CN101703670B - Hypolipidemic capsule and production and preparation process thereof - Google Patents
Hypolipidemic capsule and production and preparation process thereof Download PDFInfo
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- CN101703670B CN101703670B CN2009102238691A CN200910223869A CN101703670B CN 101703670 B CN101703670 B CN 101703670B CN 2009102238691 A CN2009102238691 A CN 2009102238691A CN 200910223869 A CN200910223869 A CN 200910223869A CN 101703670 B CN101703670 B CN 101703670B
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Abstract
The invention relates to a three-high danshu capsule and a preparation process thereof. The three-high danshu capsule is characterized by comprising the following components in parts by weight: 10-20 parts of hawthorn, 8-15 parts of prepared multiflower knotweed root, 5-10 parts of cassia seed, 5-10 parts of rhizoma alismatis, 3-8 parts of ginseng, 3-8 parts of bulbus allii macrostemi and 5-10 parts of radix salviae miltiorrhizae; the preparation process comprises the following steps: (1) extracting the ginseng, the bulbus allii macrostemi and the radix salviae miltiorrhizae by ethanol, filtering an extract, recovering the ethanol from filtrate, decompressing and concentrating; (2) after extracting by the ethanol, adding water into the medicine residues of the ginseng, the bulbus allii macrostemi and the radix salviae miltiorrhizae, the hawthorn, prepared multiflower knotweed root, the cassia seed and the rhizoma alismatis, extracting, filtering, decompressing and concentrating the filtrate; (3) after concentrating, merging the ethanol extract and the water extract and concentrating continuously; (4) drying the extract in vacuum, pulverizing, sieving and storing dry powder after pulverizing for later use; (5) adding the auxiliary materials of talcum powder and magnesium stearate with a conventional quantity into the obtained extract powder and mixing; and (6) preparing the capsule. Experiments show that the three-high danshu capsule has a better health-care function of regulating blood fat and has no adverse reaction.
Description
(1) invention field:
(1) invention field:
(2) background technology:
The invention belongs to field of health care food, relate to a kind of health product capsule and production process thereof, red relieving capsule of particularly a kind of three-hypers and production process thereof.
" Chinese residents nutrition and investigation of health conditions " (also being the blood fat Epidemiological study of China's maximum magnitude up to now) that Ministry of Public Health in 2002 is carried out in China shows: China 18 years old and above crowd's dyslipidemia total prevalence rate are 18.6%, the male 22.2%, and the women 15.9%.Calculate that in view of the above estimate that the dyslipidemia patient in the whole nation 〉=18 years old reaches 1.6 hundred million, the city crowd is 21.0%, the rural area crowd is 17.7%.The epidemiologic feature of dyslipidemia mainly shows as: (1) prevalence male is higher than the women; and increase with the age and to raise; whole nation investigation in 2002 shows: 18～44 years old, 45～59 years old and 〉=60 years old and above crowd's dyslipidemia prevalence be respectively 17.0%, 22.9% and 23.4%, person in middle and old age's prevalence is apparently higher than the youth.But middle age (45～59 years old) is close with old people (〉=60 years old) prevalence, the rejuvenation of prompting dyslipidemia age of onset trend.(2) prevalence remains the city and is higher than the rural area, but difference is and reduces trend gradually.Economy develops rapidly in China, and in 20 years that provand is enriched constantly, the food consumption behavior that people depart from " balanced diet " becomes increasingly conspicuous.Mainly show as: the increase of meat and oils and fats consumption causes the fast rise of dietary fat energy supply ratio, and the obvious decline of cereal consumption, and Sal is taken in high.The insufficient problem of body movement becomes increasingly conspicuous simultaneously, and the consciousness of independent exercising health and action do not increase thereupon.National body constitution investigation in 2000 and " Chinese residents nutrition and investigation of health conditions " result in 2002 all show: China resident participates in the ratio less than 1/3 of physical training more than 3 times weekly, and wherein the ratio of 30～49 years old middle age exercise is minimum.
(3) summary of the invention:
It is to pay close attention to and treatment hyperlipidemia state that a lot of products has been arranged at present, and for hyperlipemia, the curative effect of Western medicine is more remarkable, but costs an arm and a leg and to take side effect for a long time obvious; The Chinese medicine compound of treatment hyperlipemia is also more, but some belongs to and cure the symptoms, not the disease, and some uses expensive composition, and some in use interrupts use owing to the auxiliary treatment effect is not good.
The object of the present invention is to provide red relieving capsule of a kind of three-hypers and production process thereof, it is at the defective of above-mentioned prior art, with the traditional theory of Chinese medical science of China is support, adopt integration of edible and medicinal herbs or can be used for the article of health food, become a kind of more efficiently, natural health food with blood lipid regulation function.
Technical scheme of the present invention: the red relieving capsule of a kind of three-hypers is characterized in that its prescription and weight portion proportioning are: Fructus Crataegi 10-20, Radix Polygoni Multiflori Preparata 8-15, Semen Cassiae 5-10, Rhizoma Alismatis 5-10, Radix Ginseng 3-8, Bulbus Allii Macrostemonis 3-8, Radix Salviae Miltiorrhizae 5-10.
The processing technology of the red relieving capsule of a kind of above-mentioned three-hypers: it is characterized in that constituting by following steps:
(1) the 70-90% ethanol extraction doubly measured with 6-8 of Radix Ginseng, Bulbus Allii Macrostemonis and the Radix Salviae Miltiorrhizae of getting formula ratio is 2-4 time, and each 1-3 hour, extracting liquid filtering, filtrate recycling ethanol, being evaporated to and recording proportion at 50～55 ℃ is 1.10～1.20g/cm
3Concentrated solution;
(2) medicinal residues of the Radix Ginseng after the alcohol extraction, Bulbus Allii Macrostemonis and Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Semen Cassiae and Rhizoma Alismatis add water extraction 2-4 time that 8-10 doubly measures, and each 1-3 hour, extracting liquid filtering, filtrate decompression is concentrated into and records proportion at 50～55 ℃ is 1.10～1.20g/cm
3Concentrated solution;
(3) alcohol extract after will concentrating and water extract merge, and continue to be concentrated into that to record proportion at 50～55 ℃ be 1.30～1.40g/cm
3Extractum;
(4) above-mentioned extractum is carried out vacuum drying, pulverized the 60-100 mesh sieve, the dry powder after pulverizing is in double-layer plastic bag sealed storage, standby;
(5) with above gained extract powder, add Pulvis Talci, the magnesium stearate adjuvant of convention amount, mixed 30-50 minute;
(6) use Autocapsulefillingmachine to fill, make capsule.
Prescription mechanism of the present invention: hyperlipidemia is with the characteristic of its thickness, calmness, the category that generally is under the jurisdiction of motherland's medical science " expectorant ", modern medicine is thought exogenous, endogenous two classes, motherland's medical science is also thought the reason of two aspects: one is therefore eating and drinking without temperance outward, and two go down for the interior impairment of the spleen, kidney, liver, gallbladder function.It is starting point with traditional theory of Chinese medical science promptly that this prescription is formed: control from the spleen opinion, clear this disconnected source hinders its life; Dredge sharp soft pulse, the logical clean fat of a surname, the inhibition that promptly is equivalent to modern medicine is synthesized, is absorbed and short its drainage, use integration of edible and medicinal herbs or can be used for the article science compatibility of health food,, have the health care of blood lipid regulation really through secular scientific research, long-term use without side effects, safe in utilization.
Health-care effect analysis of the present invention:
Fructus Crataegi is the fruit of Rosaceae machaka or dungarunga plant Crataegi cuneatae Crataegus cuneata, Fructus Pyri Pashiae C.pinnatifida Bungevar.major or Fructus Crataegi C.pinnatifida, be the sweet product of acid, the cloudy gas of kindization is so promoting digestion and removing stagnation and non-impairment of YIN are really cut the good medicine in source for blood fat reducing.Modern pharmacology also confirms, give mice hyperlipidemia model hyperin 50,15mg/kg respectively, the enzyme reaction end-point method is measured serum TC, TG, HDL value, discovery has the effect of obvious reduction mice serum TC and rising HDL/TC, and its effect is relevant with removing free radical key enzyme SOD activity with rising HDL percent value.Also have blood vessel dilating in addition, bring high blood pressure down, cholesterol reducing increases effects such as gastric juice digestive enzyme.
The Radix Ginseng Radix Ginseng is the dry root of Araliaceae Radix Ginseng Panax ginseng.Modern medicine experimental studies have found that through rat, thereby ginsenoside, glycyrrhizin can make the metabolism of cholesterol increase. blood cholesterol is descended.The Radix Ginseng of invigorating spleen to remove dampness had both helped the power of fortune removing dampness, and had the energy of strong tonification again, say just as " collection of experiences of famous physicians in the Ming Dynasty ": " middle gas is both strong; its expectorant is from fortuneization, body fluid Qinghua, and how does expectorant have? " Radix Ginseng has dual regulation to blood fat, ginseng effective component ginsenoside Rb, Rc, Rd, Re, Rg can stimulate lipid metabolism, can significantly promote the biosynthesis of lipoprotein in rat cholesterol and the blood on the one hand; Also can quicken it on the other hand and decompose, so less the influence of blood plasma and liver cholesterol level.Its work is the strongest in order to Rb, and Rg and Re take second place, a little less than Rc and the Rd.
Bulbus Allii Macrostemonis is the dry bulb of liliaceous plant Allium macrostemon Allium macrostenon, contains compositions such as volatile oil, steroidal saponin, adenosine, thymidine.Clinical observation and detection confirm, Bulbus Allii Macrostemonis soft gelatin capsule (the main volatile oil that contains) energy blood fat reducing is especially better to the reduction effect of serum cholesterol, triglyceride, can reduce the serum lipid peroxide simultaneously, and raising prostacyclin content suppresses thromboxane A
2Synthetic, thus play the effect that suppresses thrombosis, alleviates atherosclerotic lesion.
Semen Cassiae is the mature seed of pulse family annual plant Semen Cassiae Cassia obtusifolia or little Semen Cassiae C.tora.Be the Chinese medicine that a kind of sweet-bitter flavor is slightly cold, mainly contain phytosterol and anthraquinones, have and suppress the effect that serum cholesterol raises and atheromatous plaque forms, lipid-lowering effect is remarkable.
Radix Polygoni Multiflori is the root piece of Polygonaceae herbaceos perennial Radix Polygoni Multiflori Polygonum multiflorum, the abnormal smells from the patient bitter cold, contain anthraquinones such as chrysophanic acid, emodin, chrysophanol, aloe-emodin, can promote intestinal peristalsis promoting, reduce cholesterol absorption, increased excretions of cholesterol is drained, thereby plays blood fat reducing, antiatherogenic effect.Radix Polygoni Multiflori extract can effectively reduce triglyceride in the rat blood serum (TG), cholesterol (TC), low density lipoprotein, LDL (LDL-C) content and LDL-C/HDL-C ratio (P＜0.01), and HDL-C content and HDL-C/TC ratio obviously raise (P＜0.01), show that Radix Polygoni Multiflori extract has tangible effect for reducing blood fat.
Rhizoma Alismatis is the tuber of the perennial limnocryptophyte Rhizoma Alismatis of Alismataceae Alismaorientalis, and slightly sweet flavor is cold in nature, contains triterpenoid compound, can influence steatolysis, the raw material of synthetic cholesterol is reduced, thereby have blood fat reducing, prevent and treat the effect of atherosclerosis and fatty liver.
Radix Salviae Miltiorrhizae has not showed effect for reducing blood fat for experimental atherosclerosis rat and the oral Radix Salviae Miltiorrhizae decoct of rabbit, but can reduce lipid in the liver, particularly triglyceride, and it has the effect that promotes fat oxidation in liver.Danshensu in the Radix Salviae Miltiorrhizae has inhibitory action to serum cholesterol synthetic, can also play obvious reduction effect to hyperlipidemia simultaneously.
In sum, hawthorn digesting eliminate indigestion, outstanding kind " grease that disappears is long-pending "; The ginseng spleen strengthening dampness removing had both helped the power of transporting removing dampness, had the energy of strong tonification again, middle gas is both strong, and its expectorant is from fortuneization, body fluid Qinghua, having of what expectorant? lung is clear respectful dirty, liver has the energy of catharsis, and turbid fat is if form, when transferring body defending system, resist its invasion and attack, the Bulbus Allii Macrostemonis activating YANG with pungent and warm drugs, the kind heap soil or fertilizer over and around the roots of loosing stagnates, and its expectorant of dispelling is turbid; Gallbladder is the mansion of middle essence, the secretion refined juice, and fatization is turbid only, if catharsis mistake degree, courage is strongly fragrant holds back, then peace and quiet having no right, the turbid difficultyization of fat, Semen Cassiae is for letting out the hot and suffocating product of liver and gall clearly, and toralactone can promote the intestinal tube motion, thereby suppresses the absorption to cholesterol; Blood fat is cloudy Tianjin instituteization, and blood fat too high consumption body fluid often causes battalion's deficiency of YIN, Radix Polygoni Multiflori invigorating the liver and kidney benefiting essence-blood, and with the pure and honest gentleness of its nature and flavor, kind nourishing the essence and strengthening QI, flat secret negative and positive; Blood fat both had been a pathological product, ought to dispel it early, and hyperlipidemia is the thing of turbid damp, had sagging property, made too high turbid fat go it from urine, and the kind sluice way that oozes of Rhizoma Alismatis specially can be urinated by tonneau; Turbid fat mixes in blood and blood viscosity is raise, and accumulation of blood was both of a specified duration, also can turn to expectorant water, in the course of time, the expectorant blood coagulation stasis of blood, Radix Salviae Miltiorrhizae has blood circulation promoting and blood stasis dispelling, and can reduce fat and triglyceride in the liver.
Below be the experimental data of function and effect:
Experimental example one: zoopery
1 material and reagent
1.1 the red relieving capsule of material three-hypers
1.2 56 of experimental animal and feedstuff male SD rats, body weight 180 ± 15g, plant provides by Green Dragon mountain, Nanjing; Fel Sus domestica salt: Chemical Reagent Co., Ltd., Sinopharm Group produces; Yolk powder, Adeps Sus domestica are made by oneself by laboratory.
2 methods
2.1 preparation 10% yolk powder of high lipid food, 4.5% Adeps Sus domestica, 0.5% Fel Sus domestica salt, 85% normal feedstuff.
2.2 the grouping and set up model and get 40 of the common male rats in the 200g left and right sides, be divided into 5 groups at random, every group 8, if matched group (feeding conventional feed), model group gives high lipid food, and other 3 groups of experimental grouies are when feeding high lipid food, after feeding high lipid food 7d, give three-hypers red relieving capsule (5 times, 10 times, 20 multiple doses) respectively, totally 25 days.
2.3 lipid determination is weighed after experiment finishes fasting 24h, eye socket is got blood, centrifuging and taking determination of serum TC behind the blood coagulation, TG, HDL-C.
3 results
3.1 behind the influence experiment end fasting 24h to hyperlipemia rat serum TC, TG, eye socket is got blood, centrifuging and taking determination of serum TC, TG behind the blood coagulation, and experimental result sees Table 1.
The influence of table 1 pair hyperlipemia rat serum TC, TG
Compare with the blank group: #P＜0.05, ##P＜0.01; Compare with model group: * P＜0.05, * * P＜0.01
3.2 behind the influence experiment end fasting 24h to the hyperlipemia rat Serum HDL-C, eye socket is got blood, centrifuging and taking determination of serum HDL-C behind the blood coagulation, and (AI=(TC-HDL-C)/HDL-C), experimental result sees Table 2 to calculate atherogenic index AI simultaneously.
The influence of table 2 pair hyperlipemia rat Serum HDL-C, AI
Compare with the blank group: #P＜0.05, ##P＜0.01; Compare with model group: * P＜0.05, * * P＜0.01
4 conclusions: as can be seen by result of the test, experimental group and model group are relatively, TC, TG have remarkable reduction, the reduction amplitude reaches 32.61% and 42.39% respectively, HDL-C has raise 49.32%, atherogenic index AI has reduced by 90.91%, and visible influences is very remarkable, and the red relieving capsule of three-hypers has good effect for reducing blood fat to the hyperlipidemia rat.
Experimental example two:
1 object of study
25 years old～50 years old adult, simple dyslipidemia, 2 empty stomaches (more than the 12h) are surveyed serum total cholesterol (TC)＞5.72mmol/L (220mg/dL) or triacylglycerol (TG)＞1.7mmol/L (150mg/dL) or LDL＞3.64mmol/L (140mg/dL) or HDL-C＜1.04mmol/L (40mg/dL).
2 take and observational technique
For avoiding the influence of diet control factor, all experimenter's dietary habit all as before.
Amount: every day 3 times, each 2, edible 3 months continuously.
Check blood fat and experimenter self-induction symptom in use changes situation after 3 months.
3 effect evaluations
3.1 evaluation criterion is drafted with reference to " new Chinese medicine is controlled hyperlipemia clinical research index principle ".Produce effects: edible back lipids detection reach following any one, TC descends 〉=20%, TG descends 〉=40%, HDL-C risings 〉=0.26mmol/L (10mg/dL), (TC-HDL-C)/HDL-C decline 〉=20%.Effectively: lipids detection reach following any one, TC descend 〉=10% but＜20%, TG descend 〉=20% but＜40%, HDL-C risings 〉=0.104mmol/L (4mg/dL) but＜0.26mmol/L (10mg/dL), (TC-HDL-C)/HDL-C decline 〉=10% but＜20%.Invalid: edible back lipids detection does not have obvious change or does not reach effective standard.
3.2 the result tests according to using method 60 experimenters, the result is as follows: produce effects 40 examples, effective 13 examples, invalid 7 examples, total effective rate 88.34%; The experimenter reflects that all to take effect better, no any discomfort sensation.
Superiority of the present invention and technique effect are: 1, experiment shows, the red relieving capsule of three-hypers has the health care of blood lipid regulation preferably, and has no adverse reaction; 2, the prescription composition has used the disconnected source of clear basis of motherland's medical science, the guiding theory that hinders its life and dredge sharp soft pulse, the logical clean fat of a surname, i.e. the inhibition of modern medicine is synthesized, absorbed and short its excretory mechanism, and scientific formulation is reasonable, long-term use without side effects; 3, carry taking convenience; 4, raw material is large source of goods, and manufacture method is simple, can successfully be amplified to suitability for industrialized production, is a kind of health food with lipid-reducing function that is worthy to be popularized.
(4) specific embodiment:
Embodiment 1: prescription and weight portion proportioning: Fructus Crataegi 15, Radix Polygoni Multiflori Preparata 12, Semen Cassiae 8, Rhizoma Alismatis 8, Radix Ginseng 5, Bulbus Allii Macrostemonis 5, Radix Salviae Miltiorrhizae 8
Manufacturing process steps:
(1) Radix Ginseng, Bulbus Allii Macrostemonis and the Radix Salviae Miltiorrhizae of getting formula ratio be with 75% ethanol extraction of 6 times of amounts 2 times, and each 2 hours, extracting liquid filtering, filtrate recycling ethanol, being evaporated to and recording proportion at 53 ℃ is 1.15g/cm
3Concentrated solution;
(2) medicinal residues of the Radix Ginseng after the alcohol extraction, Bulbus Allii Macrostemonis and Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Semen Cassiae and Rhizoma Alismatis add the water extraction 2 times of 8 times of amounts, and each 2 hours, extracting liquid filtering, filtrate decompression is concentrated into and records proportion at 55 ℃ is 1.13g/cm
3Concentrated solution;
(3) alcohol extract after will concentrating and water extract merge, and continue to be concentrated into that to record proportion at 55 ℃ be 1.33g/cm
3Extractum;
(4) above-mentioned extractum is carried out vacuum drying, pulverized 100 mesh sieves, the dry powder 18.3kg after pulverizing is in double-layer plastic bag sealed storage, standby;
(5) with above gained extract powder 18.3kg, add Pulvis Talci 0.2kg, magnesium stearate 0.1kg, mixed 50 minutes;
(6) use Autocapsulefillingmachine to fill 0# capsule, loading amount 0.45g/ grain.
Embodiment 2: prescription and weight portion proportioning: Fructus Crataegi 10, Radix Polygoni Multiflori Preparata 15, Semen Cassiae 10, Rhizoma Alismatis 10, Radix Ginseng 8, Bulbus Allii Macrostemonis 8, Radix Salviae Miltiorrhizae 5
Manufacturing process steps:
(1) Radix Ginseng, Bulbus Allii Macrostemonis and the Radix Salviae Miltiorrhizae of getting formula ratio be with 90% ethanol extraction of 8 times of amounts 4 times, and each 1 hour, extracting liquid filtering, filtrate recycling ethanol, being evaporated to and recording proportion at 50 ℃ is 1.11g/cm
3Concentrated solution;
(2) medicinal residues of the Radix Ginseng after the alcohol extraction, Bulbus Allii Macrostemonis and Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Semen Cassiae and Rhizoma Alismatis add the water extraction 4 times of 10 times of amounts, and each 1 hour, extracting liquid filtering, filtrate decompression is concentrated into and records proportion at 53 ℃ is 1.15g/cm
3Concentrated solution;
(3) alcohol extract after will concentrating and water extract merge, and continue to be concentrated into that to record proportion at 50 ℃ be 1.38g/cm
3Extractum;
(4) above-mentioned extractum is carried out vacuum drying, pulverized 80 mesh sieves, the dry powder 20.4kg after pulverizing is in double-layer plastic bag sealed storage, standby;
(5) with above gained extract powder 20.4kg, add Pulvis Talci 0.23kg, magnesium stearate 0.12kg, mixed 30 minutes;
(6) use Autocapsulefillingmachine to fill 0# capsule, loading amount 0.45g/ grain.
Embodiment 3: prescription and weight portion proportioning: Fructus Crataegi 20, Radix Polygoni Multiflori Preparata 8, Semen Cassiae 5, Rhizoma Alismatis 5, Radix Ginseng 3, Bulbus Allii Macrostemonis 3, Radix Salviae Miltiorrhizae 10
Manufacturing process steps:
(1) Radix Ginseng, Bulbus Allii Macrostemonis and the Radix Salviae Miltiorrhizae of getting formula ratio be with 80% ethanol extraction of 7 times of amounts 3 times, and each 1.5 hours, extracting liquid filtering, filtrate recycling ethanol, being evaporated to and recording proportion at 55 ℃ is 1.20g/cm
3Concentrated solution;
(2) medicinal residues of the Radix Ginseng after the alcohol extraction, Bulbus Allii Macrostemonis and Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Semen Cassiae and Rhizoma Alismatis add the water extraction 3 times of 9 times of amounts, and each 1.5 hours, extracting liquid filtering, filtrate decompression is concentrated into and records proportion at 54 ℃ is 1.18g/cm
3Concentrated solution;
(3) alcohol extract after will concentrating and water extract merge, and continue to be concentrated into that to record proportion at 55 ℃ be 1.40g/cm
3Extractum;
(4) above-mentioned extractum is carried out vacuum drying, pulverized 60 mesh sieves, the dry powder 15.12kg after pulverizing is in double-layer plastic bag sealed storage, standby;
(5) with above gained extract powder 15.12kg, add Pulvis Talci 0.18kg, magnesium stearate 0.08kg, mixed 40 minutes;
(6) use Autocapsulefillingmachine to fill 0# capsule, loading amount 0.45g/ grain.
Claims (5)
1. the capsule of a blood fat reducing is characterized in that its prescription and weight portion proportioning are: Fructus Crataegi 10-20, Radix Polygoni Multiflori Preparata 8-15, Semen Cassiae 5-10, Rhizoma Alismatis 5-10, Radix Ginseng 3-8, Bulbus Allii Macrostemonis 3-8, Radix Salviae Miltiorrhizae 5-10.
2. according to the capsule of the said a kind of blood fat reducing of claim 1, it is characterized in that prescription and weight portion proportioning are: Fructus Crataegi 15, Radix Polygoni Multiflori Preparata 12, Semen Cassiae 8, Rhizoma Alismatis 8, Radix Ginseng 5, Bulbus Allii Macrostemonis 5, Radix Salviae Miltiorrhizae 8.
3. according to the capsule of the said a kind of blood fat reducing of claim 1, it is characterized in that prescription and weight portion proportioning are: Fructus Crataegi 10, Radix Polygoni Multiflori Preparata 15, Semen Cassiae 10, Rhizoma Alismatis 10, Radix Ginseng 8, Bulbus Allii Macrostemonis 8, Radix Salviae Miltiorrhizae 5.
4. according to the capsule of the said a kind of blood fat reducing of claim 1, it is characterized in that prescription and weight portion proportioning are: Fructus Crataegi 20, Radix Polygoni Multiflori Preparata 8, Semen Cassiae 5, Rhizoma Alismatis 5, Radix Ginseng 3, Bulbus Allii Macrostemonis 3, Radix Salviae Miltiorrhizae 10.
5. the capsular processing technology of any one blood fat reducing in the claim 1～4: it is characterized in that constituting by following steps:
(1) the 70-90% ethanol extraction doubly measured with 6-8 of Radix Ginseng, Bulbus Allii Macrostemonis and the Radix Salviae Miltiorrhizae of getting formula ratio is 2-4 time, and each 1-3 hour, extracting liquid filtering, filtrate recycling ethanol, being evaporated to and recording density at 50～55 ℃ is 1.10～1.20g/cm
3Concentrated solution;
(2) medicinal residues of the Radix Ginseng after the alcohol extraction, Bulbus Allii Macrostemonis and Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Semen Cassiae and Rhizoma Alismatis add water extraction 2-4 time that 8-10 doubly measures, and each 1-3 hour, extracting liquid filtering, filtrate decompression is concentrated into and records density at 50～55 ℃ is 1.10～1.20g/cm
3Concentrated solution;
(3) alcohol extract after will concentrating and water extract merge, and continue to be concentrated into that to record density at 50～55 ℃ be 1.30～1.40g/cm
3Extractum;
(4) above-mentioned extractum is carried out vacuum drying, pulverized the 60-100 mesh sieve, the dry powder after pulverizing is in double-layer plastic bag sealed storage, standby;
(5) with above gained extract powder, add Pulvis Talci, the magnesium stearate adjuvant of convention amount, mixed 30-50 minute;
(6) use Autocapsulefillingmachine to fill, make capsule.
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| CN1429591A (en) * | 2001-12-30 | 2003-07-16 | 李东海 | Fat reducing liver protecting capsule |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1429591A (en) * | 2001-12-30 | 2003-07-16 | 李东海 | Fat reducing liver protecting capsule |
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| Title |
|---|
| 蔡一英.近年来中药治疗商脂血症的进展.《陕西中医》.1983,(第06期), * |
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