, after the cleaning, add 5~20 times the ultrasonic extraction of 60%~90% ethanol 1~3 time, each 20~100min, extract 45 ℃~95 ℃ of temperature, ultrasonic power 80~150W, supersonic frequency 15~60kHz, merge extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, 6~12KGY
60The Co irradiation sterilization is preserved standby;
Ginkgo leaf selected remove impurity, after the cleaning, the water that adds 5~20 times extracts 1~3 time, each 20~100min extracts 45 ℃~75 ℃ of temperature, merges extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, extract a, filter residue added 5~20 times the ultrasonic extraction of 60%~90% ethanol 1~3 time, each 20~100min, extract 45 ℃~75 ℃ of temperature, ultrasonic power 80~150W, supersonic frequency 15~60kHz, merge extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, get extract b, extract a and extract b are mixed 6~12KGY
60The Co irradiation sterilization is preserved standby;
Notogineng Extract, ginkgo biloba p.e added in 60~80 ℃ the vegetable oil and dissolve, add DHA (22 charcoal acid), EPA (20 charcoal pentaene acid), soybean lecithin, beeswax, ethyl cellulose again, fully mix with helical mixer, cross colloid mill, the degassing, pelleting, typing is dry, and row is coiled drying, selects ball, polishing makes blood fat reducing soft capsule health food of the present invention;
Vegetable oil is any one in soybean oil, olive oil, peanut oil, siritch, walnut oil, the bay-oil;
Formula for a product is Notogineng Extract 10~100 weight portions, ginkgo biloba p.e 10~100 weight portions, DHA 1~50 weight portion, EPA 1~50 weight portion, beeswax 10~80 weight portions, soybean lecithin 10~50 weight portions, ethyl cellulose 5~50 weight portions, vegetable oil 500~1000 weight portions.
Embodiment 2
Pseudo-ginseng selected remove impurity, after the cleaning, add 5 times the ultrasonic extraction of 85% ethanol 3 times, each 60min extracts 45 ℃ of temperature, ultrasonic power 100W, supersonic frequency 40kHz merges extracting liquid filtering, concentrates, cross silica gel column chromatography, eluent concentrates, spray-drying, 10KGY
60The Co irradiation sterilization is preserved standby;
Ginkgo leaf selected remove impurity, after the cleaning, the water that adds 5 times extracts 3 times, each 60min extracts 55 ℃ of temperature, merges extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, extract a, filter residue added 10 times the ultrasonic extraction of 80% ethanol 2 times, each 50min, extract 55 ℃ of temperature, ultrasonic power 150W, supersonic frequency 60kHz, merge extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, get extract b, extract a and extract b are mixed 10KGY
60The Co irradiation sterilization is preserved standby;
Notogineng Extract, ginkgo biloba p.e added dissolving in 70 ℃ the vegetable oil (any one in soybean oil, olive oil, peanut oil, siritch, walnut oil, the bay-oil), add DHA, EPA, soybean lecithin, beeswax, ethyl cellulose again, fully mix with helical mixer, cross colloid mill, the degassing, pelleting, typing is dry, and row is coiled drying, selects ball, polishing makes blood fat reducing soft capsule health food of the present invention.
Blood fat reducing soft capsule formula for a product of the present invention is Notogineng Extract 80 weight portions, ginkgo biloba p.e 60 weight portions, the DHA25 weight portion, EPA 15 weight portions, beeswax 40 weight portions, soybean lecithin 30 weight portions, ethyl cellulose 15 weight portions, vegetable oil 700 weight portions; Make the soft capsule of 0.5g/ grain.
Embodiment 3
Pseudo-ginseng selected remove impurity, after the cleaning, add 15 times the ultrasonic extraction of 65% ethanol 2 times, each 40min extracts 55 ℃ of temperature, ultrasonic power 120W, supersonic frequency 50kHz merges extracting liquid filtering, concentrates, cross silica gel column chromatography, eluent concentrates, spray-drying, 8KGY
60The Co irradiation sterilization is preserved standby;
Ginkgo leaf selected remove impurity, after the cleaning, the water that adds 15 times extracts 2 times, each 50min extracts 85 ℃ of temperature, merges extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, extract a, filter residue added 20 times the ultrasonic extraction of 65% ethanol 1 time, each 80min, extract 65 ℃ of temperature, ultrasonic power 80W, supersonic frequency 20kHz, merge extracting liquid filtering, concentrate, cross silica gel column chromatography, eluent concentrates, spray-drying, get extract b, extract a and extract b are mixed 8KGY
60The Co irradiation sterilization is preserved standby;
Notogineng Extract, ginkgo biloba p.e added dissolving in 65 ℃ the vegetable oil (any one in soybean oil, olive oil, peanut oil, siritch, walnut oil, the bay-oil), add DHA, EPA, soybean lecithin, beeswax, ethyl cellulose again, fully mix with helical mixer, cross colloid mill, the degassing, pelleting, typing is dry, and row is coiled drying, selects ball, polishing makes blood fat reducing soft capsule health food of the present invention.
Blood fat reducing soft capsule formula for a product of the present invention is Notogineng Extract 50 weight portions, ginkgo biloba p.e 30 weight portions, the DHA20 weight portion, EPA 10 weight portions, beeswax 25 weight portions, soybean lecithin 15 weight portions, ethyl cellulose 10 weight portions, vegetable oil 500 weight portions; Make the soft capsule of 0.3g/ grain.