CN101244126A - Composition for treating eye disease and preparation method - Google Patents
Composition for treating eye disease and preparation method Download PDFInfo
- Publication number
- CN101244126A CN101244126A CNA2007100374635A CN200710037463A CN101244126A CN 101244126 A CN101244126 A CN 101244126A CN A2007100374635 A CNA2007100374635 A CN A2007100374635A CN 200710037463 A CN200710037463 A CN 200710037463A CN 101244126 A CN101244126 A CN 101244126A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- compositions
- herba
- extract
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composition for caring eyes, the preparation method and application in the treatment of eye disease; wherein, the composition comprises (a) an acceptable carrier in cosmetic science or pharmacy, and (b) effective dose of water extract of raw herbal materials or extract of waterborne organic solution; wherein, the raw herbal materials comprise securinega suffruticosa, alangium root, groundsel, ligustrum lucidum, equisetum, schisandra chinensis, plantain seed, white tribulus and gentian.
Description
Technical field
The present invention relates to the plant extract field.Extract that relates more specifically to from Chinese crude drug, obtain and its production and use.
Background technology
" will as the love eyes cherish ... " be one commonly used, this shows how important eyes have to a people.And eyes are one of the highest organs of our human body frequency of utilization, and reading, study are worked, played, and all be unable to do without eyes.And the thing that the modern life attracts eyeball is more and more, resembles computer, TV, film, picture recording, and the eyes of let us must not be idle, and the burden of eyes is more and more heavier, and the probability of suffering from eye diseases also increases thereupon.Add the use of the serious and contact lens of environmental pollution, make the danger of suffering from eye diseases increase the weight of day by day.Incidence rate as ophthalmics such as keratitis, conjunctivitis, trachoma, myopia all has the trend that increases year by year.All can run into the problem (myopia, presbyopia, inflammation etc.) of eyes aspect people's all one's life, bring puzzlement in various degree for life, psychology, study, work.
Chinese medicine has many ancestral sides, secret recipe, some folk prescriptions that also spreading among the people for the treatment ophthalmic.Generally believe that as people Fructus Lycii, Flos Chrysanthemi, Semen Cassiae etc. have the effect of treatment ophthalmic sufferer.But various ophthalmics remain a great problem in this treatment field, and the conventional medicament curative effect is slow and be difficult to eradicate; Tonic, folk prescription among the people etc. not only are difficult to prove effective, but also have eaten the intestines and stomach bad.Some antibiotic medicament for the eyes if the colony balance of normal conjunctiva capsule is broken in the improper use meeting, cause more serious infection (as cornea fungal infection etc.), and consequence is very serious.And present ophthalmic administration, be that collyrium or eye ointment all will splash into or be applied in the eye, use pretty troublesomely, also can cause secondary infection, patient's poor compliance.
Therefore, this area presses for the compositions that a kind of new treatment ophthalmic is provided, and it is easy to use.
Summary of the invention
The present invention aims to provide a kind of compositions of new treatment ophthalmic.
In a first aspect of the present invention, a kind of compositions is provided, it contains (a) cosmetic conduct and learning or pharmaceutically goes up acceptable carrier and (b) water extract of the raw medicinal material of effective dose or the extract of aqueous organic solvent, and described raw medicinal material comprises Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and Radix Gentianae;
And the extract of described medical material accounts for the 0.02-99% of composition total weight, preferably 0.1-90%, more preferably 0.2-50%.
In another preference, described raw medicinal material also comprises one or more complementary medical materials that are selected from down group: Semen Celosiae, Cortex Fraxini, Herba Leonuri, Herba Ephedrae, Radix Bupleuri.
In another preference, described medical material comprises:
0.2-4 weight portion Cacumen Securinegae Suffruticosae;
0.2-4 weight portion Radix Alangii;
0.5-8 weight portion Herba Senecionis Scandentis;
0.1-2 weight portion Fructus Ligustri Lucidi;
0.2-4 weight portion Herba Equiseti Hiemalis;
0.3-6 weight portion Fructus Schisandrae Chinensis;
0.1-2 weight portion Semen Plantaginis;
0.2-4 weight portion Fructus Atriplicis Sibiricae; With
0.1-2 weight portion Radix Gentianae.
In another preference, described compositions also comprises one or more medical materials that are selected from down group:
0.2-4 weight portion Semen Celosiae;
0.2-4 weight portion Cortex Fraxini;
0.2-4 weight portion Herba Leonuri;
0.2-4 weight portion Herba Ephedrae;
0.2-4 weight portion Radix Bupleuri.
In another preference, described crude drug contains:
0.2-4 weight portion Cacumen Securinegae Suffruticosae;
0.2-4 weight portion Radix Alangii;
0.5-8 weight portion Herba Senecionis Scandentis;
0.1-2 weight portion Fructus Ligustri Lucidi;
0.2-4 weight portion Herba Equiseti Hiemalis;
0.3-6 weight portion Fructus Schisandrae Chinensis;
0.1-2 weight portion Semen Plantaginis;
0.2-4 weight portion Fructus Atriplicis Sibiricae;
0.1-2 weight portion Radix Gentianae;
0.2-4 weight portion Semen Celosiae;
0.2-4 weight portion Cortex Fraxini;
0.2-4 weight portion Herba Leonuri;
0.2-4 weight portion Herba Ephedrae;
With 0.2-4 weight portion Radix Bupleuri.
In another preference, described crude drug contains:
1-3 weight portion Cacumen Securinegae Suffruticosae; 1-3 weight portion Radix Alangii; 2-6 weight portion Herba Senecionis Scandentis; 0.5-1.5 weight portion Fructus Ligustri Lucidi; 1-3 weight portion Herba Equiseti Hiemalis; 1.5-4.5 weight portion Fructus Schisandrae Chinensis; 0.5-1.5 weight portion Semen Plantaginis; 1-3 weight portion Fructus Atriplicis Sibiricae; 0.5-1.5 weight portion Radix Gentianae;
1-3 weight portion Semen Celosiae; 1-3 weight portion Cortex Fraxini; 1-3 weight portion Herba Leonuri; 1-3 weight portion Herba Ephedrae; With 1-3 weight portion Radix Bupleuri.
In another preference, described compositions is spray, ointment, ointment, liniment, lotion, liniment or gel.
In another preference, by the gross dry weight amount of described medical material, every gram or every milliliter of described compositions contain corresponding to 0.01-10 and restrain dried medical material.More preferably, 0.05-2 restrains dried medical material.
In a second aspect of the present invention, a kind of above-mentioned method for compositions for preparing is provided, described method comprises step:
(i) described medical material was mixed 0.5-50 days with water or aqueous organic solvent, form mixed liquor;
(ii) filter mixed liquor, obtain filtrate, thereby obtain extract;
(iii) with extract with the cosmetic conduct and learning or pharmaceutically go up acceptable carrier and mix, form compositions;
Perhaps
Described method comprises mixes the aqueous extract of each medical material, forms and extracts mixture, will extract mixture again with the cosmetic conduct and learning or pharmaceutically go up acceptable carrier and mix, the formation compositions.
In another preference, described aqueous organic solvent is the mixed solution of water and alcohol (as ethanol), and wherein Chun percent by volume is 5-85% (v/v), more preferably is 10-50%.
In another preference, described alcohol comprises ethanol or methanol.
In another preference, comprise that also the extract to obtaining carries out drying in (ii) in step.
In another preference, described raw medicinal material also contains Semen Celosiae, Cortex Fraxini, Herba Leonuri, Herba Ephedrae, Radix Bupleuri or its combination.
In a third aspect of the present invention, a kind of method of protecting eyes is provided, promptly needed the object of maintenance to use above-mentioned compositions.
In a fourth aspect of the present invention, the purposes of a kind of Chinese medicine medicinal material composition or its aqueous extract is provided, wherein, described Chinese medicine medicinal material composition comprises: Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and Radix Gentianae; Described Chinese medicine medicinal material composition or its aqueous extract are used to prepare the compositions for the treatment of ophthalmic.
In another preference, described Chinese medicine medicinal material composition comprises:
0.2-4 weight portion Cacumen Securinegae Suffruticosae;
0.2-4 weight portion Radix Alangii;
0.5-8 weight portion Herba Senecionis Scandentis;
0.1-2 weight portion Fructus Ligustri Lucidi;
0.2-4 weight portion Herba Equiseti Hiemalis;
0.3-6 weight portion Fructus Schisandrae Chinensis;
0.1-2 weight portion Semen Plantaginis;
0.2-4 weight portion Fructus Atriplicis Sibiricae; With
0.1-2 weight portion Radix Gentianae.
In another preference, described Chinese medicine composition can also contain other complementary medical materials.
In view of the above, the invention provides a kind of compositions of new treatment ophthalmic, and it is easy to use.
The specific embodiment
The inventor is through extensively and in depth research, find Cacumen Securinegae Suffruticosae (Cacumen seu RadixSecurinegae Suf-fruticosae), Radix Alangii (Radix Alangii), Herba Senecionis Scandentis (HerbaSenecionis Scandentis), Fructus Ligustri Lucidi (Fructus Ligustri Lucidi), Herba Equiseti Hiemalis (HerbaEquiseti Hiemalis), Fructus Schisandrae Chinensis (Radix Schisandrae Bicoloris Fructus Schisandrae Chinensis), Semen Plantaginis (Semen Plantaginis), Fructus Atriplicis Sibiricae (Fructus Tribuli Fructus Tribuli), the effect that the water extract of Radix Gentianae (RadixGentianae) or its combination or the extract of aqueous organic solvent have good treatment ophthalmic, it can treat myopia effectively, hypermetropia, trachoma, and can moisten eyes effectively.
As used in this description and claims, " raw medicinal material " of the present invention is defined as follows:
Cacumen Securinegae Suffruticosae (Cacumen seu Radix Securinegae Suf-fruticosae): the browse or the root of Euphorbiaceae Suffrutescent Securinega Twig platymiscium Suffrutescent Securinega Twig.Effect with relaxing muscles and tendons to promote blood circulation.
Radix Alangii (Radix Alangii): root, fibrous root and the root bark of Alangiaceae Alangium plant Radix Alangii and melon wood.Have and dispel the wind, collateral dredging, the effect of dissipating blood stasis.
Herba Senecionis Scandentis (Herba Senecionis Scandentis): the herb of Compositae Senecio plant Herba Senecionis Scandentis.Has heat clearing away, detoxifcation, parasite killing, the effect that makes eye bright.Can treat various ophthalmology illness.
Fructus Ligustri Lucidi (Fructus Ligustri Lucidi): the fruit of Oleaceae plant Fructus Ligustri Lucidi (Ligustrum LucidumAit.).Fructus Ligustri Lucidi has the effect that reduces serum cholesterol and triglyceride; To the regressive effect that is formed with of experimental aorta lipid speckle, particularly to the tangible regressive effect of being formed with of coronary atherosclerotic score piece.And the merit that makes eye bright arranged.
Herba Equiseti Hiemalis (Herba Equiseti Hiemalis): Equisetaceae horse-tail Herba Equiseti Hiemalis's herb.Has wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, the effect of nebula removing.Order be can control and nebula, epiphora induced by wind given birth to.The special dominant eye wind syndrome of ocular connectors due to invasion of pathogenic wind of Herba Equiseti Hiemalis heat, sudden and violent nebula, arresting lacrimation.
Fructus Schisandrae Chinensis (Radix Schisandrae Bicoloris Fructus Schisandrae Chinensis): the fruit of Schisandraceae schisandra plant Fructus Schisandrae Chinensis or schisandra chinensis.Have the normal person of raising and the vision of persons suffering from ocular disorders and the effect of broadening one's vision.
Semen Plantaginis (Semen Plantaginis): the seed of Plantaginaceae Plantago plant Herba Plantaginis Plantago asiaticaL., Plantago depressa Willd Plantago depressa Willd..Has diuretic, heat clearing away, the effect that makes eye bright.Can control the conjunctival congestion blurred vision; Can control sudden and violent acute conjunctivitis pain again, the lacrimation brain is painful, the infirmity barrier order of nebula.
Fructus Atriplicis Sibiricae (Fructus Tribuli Fructus Tribuli): the fruit of zygophyllaceae Tribulus plant Fructus Tribuli and Tribulus cistoides L.Have diffusing wind, make eye bright, the therapeutic method to keep the adverse QI flowing downwards, the effect of promoting the circulation of blood.Can control the swollen nebula of conjunctival congestion.Fructus Atriplicis Sibiricae is to control the key medicine that wind makes eye bright.
Radix Gentianae (Radix Gentianae): the root and the rhizome of Gentianaceae agueweed Radix Gentianae, bar leaf Radix Gentianae, three flower Radix Gentianae and Yunnan Radix Gentianae.Effect with removing the relative excess fire.
Semen Celosiae (Semen Celosiae): the seed of Amaranthaceae Celosia argentea platymiscium Celosia argentea.Has the heat of dispeling the wind, the effect of relieving inflammation or internal heat.Can control conjunctival congestion and swelling pain, hide from view.The Semen Celosiae bitter cold is sliding sharp, kind wash hot and suffocating, so all diseases of order section wind heat liver-fire are united to control it.
Cortex Fraxini (Cortex Fraxini): the bark of Oleaceae Fraxinus plant Da Ye Ash, sharp leaf Ash, Chinese ash and Fraxinus fallax Lingelsh.Has heat clearing and damp drying, the effect that makes eye bright.Can control conjunctival congestion and swelling pain, epiphora induced by wind.Cortex Fraxini is distinguished foul smell, and diffusing shrinkage of QI is held back, so can control ophthalmology, the nebula removing film is received lacrimation.
Herba Leonuri (Herba Leomuri): the herb of Labiatae mother wort plant Herba Leonuri and Herba Leonuri Sibirici.Have and invigorate blood circulation, blood stasis dispelling, the effect of the water that disappears.Can control blood and pass through pupil of the eye, and the wind syndrome of head ophthalmalgia, remove wind with the function promoting the circulation of blood.
Herba Ephedrae (Herba Ephedrae): the herb stem of Ephedraceae ephedra Ephedra sinica, epheday intermedia and ephedra equisetina.Be the evil key medicine of loosing, YIN pathogen should be used it.
Radix Bupleuri (Radix Bupleuri): the root of Umbelliferae Bupleurum plant Radix Bupleuri or Radix Bupeuri Scorzonerfolii..Be the evil key medicine of loosing, YANG pathogen should be used it.
As used herein, " auxiliary medical material ", " extra medical material " or " optional medical material " are meant that those can add the medical material that also can not add, and can make effect better after the adding.
Compositions
The inventor provides a kind of extract according to the medication principle of Chinese medicine monarch, and it contains the water extract or the aqueous organic solvent extract of the raw medicinal material (crude preparation) of Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and Radix Gentianae formation.
Usually, the parts by weight of each raw medicinal material are as follows in the described mixture:
| Parts by weight | Preferred parts by weight | |
| Cacumen Securinegae Suffruticosae | 0.2-4 | 1-3 |
| Radix Alangii | 0.2-4 | 1-3 |
| Herba Senecionis Scandentis | 0.5-8 | 2-6 |
| Fructus Ligustri Lucidi | 0.1-2 | 0.5-1.5 |
| The Herba Equiseti Hiemalis | 0.2-4 | 1-3 |
| Fructus Schisandrae Chinensis | 0.3-6 | 1.5-4.5 |
| Semen Plantaginis | 0.1-2 | 0.5-1.5 |
| Fructus Atriplicis Sibiricae | 0.2-4 | 1-3 |
| Radix Gentianae | 0.1-2 | 0.5-1.5 |
In a preference, also can contain the water extract or the aqueous organic solvent extract of the medical material of extra treatment ophthalmic in the compositions of the present invention.Suitable hair care hair care medical material example comprises, but is not limited to: Semen Celosiae, Cortex Fraxini, Herba Leonuri, Herba Ephedrae, Radix Bupleuri or its combination.
Usually, the consumption of the medical material of these extra treatment ophthalmics is as follows:
| Parts by weight | Preferred parts by weight | |
| Semen Celosiae | 0.2-4 | 1-3 |
| Cortex Fraxini | 0.2-4 | 1-3 |
| Herba Leonuri | 0.2-4 | 1-3 |
| Herba Ephedrae | 0.2-4 | 1-3 |
| Radix Bupleuri | 0.2-4 | 1-3 |
A kind of preferred extract of the present invention is in order to medical material mixture preparation down, and this mixture contains:
| Parts by weight | Preferred parts by weight | |
| Cacumen Securinegae Suffruticosae | 0.2-4 | 1-3 |
| Radix Alangii | 0.2-4 | 1-3 |
| Herba Senecionis Scandentis | 0.5-8 | 2-6 |
| Fructus Ligustri Lucidi | 0.1-2 | 0.5-1.5 |
| The Herba Equiseti Hiemalis | 0.2-4 | 1-3 |
| Fructus Schisandrae Chinensis | 0.3-6 | 1.5-4.5 |
| Semen Plantaginis | 0.1-2 | 0.5-1.5 |
| Fructus Atriplicis Sibiricae | 0.2-4 | 1-3 |
| Radix Gentianae | 0.1-2 | 0.5-1.5 |
| Semen Celosiae | 0.2-4 | 1-3 |
| Cortex Fraxini | 0.2-4 | 1-3 |
| Herba Leonuri | 0.2-4 | 1-3 |
| Herba Ephedrae | 0.2-4 | 1-3 |
| Radix Bupleuri | 0.2-4 | 1-3 |
Can also contain the extract that comes from following optional medical material in the compositions of the present invention, as Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Angelicae Sinensis etc.
Preparation method
The available following method preparation of active component of the present invention (being the extract of medical material): with required medical material water or contain the suitable mixable organic solvent of water of 30-85% (v/v) as alcohol (preferred alcohol) extracting, filter the extract that obtains so then, can randomly filtrate be carried out drying with conventional method (as spray drying, lyophilizing or concentrate drying) then.Active component of the present invention can mix the extract of extractive each raw medicinal material respectively and prepare, and also can obtain by the mixture of extracting medical material.
Extracting can be carried out under room temperature or heating condition, but preferably at 4-35 ℃, more preferably carries out under 5-30 ℃.
Usually, extract of the present invention is mixed with suitable carriers can obtain compositions of the present invention.The method that can be used for preparing the present composition is not particularly limited, and the various conventional methods of available this area are as mixing method etc.
In preparation of the present invention, the extract that contains the above-mentioned raw materials medical material is as active component and cosmetic conduct and learning or pharmaceutically go up acceptable carrier or additives.
As used herein; term " compositions of the present invention " comprises the compositions (as eye cream etc.) of pharmaceutical composition and protection eyes, as long as they contain the extract of the water extract of Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and Radix Gentianae or aqueous organic solvent or are made of the extract of raw medicinal materials such as Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and Radix Gentianae basically.In compositions, the extract of Cacumen Securinegae Suffruticosae of the present invention, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae, Radix Gentianae and other auxiliary medical materials accounts for the 0.1-99% of composition total weight, preferably account for 1-90%, account for 5-80% best.
In addition, press the dry weight of medical material and calculate, every milliliter of fluid composition should restrain corresponding to 0.01-10, more preferably restrains total dried medical material corresponding to 0.2-5, restrains total dried medical material corresponding to 0.5-2.5 best.
As used herein, term " cosmetic conduct and learning or pharmaceutically go up acceptable carrier " refers to be used for the carrier of cosmetics.This term refers to some cosmetics carriers like this: they itself are not necessary active component, and do not have undue toxicity after using.Suitable carriers is well known to those of ordinary skill in the art.Cosmetic conduct and learning or pharmaceutically go up acceptable carrier and can contain liquid in compositions is as water, saline, glycerol and ethanol.In addition, also may there be complementary material in these carriers, as wetting agent or emulsifying agent, pH buffer substance etc.
The carrier that is fit to storage and/or transmission active component of the present invention (being the extract of medical material) can be liniment, liquor, ointment, gel, cream, spray, the drug of topical application or other form, and to have lipotropy, hydrophilic or amphipathic for good.Suitable carriers comprises vaseline, triglyceride, and various esters, aliphatic alcohol, fatty acid, alkylene glycol and ethanol, wherein preferred Polyethylene Glycol, polypropylene glycol, best with Polyethylene Glycol especially; If necessary, the compatible combinations of above carrier is also passable.
And carrier should meet the needs of required transmission system.According to the conventional practice of this area, can also contain other reagent in the carrier.For example, final compositions can contain various emollient, emulsifying agent, alcohol, pigment, essence, thickening agent (for example Xanthan gum), antiseptic, wetting agent, surfactant (anion, cation, nonionic, the amphoteric surfactant combination), dispersant, gellant, hydrating agents, skin freshener, lubricant or above-described mixture.Compositions of the present invention can contain permeation enhanced dose too, such as but not limited to oleic acid, and dimethyl sulfoxine (DMSO), alcohol, N-methyl pyrrole Lip river alkane ketone, Isosorbide dimethyl ether.
Available emollient example has: mineral oil, and the ore deposit is cured, paraffin, ceresin (ceresin); ceresine (ozokerite), microwax, perhydro-squalene, dimethyl polysiloxane; silicone, silicone-glycol copolymer, triglyceride, acetylated monoglycerides; the ethoxylated glycerol ester, the hydrocarbyl carbonate of fatty acid, fatty acid and alcohol; lanoline and lanolin derivative, polyol ester, sterol; the Cera Flava derivant, polyhydric alcohol and polyethers, and the amide of fatty acid.
The wetting agent that is fit to can improve those of skin hydration degree, for example polyhydric alcohol when being the use of known part.Suitable wetting agent example is: glycerol, propylene glycol, butanediol, diglycerol, or their ester derivant.Preferred wetting agent is a glycerol.
The local compositions of using of the present invention can be made into spray.Active component of the present invention (being the extract of medical material) can use carrier to mix mutually with the part that great majority are used for spray.Solubilizing agent can be used cellulose derivatives such as hydroxyethyl-cellulose and hydroxypropyl cellulose, polyoxyethylene groups.Antioxidant can be used sodium thiosulfate, and surfactant can be used sodium laurylsulfate, and antiseptic comprises alkanol, especially ethanol and benzylalcohol; P-Hydroxybenzoate; Sorbate; Urea derivative; And isothiazolone.
The local compositions of using of the present invention can be made into ointment or ointment.Active component of the present invention (being the extract of medical material) can use carrier to mix mutually with the part that great majority are used for ointment, ointment etc.Greasing base can be used vaseline, and water-soluble base can be used Polyethylene Glycol, and emulsion-type substrate can be used Polysorbate, and antioxidant can be used sodium thiosulfate, and antiseptic can be used sodium benzoate.
The local compositions of using of the present invention can be made into soft liniment or cream.Active component of the present invention (being the extract of medical material) can use carrier to mix mutually with the part that great majority are used for liniment, cream etc.Emulsifying agent can be with cationic, anionic, nonionic or amphoteric, or above-described mixture.Nonionic emulsifier preferably.The example of nonionic emulsifier has commercially available anhydro sorbitol, alkoxy fatty alcohols and alkyl poly glucoside.Anionic emulsifier comprises soap, sulfovinate, the two hydrocarbon esters of mono phosphoric acid ester hydrocarbon ester and phosphoric acid, the different thiosulfate of sulfonic acid hydrocarbon ester and acyl group.Available amphoteric emulsifying agent is chlorination lacto propyl group three ammoniums.
Liniment of the present invention or cream can prepare with this area routine method that homogenizes.Also can adopt little liquefaction technology, this method comprises: the water with cream and liniment in the high pressure homogenize instrument mixes with oil phase.
The local compositions of using of the present invention can be made into liniment.Active component of the present invention (being the extract of medical material) can use carrier to mix mutually with the part that great majority are used for liniment.Can add solvent (as water, ethanol, vegetable oil), plasticizer (as glycerol) and/or filmogen (as polyvinyl alcohol).
The local compositions of using of the present invention can be made into gel.Active component of the present invention (being the extract of medical material) can use carrier to mix mutually with the part that great majority are used for gel.Can add gel-type vehicle (as carbomer, liquid paraffin).
The local compositions of using of the present invention also can be mixed with microemulsion, and this belongs to a kind of of emulsion.Available oil is mineral oil and silicone oil.The example of available alcohol is a hexadecanol, isooctadecane alcohol, stearyl alcohol, dodecanol and lanolin alcohol.Non-ionic surface active agent can be a fatty acid, the ester of the alcohols of aliphatic alcohol or ethoxylation.Examples of nonionic surfactants is a Polyethylene Glycol, isopropyl myristate, isostearic acid hexadecane ester, polypropylene glycol, anhydro sorbitol and acid isopropyl.
Purposes and using method
Extract of the present invention or compositions can be used for control myopia.Can use by conventional route, comprising (but being not limited to): be sprayed on eye (on eyelid, eye pouch and the skin all around thereof), closing one's eyes to wait to do gets final product; Or spread upon on eyelid, eye pouch and the skin all around thereof.
Extract of the present invention or compositions can be used for preventing and treating hypermetropia.Can use by conventional route, comprising (but being not limited to): be sprayed on eye (comprising on eyelid, eye pouch and the skin all around thereof), closing one's eyes to wait to do gets final product; Or spread upon on eyelid, eye pouch and the skin all around thereof.
Extract of the present invention or compositions can be used for anti-treating trachoma.Can use by conventional route, comprising (but being not limited to): be sprayed on eye (on eyelid, eye pouch and the skin all around thereof), closing one's eyes to wait to do gets final product; Or spread upon on eyelid, eye pouch and the skin all around thereof.
Extract of the present invention or compositions can be used for moistening eyes.Can use by conventional route, comprising (but being not limited to): be sprayed on eye (on eyelid, eye pouch and the skin all around thereof), closing one's eyes to wait to do gets final product; Or spread upon on eyelid, eye pouch and the skin all around thereof.
The percutaneous infiltration of extract provided by the invention or compositions impels eyelid, eye pouch and peripheral myocyte to change, and has quickened blood circulation etc., and the vision of eyes is recovered gradually.
When using compositions provided by the invention, be that the water extract of Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and the Radix Gentianae (or mixture of Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae, Radix Gentianae and other auxiliary medical materials) of safe and effective amount or the extract of aqueous organic solvent are applied to the people.Wherein this safe and effective amount is generally everyone 0.1-100 gram, preferably for the 0.5-50 gram, by the dried medical material amount of Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and Radix Gentianae (or mixture of Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae, Radix Gentianae and other auxiliary medical materials).Certainly, concrete dosage also should be considered the factors such as health of method of application, subject, and these all are within the skill of this area.
Major advantage of the present invention is:
1, extract provided by the invention or compositions can be prevented and treated myopia, hypermetropia, trachoma and central serous chorioretinopathy effectively.
2, extract provided by the invention or compositions can be moistened eyes effectively.
3, easy to use, the intestines and stomach there is not damage.
4, extract provided by the invention or compositions can't be brought injury to eyes, as long as with after the present invention's dilution, can make the liquid medicine of eye dripping fully.Because there are many people to fear eye dripping liquid medicine, thus solved the feared state of mind of many people with the dialysis of medicine to eye dripping liquid medicine, even if therefore the present invention's external can not lessen the curative effect yet.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example is usually according to the normal condition or the condition of advising according to manufacturer.Unless otherwise indicated, otherwise all percentage ratio and umber by weight.
Unless otherwise defined, the same meaning that employed all specialties and scientific words and one skilled in the art are familiar with in the literary composition.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The usefulness that preferable implementation method described in the literary composition and material only present a demonstration.
Preparation embodiment 1-4
Take by weighing the raw medicinal material of following quantity,
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| Consumption (kilogram) | Consumption (kilogram) | Consumption (kilogram) | Consumption (kilogram) |
| Cacumen Securinegae Suffruticosae | 0.2 | 1 | 3 | 4 |
| Radix Alangii | 0.2 | 1 | 3 | 4 |
| Herba Senecionis Scandentis | 0.5 | 2 | 6 | 8 |
| Fructus Ligustri Lucidi | 0.1 | 0.5 | 1.5 | 2 |
| The Herba Equiseti Hiemalis | 0.2 | 1 | 3 | 4 |
| Fructus Schisandrae Chinensis | 0.3 | 1.5 | 4.5 | 6 |
| Semen Plantaginis | 0.1 | 0.5 | 1.5 | 2 |
| Fructus Atriplicis Sibiricae | 0.2 | 1 | 3 | 4 |
| Radix Gentianae | 0.1 | 0.5 | 1.5 | 2 |
Clean, dry, be crushed to Powdered (mean diameter is about 250-500 μ m).Placing the bottom that the column shape container (solvent flows through the medicated powder on the dividing plate from top to bottom) of dividing plate is arranged in powder, is that 40% (v/v) ethanol water is solvent (consumption is 10 times of each medical material gross dry weight) with concentration.Medical material flooded 48 hours with solvent, filtered then, collected filtrate and obtained liquid extract.
In liquid extract, add polyoxyethylene groups, sodium thiosulfate, sodium laurylsulfate and sodium benzoate to 0.5wt%.Make spray a, b, c and d respectively, each 1000 milliliters, close 1 gram medical material/1ml.
Preparation embodiment 5-8
Repeat to prepare the method for embodiment 1-4, difference is: also additionally contain in the medical material mixture
| Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | |
| Consumption (kilogram) | Consumption (kilogram) | Consumption (kilogram) | Consumption (kilogram) | |
| Semen Celosiae | 0.2 | 1 | 3 | 4 |
| Cortex Fraxini | 0.2 | 1 | 3 | 4 |
| Herba Leonuri | 0.2 | 1 | 3 | 4 |
| Herba Ephedrae | 0.2 | 1 | 3 | 4 |
| Radix Bupleuri | 0.2 | 1 | 3 | 4 |
Make spray e, f, g and h respectively.
Test implementation example 1
Control myopia
During long-time close eye, in order to see object clearly, regulate constantly and strengthen, ciliary muscle continues to shrink, engender tension or spasm and the myopia that causes.
Give the myope (wherein 2 for using commercially available profit eye liquid not have obvious improver) of 5 (age 20-30 year), the spray c that sprinkling embodiment 3 makes, every day secondary, two weeks is effective.Reducing to average 450 from average near-sighted 500 degree in two months spends.
The result shows that compositions provided by the invention can be prevented and treated myopia.
Test implementation example 2
Prevent and treat hypermetropia
Presbyopic cause is because human eye's crystalline lens is degenerated.At an early age, the soft high resilience of crystalline lens, thickening attenuation at any time has the ability of well adjusting when seeing nearly thing.Along with the increase at age, crystalline lens hardens gradually, has lost pliability and elasticity.When seeing near object, the lenticular ability of adjusting reduces, and can't focus on exactly on the retina, has the sensation of " looking at flowers in a fog ".
Because the presbyopia is the symptom that process showed of physiological ageing, to so far, does not have medicine, food, or can treat or prevent its generation by motion.
Spray the spray c that embodiment 3 makes for the farsighted person of 8 (age 50-60 year), every day secondary, two weeks is effective.Reducing to average 200 from average hypermetropia 250 degree in two months spends.Simultaneously eye pouch lax, sagging there is great help.
The result shows that compositions provided by the invention can be prevented and treated hypermetropia.
Test implementation example 3
Prevent and treat keratitis
Spray the spray c that embodiment 3 makes for 3 keratitis patients, every day two to three times, average 1 day effectively, and a week cures.
The result shows that compositions provided by the invention can be prevented and treated keratitis.
Test implementation example 4
Moisten eyes
Give 10 to have the volunteer of the puckery phenomenon of eye to spray the spray a that embodiment 1 makes, just have obvious effects to secondary after average 2 days every day one.
The result shows that compositions provided by the invention has the effect of moist eyes.
Test implementation example 5-8
Spray b, the d, e, f, g and the h difference retest embodiment 1-4 that use embodiment 2,4-8 to make respectively, effect is similar, can prevent and treat myopia, hypermetropia, keratitis and moist eyes.
Comparative Examples
The eye drop that does not contain medical material is used for above-mentioned test implementation example 1-4, poor effect.
The above only is preferred embodiment of the present invention, be not in order to limit essence technology contents scope of the present invention, essence technology contents of the present invention is broadly to be defined in the claim scope of application, any technology entity or method that other people finish, if it is defined identical with the claim scope of application, also or a kind of change of equivalence, all will be regarded as being covered by among this claim scope.
Claims (10)
1. compositions, it is characterized in that, it contains (a) cosmetic conduct and learning or pharmaceutically goes up acceptable carrier and (b) water extract of the raw medicinal material of effective dose or the extract of aqueous organic solvent, and described raw medicinal material comprises Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and Radix Gentianae;
And the extract of described medical material accounts for the 0.02-99% of composition total weight.
2. compositions as claimed in claim 1 is characterized in that, described raw medicinal material also comprises one or more complementary medical materials that are selected from down group: Semen Celosiae, Cortex Fraxini, Herba Leonuri, Herba Ephedrae, Radix Bupleuri.
3. compositions as claimed in claim 1 is characterized in that, described medical material comprises:
0.2-4 weight portion Cacumen Securinegae Suffruticosae;
0.2-4 weight portion Radix Alangii;
0.5-8 weight portion Herba Senecionis Scandentis;
0.1-2 weight portion Fructus Ligustri Lucidi;
0.2-4 weight portion Herba Equiseti Hiemalis;
0.3-6 weight portion Fructus Schisandrae Chinensis;
0.1-2 weight portion Semen Plantaginis;
0.2-4 weight portion Fructus Atriplicis Sibiricae; With
0.1-2 weight portion Radix Gentianae.
4. compositions as claimed in claim 3 is characterized in that, described compositions also comprises one or more medical materials that are selected from down group:
0.2-4 weight portion Semen Celosiae;
0.2-4 weight portion Cortex Fraxini;
0.2-4 weight portion Herba Leonuri;
0.2-4 weight portion Herba Ephedrae;
0.2-4 weight portion Radix Bupleuri.
5. compositions as claimed in claim 4 is characterized in that, described crude drug contains:
0.2-4 weight portion Cacumen Securinegae Suffruticosae;
0.2-4 weight portion Radix Alangii;
0.5-8 weight portion Herba Senecionis Scandentis;
0.1-2 weight portion Fructus Ligustri Lucidi;
0.2-4 weight portion Herba Equiseti Hiemalis;
0.3-6 weight portion Fructus Schisandrae Chinensis;
0.1-2 weight portion Semen Plantaginis;
0.2-4 weight portion Fructus Atriplicis Sibiricae;
0.1-2 weight portion Radix Gentianae;
0.2-4 weight portion Semen Celosiae;
0.2-4 weight portion Cortex Fraxini;
0.2-4 weight portion Herba Leonuri;
0.2-4 weight portion Herba Ephedrae;
With 0.2-4 weight portion Radix Bupleuri.
6. as the arbitrary described compositions of claim 1-5, it is characterized in that described compositions is spray, ointment, ointment, liniment, lotion, liniment or gel.
7. one kind prepares method for compositions as claimed in claim 1, it is characterized in that, described method comprises step:
(i) described medical material was mixed 0.5-50 days with water or aqueous organic solvent, form mixed liquor;
(ii) filter mixed liquor, obtain filtrate, thereby obtain extract;
(iii) with extract with the cosmetic conduct and learning or pharmaceutically go up acceptable carrier and mix, form compositions;
Perhaps
Described method comprises mixes the aqueous extract of each medical material, forms and extracts mixture, will extract mixture again with the cosmetic conduct and learning or pharmaceutically go up acceptable carrier and mix, the formation compositions.
8. method as claimed in claim 7 is characterized in that, described raw medicinal material also contains Semen Celosiae, Cortex Fraxini, Herba Leonuri, Herba Ephedrae, Radix Bupleuri or its combination.
9. a method of protecting eyes is characterized in that, is needed the object of maintenance to use the described compositions of claim 1.
10. the purposes of a Chinese medicine medicinal material composition or its aqueous extract, wherein, described Chinese medicine medicinal material composition comprises: Cacumen Securinegae Suffruticosae, Radix Alangii, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Equiseti Hiemalis, Fructus Schisandrae Chinensis, Semen Plantaginis, Fructus Atriplicis Sibiricae and Radix Gentianae;
It is characterized in that described Chinese medicine medicinal material composition or its aqueous extract are used to prepare the compositions for the treatment of ophthalmic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100374635A CN101244126B (en) | 2007-02-13 | 2007-02-13 | Composition for treating eye disease and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100374635A CN101244126B (en) | 2007-02-13 | 2007-02-13 | Composition for treating eye disease and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101244126A true CN101244126A (en) | 2008-08-20 |
| CN101244126B CN101244126B (en) | 2012-01-25 |
Family
ID=39944946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100374635A Expired - Fee Related CN101244126B (en) | 2007-02-13 | 2007-02-13 | Composition for treating eye disease and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101244126B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940739A (en) * | 2012-12-03 | 2013-02-27 | 田昭鸾 | Chinese medicinal composition for treating vernal keratoconjunctivitis |
| CN104689125A (en) * | 2015-03-27 | 2015-06-10 | 李佃场 | Medicine for treatment of trachoma and preparation method thereof |
| CN105031027A (en) * | 2015-06-22 | 2015-11-11 | 林润泓 | Chinese herbal medicine ointment for treating myopia |
| CN105998808A (en) * | 2016-06-27 | 2016-10-12 | 吕伟 | Traditional Chinese medicine composition for treating trachoma |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085792A (en) * | 1993-07-30 | 1994-04-27 | 高峰 | Treat bathomorphic liniment and preparation method thereof |
-
2007
- 2007-02-13 CN CN2007100374635A patent/CN101244126B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940739A (en) * | 2012-12-03 | 2013-02-27 | 田昭鸾 | Chinese medicinal composition for treating vernal keratoconjunctivitis |
| CN102940739B (en) * | 2012-12-03 | 2014-03-12 | 田昭鸾 | Traditional Chinese medicine composition for treating vernal keratoconjunctivitis |
| CN104689125A (en) * | 2015-03-27 | 2015-06-10 | 李佃场 | Medicine for treatment of trachoma and preparation method thereof |
| CN105031027A (en) * | 2015-06-22 | 2015-11-11 | 林润泓 | Chinese herbal medicine ointment for treating myopia |
| CN105998808A (en) * | 2016-06-27 | 2016-10-12 | 吕伟 | Traditional Chinese medicine composition for treating trachoma |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101244126B (en) | 2012-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN100404054C (en) | Decoction Chinese medicine sterilizing antiphlogistic, preparation and use thereof | |
| CN102205026B (en) | Chinese medicinal composition for treating children chronic sinusitis and preparation method thereof | |
| CN104274383A (en) | Composition for promoting skin compliance and active ingredient absorption of eye wet compressing agent | |
| CN102228485B (en) | Composition for burn rehabilitation and preparation method thereof | |
| CN102614102A (en) | Dandruff-removing medicinal composition and preparation method thereof | |
| CN101797293B (en) | Chinese medicinal pillow core for treating cervical spondylosis and preparation method thereof | |
| CN100518808C (en) | Wanhua oil spray for traumatic injury and preparing method | |
| CN105919863A (en) | Acne removing and skin beautifying cream rich in extracts of natural ingredients and preparation method thereof | |
| CN105496917A (en) | Herba centellae anti-wrinkling face cream and preparation method thereof | |
| CN104740644A (en) | Preparation method of composition for promoting skin compliance and ingredient absorption of eye hydropathic compress agent | |
| CN101244126B (en) | Composition for treating eye disease and preparation method | |
| CN105616318A (en) | Anti-wrinkle and skin-firming herba centellae traditional Chinese medicine facial mask and preparation method therefor | |
| CN106580838A (en) | Traditional Chinese medicine essence with effects of whitening and fading spots and preparation method of traditional Chinese medicine essence | |
| CN109939193A (en) | A kind of composition for treating skin eczema, preparation and preparation method and application | |
| CN112022767B (en) | Anti-inflammatory antibacterial immunity-enhancing acne-removing composition and application thereof | |
| CN104922051A (en) | Traditional Chinese medicine eye cream capable of relieving canthus wrinkles and eye pouches and preparation method thereof | |
| CN110339249B (en) | Traditional Chinese medicine composition for treating hemorrhoids and anal fissure as well as preparation method and application thereof | |
| CN106890120A (en) | A kind of Chinese medicine Whitening, spot breast and preparation method thereof | |
| CN106924134A (en) | A kind of Chinese medicine whitening spot-relieving cream and preparation method thereof | |
| CN106074959A (en) | Black-eyed Chinese medicine composition of a kind of alleviation and preparation method thereof | |
| CN103721138B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating rosacea | |
| CN105343660A (en) | Traditional Chinese medicinal preparation for treating peripheral vertigo and preparation method of traditional Chinese medicinal preparation | |
| CN108403932A (en) | A kind of Chinese medicine compound prescription external preparation and its preparation method and application for treating steroid dependent dermatitis | |
| CN1160091C (en) | Medicine for treating ophthalmopathy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120125 Termination date: 20140213 |