CN101209310A - Compound Chinese medicinal injection for treating mastitis of cow - Google Patents
Compound Chinese medicinal injection for treating mastitis of cow Download PDFInfo
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- CN101209310A CN101209310A CNA2006101305337A CN200610130533A CN101209310A CN 101209310 A CN101209310 A CN 101209310A CN A2006101305337 A CNA2006101305337 A CN A2006101305337A CN 200610130533 A CN200610130533 A CN 200610130533A CN 101209310 A CN101209310 A CN 101209310A
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Abstract
The invention relates to a traditional Chinese medicine compound injection for the treatment of dairy cow mastitis, including three medicines of largetrifoliolious bugbane rhizome, rhubarb and heartleaf houttuynia herb. The invention has the effects of clearing heat, removing toxicity, promoting lactation and resolving masses. The indications are breast swelling, red swelling and pain, reduced milk secretion, no milk, the milk containing bacteria, curds and flocculation precipitation, body temperature rise and other symptoms which are caused by breast infection, mechanical bruise, breast duct stoppage and other reasons. The invention can be prepared into the injection by the combination of the special physiological structure of dairy cows, and the invention can be absorbed rapidly after administration, so as to achieve the purpose of rapid onset of action.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of herbal mixture injection that is used for the treatment of mammitis of cow.
Background technology
Mastitis is one of modal disease of milch cow, 20%～60% mastitis all took place through milking cow.After the breast inflammation, lactogenic reduces, and milk is rotten.Inflammation finally can be destroyed mammary gland tissue, makes its part or all of breast forfeiture lactogenic function.The generation of primary disease and accumulation of stomach-heat and hepatic depression have the pass.Antibiotic therapy is the most general Therapeutic Method at present, and medicine commonly used has penicillin, streptomycin, gentamycin etc.Because the kind complexity of mastitis pathogenic bacterium needs these medicines are made up and the excess use, still usually, by this method after the treatment, the residual a large amount of antibiotics of meeting in the milk that milch cow is extruded, according to state health standards, the milk unable to drink that milch cow is produced in 7 days behind antibiotic therapy is used.And life-time service antibiotics causes the appearance of Resistant strain easily, can influence the therapeutic effect to cattle, the person's that also is unfavorable for the milk drink health.If use the Chinese herbal treatment mammitis of cow can overcome these shortcomings of antibiotic, but the Chinese herbal medicine dosage form that present milch cow is used mostly is powder, and its shortcoming is that abnormal smells from the patient is dense, is difficult for absorbing, and uses inconvenient.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind of herbal mixture injection that is used for the treatment of mammitis of cow.
The object of the present invention is achieved like this: a kind of Chinese traditional compound medicine that is used for the treatment of mammitis of cow is characterized in that: Rhizoma Cimicifugae 3-5 part, Radix Et Rhizoma Rhei 2-4 part, Herba Houttuyniae 4-6 part.
Be preferably: 4 parts of Rhizoma Cimicifugaes, 3 parts of Radix Et Rhizoma Rhei, 6 parts of Herba Houttuyniae.
A kind of Chinese traditional compound medicine that is used for the treatment of mammitis of cow is characterized in that: the dosage form of described Chinese traditional compound medicine is an injection.
According to the dialectical improvement opinion of executing of the traditional Chinese medical science, Rhizoma Cimicifugae has the effect of the rash of delivering, heat-clearing and toxic substances removing, ascending up spleen-Qi and Yang." book on Chinese herbal medicine converges and says " claims " pathogen of all wind and cold, fever without perspiration; The heresy of wind heat, wind syndrome of head are attacked pain, and swollen red, the tonsillitis larynx of order disease expands, and Rhizoma Cimicifugae is also all controlled it." modern study shows: Rhizoma Cimicifugae has analgesic, calm, blood pressure lowering and convulsion and inhibition tubercule bacillus, dermatophytes, plasmodial effect.
Herba Houttuyniae " wooden careless detailed outline " claims can " malicious carbuncle dispels the heat ", and " Bencao Jingshu " claims it " control phlegm-heat obstructing in the lung, send out be lung abscess vomiting pus key medicine ".Modern study shows: the Herba Houttuyniae herb contains volatile oil 0.0049%, contain houttuynine sodium bisulfite (being decanoylacetaldehyde) methyl n nonyl ketone, lauryl aldehyde, capraldehyde, capric acid and potassium chloride, potassium sulfate and quercitrin in the oil, houttuynine sodium bisulfite (decanoylacetaldehyde), staphylococcus aureus and Resistant strain, streptococcus pneumoniae, alpha streptococcus, hemophilus influenza, micrococcus catarrhalis, Bacillus typhi and tubercule bacillus etc. are all had in various degree inhibitory action, are 62.5～80 μ g/ml to the minimal inhibitory concentration (MIC) of staphylococcus aureus and Resistant strain thereof; A large amount of potassium salt and the expansible kidney blood vessel of quercitrin improve renal blood flow and a diuresis.That Herba Houttuyniae has is antibiotic, antiinflammatory, diuresis, analgesia, hemostasis, antitussive action; Have the enhancing human body immunity function, can obviously promote the leukocytes phagocytic ability, improve rabbit anteserum properdin level; Obviously improve blood and apoplexy due to phlegm lyase vigor; Other still have calmness, anti-frightened effect.Be mainly used in lung abscess clinically, dysentery, acute mastitis, stranguria with turbid discharge.
Radix Et Rhizoma Rhei is good at cleansing the intestines and stomach excess-heat, and dryness accumulated in the stomach and intestine is stagnant, is the key medicine that bitter cold is captured, and can rush down down, purges heat blood circulation promoting and blood stasis dispelling; But Qinghua is damp and hot again.
We are the plus-minus side of " Shengji Zonglu " Cimicifugae Decoction, and Rhizoma Cimicifugae heat-clearing and toxic substances removing in the side is warded off warm disease, principal agent in the dissipation carbuncle sore side of being; Herba Houttuyniae heat-clearing and toxic substances removing, detumescence and apocenosis are accessory drugs, the Radix Et Rhizoma Rhei bitter cold, and purging heat to relax the bowels, cleansing the stagnant stagnation of pathogenic heat of the intestines and stomach is adjuvant drug, all medicine compatibilities are played heat-clearing and toxic substances removing altogether, removing blood stasis evacuation of pus, the effect of lactogenesis eliminating stagnation.
The present invention adopts the industry method in common to make: get Radix Et Rhizoma Rhei, Rhizoma Cimicifugae coarse powder (or fragment) and add injection water wetness impregnation one hour, decocted filtration 40～60 minutes, residue adds water for injection again and decocts secondary, merging filtrate, and evaporation and concentration is to syrupy shape, add 2～3 times of amount 95% ethanol, fully stir, place more than 12 hours, filter, disgorging reclaims ethanol, add ethanol 2～3 times till do not have a precipitation by last method, put freezer cold preservation more than 24 hours, filter, standby; Get Herba Houttuyniae, add the injection water, extract with the way of distillation, collect distillate, merge with above-mentioned filtrate, add benzyl alcohol, tween 80, be diluted to 1000 milliliters with water for injection, mixing left standstill 12 hours, filter, and packing, embedding, 100 ℃ of sterilizations in 30 minutes are promptly.
Below with concrete description of test effect of the present invention:
1 material and method
1.1 test drug
Medicine main component Rhizoma Cimicifugae of the present invention, Radix Et Rhizoma Rhei, Herba Houttuyniae, recommended dose is the 0.1ml/kg body weight, intramuscular injection; The contrast medicine is a palace breast chain, and Xinxiang City animal pharmaceutical factory produces, and lot number is 20030201.
1.2 experimental animal
Epidemic situation takes place one time in cattle farm, city, Hai'an, Jiangsu Province in February, 2003.The morbidity of nearly 70 cow heads, clinical symptoms breast all or a side redness, burning pain, mammary gland is hard, the refusal young stock is sucked the breast.For sleeping in less, lazyness is walked, and back leg opens stands.Severe patient, coma lack of appetite, even useless food, body temperature promotion, dry mouth and tougue.Dark coloured urine is short, full and rapid pulse.Breast amount descends and degeneration is light brown or yellowish-brown, and the sheet or the blood streak of coagulating arranged.According to comprehensive diagnos such as epidemiology, clinical symptoms, microbiology and Serological testings is mammitis of cow.
1.3 EXPERIMENTAL DESIGN
Select at random this cattle farm body weight be 60 of the ill milch cows of 300 ± 50kg pathological state basically identical as experimental animal, be divided into six test group.Test one group and be medicine high dose group of the present invention (per kilogram of body weight injection 0.2ml); Test two groups and be dosage group in the medicine of the present invention (per kilogram of body weight injection 0.1ml); Test three groups and be medicine low dose group of the present invention (per kilogram of body weight injection 0.025ml); Testing four groups is newborn indoor perfusion (10 milliliters/newborn chamber); Testing five groups is palace breast chain matched group (per kilogram of body weight injection 0.5ml); Test six groups and be not administration matched group; It is 20 of 300 ± 50kg healthy cows that alternative is selected body weight, and being divided into two experimental grouies is respectively test seven groups of (the not administration of not falling ill) and eight groups (safe dose groups) of test.Make a definite diagnosis and tested one group, two groups, three groups and five groups the same day by each group dosage intramuscular injection; Test the indoor perfusion administration of four groups of breasts; The safe dose group is the multi-point injection administration.Each test group cattle feedstuff is identical, and other management all are consistent.Grouping sees Table 1
1.3 test method
Treat by table 1 pair morbidity milk beef injection or the perfusion administration of newborn chamber, successive administration 3-5 days, observe situations such as suffering from cattle clinical change, healing, improvement, body temperature every day, the line item of going forward side by side.
1.4 curative effect determinate standard
1.4.1 inefficiency: typical mammitis of cow clinical symptoms appears in duration of test, does not feel any better after the medication or the state of an illness increases the weight of the ratio that milch cow accounts for this group milch cow.
1.4.2 cure rate: spirit, appetite, clinical symptoms are recovered the ratio that normal milch cow accounts for this group milch cow fully after the off-test.
Effective percentage: the milch cow that spirit, appetite, clinical symptoms are clearly better after the off-test accounts for the ratio of this group milch cow.
1.5 the analyzing and processing of data
Carry out the significance test of data with biometrics.
Table 1 medicine of the present invention is to the therapeutic test of mammitis of cow
2 results
Sick milch cow therapeutic outcome sees Table 2
Table 2 clinical test results
2.1 inefficiency
Each medication group is compared, and medicine intramuscular injection height of the present invention, middle dosage group and breast perfusion group inefficiency are lower, are 10%.Statistical analysis shows that medicine height of the present invention, middle dosage group and breast perfusion group mortality rate significantly are lower than the mortality rate (p＜0.05) that infects matched group.
2.2 cure rate and effective percentage
Medicine intramuscular injection height of the present invention, middle dosage group and breast perfusion group cure rate are higher, are 80%.Above-mentioned two groups effective percentage is also higher, is 90%.Cure rate, the effective percentage of medicine low dose group of the present invention are relatively low.
2.2.3 Comparison of therapeutic
The inefficiency of medicine intramuscular injection low dose group of the present invention, medicine matched group is compared relative higher with medicine intramuscular injection height of the present invention, middle dosage group.Dosage group cure rate is all identical with effective percentage in breast perfusion group and the medicine intramuscular injection of the present invention.
3 discuss
3.1 curative effect of medication of the present invention
Medicine of the present invention is that the ill milch cow of mastitis has excellent curative to suffering from clinical manifestation, can obviously alleviate the clinical slight illness because of ill milch cow due to a variety of causes, shortens the disease persistent period, improves the cure rate of eqpidemic disease.The cure rate of intramuscular injection height, middle dosage group and breast perfusion group all is 90%, so clinical recommended dose is intramuscular injection: 0.05～0.1ml/kg body weight; The indoor perfusion of breast: each newborn chamber 5～10ml.
3.2 safety testing
Show through safety testing (5 times of drug administration by injection of recommended dose, logotype 3 days), do not see clinical unusual performance between the operating period, healthy cow is not had obvious influence, illustrate that this preparation is safe healthy cow.
Beneficial effect: medicine of the present invention is used for the treatment of mammitis of cow, has the effect of heat-clearing and toxic substances removing, lactogenesis eliminating stagnation, and the special physiological structure in conjunction with milch cow is made into injection, effectively raises bioavailability of medicament, has improved the cure rate of disease.
The specific embodiment
Embodiment 1: 3 parts of Rhizoma Cimicifugaes, 2 parts of Radix Et Rhizoma Rhei, 4 parts of Herba Houttuyniae.Get Radix Et Rhizoma Rhei, Rhizoma Cimicifugae coarse powder (or fragment) and add injection water wetness impregnation one hour, decocted filtration 40～60 minutes, residue adds water for injection again and decocts secondary, merging filtrate, and evaporation and concentration is to syrupy shape, add 2～3 times of amount 95% ethanol, fully stir, place more than 12 hours, filter, disgorging reclaims ethanol, add ethanol 2～3 times till do not have a precipitation by last method, put freezer cold preservation more than 24 hours, filter, standby; Get Herba Houttuyniae, add the injection water, extract with the way of distillation, collect distillate, merge with above-mentioned filtrate, add benzyl alcohol, tween 80, be diluted to 1000 milliliters with water for injection, mixing left standstill 12 hours, filter, and packing, embedding, 100 ℃ of sterilizations in 30 minutes are promptly.
Has heat-clearing and toxic substances removing, the effect of lactogenesis eliminating stagnation.Cure mainly that breast infection, machinery squeeze to be hindered, milk duct is obstructed and other reasons causes breast swelling, congestion and swelling pain, contains symptoms such as antibacterial, ziega, flocculent deposit, fervescence in lactogenic minimizing, agalactia, the milk.Intramuscular injection: once measure per 1 kg body weight 0.05-0.1 milliliter, every day 1-2 time, logotype 3-5 day; The indoor perfusion of Lac Bovis seu Bubali: once measure, each newborn chamber 5-10 milliliter, once a day, logotype 2-3 day; Perfusion in the cattle uterus: amount once, the 15-20 milliliter, the next day once, logotype 2-3 time.
Embodiment 2: 4 parts of Rhizoma Cimicifugaes, 3 parts of Radix Et Rhizoma Rhei, 6 parts of Herba Houttuyniae.Get Radix Et Rhizoma Rhei, Rhizoma Cimicifugae coarse powder (or fragment) and add injection water wetness impregnation one hour, decocted filtration 40～60 minutes, residue adds water for injection again and decocts secondary, merging filtrate, and evaporation and concentration is to syrupy shape, add 2～3 times of amount 95% ethanol, fully stir, place more than 12 hours, filter, disgorging reclaims ethanol, add ethanol 2～3 times till do not have a precipitation by last method, put freezer cold preservation more than 24 hours, filter, standby; Get Herba Houttuyniae, add the injection water, extract with the way of distillation, collect distillate, merge with above-mentioned filtrate, add benzyl alcohol, tween 80, be diluted to 1000 milliliters with water for injection, mixing left standstill 12 hours, filter, and packing, embedding, 100 ℃ of sterilizations in 30 minutes are promptly.
Has heat-clearing and toxic substances removing, the effect of lactogenesis eliminating stagnation.Cure mainly that breast infection, machinery squeeze to be hindered, milk duct is obstructed and other reasons causes breast swelling, congestion and swelling pain, contains symptoms such as antibacterial, ziega, flocculent deposit, fervescence in lactogenic minimizing, agalactia, the milk.Intramuscular injection: once measure per 1 kg body weight 0.05-0.1 milliliter, every day 1-2 time, logotype 3-5 day; The indoor perfusion of Lac Bovis seu Bubali: once measure, each newborn chamber 5-10 milliliter, once a day, logotype 2-3 day; Perfusion in the cattle uterus: amount once, the 15-20 milliliter, the next day once, logotype 2-3 time.
Embodiment 3: 5 parts of Rhizoma Cimicifugaes, 4 parts of Radix Et Rhizoma Rhei, 6 parts of Herba Houttuyniae.Get Radix Et Rhizoma Rhei, Rhizoma Cimicifugae coarse powder (or fragment) and add injection water wetness impregnation one hour, decocted filtration 40～60 minutes, residue adds water for injection again and decocts secondary, merging filtrate, and evaporation and concentration is to syrupy shape, add 2～3 times of amount 95% ethanol, fully stir, place more than 12 hours, filter, disgorging reclaims ethanol, add ethanol 2～3 times till do not have a precipitation by last method, put freezer cold preservation more than 24 hours, filter, standby; Get Herba Houttuyniae, add the injection water, extract with the way of distillation, collect distillate, merge with above-mentioned filtrate, add benzyl alcohol, tween 80, be diluted to 1000 milliliters with water for injection, mixing left standstill 12 hours, filter, and packing, embedding, 100 ℃ of sterilizations in 30 minutes are promptly.
Has heat-clearing and toxic substances removing, the effect of lactogenesis eliminating stagnation.Cure mainly that breast infection, machinery squeeze to be hindered, milk duct is obstructed and other reasons causes breast swelling, congestion and swelling pain, contains symptoms such as antibacterial, ziega, flocculent deposit, fervescence in lactogenic minimizing, agalactia, the milk.Intramuscular injection: once measure per 1 kg body weight 0.05-0.1 milliliter, every day 1-2 time, logotype 3-5 day; The indoor perfusion of Lac Bovis seu Bubali: once measure, each newborn chamber 5-10 milliliter, once a day, logotype 2-3 day; Perfusion in the cattle uterus: amount once, the 15-20 milliliter, the next day once, logotype 2-3 time.
Claims (3)
1. a Chinese traditional compound medicine that is used for the treatment of mammitis of cow is characterized in that: Rhizoma Cimicifugae 3-5 part, Radix Et Rhizoma Rhei 2-4 part, Herba Houttuyniae 4-6 part.
2. a kind of Chinese traditional compound medicine that is used for the treatment of mammitis of cow according to claim 1 is characterized in that optimizing prescriptions of the present invention is: 4 parts of Rhizoma Cimicifugaes, 3 parts of Radix Et Rhizoma Rhei, 6 parts of Herba Houttuyniae.
3. a kind of Chinese traditional compound medicine that is used for the treatment of mammitis of cow according to claim 1 is characterized in that: the dosage form of described Chinese traditional compound medicine is an injection.
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| CNA2006101305337A CN101209310A (en) | 2006-12-25 | 2006-12-25 | Compound Chinese medicinal injection for treating mastitis of cow |
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| CNA2006101305337A CN101209310A (en) | 2006-12-25 | 2006-12-25 | Compound Chinese medicinal injection for treating mastitis of cow |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257913A (en) * | 2014-09-17 | 2015-01-07 | 黑龙江省兽医科学研究所 | Traditional Chinese medicine concentrated solution for treating cow mastitis and coating agent prepared from concentrated solution |
| CN105030926A (en) * | 2015-07-10 | 2015-11-11 | 陕西溯源农业发展有限公司 | Preparation method of compound Chinese herb and extract thereof for treating bovine mastitis |
-
2006
- 2006-12-25 CN CNA2006101305337A patent/CN101209310A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257913A (en) * | 2014-09-17 | 2015-01-07 | 黑龙江省兽医科学研究所 | Traditional Chinese medicine concentrated solution for treating cow mastitis and coating agent prepared from concentrated solution |
| CN105030926A (en) * | 2015-07-10 | 2015-11-11 | 陕西溯源农业发展有限公司 | Preparation method of compound Chinese herb and extract thereof for treating bovine mastitis |
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Open date: 20080702 |