CN1062749C - Xuezhikangtai medicine for curing dyslipoproteinemia and its preparing process - Google Patents
Xuezhikangtai medicine for curing dyslipoproteinemia and its preparing process Download PDFInfo
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- CN1062749C CN1062749C CN95121570A CN95121570A CN1062749C CN 1062749 C CN1062749 C CN 1062749C CN 95121570 A CN95121570 A CN 95121570A CN 95121570 A CN95121570 A CN 95121570A CN 1062749 C CN1062749 C CN 1062749C
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Abstract
The present invention relates to medicine-Xuezhikangtai for treating hyperlipemia due to spleen vacuity with damp encumbrance, which performs functions of invigorating spleen, eliminating phlegm, dissolving stasis and eliminating accumulation. Health-care medicine-Xuezhikangtai has dual purposes of medicine and food, mainly uses the traditional Chinese medicine and is used for preventing and treating hyperlipemia; a prescription of the present invention is composed of raw ginger, hawkthorn, lucid ganoderma, semen cassiae torae, lotus leaves and Chinese date. The prescription combines decoction and alcohol reflux in preparation technology, and the raw ginger mainly uses volatile oil ingredients, and combines juice-squeeze and residue alcohol reflux; the lucid ganoderma and the semen cassiae torae use the alcohol reflux in the technology so as to extract effective ingredients of alcohol solubility; the Chinese date and the lotus leaves use the decoction so as to extract ingredients of water solubility, and thus, the present invention has the advantages of reasonable technology and good clinical therapeutic effects.
Description
The present invention relates to a kind of medicine for the treatment of insufficiency of the spleen damp-obstruction type hyperlipidemia, its commodity are called Xuezhikang Thailand, and its function is invigorating the spleen for dissipating phlegm, the blood stasis dispelling removing food stagnancy.
Hyperlipidemia is the main hazard factor of coronary heart disease, and and the generation of diseases such as cerebrovascular disease, diabetes, obesity, fatty liver and the contact that development has countless ties, be the formidable enemy of human health, and its sickness rate is higher.If the early prevention and treatment hyperlipidemia can effectively reduce evidence of coronary heart diseases, so blood fat reducing is an importance of preventing and treating coronary heart disease.At present fat-reducing medicament is more, and Western medicine has fenofibrate clofibrate simvastatin etc., and it not only costs an arm and a leg, and side effect is many, and there is infringement in liver village of patient, and Chinese medicine has YUEJIANCAOYOU WAN, Herb Gynostemmae Pentaphylli, fat regulating tablet, and their curative effect effect is slow, and effective percentage is low.
The objective of the invention is to develop a kind of medicine-food two-purpose, safe based on the health medicine blood fat in order to the prophylactic treatment hyperlipidemia of Chinese medicine, its prescription is by Rhizoma Zingiberis Recens, Fructus Crataegi, Ganoderma, Semen Cassiae, and Folium Nelumbinis, Fructus Jujubae are formed.This prescription adopts decocting in water and alcohol reflux to combine on preparation technology; Rhizoma Zingiberis Recens adopts squeezing extracting juice and residue alcohol reflux to combine based on the volatile oil composition; Ganoderma, Semen Cassiae are pure dissolubility because of active ingredient, so adopt alcohol reflux on technology; Fructus Jujubae, Folium Nelumbinis are that water-soluble components adopts decocting in water, thereby guarantee that technology rationally reaches clinical efficacy.
The present invention is achieved in that a kind of blood fat that is prepared from by natural Chinese medicines in order to the treatment hyperlipidemia is safe, and the prescription of this medicine is: 200 parts in Rhizoma Zingiberis Recens, 180 parts of Fructus Crataegis, 180 parts of Ganodermas, 160 parts of Semen Cassiaes, 160 parts on Folium Nelumbinis, 120 parts in Fructus Jujubae.
The present invention can be achieved in that also the Rhizoma Zingiberis Recens in this medicine composition is to adopt fresh ginger.
The safe preparation technology of blood fat of the present invention is:
The first step, fresh ginger is squeezed extracting juice with squeezer, collect fresh ginger juice (yield is 10%) and stay residue standby.
Second step, the fresh ginger juice steam distillation that squeezing is collected, extraction Rhizoma Zingiberis Recens volatile oil (oil yield is 0.1-0.3%), remaining is mother solution.
The 3rd step, get 100 parts of Semen Cassiaes, be ground into coarse powder, in coarse powder, add the Ganoderma decoction pieces with pulverizer, Fructus Crataegi decoction pieces and Rhizoma Zingiberis Recens residue, the alcohol reflux secondary with 75%, each 2 hours, merge backflow twice, filter float, must filtrate; With decompression filtrate recycling ethanol, till the no ethanol flavor, this filtrate is A liquid, stays residue standby in filtrate then.
The 4th goes on foot, Fructus Jujubae is broken, the Folium Nelumbinis shredding, and the residue in then they being gone on foot with the 3rd adds the water of 10 times of amounts, decocts three times, and three times decocting time is 1.5 hours, 1 hour, 0.5 hour, merges three times decoction liquor, filters float, and filtering filtrate is B liquid.
The 5th step, merging mother solution, A liquid and B liquid, then with the amalgamation liquid concentrating under reduced pressure, being evaporated to relative density is the thick paste of 1.30 (heat is surveyed concentrate under 60 ℃ of temperature).
The 6th step, 60 parts of Semen Cassiaes are ground into fine powder with pulverizer, then fine powder are joined in the thick paste, spray into Rhizoma Zingiberis Recens volatile oil, stir, (below 80 ℃) oven dry is pulverized at low temperatures, is the powder finished product that makes.
The present invention can also be achieved in that through preparation technology's processed powders shape blood fat safe, or reprocessing is sharp in flakes, capsule and dietetic therapy additive.
Theory of Chinese medical science of the present invention is according to being:
Rhizoma Zingiberis Recens, Xin Wen, go into the lung taste through, deliver cold expelling, preventing or arresting vomiting reduces phlegm, control the phlegm retention cough with asthma, vomit, have loose bowels.Rhizoma Zingiberis Recens is natural drug for invigorating blood circulation and eliminating stasis, and its active ingredient is relevant with acid, and the sensible effect of temperature fortune is arranged.Fructus Crataegi, sour sweet tepor is gone into the taste Liver Channel, and that its effect helps digestion is long-pending, dissipating blood stasis blood, control inner product, lump in the abdomen, feeling of fullness, acid regurgitation, diarrhea.So Rhizoma Zingiberis Recens, Fructus Crataegi are all with invigorating the spleen for dissipating phlegm, the removing food stagnancy dissipating blood stasis is main.Ganoderma, sweet in the mouth is flat, goes into lung spleen two and breathes with cough through controlling asthenia, is insomnia and to receive food not good.Semen Cassiae, bitter sweet cold is slightly cold, and goes into Liver and kidney, department's liver heat removing and eyesight improving, diuretic relieving constipation.Folium Nelumbinis, pained flat, going into the conscience spleen channel can clearing away summer-heat, develop clear sun control dizzy, have loose bowels, aqueous vapor is floated liver, and is various hemorrhage.Semen Cassiae and Folium Nelumbinis are all gone into liver, and clearing away liver-fire is in case liver-yang hyperactivity gram spleen or because of other medicine heat impairment of YIN.Fructus Jujubae, is gone into taste spleen reinforcing stomach function regulating at Gan Wen, and supplementing QI for promoting the production of body fluid transfers battalion to defend, and separates poison of drug, controls few food loose stool, insufficiency of vital energy and blood, disharmony of nutrient QI with defensive QI, palpitation with fear, palpitation with a distress feeling.Blood fat is too high in a word belongs to the more of insufficiency of the spleen damp-obstruction type, these side's nature and flavor are with hot Wen Weizhu, how relatively Gui Jing the taste lung, and prescription of the present invention has invigorating the spleen for dissipating phlegm, the merit of blood stasis dispelling removing food stagnancy, the strong source abundance of then changing of spleen, function is vigorous, normal circulation of qi and blood, and the bodily form is moderate, the expectorant stasis of blood have no way of give birth to, then blood fat naturally can be controlled.
Good effect of the present invention is:
1, the present invention has good effect, instant effect, taking convenience, the characteristics of safety non-toxic.
2, the present invention truly has curative effect to high lipoprotein mass formed by blood stasis; though onset is slow; but blood fat all can recover normal or approaching normal after most patients used for five weeks; and continue to take; sustainable improvement; with the fenofibrate contrast same period, though cholesterol, Gao Dingdu protein cholesterol improve not as fenofibrate rapid.Cholesterol and triglyceride fall are also especially big not as FENOBRATE, and more obvious than fenofibrate after 5 weeks but the improvement of its ratio is taken medicine, hepatic injury accounted for 10% during fenofibrate was used, and the safe effect for reducing fat of blood fat is better than YUEJIANCAOYOU WAN.Taking the safe patient of blood fat has 11.3% patient to tell slight stomach discomfort in early days, the 4-7 days above-mentioned transference cures that continue to take medicine, and surplus having no adverse reaction, the hepatic and renal function inspection is all normal during all patient's medications.Appetite was improved after 45% patient took medicine, and conscious muscle power strengthens.
3, the present invention is with prescriptions such as the Chinese medicine that can eat such as Rhizoma Zingiberis Recens, Folium Nelumbinis, Fructus Jujubae, Fructus Crataegis.Rhizoma Zingiberis Recens belongs to drugs for dispelling internal cold, except that blood fat reducing and anti-aging effects are arranged, can also make keto consumpting speed by the machine that slows down, and brings into play its antioxidation, and the energy anticoagulant, brings into play its anticoagulation.
4, effect for reducing fat of the present invention is realized by number of ways, and is relevant with following effect: 1. impel and the solid salt binding of gallbladder, blocking-up intestinal liver follows bad, and the DL acceptor quantity is increased.2. improve hepatic metabolism, it is synthetic to reduce endogenous cholesterol, suppresses three hydroxyl trimethyl glutaryl coenzyme A (HMGCOA) reductases.3. prevent peroxidating and suppress lipoprotein synthetic.
5, the present invention has good effect, instant effect, and taking convenience, safety non-toxic by blood fat reducing, reduces to normally blood fat, and health is safe.
6, followingly go out 336 routine patient's therapeutic evaluatioies with the table example:
| Name TC claim (cholesterol) | TG (triglyceride cholesterol) | HDL-C (high density lipoprotein) | HDL-C/LDL-C (ratio) |
| Produce effects 289 | 215 | 202 | 279 |
| Effective 40 | 85 | 88 | 57 |
| Invalid 7 | 36 | 46 | 0 |
| Effective 97.9% rate | 89.2％ | 86.3％ | 100％ |
| Total effective rate 98% |
Fig. 1 is preparation technology's flow chart of the present invention.
Safe preparation technology elaborates below in conjunction with accompanying drawing row blood fat.
The first step, get 200 parts in fresh Rhizoma Zingiberis Recens, squeeze extracting juice, collect fresh ginger juice (yield is 10%), stay residue standby with squeezer.
Second step, the fresh ginger juice steam distillation that squeezing is collected, extraction Rhizoma Zingiberis Recens volatile oil (oil yield is 0.1-03%), remaining is mother solution.
The 3rd step, get 100 parts of Semen Cassiaes, be ground into coarse powder, in coarse powder, add 180 parts of Ganoderma decoction pieces with pulverizer, 180 parts of Fructus Crataegi decoction pieces and Rhizoma Zingiberis Recens residue, the alcohol reflux secondary with 75%, each 2 hours, merge backflow twice, filter float, must filtrate; With decompression filtrate recycling ethanol, till the no ethanol flavor, this filtrate is A liquid, stays residue standby in filtrate then.
The 4th goes on foot, 120 portions of Fructus Jujubaes is broken, 160 parts of Folium Nelumbinis shreddings, the decocting that residue in then they being gone on foot with the 3rd adds 10 times of amounts boils three times, primary decocting time is that 1.5 hours, secondary decocting time are that 1 hour, decocting time for the third time are 0.5 hour, merge three times decoction liquor, filter float, filtrate filtered is a B liquid.
The 5th step, merging mother solution, A liquid and B liquid, then with the amalgamation liquid concentrating under reduced pressure, being evaporated to relative density is the thick paste of 130 (heat is surveyed concentrate under 60 ℃ of temperature).
The 6th step, 60 parts of Semen Cassiaes are ground into fine powder with pulverizer, then fine powder are joined in the thick paste, spray into Rhizoma Zingiberis Recens volatile oil, stir, (below 80 ℃) oven dry is pulverized at low temperatures, is 150 parts of powder finished products that make.
Safe through the Powdered blood fat that preparation technology is processed into, or be reprocessed into tablet, capsule and dietetic therapy additive.
Claims (3)
1, a kind of medicine for the treatment of hyperlipidemia is characterized in that it makes with following raw materials in weight: 200 parts in Rhizoma Zingiberis Recens, 180 parts of Fructus Crataegis, 180 parts of Ganodermas, 160 parts of Semen Cassiaes, 160 parts on Folium Nelumbinis, 120 parts in Fructus Jujubae.
2, a kind of medicine as claimed in claim 1 is characterized in that Rhizoma Zingiberis Recens wherein is meant fresh ginger.
3, a kind of preparation technology of medicine as claimed in claim 2 is characterized in that it comprises the following steps:
The first step, fresh ginger is squeezed extracting juice with squeezer, collect fresh ginger juice, yield is 10%, stays residue stand-by;
Second step, the fresh ginger juice steam distillation that squeezing is collected, the extraction Rhizoma Zingiberis Recens volatile oil, oil yield is 0.1-0.3%, remaining is mother solution;
The 3rd step, get 100 parts of Semen Cassiaes, be ground into coarse powder with pulverizer, add the Ganoderma decoction pieces in coarse powder, Fructus Crataegi decoction pieces and Rhizoma Zingiberis Recens residue be with 75% alcohol reflux secondary, and each 2 hours, merge backflow twice, filter float, must filtrate; With decompression filtrate recycling ethanol, till the no ethanol flavor, this filtrate is A liquid, stays residue standby in filtrate then;
The 4th goes on foot, Fructus Jujubae is broken, the Folium Nelumbinis shredding, and the residue in then they being gone on foot with the 3rd adds the water of 10 times of amounts, decocts three times, and three times decocting time is 1.5 hours, 1 hour, 0.5 hour, merges three times decoction liquor, filters float, and filtering filtrate is B liquid;
The 5th step, merge mother solution, A liquid and B liquid,, be evaporated to relative density and be 130 thick paste then with the amalgamation liquid concentrating under reduced pressure;
The 6th step, 60 parts of Semen Cassiaes are ground into fine powder with pulverizer, then fine powder are joined in the thick paste, spray into Rhizoma Zingiberis Recens volatile oil, stir,, pulverize in oven dry below 80 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95121570A CN1062749C (en) | 1995-12-26 | 1995-12-26 | Xuezhikangtai medicine for curing dyslipoproteinemia and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95121570A CN1062749C (en) | 1995-12-26 | 1995-12-26 | Xuezhikangtai medicine for curing dyslipoproteinemia and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1131038A CN1131038A (en) | 1996-09-18 |
| CN1062749C true CN1062749C (en) | 2001-03-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95121570A Expired - Fee Related CN1062749C (en) | 1995-12-26 | 1995-12-26 | Xuezhikangtai medicine for curing dyslipoproteinemia and its preparing process |
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| Country | Link |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1068212C (en) * | 1997-01-31 | 2001-07-11 | 于全义 | Chinese patent drug for treating hyperlipemia |
| CN103815086A (en) * | 2012-11-16 | 2014-05-28 | 郭天伊 | Preparation method of lucid ganoderma health tea |
| CN105963414A (en) * | 2016-05-27 | 2016-09-28 | 张媛 | Composition for regulating blood lipid and blood pressure in cardiology department and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066786A (en) * | 1992-05-15 | 1992-12-09 | 东北第六制药厂二分厂 | The reparation technology of long-life and fat-reducing powder |
| CN1089152A (en) * | 1993-01-01 | 1994-07-13 | 郭如明 | Bulbus Allii Cepae is developed as the series of products of single and compound recipe |
-
1995
- 1995-12-26 CN CN95121570A patent/CN1062749C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066786A (en) * | 1992-05-15 | 1992-12-09 | 东北第六制药厂二分厂 | The reparation technology of long-life and fat-reducing powder |
| CN1089152A (en) * | 1993-01-01 | 1994-07-13 | 郭如明 | Bulbus Allii Cepae is developed as the series of products of single and compound recipe |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1131038A (en) | 1996-09-18 |
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Applicant after: Ding Hongli Applicant after: Gao Enmin Applicant after: Peng Junying Applicant after: Li Hangsheng Applicant after: Ding Lijuan Applicant after: Zhang Weiqi Applicant after: Liu Xiaoyu Applicant after: Xue Guoping Applicant before: Ding Hongli Applicant before: Gao Enmin Applicant before: Peng Junying Applicant before: Li Hangsheng Applicant before: Xue Guoping Applicant before: Ding Lijuan |
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Free format text: CORRECT: APPLICANT; FROM: DING HONGLI; GAO ENMIN; PENG JUNYING; LI HANGSHENG; XUE GUOPING; DING LIJUAN TO: DING HONGLI; GAO ENMIN; PENG JUNYING; LI HANGSHENG; DING LIJUAN; ZHANG WEIQI; LIU XIAOYU; XUE GUOPING |
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