CN101257903A - 用于癌症治疗的包括二芳基脲化合物和PI3、AKT激酶或mTOR抑制剂(雷帕霉素类)的组合治疗 - Google Patents
用于癌症治疗的包括二芳基脲化合物和PI3、AKT激酶或mTOR抑制剂(雷帕霉素类)的组合治疗 Download PDFInfo
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- 210000000626 ureter Anatomy 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 201000000365 urinary system benign neoplasm Diseases 0.000 description 1
- 208000029584 urinary system neoplasm Diseases 0.000 description 1
- 201000003365 uterine corpus sarcoma Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 208000006542 von Hippel-Lindau disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 description 1
- 229950009819 zotarolimus Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05011477 | 2005-05-27 | ||
| EP05011477.6 | 2005-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101257903A true CN101257903A (zh) | 2008-09-03 |
Family
ID=36636325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800185177A Pending CN101257903A (zh) | 2005-05-27 | 2006-05-13 | 用于癌症治疗的包括二芳基脲化合物和PI3、AKT激酶或mTOR抑制剂(雷帕霉素类)的组合治疗 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1888067A1 (enExample) |
| JP (1) | JP2008542214A (enExample) |
| KR (1) | KR20080018908A (enExample) |
| CN (1) | CN101257903A (enExample) |
| AU (1) | AU2006251429A1 (enExample) |
| BR (1) | BRPI0610048A2 (enExample) |
| CA (1) | CA2609389A1 (enExample) |
| IL (1) | IL187508A0 (enExample) |
| MX (1) | MX2007014726A (enExample) |
| RU (1) | RU2007148266A (enExample) |
| WO (1) | WO2006125540A1 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885814A (zh) * | 2012-01-17 | 2013-01-23 | 湖南有色凯铂生物药业有限公司 | 一种化合物及其作为抗癌药物的应用 |
| CN102940884A (zh) * | 2012-11-19 | 2013-02-27 | 上海市肿瘤研究所 | 一种肝癌细胞的抑制剂及其在抑制肿瘤生长方面的应用 |
| CN104892632A (zh) * | 2015-06-03 | 2015-09-09 | 道中道(菏泽)制药有限公司 | 一种晶体形式的依维莫司及其制备方法 |
| CN104906086A (zh) * | 2015-06-24 | 2015-09-16 | 安徽四正医药科技有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗肾小球肾炎药物的应用 |
| CN107205923A (zh) * | 2014-12-17 | 2017-09-26 | 辉瑞大药厂 | 用于静脉内给药的pi3k/mtor‑抑制剂的制剂 |
| CN115804844A (zh) * | 2022-09-26 | 2023-03-17 | 郑州大学 | 靶向抑制pak4的抑制剂在制备肿瘤防治药剂中的应用 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| EP1636585B2 (en) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl ureas with kinase inhibiting activity |
| HRP20060073B1 (hr) | 2003-07-23 | 2014-03-14 | Bayer Healthcare Llc | Fluoro supstituirana omega-karboksiaril difenil urea za lijeäśenje i prevenciju bolesti i stanja |
| CN104688697A (zh) | 2005-03-07 | 2015-06-10 | 拜尔健康护理有限责任公司 | 用于治疗癌症的包含ω-羧芳基取代的二苯基脲的药物组合物 |
| CA2633400A1 (en) * | 2005-12-15 | 2007-06-21 | Bayer Healthcare Ag | Diaryl urea for treating virus infections |
| AR062927A1 (es) | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
| JP2010516692A (ja) * | 2007-01-19 | 2010-05-20 | バイエル・ヘルスケア・エルエルシー | 化学療法剤に対し抵抗性を有する癌の処置 |
| CA2675980C (en) | 2007-01-19 | 2016-06-21 | Bayer Healthcare Llc | Use of dast for treatment of cancers with acquired resistance to kit inhibitors |
| US7947723B2 (en) | 2008-02-01 | 2011-05-24 | Spelman College | Synthesis and anti-proliferative effect of benzimidazole derivatives |
| AU2009225434B2 (en) * | 2008-03-21 | 2014-05-22 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
| EP2296641A1 (en) * | 2008-06-25 | 2011-03-23 | Bayer Schering Pharma Aktiengesellschaft | Diaryl urea for treating heart failure |
| EP2356120B1 (en) * | 2008-09-30 | 2016-10-12 | Pfizer Inc. | Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions |
| CA2763589A1 (en) | 2009-05-28 | 2010-12-02 | President And Fellows Of Harvard College | N,n'-diarylurea compounds and n,n'-diarylthiourea compounds as inhibitors of translation initiation |
| CN102775385A (zh) * | 2011-05-10 | 2012-11-14 | 湖南有色凯铂生物药业有限公司 | N-取代苯基-n’-取代杂环脲类化合物及其作为抗癌药物的应用 |
| CN102643229A (zh) * | 2012-01-17 | 2012-08-22 | 湖南有色凯铂生物药业有限公司 | N-((4-氯-3-三氟甲基)苯基)-n’-((2-氟-4-(2-氨基甲酰基)-4-吡啶基氧)苯基)脲及其作为抗癌药物的应用 |
| US10420761B2 (en) | 2013-03-15 | 2019-09-24 | University Of Florida Research Foundation, Inc. | Allosteric inhibitors of thymidylate synthase |
| WO2016209688A1 (en) | 2015-06-24 | 2016-12-29 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of cancer and uses thereof |
| KR102544163B1 (ko) * | 2022-08-10 | 2023-06-16 | 주식회사 하이밸 | 소음저감형 유량 및 압력 조절용 감압밸브 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20060073B1 (hr) * | 2003-07-23 | 2014-03-14 | Bayer Healthcare Llc | Fluoro supstituirana omega-karboksiaril difenil urea za lijeäśenje i prevenciju bolesti i stanja |
-
2006
- 2006-05-13 MX MX2007014726A patent/MX2007014726A/es not_active Application Discontinuation
- 2006-05-13 CA CA002609389A patent/CA2609389A1/en not_active Abandoned
- 2006-05-13 EP EP06724813A patent/EP1888067A1/en not_active Withdrawn
- 2006-05-13 JP JP2008512730A patent/JP2008542214A/ja active Pending
- 2006-05-13 WO PCT/EP2006/004524 patent/WO2006125540A1/en not_active Ceased
- 2006-05-13 RU RU2007148266/15A patent/RU2007148266A/ru not_active Application Discontinuation
- 2006-05-13 BR BRPI0610048-1A patent/BRPI0610048A2/pt not_active Application Discontinuation
- 2006-05-13 AU AU2006251429A patent/AU2006251429A1/en not_active Abandoned
- 2006-05-13 CN CNA2006800185177A patent/CN101257903A/zh active Pending
- 2006-05-13 KR KR1020077030272A patent/KR20080018908A/ko not_active Withdrawn
-
2007
- 2007-11-20 IL IL187508A patent/IL187508A0/en unknown
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885814A (zh) * | 2012-01-17 | 2013-01-23 | 湖南有色凯铂生物药业有限公司 | 一种化合物及其作为抗癌药物的应用 |
| CN102940884A (zh) * | 2012-11-19 | 2013-02-27 | 上海市肿瘤研究所 | 一种肝癌细胞的抑制剂及其在抑制肿瘤生长方面的应用 |
| CN107205923A (zh) * | 2014-12-17 | 2017-09-26 | 辉瑞大药厂 | 用于静脉内给药的pi3k/mtor‑抑制剂的制剂 |
| CN107205923B (zh) * | 2014-12-17 | 2021-03-05 | 辉瑞大药厂 | 用于静脉内给药的pi3k/mtor-抑制剂的制剂 |
| CN104892632A (zh) * | 2015-06-03 | 2015-09-09 | 道中道(菏泽)制药有限公司 | 一种晶体形式的依维莫司及其制备方法 |
| CN104906086A (zh) * | 2015-06-24 | 2015-09-16 | 安徽四正医药科技有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗肾小球肾炎药物的应用 |
| CN115804844A (zh) * | 2022-09-26 | 2023-03-17 | 郑州大学 | 靶向抑制pak4的抑制剂在制备肿瘤防治药剂中的应用 |
| CN115804844B (zh) * | 2022-09-26 | 2024-05-10 | 郑州大学 | 靶向抑制pak4的抑制剂在制备肿瘤防治药剂中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080018908A (ko) | 2008-02-28 |
| JP2008542214A (ja) | 2008-11-27 |
| EP1888067A1 (en) | 2008-02-20 |
| RU2007148266A (ru) | 2009-07-10 |
| WO2006125540A1 (en) | 2006-11-30 |
| IL187508A0 (en) | 2008-06-05 |
| MX2007014726A (es) | 2008-02-14 |
| CA2609389A1 (en) | 2006-11-30 |
| AU2006251429A1 (en) | 2006-11-30 |
| BRPI0610048A2 (pt) | 2010-05-25 |
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Open date: 20080903 |