CN1296061C - Health care food for preventing and treating heart brain blood vessel disease and its preparation method - Google Patents
Health care food for preventing and treating heart brain blood vessel disease and its preparation method Download PDFInfo
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Abstract
The present invention relates to healthcare food and a preparing method thereof for preventing and treating cardiovascular and cerebrovascular diseases, which belongs to the technical field of healthcare food. In order to solve the problems of single functions and insufficient function strength of the healthcare food for preventing and treating cardiovascular and cerebrovascular diseases at present, the healthcare food with the functions of both prevention and treatment and both long effects and short effects is prepared from red koji, chuanxiong rhizome, notoginseng extract, folium ginkgo extract, vitamin B1, vitamin B6 and starch which are used as raw materials. The healthcare food has the advantages of safety, no toxic or side effects, short course of treatment, fast effects, health, health care, etc.
Description
Technical field
The present invention relates to a kind of health food, more particularly, the present invention relates to a kind of health food of preventing and treating cardiovascular and cerebrovascular disease.
Background technology
The morbidity of cardiovascular and cerebrovascular disease and vascular health state are closely related." blood dirt---anoxia theory "---the blood dirt is meant and is deposited in the ventricle or brown deposit (being speckle) on the blood vessel wall, is to cause thromboembolism and angiosclerotic main cause, can't realize cell normal blood supply oxygen supply function and causes the cell hypoxia necrosis.The main component of blood dirt is cholesterol, triglyceride, free radical, refer to hold the mixture of peroxide, blood proper constituent.Must make the blood dirt resolve into water-soluble substances, control the formation of blood dirt main component simultaneously, just can reach the purpose of basic treatment.Can blood vessel wall may form some damages because of speckle adheres to, and anoxia also can cause damage to body tissue and cell, therefore, these damages of effective for repairing also become a major issue that improve the cardiovascular and cerebrovascular disease patients ' life quality.
The health food functional component of control cardiovascular and cerebrovascular disease in the market is single in addition, the action intensity deficiency.
Summary of the invention
The present invention lacks a kind of problem that cardiovascular and cerebrovascular disease is had the curative effect combination of long drives and drop shots, prevents and treats the health food of giving consideration to both the incidental and fundamental at present in order to solve, and has proposed health food of the present invention and preparation method thereof.
Concrete technical scheme is as follows.
A kind of health food of preventing and treating cardiovascular and cerebrovascular disease, the health food of per 100 weight portions is made by the raw material of following weight parts:
Monas cuspurpureus Went 10-60, Radix Notoginseng extract 10-30, Folium Ginkgo extract 10-30, Rhizoma Chuanxiong 10-30, vitamin B1 0.05-0.1, vitamin B6 0.05-0.1, starch 7-12.
The health food of per 100 weight portions is preferably made by the raw material of following weight parts:
Monas cuspurpureus Went 37.5, Radix Notoginseng extract 17.5, Folium Ginkgo extract 17.5, Rhizoma Chuanxiong 17.5, vitaminB10 .075, vitamin B6 0.075, starch 9.85.
The preparation method of the health food of control cardiovascular and cerebrovascular disease of the present invention may further comprise the steps:
(1), is crushed to the 80-100 order with the Rhizoma Chuanxiong cleaning, drying; Vitamin B1, vitamin B6 and starch are ground to the 80-100 order respectively;
(2) Rhizoma Chuanxiong, vitamin B1, vitamin B6 and the starch that Monas cuspurpureus Went, Radix Notoginseng extract, Folium Ginkgo extract and step (1) are obtained respectively bacterium examine qualified standby;
(3) under the lucifuge state, step (2) bacterium is examined qualified Monas cuspurpureus Went, Radix Notoginseng extract, Folium Ginkgo extract, Rhizoma Chuanxiong, vitamin B1, vitamin B6 and starch mix homogeneously, be filled to capsule with Autocapsulefillingmachine then;
(4) capsule granulate, polishing, check and the packing that under other environment of air cleaning level more than the relative humidity and 100000 of 18-26 ℃ temperature, 45-65%, step (3) is obtained.
The Autocapsulefillingmachine that uses in the step (3) is commercially available engineering goods.
Granulate described in the step (4) and polishing are in order to make capsule appearance more attractive in appearance.Described check is meant that outward appearance is clean and tidy, does not have bonding, is out of shape and breaks, and content does not have drying, degree of tightness appropriateness, mix homogeneously, moisture is no more than 9.1%, to get 20 precisions and weigh, every weight differential is no more than ± and 7.5%, all other indexs reach the Q/DFT001-2001 standard.Described packing is meant and adds cover compound membrane bag and outer package.
The various raw materials that use among the present invention are the commercially available prod.For example Monas cuspurpureus Went becomes bio tech ltd to produce by east, Zhuozhou Bioisystech Co., Ltd and Wuhan are good; Rhizoma Chuanxiong is produced by the Central Asia, Chengdu pharmaceutical Co. Ltd and Chengdu Kanghong Pharmaceutical Co., Ltd; Folium Ginkgo extract is produced by biochemical group limited company of Pi Zhou city Semen Ginkgo and the big Folium Ginkgo company limited in Pi Zhou city; Radix Notoginseng extract is produced by Yuxi, Yunnan Province peacekeeping pharmaceutical Co. Ltd and Yunnan biological oil lamp floral business company limited; Vitamin B1 and B6 are produced by Shanghai Luo Shi pharmaceutcal corporation, Ltd and sky, Shanghai peace pharmaceutcal corporation, Ltd; Capsule shells is produced by sharp capsule company limited in Guangde, Shanghai and all capsules of Zhenjiang power factory.
Health food of the present invention is a capsule, every 400mg, and the shelf-life is 24 months, every day 2 times, each 2.
Monas cuspurpureus Went is that rice is sent out alcohol through monascus and formed.Selected monascus is to utilize biotechnology monascus to be divided into the bacterium colony of various trait, choosing good flora cultivates, send in the space capsule again and induced, then through flora separation repeatedly, relatively with preferably, choose active by force, can produce that the flora of his fourth of natural open loop structure gets, his the fourth blood fat reducing activity that is produced is stronger, and safety is higher.Be rich in lovastatin in the metabolite of monascus.Clinically, T-CHOL (TC) will fall in his class D drug main, and the triglyceride reducing (TG) of holding concurrently can make the slight rising of serum high-density LP (HDL) simultaneously.In addition, this class medicine also can make coronary occlusion and new atherosclerotic lesion obviously reduce.
Find after deliberation, lovastatin mainly reduces effectively by suppressing liver 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase or the blocking-up endogenous cholesterol generates, but, the lovastatin of chemosynthesis is interior ester type structure, need bring into play drug effect activated open acid formation of liver after the absorption, owing to need to consume intravital hydroxyl esterase, life-time service can increase the Liver and kidney burden, gastrointestinal symptoms such as its common adverse effect also has stomachache, diarrhoea, constipation, feels sick, vomiting and dyspepsia.Lovastatin in the natural Monas cuspurpureus Went mostly is acid, and HMG-CoA is more approaching in its space structure and the body, need not hydrolysis, directly brings into play the synthetic effect of competitive inhibition body inner cholesterol, and its activity is high about one times than the lactone formula.Clinical trial shows that when the concentration of lovastatin in the blood reached 0.001～0.005 μ g/ml, the synthetic of body inner cholesterol will be obstructed.The discovery of lovastatin is used as in the natural drug Monas cuspurpureus Went to suppress the at first thing of the synthetic and blood fat reducing of cholesterol in the natural Monas cuspurpureus Went, is caught people's attention.
The main component Radix Notoginseng total arasaponins of Radix Notoginseng extract.After testing, content of the total saponins in radix notoginseng reaches 90.25% in the selected Radix Notoginseng extract of the present invention, adopts mountain of papers lifes in 7 years in Yunnan for expecting.Because the Yunnan located in subtropical zone is subjected to the influence of tropical marine climate, it's like spring all the year round for a long time, and various mine trace elements are higher in the soil property, and underground water source pollutes few, and efficacy component content is local higher tens times than other.There is the history records record to be " hired Radix Notoginseng " by envelope.After extracting, purity is above " Chinese pharmacopoeia version standard in 2000 is present clinical unique Chinese medicine ingredients that can be used for the cardiovascular and cerebrovascular vessel first aid.Clinical practice in hemostasis invigorate blood circulation, the anti-heart, brain, hepatic ischemia, treatment coronary heart disease and arrhythmia, antiinflammatory, detoxifcation, blood fat reducing blood glucose etc.Experiment shows that Radix Notoginseng total arasaponins has tangible blood vessel dilating, increase coronary flow, lowers the effect of coronary resistance and reduction myocardial oxygen consumption, is ideal coronary dilating medicine.The effect that reduces arterial pressure and slightly subtract heart rate is arranged again, the heart working amount is lowered, thereby can be used for the treatment of myocardial ischemia, angina pectoris and shock.Also can obviously reduce the oxygen consumption of cardiac muscle, under anaerobic condition, the heart, brain cell be had protective effect, improve heart and brain cell hypoxia tolerance.Radix Notoginseng total arasaponins can be repaired tunica intima, increase the inner membrance smoothness, recovers vessel wall elasticity, anti-hemostasis dirt deposition.To apoplexy sequela, particularly the acute ischemic cerebrovascular disease curative effect is better, and symptoms such as dizziness, headache, ataxia, aphasis are had clear improvement.Wherein, best to cerebral arteriosclerosis, cerebral blood supply insufficiency patient curative effect.
The main component Ginkgo total flavones of Folium Ginkgo extract.Folium Ginkgo is made content and the bioavailability that has not only improved Ginkgo total flavones behind the extract, has also removed harmful components Semen Ginkgo bolt.Folium Ginkgo extract among the present invention is adopted the perennial ginkgo leaf in the Shandong Province by Semen Ginkgo.Folium Ginkgo has the good reputation of " living fossil ", and is just on the books in " daily book on Chinese herbal medicine " before more than 1,000 years.After testing, except that the Semen Ginkgo general flavone content reaches 24.6%, harmful components Semen Ginkgo bolt content≤5ppm has reached export standard.But anti-platelet activating factor prevents the blood coagulation, reduces blood viscosity, reduces thrombosis, blood flow increasing: anti peroxidation of lipid prevents that peroxide from generating, and reduces free radical; Strengthen histiocyte non-oxidation metabolic function, improve oxygen reasonable distribution ability under the anaerobic condition; Repair the histiocyte of anoxia-induced apoptosis, anti-brain injury improves dysmnesia etc.
The effective ingredient ligustrazine of Rhizoma Chuanxiong.Rhizoma Chuanxiong in the gold arteries and veins capsule is adopted to give birth to more than 3 years and is the raw material that is used as medicine.Rhizoma Chuanxiong is gained the name because of be grown in Sichuan from ancient times.Sichuan is located in China middle part, and weather is moistening, few cold, adopts " the Siberian cocklebur method is educated in the strange land " cultivation, and Rhizoma Chuanxiong is of fine quality, for Rhizoma Chuanxiong top grade.After testing, reach " Chinese pharmacopoeia version standard in 2000.
But the metabolism of vitamin B1 involved in sugar promotes energy metabolism, safeguards political party's function neural and digestive system, promotes growth promoter.Because the form of vitamin B1 possibility coenzyme participates in the process that conversion of glucose is a fat, therefore, in the blood lipid regulation process, can play the effect of auxiliary treatment.If lack, can cause vitamin B1 deficiency and some cardiovascular disease.Short-term lacks the tonicity and the elasticity that can cause cardiac muscle and reduces greatly and arrhythmia, and the long-term lacking heart can sustain damage, and easily causes death.
Vitamin B6 is requisite a kind of materials such as energy generation, amino acid metabolism and lipid metabolism, central nervous system's activity and hemoglobin be synthetic.
Vitamin B1 that the present invention selects for use and vitamin B6 are Shanghai Luo Shi pharmaceutcal corporation, Ltd and produce, and the product of Yu'an Pharmaceutical Co., Ltd., Shanghai's packing meets " 200 years version standards of Chinese pharmacopoeia.
Starch is medical starch, is capsule adjuvant commonly used, can with can improve material fluidity, the disintegrate of acceleration capsule after other material powders mix.
Capsule shells and the capsular inner packing of direct contact are GMP pharmaceutical producing enterprise up to standard and produce, and the production environment air cleaning is not less than 100000 grades, meets " the product of Chinese pharmacopoeia version standard in 2000.
Health-caring capsule of the present invention is the compound type product that is become to be grouped into by four kinds of clinical line medications.Through biology gene engineering technology cultivate female bacterium, again by the preferred strain of space technology, synthetic by the fused technology in the adjacent boundary of biology, the functional component factor active improves thousands of times than 1500 times of original raisings, dissolving blood dirt ability, and product has the advantages that thrombolytic is fast, produce effects is strong.Succeeding in developing of health-caring capsule of the present invention filled up the blank that China prevents and treats cardiovascular and cerebrovascular disease.
Health food of the present invention has quick-acting, middle effect, long-acting composition concurrently.The total soap of Radix Notoginseng is quick-acting compositions, can improve symptoms such as weak, uncomfortable in chest, angina pectoris in 3-7 days.Lovastatin is middle effect composition, and blood fat is near normal after 7-15 days, and blood is sticking to be reduced.Ginkgo total flavones is long-acting composition, continues to take to improve the body cell anoxia endurance.
Health food of the present invention has prevention, treatment, the back function of health care heals.Lovastatin can effectively be controlled blood fat, but the silver total flavones can resist and refer to the matter peroxidating, reduce free radical, but anti-platelet activating factor also, reduce the probability of blood proper constituent at intravascalar agglutination, stop the possibility that the blood dirt produces from root, played the effect of effective prevention cardiovascular and cerebrovascular disease.For the patient who suffers from cardiovascular and cerebrovascular disease, Radix Notoginseng total arasaponins and ligustrazine relief of symptoms rapidly in the capsule of the present invention, lovastatin can make established arteriosclerosis and block pathological changes and reduce the effect that has reached specimen and controlled.Radix Notoginseng total arasaponins can be repaired tunica intima, increase the inner membrance smoothness, recovers vessel wall elasticity, and these effects both had repair to damaged vessel walls, had the dirt of can preventing stopping blooding to deposit once more.Ginkgo total flavones then has repair to the histiocyte because of anoxia-induced apoptosis.
Health food of the present invention is 100% pure Chinese medicinal ingredients, and taking convenience is safe and reliable, without any side effects, short treating period, instant effect.
Health food of the present invention has six large effects: (1), blood lipid regulation, reduction blood are sticking, blood pressure, blood glucose; (2), remove established blood dirt thromboembolism, the blood dirt rubbish in the cleaning blood prevents that thromboembolism from forming again; (3), repair cured in cardiac muscle and the blood vessel, as to activate dormancy histiocyte, enhancing body cell vigor; (4), improve the vascular protection factor concentration, make tunica intima Paint Gloss, anti-hemostasis dirt deposition increases vessel wall elasticity, avoids angiorrhexis, effectively treats arteriosclerosis, keeps the young attitude of blood vessel; (5), strengthen the anaerobic metabolism function of cell, improve human body anoxia tolerance, prevent that the heart, brain and histiocyte from causing necrosis because of anoxia; (6), remove free radical, prevent lipid peroxidation, improve oxygen utilization rate.
The present invention adopts quality raw materials and advanced technologies.Each main component is all selected for use from the original producton location, process the product that gets with at present domestic state-of-the-art technology, capsular fill packing storage and transport process then is to finish in the workshop of GMP manufacturing enterprise up to standard, and every index all meets or exceeds drug standard.
The present invention is directed to cardiovascular diseases's basic reason, started removing blood dirt, repaired inner membrance, the three step therapies that stop the blood dirt to form again, increase blood supply of cardiac muscle simultaneously, activate myocardial cell, recover cardiac function, antiplatelet aggregation, reduce blood viscosity, microcirculation improvement is really accomplished the hold concurrently composite treatment of smelting of specimen, makes cardiovascular patient really take leave of the misery that obstinate shows effect repeatedly.
Test and the result for the partial test of health food of the present invention below.
One, the sick prevention and control of in March, 2003 Hunan diagnosing disease center has been carried out the safety toxicological evaluation according to " toxicological evaluation of food safety procedure and method " GB15193-94 to health food of the present invention, and the result is as follows:
1. acute oral LD
50Result: to the acute oral LD of male and female mice
50All, belong to non-poisonous material greater than 21500mg/kgbw.
2. three genetic toxicity tests: the result of Salmonella reversion test, PCEMNR micronucleus test and mouse sperm deformity test is all negative.
3. 30 days feeding trial results: the health food of the present invention with 0.67g/kgbw, 1.33g/kgbw, 2.67g/kgbw dosage is given rat jar stomach 30 days, each dosage group rat body weight growth of duration of test, food utilization and matched group comparison there was no significant difference (P＞0.05).There are no significant (P＞0.05) for every blood biochemistry index, routine blood test index and liver/body, spleen/body, kidney/body, male Mus testis/body ratio and matched group comparing difference.Liver,spleen,kidney, stomach, duodenum, testis (ovary) tissue pathology checking do not have obvious damage.Point out to feed in 30 days the every observation index of rat is not produced obvious toxic-side effects.
Two, the disease prevention and control center, Shaanxi Province is to the test of health food blood lipid regulation of the present invention effect
Test specimen: the health food of the embodiment of the invention 1.
Laboratory animal: provide 50 of the male secondary SD of healthy adult rat (the moving card of doctor word 08-014), body weight 158-204g by The Fourth Military Medical University's Experimental Animal Center.The Animal House quality certification number is the moving word of doctor 08-32 number, 20 ℃-22 ℃ of temperature, humidity 55%-60%.Normal feedstuff, high lipid food (prescription: 79% normal feedstuff, 1% cholesterol, 10% yolk powder, 10% Adeps Sus domestica), bedding and padding provide by The Fourth Military Medical University's Experimental Animal Center.
Instrument and reagent: dissecting instrument, the U.S. produce AG II automatic clinical chemistry analyzer, T-CHOL, sweetly do not have three esters, a HDL-C test kit (production of Beijing Zhong Shengbei control bio tech ltd).
Dosage design: 50 male rats are divided into five groups at random: tried object height dosage (0.54g/kg.bw), middle dosage (0.27g/kg.bw), three dosage levels of low dosage (0.14g/kg.bw), be equivalent to human body respectively and recommend 20 times, 10 times, 5 times of consumption, other establishes a hyperlipidemia model group and a solvent control group (distilled water), every grade of 10 rats.
Experimental technique: buy test and use rat, adapt to feed and observe a blow, serum total cholesterol is measured in endocanthion blood sampling in the 7th day, carries out random packet according to blood fat (TC) level.The equal feed high lipid food of each dosage group and hyperlipidemia model group, solvent control group feed normal feedstuff.Each dosage group is irritated stomach by above-mentioned dosage and tried thing once every day then, and hyperlipidemia model group and solvent control group wait the distilled water of capacity, continuous irrigation stomach 30 days.Pull out eyeball and get blood (getting the preceding fasting of blood 16 hours), separation of serum is measured every blood lipids index with automatic clinical chemistry analyzer.Decide hyperlipidemia model at gram and set up successfully afterwards every blood lipids index is added up, each dosage group result and hyperlipidemia model group are relatively and carry out variance analysis.
Result of the test is as follows:
1 health food of the present invention is to the influence of rat body weight
Table 1 health food of the present invention is to the influence of rat body weight (X ± S)
| Group (g/kg.bw) | Number of animals (only) | Starting weight | Middle heavy | Heavy eventually | Weightening finish | The P value |
| 0.54 | 10 | 177.4±14.3 | 254.8±14.4 | 3201.±32.0 | 149.3±26.3 | 0.942 |
| 0.27 | 10 | 176.3±15.5 | 262.1±17.9 | 315.4±18.4 | 142.7±31.0 | 0.787 |
| 0.14 | 10 | 179.4±12.2 | 260.4±13.9 | 314.7±19.5 | 139.1±14.5 | 0.560 |
| Hyperlipidemia model | 10 | 179.22±10.8 | 267.7±15.8 | 328.5±26.5 | 135.3±20.7 | |
| Solvent control | 10 | 180.7±13.6 | 276.0±17.7 | 323.0±27.8 | 142.3±31.8 | 0.930 |
By table 1 as seen, each dosage group, solvent control group rat body weight increase weight, and there are no significant (P＞0.05) with hyperlipidemia model group comparing difference.
The foundation of 2 hyperlipidemia models
Each blood lipids index of table 2 hyperlipidemia model and solvent control relatively
| Group (g/kg.bw) | Number of animals (only) | T-CHOL (mmol, L) | Triglyceride (mmol, L) | ||
| (X±S) | The P value | (X±S) | The P value | ||
| Hyperlipidemia model | 10 | 2.43±0.33 | 0.000 | 1.70±0.29 | 0.000 |
| Solvent control | 10 | 1.30±0.26 | 0.98±0.27 | ||
By table 2 as seen, hyperlipidemia model group rat blood serum T-CHOL, triglyceride result all are significantly higher than the solvent control group, and difference all has highly significant (P＜0.01), the model establishment.
3 serum total cholesterols, triglyceride
The influence of table 3 pair rat blood serum T-CHOL (X ± S)
| Group (g/kg.bw) | Number of animals (only) | T-CHOL (mmol, L) | The P value |
| 0.54 | 10 | 1.43±0.34 | 0.000 |
| 0.27 | 10 | 1.52±0.34 | 0.000 |
| 0.14 | 10 | 1.52±0.32 | 0.000 |
| The hyperlipidemia model group | 10 | 2.43±0.33 |
F＝20.352 P＝0.000
By table 3 as seen, each dosage group rat blood serum T-CHOL of health food of the present invention all is lower than the hyperlipidemia model group, and difference all has highly significant (P＜0.01).
The influence of table 4 pair rat blood serum triglyceride (X ± S)
| Group (g/kg.bw) | Number of animals (only) | Triglyceride (mmol, L) | The P value |
| 0.54 | 10 | 0.53±0.15 | 0.000 |
| 0.27 | 10 | 0.75±0.24 | 0.000 |
| 0.14 | 10 | 0.81±0.22 | 0.000 |
| The hyperlipidemia model group | 10 | 1.70±0.29 |
F＝50.765 P＝0.000
By table 4 as seen, each dosage group rat blood serum triglyceride of health food of the present invention all is lower than the hyperlipidemia model group, and difference all has highly significant (P＜0.01).
Conclusion (of pressure testing) is as follows:
(1) rat blood serum T-CHOL (TC) is determined as positive findings (high, in low three dosage groups positive).
(2) rat blood serum triglyceride (TC) is determined as positive findings (high, in low three dosage groups positive).
This test above (1), (2) two positive results of index are so decidable health food of the present invention has the effect of blood lipid regulation to rat.
The specific embodiment
Further explain the present invention in the mode of specific embodiment below.
Embodiment 1
The health food for preparing present embodiment according to the following step.
(1), is crushed to the 80-100 order with the Rhizoma Chuanxiong cleaning, drying; Vitamin B1, vitamin B6 and starch are ground to the 80-100 order respectively;
(2) 70g Rhizoma Chuanxiong, 0.3g vitamin B1,0.3g vitamin B6 and the 39.4g starch that 150g Monas cuspurpureus Went, 70g Radix Notoginseng extract, 70g Folium Ginkgo extract and step (1) are obtained respectively bacterium examine qualified standby;
(3) under the lucifuge state, step (2) bacterium is examined qualified Monas cuspurpureus Went, Radix Notoginseng extract, Folium Ginkgo extract, Rhizoma Chuanxiong, vitamin B1, vitamin B6 and starch mix homogeneously, be filled to capsule with Autocapsulefillingmachine then, the content of every capsules is 400mg, makes 1000 altogether;
(4) capsule granulate, polishing, check and the packing that under other environment of air cleaning level more than the relative humidity and 100000 of 18-26 ℃ temperature, 45-65%, step (3) is obtained.
Embodiment 2
The health food for preparing present embodiment according to the following step.
(1), is crushed to the 80-100 order with the Rhizoma Chuanxiong cleaning, drying; Vitamin B1, vitamin B6 and starch are ground to the 80-100 order respectively;
(2) 80g Rhizoma Chuanxiong, 0.4g vitamin B1,0.2g vitamin B6 and the 48g starch that 120g Monas cuspurpureus Went, 80g Radix Notoginseng extract, 71.4g Folium Ginkgo extract and step (1) are obtained respectively bacterium examine qualified standby;
(3) under the lucifuge state, step (2) bacterium is examined qualified Monas cuspurpureus Went, Radix Notoginseng extract, Folium Ginkgo extract, Rhizoma Chuanxiong, vitamin B1, vitamin B6 and starch mix homogeneously, be filled to capsule with Autocapsulefillingmachine then, the content of every capsules is 400mg, makes 1000 altogether;
(4) capsule granulate, polishing, check and the packing that under other environment of air cleaning level more than the relative humidity and 100000 of 18-26 ℃ temperature, 45-65%, step (3) is obtained.
Embodiment 3
The health food for preparing present embodiment according to the following step.
(1), is crushed to the 80-100 order with the Rhizoma Chuanxiong cleaning, drying; Vitamin B1, vitamin B6 and starch are ground to the 80-100 order respectively;
(2) 73.4g Rhizoma Chuanxiong, 0.2g vitamin B1,0.2g vitamin B6 and the 28g starch that 175g Monas cuspurpureus Went, 60g Radix Notoginseng extract, 70g Folium Ginkgo extract and step (1) are obtained respectively bacterium examine qualified standby;
(3) under the lucifuge state, step (2) bacterium is examined qualified Monas cuspurpureus Went, Radix Notoginseng extract, Folium Ginkgo extract, Rhizoma Chuanxiong, vitamin B1, vitamin B6 and starch mix homogeneously, be filled to capsule with Autocapsulefillingmachine then, the content of every capsules is 400mg, makes 1000 altogether;
(4) capsule granulate, polishing, check and the packing that under other environment of air cleaning level more than the relative humidity and 100000 of 18-26 ℃ temperature, 45-65%, step (3) is obtained.
Claims (3)
1. a health food of preventing and treating cardiovascular and cerebrovascular disease is characterized in that, the health food of per 100 weight portions is made by the raw material of following weight parts:
Monas cuspurpureus Went 10-60, Radix Notoginseng extract 10-30, Folium Ginkgo extract 10-30, Rhizoma Chuanxiong 10-30, vitamin B1 0.05-0.1, vitamin B6 0.05-0.1, starch 7-12.
2. health food according to claim 1 is characterized in that, the health food of per 100 weight portions is made by the raw material of following weight parts:
Monas cuspurpureus Went 37.5, Radix Notoginseng extract 17.5, Folium Ginkgo extract 17.5, Rhizoma Chuanxiong 17.5, vitaminB10 .075, vitamin B6 0.075, starch 9.85.
3. the preparation method of the health food of the described control cardiovascular and cerebrovascular disease of claim 1 is characterized in that it may further comprise the steps:
(1), is crushed to the 80-100 order with the Rhizoma Chuanxiong cleaning, drying; Vitamin B1, vitamin B6 and starch are ground to the 80-100 order respectively;
(2) Rhizoma Chuanxiong, vitamin B1, vitamin B6 and the starch that Monas cuspurpureus Went, Radix Notoginseng extract, Folium Ginkgo extract and step (1) are obtained respectively bacterium examine qualified standby;
(3) under the lucifuge state, step (2) bacterium is examined qualified Monas cuspurpureus Went, Radix Notoginseng extract, Folium Ginkgo extract, Rhizoma Chuanxiong, vitamin B1, vitamin B6 and starch mix homogeneously, be filled to capsule with Autocapsulefillingmachine then;
(4) capsule granulate, polishing, check and the packing that under other environment of air cleaning level more than the relative humidity and 100000 of 18-26 ℃ temperature, 45-65%, step (3) is obtained.
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| US7906159B2 (en) | 2008-04-17 | 2011-03-15 | Vivien Chou | Herbal compositions and methods for enhancing vital energy and athletic performance |
| CN101263908B (en) * | 2008-04-25 | 2011-12-21 | 北京市科威华食品工程技术有限公司 | Blood fat reducing soft capsule health care food and its preparation |
| CN103372172B (en) * | 2012-04-20 | 2016-01-20 | 北京北大维信生物科技有限公司 | Monas cuspurpureus Went Rhizoma Curcumae drug regimen of a kind of adjusting blood lipid and preparation method thereof |
| CN113350453B (en) * | 2021-06-16 | 2022-08-26 | 广州市赛普特医药科技股份有限公司 | Composition for raising HDL-C |
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2004
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