CN101262847B - 包含嘧啶-磺酰胺的稳定性医药组合物 - Google Patents

包含嘧啶-磺酰胺的稳定性医药组合物 Download PDF

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CN101262847B
CN101262847B CN2006800333751A CN200680033375A CN101262847B CN 101262847 B CN101262847 B CN 101262847B CN 2006800333751 A CN2006800333751 A CN 2006800333751A CN 200680033375 A CN200680033375 A CN 200680033375A CN 101262847 B CN101262847 B CN 101262847B
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CN101262847A (zh
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查理斯·托昆伯·阿德苏伊
拉维雷斯·霍曼
奥利维尔·莱姆伯特
布鲁斯·哈米尔顿·莱高
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Actelion Pharmaceuticals Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2006800333751A 2005-09-12 2006-09-11 包含嘧啶-磺酰胺的稳定性医药组合物 Active CN101262847B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2005/009775 2005-09-12
EP2005009775 2005-09-12
PCT/IB2006/053210 WO2007031933A2 (en) 2005-09-12 2006-09-11 Stable pharmaceutical composition comprising a pyrimidine-sulfamide

Publications (2)

Publication Number Publication Date
CN101262847A CN101262847A (zh) 2008-09-10
CN101262847B true CN101262847B (zh) 2010-11-24

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US (6) US20080233188A1 (https=)
EP (2) EP2292209A3 (https=)
JP (2) JP4955685B2 (https=)
KR (1) KR101313395B1 (https=)
CN (1) CN101262847B (https=)
AU (1) AU2006290309B2 (https=)
BR (1) BRPI0615898B8 (https=)
CA (1) CA2621273C (https=)
CY (1) CY1113395T1 (https=)
DK (1) DK1928409T3 (https=)
ES (1) ES2393117T3 (https=)
HR (1) HRP20120957T1 (https=)
IL (1) IL190072A (https=)
MY (1) MY151003A (https=)
NO (1) NO341325B1 (https=)
NZ (1) NZ567188A (https=)
PL (1) PL1928409T3 (https=)
PT (1) PT1928409E (https=)
RU (1) RU2424805C2 (https=)
SI (1) SI1928409T1 (https=)
TW (1) TWI323661B (https=)
WO (1) WO2007031933A2 (https=)
ZA (1) ZA200802947B (https=)

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TW202042818A (zh) * 2019-01-25 2020-12-01 瑞士商艾克泰聯製藥有限公司 用於治療慢性血栓性肺高血壓之醫藥組成物
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WO2007031933A2 (en) 2007-03-22
WO2007031933A3 (en) 2007-10-18
CA2621273C (en) 2014-07-29
KR20080055897A (ko) 2008-06-19
ZA200802947B (en) 2009-12-30
EP2292209A2 (en) 2011-03-09
CA2621273A1 (en) 2007-03-22
CY1113395T1 (el) 2016-06-22
HK1121950A1 (en) 2009-05-08
US20160136163A1 (en) 2016-05-19
JP4955685B2 (ja) 2012-06-20
US20210186966A1 (en) 2021-06-24
PL1928409T3 (pl) 2013-02-28
US20130190336A1 (en) 2013-07-25
EP2292209A3 (en) 2011-05-04
JP2009519893A (ja) 2009-05-21
JP2009235073A (ja) 2009-10-15
DK1928409T3 (da) 2012-11-05
NO20081724L (no) 2008-04-09
US8367685B2 (en) 2013-02-05
NO341325B1 (no) 2017-10-16
TWI323661B (en) 2010-04-21
IL190072A0 (en) 2008-08-07
US11648249B2 (en) 2023-05-16
BRPI0615898B1 (pt) 2020-02-18
RU2424805C2 (ru) 2011-07-27
PT1928409E (pt) 2012-11-27
BRPI0615898A2 (pt) 2011-05-31
BRPI0615898B8 (pt) 2021-05-25
HRP20120957T1 (hr) 2012-12-31
US10946015B2 (en) 2021-03-16
EP1928409B1 (en) 2012-09-12
AU2006290309A1 (en) 2007-03-22
ES2393117T3 (es) 2012-12-18
US20080233188A1 (en) 2008-09-25
CN101262847A (zh) 2008-09-10
EP1928409A2 (en) 2008-06-11
US9265762B2 (en) 2016-02-23
IL190072A (en) 2013-08-29
TW200803860A (en) 2008-01-16
SI1928409T1 (sl) 2012-12-31
AU2006290309B2 (en) 2012-04-05
KR101313395B1 (ko) 2013-10-02
US20100004274A1 (en) 2010-01-07
RU2008113869A (ru) 2009-10-20
US20180263980A1 (en) 2018-09-20
US10117870B2 (en) 2018-11-06
NZ567188A (en) 2011-04-29
JP5054061B2 (ja) 2012-10-24
MY151003A (en) 2014-03-31

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