CN100404048C - Method for preparing blood fat-reducing product - Google Patents

Abstract

The present invention relates to a blood fat reducing product preparing method. The present invention uses industrial residues of tomato paste as raw materials, extraction and separation are carried out, and a product with the action of blood fat reduction in hyperlipemia blood is prepared. Compared with other blood fat reducing preparations, the present invention has the advantages of low cost, simple production process, favorable effects of blood fat reduction, and no toxic and side effects.

Description

A kind of preparation method of blood fat-reducing product

Technical field

The present invention relates to a kind of preparation method of blood fat-reducing product.

Background technology

Along with the raising of people's living standard, high protein, high fat diet chance increase, and quantity of motion reduces, and the fat in the blood gathers owing to burning, and causes one of contemporary rich and honour ciril disease---the appearance of hyperlipemia.The chance that the hyperlipemia person suffers from a heart complaint is four times of normal person, China hyperlipemia patient has reached 1.6 hundred million people, the sickness rate of severe overweight people's fatty liver is up to 61～94%, the cardiovascular diseases who is caused by hyperlipidemia and the causing death number height in all diseases of dying ranks first, hyperlipidemia population increases with expanding economy, and more and more is tending towards rejuvenation.The hyperlipemia that is called as " reticent killer " to the infringement of health be concealment, gradually, carrying out property and general, it directly damages is to quicken systemic atherosclerosis, finally cause cardiovascular disease and renal failure, cause fatty liver, liver cirrhosis, hyperuricemia etc.Eliminate this symptom, except reinforcement physical exercise, relaxation of tension emotion, reasonable arrangement are had a rest, also need to nourish adjustment with health medicine, to regulate physiology now, guarantee people's physical and mental health is put in work or the study with abundant energy.

At present being seen effectively blood lipid-lowering medicine great majority are chemical synthetic drug, and liver function, skeletal muscle, kidney or other internal organs are had damaging action.Little, the blood fat reducing of exploitation toxic and side effects effectively, taking convenience, preparation with low cost be that world today's medical circle needs to be resolved hurrily and one of the emphasis problem of capturing.Carrying out a large amount of research aspect the treatment hyperlipemia both at home and abroad.Patent PCT.GB95/0188495.8.9 has applied for a kind of blood fat reducing chemical compound-blood fat reducing 1,4-benzo-aza ∴-1,1-dioxide and preparation method thereof and contain its pharmaceutical composition and the application in prevention and treatment hyperlipidemia such as Atheromatosis thereof.Number of patent application be CN93109943.9 application for a patent for invention a kind of blood fat reducing, arteriosclerosis, total alkanol that can also be used to lose weight of being used for.It is to contain the mixture of octacosanol to n-Dotriacontanol; Can add adjuvant and make oral formulations.Number of patent application be CN92104730.4 application for a patent for invention a kind of prescription of hypolipidemic, be characterized in by 8 flavor Chinese prescriptions such as Radix Polygoni Multiflori through certain processing technique, make dosage forms such as oral liquid, electuary, be applicable to control middle-aged and elderly people lipid cholesterol height, brain cardiovascular disease.Number of patent application be CN97104308.6 application for a patent for invention a kind of health product preparation of blood fat reducing, blood sugar lowering and the adjusting immunization of forming by propolis and Herba bromi japonici; Number of patent application is that the patent of invention of CN200410016413.5 is to be the soft capsule with remarkable blood lipid regulation and deferring senility effect of active component development with resveratrol and tea polyphenols; Number of patent application be CN200310105652.3 application for a patent for invention a kind of health food that contains polysaccharide and preparation method thereof, this invention mixes with Fructus Lycii, Fructus Jujubae, Flos Carthami Semen sojae atricolor, Ganoderma, Zaocys by proportioning, through oral granule or the capsule that steps such as immersion, slow fire boiling, filtration, alcohol extraction make, this product has immunologic function, elimination airway inflammation, the liver protecting, vessel softening, slow down aging, the constitutional health-care effect of regulating human body; Number of patent application be the patent of invention of CN03100599.3 announced by preparation of raw material such as oligosaccharide a kind of can improve human body the intestines and stomach environment, promote bacillus bifidus propagation, prevent constipation, the liver protecting function, reduce serum cholesterol, bring high blood pressure down, the low-yield natural oligosaccharide beverage of antifatigue effect etc.; Number of patent application has been the CN03100308.7 application for a patent for invention a kind of soybean oligo saccharide health-care beer and compound method thereof, this prescription can promote bacillus bifidus propagation in the human intestine, clean intestinal relieving constipation, reduction serum cholesterol, the liver protecting, defying age and prevent and treat health-care effect such as human primary gastrointestinal cancers; Number of patent application is that CN03134284.1 has applied for that a kind of is to form medicine for the treatment of fatty liver and preparation method thereof with the polydatin, this invention can reduce T-CHOL and triglyceride level in the rat model liver, the fatty liver rat model is presented significant hepatoprotective effect, and can obviously reduce the T-CHOL and the triglyceride level of Golden Hamster high blood lipid model; Number of patent application is the CN03128754.9 application for a patent for invention a kind ofly has blood lipid regulation, liver-protective product and a preparation technology thereof with compositions such as Fructus Hippophae, Fructus Lycii, tea polyphenols and Fructus Crataegi powder; Number of patent application is the CN03100309.5 application for a patent for invention a kind ofly has bacillus bifidus propagation in the human intestine of promotion, clean intestinal relieving constipation, reduction serum cholesterol, the liver protecting, defying age and control the intestines and stomach cancer aspect and has tangible health-care effect soybean oligo saccharide water beverage and compound method thereof; A kind of health care liquid and production technology of forming by acetic acid leachate, fresh hen egg, edible Gelatinum oxhide, rice vinegar, pancreatin, polysorbate40, agar, maltodextrin and the water of Fructus Hippophae concentrated juice, Fructus Hippophae flavone thereof that number of patent application has been the CN00105284.5 application for a patent for invention with effects such as coronary dilating, blood fat reducing, reduction blood viscosity, the liver protecting, slow down aging.

But the cost that above-mentioned patented technology has is higher, the complex manufacturing that has, and the lipid-lowering effect that has is poor, the toxic side effect that has.

Summary of the invention

The purpose of this invention is to provide a kind of is that raw material, lipid-lowering effect are good, the preparation method of the blood fat-reducing product that has no side effect with the tomato paste industry waste residue.

For achieving the above object, preparation method step of the present invention is as follows:

1) take by weighing a certain amount of dried tomato paste industry waste residue, pulverized 40～60 mesh sieves, through CO ₂The liposoluble constituent that supercritical extraction obtains, heating in water bath is 30～50 minutes under 50 ℃～60 ℃ temperature, and sucking filtration gets substance A under 0.06～0.08MPa pressure;

2) taking by weighing a certain amount of substance A concentration expressed in percentage by weight is the extraction of 1% copperas solution, and substance A and extract volume left standstill 18～24 hours than 1: 1～3, discarded lower floor, and the collection upper solution gets substance B;

3) substance B removes carbonyl compound through vapor distillation 1～2 hour, substance C;

4) the substance C concentration expressed in percentage by weight is 0.05～0.1% NaOH solution extraction, and substance C is 1: 2～3 with NaOH extract volume ratio, leaves standstill 18～24 hours, discards lower floor, collects upper solution and gets material D;

5) under 70 ℃～80 ℃ temperature conditions, add active hargil in material D, material D and active hargil weight ratio are 20: 3～5, stir under 300～350 rev/mins rotating speed 30～60 minutes, slough pigment composition; Sucking filtration under the pressure condition of 0.06～0.08MPa is then sloughed moisture with the 3A molecular sieve, gets blood fat-reducing product.

Utilize the chemical constituent of gas chromatogram, liquid chromatograph characterization natural blood fat reducing material to contain lauric acid 0.06%, myristic acid 0.09%, Palmic acid 13.25%, palmitic olefinic acid 0.11%, Petiolus Trachycarpi dienoic acid 0.06%, stearic acid 6.53%, oleic acid 26.46%, linoleic acid 50.11%, linolenic acid 2.59%, arachidic acid 0.41%, arachidonic acid 0.10%, class V _E1.6 * 10 ^-2%, lycopene 0.36mg/100g.

The main physical and chemical index and the sanitary index of blood fat-reducing product

The blood fat reducing result of the test:

Through the rat pharmacological evaluation is shown: took this natural product low density lipoprotein, LDL in the hyperlipidemia animal blood, triglyceride, total cholesterol level are reduced in 30 days, can reduce the deposition of fat in the hyperlipidemia laboratory animal hepatic tissue, the effect that prevents and improve fatty liver is arranged.

Advantage of the present invention:

1, the present invention is a raw material with the tomato paste industry waste residue, a kind of natural content that can reduce low density lipoprotein, LDL, triglyceride, T-CHOL in the hyperlipidemia animal blood through preparations such as extraction, separation, increase hdl concentration, can reduce the deposition of fat in the hyperlipidemia laboratory animal hepatic tissue.

2, production technology of the present invention is simple, and product has no side effect.

3, cost of the present invention is low.Because the raw material abundance, this preparation method is fully utilized the tomato paste industry waste residue, has improved the Fructus Lycopersici esculenti added value, has reduced environmental pollution, for a new channel has been opened up in Fructus Lycopersici esculenti commercialization action.

Description of drawings

Fig. 1 is the effect of product of the present invention to hyperlipidemia animal serum cholesterol;

Fig. 2 is the effect of product of the present invention to hyperlipidemia animal serum triglyceride;

Fig. 3 is the effect of product of the present invention to hyperlipidemia animal serum low density lipoprotein, LDL.

The specific embodiment

Embodiment 1

1) take by weighing tomato paste industry waste residue that 100 grams do, pulverized 40 mesh sieves, through CO ₂The liposoluble constituent that supercritical extraction obtains, heating in water bath is 30 minutes under 50 ℃ temperature, and sucking filtration gets substance A under 0.06MPa pressure;

2) the substance A concentration expressed in percentage by weights that take by weighing 5 grams are the extraction of 1% copperas solution, and substance A and extract volume left standstill 18 hours than 1: 1, discarded lower floor, and the collection upper solution gets substance B;

3) substance B removes carbonyl compound through vapor distillation 1 hour, substance C;

4) the substance C concentration expressed in percentage by weight is 0.05% NaOH solution extraction, and substance C is 1: 2 with NAOH extract volume ratio, leaves standstill 18 hours, discards lower floor, collects upper solution and gets material D;

5) under 70 ℃ temperature conditions, in material D, add active hargil, material D and active hargil weight ratio are 20: 3, stir 30 minutes under 300 rev/mins rotating speed, slough pigment composition; Sucking filtration under the pressure condition of 0.06MPa is then sloughed moisture with the 3A molecular sieve, gets blood fat-reducing product.

Embodiment 2

1) take by weighing tomato paste industry waste residue that 200 grams do, pulverized 60 mesh sieves, through C0 ₂The liposoluble constituent that supercritical extraction obtains, heating in water bath is 50 minutes under 60 ℃ temperature, and sucking filtration gets substance A under 0.08MPa pressure;

2) the substance A concentration expressed in percentage by weights that take by weighing 10 grams are the extraction of 1% copperas solution, and substance A and extract volume left standstill 24 hours than 1: 3, discarded lower floor, and the collection upper solution gets substance B;

3) substance B removes carbonyl compound through vapor distillation 2 hours, substance C;

4) the substance C concentration expressed in percentage by weight is 0.1% NaOH solution extraction, and substance C is 1: 3 with NAOH extract volume ratio, leaves standstill 24 hours, discards lower floor, collects upper solution and gets material D;

5) under 80 ℃ temperature conditions, in material D, add active hargil, material D and active hargil weight ratio are 4: 1, stir 60 minutes under 350 rev/mins rotating speed, slough pigment composition; Sucking filtration under the pressure condition of 0.08MPa is then sloughed moisture with the 3A molecular sieve, gets blood fat-reducing product.

Embodiment 3

1) take by weighing tomato paste industry waste residue that 500 grams do, pulverized 50 mesh sieves, through CO ₂The liposoluble constituent that supercritical extraction obtains, heating in water bath is 40 minutes under 55 ℃ temperature, and sucking filtration gets substance A under 0.07MPa pressure;

2) the substance A concentration expressed in percentage by weights that take by weighing 20 grams are the extraction of 1% copperas solution, and substance A and extract volume left standstill 21 hours than 1: 2, discarded lower floor, and the collection upper solution gets substance B;

3) substance B removes carbonyl compound through vapor distillation 1.5 hours, substance C;

4) the substance C concentration expressed in percentage by weight is 0.08% NaOH solution extraction, and substance C is 1: 2.5 with NAOH extract volume ratio, leaves standstill 21 hours, discards lower floor, collects upper solution and gets material D;

5) under 75 ℃ temperature conditions, in material D, add active hargil, material D and active hargil weight ratio are 5: 1, stir 45 minutes under 320 rev/mins rotating speed, slough pigment composition; Sucking filtration under the pressure condition of 0.07MPa is then sloughed moisture with the 3A molecular sieve, gets blood fat-reducing product.

Claims (1)

1. the preparation method of a blood fat-reducing product, its step is as follows:

1) take by weighing a certain amount of dried tomato paste industry waste residue, pulverized 40～60 mesh sieves, through CO ₂The liposoluble constituent that supercritical extraction obtains, heating in water bath is 30～50 minutes under 50 ℃～60 ℃ temperature, and sucking filtration gets substance A under 0.06～0.08MPa pressure;

2) taking by weighing a certain amount of substance A concentration expressed in percentage by weight is the extraction of 1% copperas solution, and A and extract volume left standstill 18～24 hours than 1: 1～3, discarded lower floor, and the collection upper solution gets substance B;

3) substance B removes carbonyl compound through vapor distillation 1～2 hour, substance C;

4) the substance C concentration expressed in percentage by weight is 0.05～0.1% NaOH solution extraction, and substance C is 1: 2～3 with NaOH extract volume ratio, leaves standstill 18～24 hours, discards lower floor, collects upper solution and gets material D;

5) under 70 ℃～80 ℃ temperature conditions, add active hargil in material D, material D and active hargil weight ratio are 20: 3～5, stir under 300～350 rev/mins rotating speed 30～60 minutes, slough pigment composition; Sucking filtration under the pressure condition of 0.06～0.08MPa is then sloughed moisture with the 3A molecular sieve, gets blood fat-reducing product.

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