CN1155375C - Linolic acid and linolenic acid capsule and its making process - Google Patents
Linolic acid and linolenic acid capsule and its making process Download PDFInfo
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- CN1155375C CN1155375C CNB011060948A CN01106094A CN1155375C CN 1155375 C CN1155375 C CN 1155375C CN B011060948 A CNB011060948 A CN B011060948A CN 01106094 A CN01106094 A CN 01106094A CN 1155375 C CN1155375 C CN 1155375C
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- linolenic acid
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Abstract
The present invention relates to a linolic acid and linolenic acid capsule and a preparation method thereof. The linolic acid and linolenic acid capsule comprises the efficacy components of alpha-linolenic acid and linoleic acid whose proportion is 1: 2.5 to 6.3. Sunflower seed oil containing 74 to 84% of linoleic acid, linseed oil containing 45 to 50% of alpha-linolenic acid, and medicinal vitamin E are selected, the medicinal vitamin E of 0.5 to 1.0% of the total weight of a formulation is added in according to a proportion by weight of 100: 169 to 338, and the proportion of the efficacy components of a medicament is 1: 2.5 to 6.3. The medicament has the functions of lowering cholesterin, triglyceride and low-density lipoprotein in blood and enhancing high density albumen after being taken, has no influence on phospholipid, prevents atherosclerosis, improves cardiac and cerebral blood vessels, and enhances memory.
Description
The medicine that the present invention relates to keep healthy preparation is meant blood fat reducing brain-strengthening health medicine and preparation thereof especially.
Along with the raising of people's living standard, the people of hyperlipidemia is more and more, the blood fat chemical examination, T-CHOL, triglyceride and low density lipoprotein, LDL raise or the high density lipoprotein reduction all can be described as hyperlipemia, and these compositions of T-CHOL, triglyceride and low density lipoprotein, LDL are mixed in the blood, just as the silt in the river, at any time be deposited on the blood vessel wall, and in the intrusion blood vessel wall, adding other factors, the part can form speckle, lumen of vessels is narrowed down, the blood vessel wall thickening follows the string, and forms arteriosclerosis.Arteries is distributed in all organs of health, and these organs all can be got involved because of arteriosclerosis, cause diseases such as angina pectoris, myocardial infarction, cerebral arteriosclerosis, cerebral hemorrhage, apoplexy.The lipid lowerers of determined curative effect mainly contains two big classes, i.e. the special class of his class D (simvastatin, fluvastatin and atorvastatin etc.) and shellfish.These synthetic drugs, life-time service has side effect, and therapeutic effect is not remarkable.Brain-strengthening health care medicine is also a lot of in addition, and brain-strengthening health care medicine is started with from different perspectives, plays brain-strengthening, and the memory reinforcing effect is not also with the health care medicine of blood fat reducing and cerebral tonic mixed preparing.
The purpose of this invention is to provide a kind of blood fat reducing brain-strengthening, prevention of arterial is atherosis, improves cardiovascular and cerebrovascular vessel, the linolic acid and linolenic acid capsule of memory reinforcing and method for making thereof.
The object of the present invention is achieved like this, and the linolic acid and linolenic acid capsule effective component is: alpha-linolenic acid: linoleic acid=1: 2.5 ~ 6.3.
The method for making of linolic acid and linolenic acid capsule is:
The first step: select the safflower oil that contains linoleic acid 74 ~ 84% for use, contain Semen Lini oil and the medicinal vitamin E of alpha-linolenic acid 45 ~ %, weigh up by the prescription weight ratio.Weight ratio is:
Semen Lini oil: safflower oil=100: 169 ~ 338
Weigh up the medicinal vitamin E that accounts for prescription gross weight 0.5 ~ 1.0% again.
Second the step: with vitamin E be dissolved in the safflower oil total amount 1/3 in, stir, add in the material-compound tank then.
The 3rd step: while stirring under the condition of nitrogen, nitrogen pressure is that 0.1 ~ 0.5Pa adds safflower oil in the material-compound tank, stirs.
The 4th step: in the safflower oil in the Semen Lini oil adding stirring, continue to stir 20 ~ 30 minutes.
The 5th step: get sample, chemical examination is satisfied alpha-linolenic acid: linoleic acid=1: 2.5 ~ 6.3.
The 6th step: soft capsule preparation.Capsule 's content 0.5g/ grain.
Through the linolic acid and linolenic acid capsule that said method makes, mouthfeel is good, and instructions of taking is: each 3 ~ 5, and twice of every day.
Linolic acid and linolenic acid capsule effective component preferable range is: alpha-linolenic acid: linoleic acid=1: 2.5 ~ 3.8.
The method for making preferable range of linolic acid and linolenic acid capsule is:
The safflower oil that contains linoleic acid 74 ~ 84% contains the Semen Lini oil and the medicinal vitamin E of alpha-linolenic acid 45 ~ 50%, and weight ratio is: Semen Lini oil: safflower oil=100: 169 ~ 203.
Advantage of the present invention is: both claim essential fatty acid alpha-linolenic acid (chemical name is a jeceric acid) and linoleic acid (chemical name octadecadienoic acid) on biochemistry, human body self can not synthesize, must be by food supply, safflower oil is rich in linoleic acid, linoleic acid has the blood cholesterol of reduction, triglyceride, low density lipoprotein, LDL, increase the effect of high-density protein, phospholipid is not had influence.Semen Lini oil is rich in alpha-linolenic acid, but alpha-linolenic acid metabolic conversion in human body is eicosapentaenoic acid and the docosahexenoic acid that is commonly called as NAOHUANGJIN, has the function that activates the brain cell improving memory.According to the requirement of the person to these two kinds of unsaturated fatty acids, scientific composition is had complementary advantages, coordinative role, and edible back is directly absorbed by human body.Two of effects are obviously complementary, have no side effect, and play blood fat reducing, and improving memory is very favourable to preventing senile cardiovascular disease and dementia.Production technology is simple relatively, and is with low cost, is beneficial to and applies.
The present invention is described in detail below in conjunction with embodiment.
Embodiment 1
The method for making of linolic acid and linolenic acid capsule:
The first step: selecting linoleic acid content for use is 74% safflower oil, and selecting alpha-linolenic acid content for use is 45% Semen Lini oil, the drug of choice vitamin E.Weigh up by the prescription weight ratio.Weight ratio is:
Semen Lini oil: safflower oil=100: 169.
Weigh up the medicinal vitamin E that accounts for prescription gross weight 0.5% again.
Second the step: with vitamin E be dissolved in the safflower oil total amount 1/3 in, stir, add in the material-compound tank then.
The 3rd step: while stirring under the condition of nitrogen, nitrogen pressure is 0.1Pa, and safflower oil is added in the material-compound tank, stirs.
The 4th step: in the safflower oil in the Semen Lini oil adding stirring, continue to stir in 20 minutes.
The 5th step: get the sample chemical examination and learn:
Alpha-linolenic acid: linoleic acid=1: 2.5
The 6th step: soft capsule preparation, capsule 's content are the 0.5g/ grain.
The linolic acid and linolenic acid capsule effective component that makes through said method is:
Alpha-linolenic acid: linoleic acid=1: 2.5.
Model case: man, 37 years old, government functionary, obesity, serum triglycerides height (4.56mmol/L, normal value is in 2), dizziness, lethargy, weak, hypomnesis.Take one week of capsule, symptom is improved, and chemically examines after January, and triglyceride is reduced to 2.34mmol/L, loses weight 5 kilograms, and constipation disappears.
Embodiment 2
The method for making of linolic acid and linolenic acid capsule:
The first step is selected the safflower oil that contains linoleic acid 84% for use, contains the Semen Lini oil and the medicinal vitamin E of alpha-linolenic acid 45%.Weigh up by the prescription weight ratio.Weight ratio is:
Semen Lini oil: safflower oil=100: 203.
Weigh up the medicinal vitamin E that accounts for prescription gross weight 1% again.
Second the step: with vitamin E be dissolved in the safflower oil total amount 1/3 in, stir, add in the material-compound tank then.
The 3rd step: while stirring under the condition of nitrogen, nitrogen pressure is 0.3Pa, and safflower oil is added in the material-compound tank, stirs.
The 4th step: in the safflower oil in the Semen Lini oil adding stirring, continue to stir 25 minutes.
The 5th step: get sample, chemical examination is learnt.
Alpha-linolenic acid: linoleic acid=1: 3.8.
The 6th step: soft capsule preparation, capsule 's content are the 0.5g/ grain.
The linolic acid and linolenic acid capsule effective component that makes through said method is:
Alpha-linolenic acid: linoleic acid=1: 3.8.
Bent type case: woman, 55 years old, engineer, self-induction dizziness headache uncomfortable in chest before taking has the constipation phenomenon, health check-up cholesterol 8.1mmol/L once in a while, be hypercholesterolemia, two months no positive effects of treatment by Chinese herbs are taken above-mentioned one week of medicine, and subjective symptoms alleviates, condition of illness greatly all improves after January, cholesterol drops to 6.8mmol/L, and condition of illness disappears after March, and cholesterol is reduced to normally.
Embodiment 3
The method for making of linolic acid and linolenic acid capsule.
The first step: select the safflower oil that contains linoleic acid 84% for use, contain the Semen Lini oil and the medicinal vitamin E of alpha-linolenic acid 50%, weigh up by the prescription weight ratio.Weight ratio is:
Semen Lini oil: safflower oil=100: 179
Weigh up the medicinal vitamin E that accounts for prescription gross weight 1.0% again.
Second to the 4th step and the 6th step are identical with embodiment 1.
The 5th step: get the sample chemical examination and learn.
Alpha-linolenic acid: linoleic acid=1: 3
The linolic acid and linolenic acid capsule effective component that makes through said method is:
Alpha-linolenic acid: linoleic acid=1: 3.
Carry out clinical experiment, laboratory report is as follows: crowd 60 people in 35-80 year have carried out the clinical experiment of linolic acid and linolenic acid capsule to the age.Being divided into three groups, is foundation with clinical blood fat result of laboratory test, and hypercholesterolemia, the higher constipation person of having concurrently of glyceride are first group; It is second group that triglyceride height, cholesterol substantially normally have constipation person concurrently; [the fat chemical examination is normal, has slight constipation person to be matched group for blood.The people of experimental group exists hyperlipidemia symptoms such as dizziness, weak, insobriety poor memory to some extent.Dose: take the 6-10 grain for each person every day; 6 of matched group (20 people) every days, took continuously 3 months.Observing effect: a, invalid: the user feels symptom and does not disappear, and memory not to be improved, and constipation is to no effect; B, effectively: the user feels clearheaded, and memory increases, freedom of movement, constipation is eliminated; C, produce effects: the user is except that the sensation that b is arranged, and clinical blood fat is chemically examined visible cholesterol, triglyceride obviously descend (normal or near normal value).The result is as follows:
Experimental group number of participant dose
Effect (number)
(grain) a b c
Experimental group 1 20 6-10--20 19
Experimental group 2 20 6-10--20 17
Matched group 20 6--10*--* *
It is constipation person that 10 people are arranged in the matched group; * blood fat chemical examination normal range as can be known from the table data: experimental group effectively reaches 100%; Obvious effective rate reaches 90%; To not influence of normal lipid, be 100% to constipation person's effective percentage.
Embodiment 4
The method for making of linolic acid and linolenic acid capsule.
The first step: select the safflower oil that contains linoleic acid 84% for use, contain the Semen Lini oil and the medicinal vitamin E of alpha-linolenic acid 45%, weigh up by the prescription weight ratio, weight ratio is:
Semen Lini oil: safflower oil=100: 338
Weigh up the medicinal vitamin E that accounts for prescription gross weight 0.8% again.
Second to the 4th step and the 6th step are identical with embodiment 1.
The 5th step: get the sample chemical examination and learn.
Alpha-linolenic acid: linoleic acid=1: 6.3
The linolic acid and linolenic acid capsule effective component that makes through said method is:
Alpha-linolenic acid: linoleic acid=1: 6.3
Bent type case: the woman, 61 years old, the Uygur nationality, obesity, hyperlipidemia, hypertension, take capsule before and after (three months) blood fat result of laboratory test as follows:
After taking before inspection item is taken
Cholesterol ch 7.79mmol/L 4.34mmol/L
Triglyceride TG 1.94mmol/L 1.06mmol/L
High density lipoprotein HDL-c 1.20mmol/L 1.28mmol/L
Low density lipoprotein, LDL is at LDL-c 5.78mmol/L 2.32mmol/L
Drop to normal and near normal, triglyceride slightly descends from the visible cholesterol of analysis data and low density lipoprotein, LDL, high density lipoprotein has rising trend.
Claims (5)
1, linolic acid and linolenic acid capsule is characterized in that: the linolic acid and linolenic acid capsule effective component is: alpha-linolenic acid: linoleic acid=1: 2.5 ~ 6.3.
2, linolic acid and linolenic acid capsule according to claim 1 is characterized in that: linolic acid and linolenic acid capsule effective component preferable range is: alpha-linolenic acid: linoleic acid=1: 2.5 ~ 3.8.
3, the method for making of linolic acid and linolenic acid capsule is characterized in that:
The first step: select the safflower oil that contains linoleic acid 74 ~ 84% for use, contain the Semen Lini oil and the medicinal vitamin E of alpha-linolenic acid 45 ~ 50%, weigh up by the prescription weight ratio, weight ratio is:
Semen Lini oil: safflower oil=100: 169 ~ 338
Weigh up the medicinal vitamin E that accounts for prescription gross weight 0.5 ~ 1.0% again;
Second the step: with vitamin E be dissolved in the safflower oil total amount 1/3 in, stir, add then in the material-compound tank;
The 3rd step: while stirring under the condition of nitrogen, nitrogen pressure is 0.1 ~ 0.5Pa, and safflower oil is added in the material-compound tank, stirs;
The 4th step: in the safflower oil in the Semen Lini oil adding stirring, continue to stir 20 ~ 30 minutes;
The 5th step: get sample, chemical examination is satisfied alpha-linolenic acid: linoleic acid=1: 2.5 ~ 6.3;
The 6th step: soft capsule preparation.
4, will be according to the method for making of the described linolic acid and linolenic acid capsule of claim 3, it is characterized in that: the method for making preferable range of linolic acid and linolenic acid capsule is: the safflower oil that contains linoleic acid 74 ~ 84%, contain the Semen Lini oil and the medicinal vitamin E of alpha-linolenic acid 45 ~ 50%, the prescription weight ratio is: Semen Lini oil: safflower oil=100: 169 ~ 203.
5, will be according to the method for making of the described linolic acid and linolenic acid capsule of claim 3, it is characterized in that: the method for making preferred plan of linolic acid and linolenic acid capsule is: select the safflower oil that contains linoleic acid 84% for use, contain the Semen Lini oil and the medicinal vitamin E of alpha-linolenic acid 50%, the prescription weight ratio is: Semen Lini oil: safflower oil=100: 179.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011060948A CN1155375C (en) | 2001-01-17 | 2001-01-17 | Linolic acid and linolenic acid capsule and its making process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011060948A CN1155375C (en) | 2001-01-17 | 2001-01-17 | Linolic acid and linolenic acid capsule and its making process |
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| CN1312071A CN1312071A (en) | 2001-09-12 |
| CN1155375C true CN1155375C (en) | 2004-06-30 |
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| US8092839B2 (en) * | 2004-12-13 | 2012-01-10 | Swing Aerobics Licensing, Inc. | Medicament for treatment of cancer and other diseases |
| CN102356880B (en) * | 2011-10-24 | 2016-02-17 | 陈元涛 | A kind of linseed oil microcapsule and preparation method |
| CN102697046A (en) * | 2012-06-09 | 2012-10-03 | 东莞市照燕生物科技有限公司 | Dietary supplement for lowering blood lipid |
| CN102934703B (en) * | 2012-11-13 | 2015-07-15 | 中国食品发酵工业研究院 | Flaxseed oil microcapsule and production method thereof |
| US8728546B1 (en) | 2013-03-15 | 2014-05-20 | Swing Aerobics Licensing, Inc. | Medicament for treatment of cancer, cardiovascular diseases and inflammation |
| CN103284151A (en) * | 2013-06-01 | 2013-09-11 | 赵全成 | Omega-3 unsaturated vegetable combined oil with effect of reducing blood fat |
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