CN101214362A - Preparations for treating bacterial infection disease in fishes and preparation - Google Patents
Preparations for treating bacterial infection disease in fishes and preparation Download PDFInfo
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- CN101214362A CN101214362A CNA2007101919206A CN200710191920A CN101214362A CN 101214362 A CN101214362 A CN 101214362A CN A2007101919206 A CNA2007101919206 A CN A2007101919206A CN 200710191920 A CN200710191920 A CN 200710191920A CN 101214362 A CN101214362 A CN 101214362A
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Abstract
The present invention discloses a preparation for curing fish bacterial infectious disease. The raw materials include 100 to 300g of Chinese teasel root, 10 to 100g of Chinese arborvitae leafy twig, 2 to 20g of Chinese gall and 50 to 500g of garlic. The present invention also discloses a preparation method: 1. Chinese teasel root, Chinese arborvitae leafy twig, Chinese gall and garlic are taken; 2. garlic is mashed, squeezed to get the juice and filtered if necessary and the garlic juice is taken as the active component I; 3. Chinese gall is added with vitriol liquid for regurgitant hydrolyzation and filtration and the filtrate is neutralized to be the active component II; 4. Chinese teasel root and Chinese arborvitae leafy twig are added with ethanol for regurgitant hydrolyzation twice and the liquid after two regurgitant hydrolyzations is respectively filtered; the filtrate of two times is mixed and decompressed to recover ethanol and condensed to be the active component III; 5. the active component II is heated for crystal precipitation and the crystal is melted and poured into the active component III so as to get the component IV; after cooling, the active component I is gradually added into the active component IV and added with purified water so as to get the solution.
Description
Technical field
The present invention relates to a kind of preparation and preparation method for the treatment of bacterial infection disease in fishes.
Background technology
Antibiotic remains is subjected to the extensive concern of countries in the world, and people are not intended to picked-up to aquaculture products Chinese medicine is residual by consumer, and directly cause the worry and day sharp increase of harm humans health status.Developed countries such as European Union constantly reduce the MRL of agricultural and veterinary chemicals residuals, thereby reach limiting inlet, protect the purpose of national interests.Because China's fisheries drug is former all to be borrower, veterinary drug, is the extension on the medicinal way of people, animal, quality management system is unsound, thereby introduces concern because of the fisheries drug abuse causes cultured product drug residue problem in recent years in China's aquaculture.This has had a strong impact on China's aquatic products market development, makes China's aquaculture suffer economic loss, has also influenced the prestige of China's aquatic products.
Summary of the invention
The invention provides a kind of preparation for the treatment of bacterial infection disease in fishes and preparation method thereof.
The present invention has adopted following technical scheme: a kind of preparation for the treatment of bacterial infection disease in fishes, it makes solution by the reflux, extract, thing of following raw materials according or following raw materials according as active component, and its raw material consists of: Radix Et Rhizoma Rhei 100-300g, Cacumen Platycladi 10-100g, Galla Chinensis 2-20g and Bulbus Allii 50-500g.
Raw material of the present invention consists of: Radix Et Rhizoma Rhei 200g, Cacumen Platycladi 50g, Galla Chinensis 14g and Bulbus Allii 200g.Described reflux, extract, thing is the extract of ethanol or sulphuric acid liquid.
The present invention also can be a kind of preparation method for the treatment of the preparation of bacterial infection disease in fishes, and it may further comprise the steps: step 1 takes by weighing Radix Et Rhizoma Rhei 100-300g, Cacumen Platycladi 10-100g, Galla Chinensis 2-20g and Bulbus Allii 50-500g; Step 2 batters down into mud with Bulbus Allii, the extruding extracting juice, filter and remove residue in case of necessity, with Bulbus Allii juice cold preservation as being active component I; Step 3 is got Galla Chinensis and is added sulphuric acid liquid and carry out back hydrolysis, filters, and filtrate neutralizes the back as active component II; Step 4 is got Radix Et Rhizoma Rhei, Cacumen Platycladi adds alcohol reflux 2 times, and the liquid after twice backflow is filtered respectively, merges 2 times filtrate, decompression recycling ethanol, and concentrate, concentrate the back as active component III; Step 5, II heats with active component, and the crystallization of separating out is dissolved, and pours among the active component III, obtains composition IV, puts active component I slowly to be joined among the active component IV after cold, adds purified water and makes solution.
Sulphuric acid liquid is 5 times of amounts in the step 3 of the present invention, and the concentration of sulphuric acid liquid is 2.8mol/L.The time of back hydrolysis is 3h in the step 3 of the present invention, and it is 5 that filtrate is neutralized to pH value.The ethanol that refluxes in the step 4 of the present invention is 70% ethanol, and the number of times of backflow is 2 times, adds 5 times of amounts for the first time, soaks 1h, and backflow 2h adds 3 times of amounts for the second time, backflow 1h, and the weight after step 4 filtrate of the present invention concentrates is 4.5 times of Radix Et Rhizoma Rhei weight.The capacity of purified water is 1000ML in the step 5 of the present invention.
The present invention can treat bacterial infection diseases such as Fish septicemia, gill rot, skin fester disease, tail-rot disease, erythroderma, vibriosis and enteritis.The application of Chinese herb medicine in aquaculture that the present invention adopts Chinese herbal medicine to make, it can avoid destroying the aquatic animal ecological balance, and it is residual to prevent that medicine from producing; Prophylactic treatment is effective, can protect water area ecological environment.
The specific embodiment
The present invention is a kind of preparation method for the treatment of the preparation of bacterial infection disease in fishes.
Embodiment one: step 1 takes by weighing Radix Et Rhizoma Rhei 200g, Cacumen Platycladi 50g, Galla Chinensis 14g and Bulbus Allii 200g; Step 2 batters down into mud with Bulbus Allii, the extruding extracting juice, and filter and remove residue in case of necessity, Bulbus Allii juice cold preservation is as being active component I; Step 3 is got Galla Chinensis, and it is 3h that the sulphuric acid liquid that to add 5 times of amounts, concentration in Galla Chinensis be 2.8mol/L carries out back hydrolysis, filters, and filtrate neutralization is neutralized to behind the PH=5 as active component II; Step 4 is got Radix Et Rhizoma Rhei, Cacumen Platycladi and is added 70% alcohol reflux 2 times, adds 5 times of amounts for the first time, soaks 1h, backflow 2h filters, and adds 3 times of amounts, backflow 1h for the second time, filter, merge 2 times filtrate, decompression recycling ethanol, and be concentrated into 4.5 times of Radix Et Rhizoma Rhei weight as active component III.Step 5, II heats with active component, and the crystallization of separating out is dissolved, and pours among the active component III, obtains active component IV, puts active component I slowly to be joined among the active component IV after cold, adds purified water and makes solution to 1000ML.
Embodiment two: step 1 takes by weighing Radix Et Rhizoma Rhei 250g, Cacumen Platycladi 80g, Galla Chinensis 16g and Bulbus Allii 250g; Step 2 batters down into mud with Bulbus Allii, the extruding extracting juice, and filter and remove residue in case of necessity, Bulbus Allii juice cold preservation is as being active component I; Step 3 is got Galla Chinensis, and it is 3h that the sulphuric acid liquid that to add 5 times of amounts, concentration in Galla Chinensis be 2.8mol/L carries out back hydrolysis, filters, and filtrate neutralization is neutralized to behind the PH=5 as active component II; Step 4 is got Radix Et Rhizoma Rhei, Cacumen Platycladi and is added 70% alcohol reflux 2 times, adds 5 times of amounts for the first time, soaks 1h, backflow 2h filters, and adds 3 times of amounts, backflow 1h for the second time, filter, merge 2 times filtrate, decompression recycling ethanol, and be concentrated into 4.5 times of Radix Et Rhizoma Rhei weight as active component III.Step 5, II heats with active component, and the crystallization of separating out is dissolved, and pours among the active component III, obtains active component IV, puts active component I slowly to be joined among the active component IV after cold, adds purified water and makes solution to 1000ML.
The present invention makes solution by the reflux, extract, thing of following raw materials according or following raw materials according as active component, and its raw material consists of: Radix Et Rhizoma Rhei 100-300g, Cacumen Platycladi 10-100g, Galla Chinensis 2-20g and Bulbus Allii 50-500g.
The present invention adds with 0.1% forage volume, earlier the water of this product with 10 times is diluted, and gradation mixes with feedstuff then, evenly mix raise for oral administration.Once a day, logotype three days was a course of treatment.
Claims (9)
1. preparation for the treatment of bacterial infection disease in fishes, it makes solution by the reflux, extract, thing of following raw materials according or following raw materials according as active component, and its raw material consists of:
Radix Et Rhizoma Rhei 100-300g, Cacumen Platycladi 10-100g, Galla Chinensis 2-20g and Bulbus Allii 50-500g.
2. the preparation of treatment bacterial infection disease in fishes according to claim 1 is characterized in that raw material consists of: Radix Et Rhizoma Rhei 200g, Cacumen Platycladi 50g, Galla Chinensis 14g and Bulbus Allii 200g.
3. the preparation of treatment bacterial infection disease in fishes according to claim 1 is characterized in that described reflux, extract, thing is the extract of ethanol or sulphuric acid liquid.
4. preparation method for the treatment of the preparation of bacterial infection disease in fishes, it may further comprise the steps:
Step 1 takes by weighing Radix Et Rhizoma Rhei 100-300g, Cacumen Platycladi 10-100g, Galla Chinensis 2-20g and Bulbus Allii 50-500g;
Step 2 batters down into mud with Bulbus Allii, the extruding extracting juice, filter and remove residue in case of necessity, with Bulbus Allii juice cold preservation as being active component I;
Step 3 is got Galla Chinensis and is added sulphuric acid liquid and carry out back hydrolysis, filters, and filtrate neutralizes the back as active component II;
Step 4 is got Radix Et Rhizoma Rhei, Cacumen Platycladi adds alcohol reflux 2 times, and the liquid after twice backflow is filtered respectively, merges 2 times filtrate, decompression recycling ethanol, and concentrate, concentrate the back as active component III;
Step 5, II heats with active component, and the crystallization of separating out is dissolved, and pours among the active component III, obtains composition IV, puts active component I slowly to be joined among the active component IV after cold, adds purified water and makes solution.
5. the preparation method of the preparation of treatment bacterial infection disease in fishes according to claim 4 is characterized in that sulphuric acid liquid is 5 times of amounts in the step 3, and the concentration of sulphuric acid liquid is 2.8mol/L.
6. the preparation method of the preparation of treatment bacterial infection disease in fishes according to claim 4, the time that it is characterized in that back hydrolysis in the step 3 is 3h, it is 5 that filtrate is neutralized to pH value.
7. the preparation method of the preparation of treatment bacterial infection disease in fishes according to claim 4 is characterized in that the ethanol that refluxes in the step 4 is 70% ethanol, and the number of times of backflow is 2 times, add for the first time 5 times of amounts, soak 1h, backflow 2h, add for the second time 3 times of amounts, backflow 1h.
8. the preparation method of the preparation of treatment bacterial infection disease in fishes according to claim 4 is characterized in that weight after step 4 filtrate concentrates is 4.5 times of Radix Et Rhizoma Rhei weight.
9. the preparation method of the preparation of treatment bacterial infection disease in fishes according to claim 4, the capacity that it is characterized in that purified water in the step 5 is 1000ML.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101919206A CN101214362A (en) | 2007-12-27 | 2007-12-27 | Preparations for treating bacterial infection disease in fishes and preparation |
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| CNA2007101919206A CN101214362A (en) | 2007-12-27 | 2007-12-27 | Preparations for treating bacterial infection disease in fishes and preparation |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225077A (en) * | 2011-06-23 | 2011-10-26 | 广西壮族自治区中国科学院广西植物研究所 | Application of Chinese gall extract for controlling streptococcal disease in aquaculture animals |
| CN102552647A (en) * | 2011-03-16 | 2012-07-11 | 李勇军 | Traditional Chinese medicine preparation for treating canine parvoviral enteritis and preparation method of traditional Chinese medicine preparation |
| CN103272005A (en) * | 2013-06-04 | 2013-09-04 | 江苏中洋集团股份有限公司 | Preparation method and application of Chinese herbal medicine for ecologically preventing and treating Australia dragon spot saprolegniasis |
| CN104026394A (en) * | 2014-06-09 | 2014-09-10 | 安徽省肥东县管湾水产养殖场 | Soybean formula feed for mandarin fishes and preparation method of feed |
| CN104258008A (en) * | 2014-09-25 | 2015-01-07 | 浙江海洋学院 | Composition for treating bacterial gill-rot disease of fancy carp |
| CN104258071A (en) * | 2014-09-25 | 2015-01-07 | 浙江海洋学院 | Composition for treating parasite-caused gill-rot disease of fancy carp |
| CN104983845A (en) * | 2015-06-24 | 2015-10-21 | 河北科技师范学院 | Traditional herbal medicine for treating marine fish skin canker |
| CN105249003A (en) * | 2015-10-29 | 2016-01-20 | 青岛海之源智能技术有限公司 | Feed additive for preventing stigmatosis of Siamese fighting fish and preparation method thereof |
| CN105327305A (en) * | 2015-10-29 | 2016-02-17 | 青岛海之源智能技术有限公司 | Environment-friendly preparation treating betta splendens stigmatosis and preparation method thereof |
| CN105327318A (en) * | 2015-11-27 | 2016-02-17 | 青岛海之源智能技术有限公司 | Feed additive for preventing and treating bacterial gill-rot disease of ictalurus punctatus and preparation method of feed additive |
| CN105327319A (en) * | 2015-11-27 | 2016-02-17 | 青岛海之源智能技术有限公司 | Tincture for treating bacterial gill-rot disease of channel catfish and preparation method thereof |
| CN105396097A (en) * | 2015-11-27 | 2016-03-16 | 青岛海之源智能技术有限公司 | Compound preparation capable of preventing and treating channel catfish bacterial gill-rot disease and preparation method of compound preparation |
| CN106492109A (en) * | 2016-10-28 | 2017-03-15 | 青岛海之星生物科技有限公司 | A kind of compound preparation for treating Paralichthys olivaceuss infectiousness intestinal nebulousurine disease and preparation method thereof |
-
2007
- 2007-12-27 CN CNA2007101919206A patent/CN101214362A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552647A (en) * | 2011-03-16 | 2012-07-11 | 李勇军 | Traditional Chinese medicine preparation for treating canine parvoviral enteritis and preparation method of traditional Chinese medicine preparation |
| CN102552647B (en) * | 2011-03-16 | 2013-12-04 | 李勇军 | Traditional Chinese medicine preparation for treating canine parvoviral enteritis and preparation method of traditional Chinese medicine preparation |
| CN102225077B (en) * | 2011-06-23 | 2013-02-13 | 广西壮族自治区中国科学院广西植物研究所 | Application of Chinese gall extract for controlling streptococcal disease in aquaculture animals |
| CN102225077A (en) * | 2011-06-23 | 2011-10-26 | 广西壮族自治区中国科学院广西植物研究所 | Application of Chinese gall extract for controlling streptococcal disease in aquaculture animals |
| CN103272005A (en) * | 2013-06-04 | 2013-09-04 | 江苏中洋集团股份有限公司 | Preparation method and application of Chinese herbal medicine for ecologically preventing and treating Australia dragon spot saprolegniasis |
| CN104026394B (en) * | 2014-06-09 | 2016-03-30 | 安徽省肥东县管湾水产养殖场 | A kind of mandarin fish soy formulations feed and preparation method thereof |
| CN104026394A (en) * | 2014-06-09 | 2014-09-10 | 安徽省肥东县管湾水产养殖场 | Soybean formula feed for mandarin fishes and preparation method of feed |
| CN104258008A (en) * | 2014-09-25 | 2015-01-07 | 浙江海洋学院 | Composition for treating bacterial gill-rot disease of fancy carp |
| CN104258071A (en) * | 2014-09-25 | 2015-01-07 | 浙江海洋学院 | Composition for treating parasite-caused gill-rot disease of fancy carp |
| CN104983845A (en) * | 2015-06-24 | 2015-10-21 | 河北科技师范学院 | Traditional herbal medicine for treating marine fish skin canker |
| CN104983845B (en) * | 2015-06-24 | 2018-01-26 | 河北科技师范学院 | Treat the Chinese herbal medicine of seawater fish skin ulcer |
| CN105327305A (en) * | 2015-10-29 | 2016-02-17 | 青岛海之源智能技术有限公司 | Environment-friendly preparation treating betta splendens stigmatosis and preparation method thereof |
| CN105249003A (en) * | 2015-10-29 | 2016-01-20 | 青岛海之源智能技术有限公司 | Feed additive for preventing stigmatosis of Siamese fighting fish and preparation method thereof |
| CN105327318A (en) * | 2015-11-27 | 2016-02-17 | 青岛海之源智能技术有限公司 | Feed additive for preventing and treating bacterial gill-rot disease of ictalurus punctatus and preparation method of feed additive |
| CN105327319A (en) * | 2015-11-27 | 2016-02-17 | 青岛海之源智能技术有限公司 | Tincture for treating bacterial gill-rot disease of channel catfish and preparation method thereof |
| CN105396097A (en) * | 2015-11-27 | 2016-03-16 | 青岛海之源智能技术有限公司 | Compound preparation capable of preventing and treating channel catfish bacterial gill-rot disease and preparation method of compound preparation |
| CN106492109A (en) * | 2016-10-28 | 2017-03-15 | 青岛海之星生物科技有限公司 | A kind of compound preparation for treating Paralichthys olivaceuss infectiousness intestinal nebulousurine disease and preparation method thereof |
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Open date: 20080709 |