CN101209291A - Chinese medicine injection for animals with heat-clearing, detoxication wind-heat-removing efficacy - Google Patents
Chinese medicine injection for animals with heat-clearing, detoxication wind-heat-removing efficacy Download PDFInfo
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- CN101209291A CN101209291A CNA2006101305445A CN200610130544A CN101209291A CN 101209291 A CN101209291 A CN 101209291A CN A2006101305445 A CNA2006101305445 A CN A2006101305445A CN 200610130544 A CN200610130544 A CN 200610130544A CN 101209291 A CN101209291 A CN 101209291A
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Abstract
The invention relates to a veterinary traditional Chinese medicine injection which has the effects of clearing heat, removing toxicity and clearing heat and wind-heat, and the invention includes three medicines of honeysuckle flower, largetrifoliolious bugbane rhizome and baical skullcap root. The medicine of the invention has the effects of clearing heat, removing toxicity and clearing heat and wind-heat. The invention is applicable to the infections which are caused by virus and bacteria. The medicine is prepared into the injection by the combination of the special physiological structure of the livestock and poultry, and the invention can be absorbed rapidly after muscle injection, so as to achieve the purpose of rapid onset of action.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to and a kind ofly have heat-clearing and toxic substances removing, declare the Chinese medicine for animals of wind heat effect clearly.
Background technology
Antibacterial, viral disease are one of principal diseases of harm aquaculture always, have caused serious economy loss to aquaculture.Because it is uncertain that some antibacteriums commonly used clinically, viral medication are imitated, therefore clinically conservative treatment and serum therapies of adopting more.In recent years, after viral infection took place poultry, traditional conservative treatment is owing to following reason also has been subjected to certain restriction: 1) effective percentage was low.2) generation of Resistant strain.3) drug residue is to the mankind's influence.4) outlet group is to the residual control of medicine.More than these reasons make the application of Chinese medicine on domestic animal have vast market prospect,
Use at present treatment by Chinese herbs poultry antibacterial, viral disease more and more general, but the Chinese medicine preparation of Shi Yonging mostly is powder clinically, because of its dissolubility relatively poor, abnormal smells from the patient is big, exist difficulties such as administration inconvenience, therefore the drug bioavailability that causes is poor, and consumption is big, has caused the shortcomings such as waste of medical material.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind ofly to have heat-clearing and toxic substances removing, declares the Chinese medicine for animals of wind heat effect clearly.
The object of the present invention is achieved like this: a kind ofly have heat-clearing and toxic substances removing, declare the Chinese medicine preparation for animals of wind heat effect clearly, it is characterized in that Flos Lonicerae 2-5 part, Rhizoma Cimicifugae 2-4 part, Radix Scutellariae 4-8 part.
Be preferably: 3 parts of Flos Loniceraes, 2 parts of Rhizoma Cimicifugaes, 5 parts of Radix Scutellariaes.
A kind ofly have heat-clearing and toxic substances removing, declare the Chinese medicine preparation for animals of wind heat effect clearly, it is characterized in that: the dosage form of described Chinese medicine preparation for animals is an injection.
Medicine of the present invention is to extract the refining pure Chinese medicine injection that forms by Flos Lonicerae, Radix Scutellariae, Rhizoma Cimicifugae, has heat-clearing and toxic substances removing, declares the effect of wind heat clearly.Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication in the side, inhibited to Bacillus typhi, dysentery bacterium, bacillus pyocyaneus, staphylococcus, influenza virus etc.; Flos Lonicerae heat-clearing and toxic substances removing, expelling wind and cold have antibiotic, antivirus action; Rhizoma Cimicifugae is delivered rash, heat-clearing and toxic substances removing, ascending up spleen-Qi and Yang, has analgesic, analgesia, blood pressure lowering and anticonvulsant action.All medicines share and can play broad-spectrum antiseptic, antivirus action, and have refrigeration function, are applicable to the heating that viral influenza, pneumonia and respiratory tract infection cause.
The present invention adopts the industry method in common to make: extracting honeysuckle, Radix Scutellariae, Rhizoma Cimicifugae, add 5～6 times of water gagings, and decocted 1 hour, filter, collect filtrate.Residue adds 2 times of water gagings again and decocts 1 time, filters, and merges twice filtrate and be concentrated into syrupy shape in water-bath, adds 3 times of amount 95% ethanol, stir, placed 24 hours, filter, filtrate recycling ethanol is concentrated into syrupy shape, adds 3 times of amount 95% ethanol again, stir, place a night, filter, filtrate recycling ethanol adds the injection water and stirs evenly filtration to 100ml, fill, sterilization, promptly.
Below with concrete description of test effect of the present invention:
1 material and method
1.1 test drug
Medicine main component of the present invention is Flos Lonicerae, Rhizoma Cimicifugae, Radix Scutellariae, and recommended dose is the 0.1ml/kg body weight, intramuscular injection; The control drug astragalin injection, Harbin animal pharmaceutical factory produces, and lot number is 20030201.
1.2 experimental animal
Yancheng City pig farm, Jiangsu have approximately 300 1 age in week the pig natural occurrence, the piglet classical symptom is vomiting to occur earlier, with or then be watery diarrhea, body weight descends rapidly, dewaters to be feature.Often contain indigested ziega in the serious diarrhoea piglet feces, abnormal smells from the patient is stench.All there is the popular medical history of transmissible gastroenteritis of swine for many years on this pig farm.According to comprehensive diagnos such as epidemiology, clinical symptoms, microbiology and Serological testings is transmissible gastroenteritis of swine.
1.3 EXPERIMENTAL DESIGN
Select at random this pig farm body weight be 4 ± 1kg, 1 week age and pathological state basically identical 100 of trouble pigs as experimental animal, be divided into 5 test group.Test one group and be medicine high dose group of the present invention (0.2ml/kg body weight); Test two groups and be dosage group (0.1ml/kg body weight) in the medicine of the present invention; Test three groups and be medicine low dose group of the present invention (0.025ml/kg body weight); Testing four groups is the astragalin injection matched group; Test five groups and be not administration matched group; Alternative select body weight be 4 ± 1kg, 1 age in week 40 of health pig, to be divided into two experimental grouies be respectively test six groups (the not administrations of not falling ill) and test seven groups (safe dose groups).Make a definite diagnosis the same day by each group dosage administered intramuscular.Identical each group of other management of each test group pig feed all is consistent.Grouping sees Table 1
Table 1 compound recipe Rhizoma Et Radix Notopterygii injection is to the therapeutic test of piglet transmissible gastroenteritis of swine
1.4 test method
Pair respectively organize the pig drug administration by injection by table 1 and treat, successive administration 5 days is observed situations such as suffering from pig clinical change, healing, improvement, death every day, the line item of going forward side by side.
1.5 curative effect determinate standard
Mortality rate: the ratio that the also dead pig of typical transmissible gastroenteritis of swine clinical symptoms accounts for this group pig appears in duration of test.
Cure rate: spirit, appetite, clinical symptoms are recovered the ratio that normal pig accounts for this group pig fully after the off-test.
Effective percentage: the pig that spirit, appetite, clinical symptoms are clearly better after the off-test accounts for the ratio of this group pig.
1.6 the analyzing and processing of data
Carry out the significance test of data with biometrics.
2 results
2.1 mortality rate
Each medication group is compared, and medicine height of the present invention, middle dosage group mortality rate are lower, are 5%.Statistical analysis shows that medicine height of the present invention, middle dosage group mortality rate significantly are lower than the mortality rate (p＜0.05) that infects matched group.
2.2 cure rate and effective percentage
Medicine height of the present invention, middle dosage group cure rate are higher, are 80%.Above-mentioned two groups effective percentage is also higher, is 95%.Cure rate, the effective percentage of medicine low dose group of the present invention are relatively low.
2.3 Comparison of therapeutic
The mortality rate of medicine low dose group of the present invention, astragalin injection matched group all significantly is lower than the infection matched group, but with medicine height of the present invention, that middle dosage group is compared curative effect is relatively low.
Table 2 clinical test results
3 discuss
3.1 curative effect of medication of the present invention
Medicine of the present invention is that the trouble pig of transmissible gastroenteritis has excellent curative to suffering from clinical manifestation, can obviously alleviate because of suffering from the clinical slight illness of pig due to the transmissible gastroenteritis, shortens the disease persistent period, improves the cure rate of eqpidemic disease.
3.2 safety testing
Show through safety testing (10 times of drug administration by injection of recommended dose, logotype 5 days), do not see clinical unusual performance between the operating period, health pig is not had obvious influence, illustrate that this preparation is safe health pig.
Beneficial effect: medicine of the present invention has the effect of heat-clearing and toxic substances removing, fresh breeze a surname heat, in conjunction with the special physiological structure of poultry, is made into injection, makes medicine inject the back in vivo and absorbs rapidly, effectively raises medicine bioavailability in vivo.
The specific embodiment
Embodiment 1: 2 parts of Flos Loniceraes, 2 parts of Rhizoma Cimicifugaes, 4 parts of Radix Scutellariaes.Extracting honeysuckle, Radix Scutellariae, Rhizoma Cimicifugae add 5～6 times of water gagings, decoct 1 hour, filter, and collect filtrate.Residue adds 2 times of water gagings again and decocts 1 time, filters, and merges twice filtrate and be concentrated into syrupy shape in water-bath, adds 3 times of amount 95% ethanol, stir, placed 24 hours, filter, filtrate recycling ethanol is concentrated into syrupy shape, adds 3 times of amount 95% ethanol again, stir, place a night, filter, filtrate recycling ethanol adds the injection water and stirs evenly filtration to 100ml, fill, sterilization, promptly.
Have heat-clearing and toxic substances removing, declare the effect of wind heat clearly.Be applicable to virus and bacterial infection.Intramuscular injection.Once measure per 1 kg body weight 0.05-0.1 milliliter, 1 time on the one, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 2: 3 parts of Flos Loniceraes, 2 parts of Rhizoma Cimicifugaes, 5 parts of Radix Scutellariaes.Extracting honeysuckle, Radix Scutellariae, Rhizoma Cimicifugae add 5～6 times of water gagings, decoct 1 hour, filter, and collect filtrate.Residue adds 2 times of water gagings again and decocts 1 time, filters, and merges twice filtrate and be concentrated into syrupy shape in water-bath, adds 3 times of amount 95% ethanol, stir, placed 24 hours, filter, filtrate recycling ethanol is concentrated into syrupy shape, adds 3 times of amount 95% ethanol again, stir, place a night, filter, filtrate recycling ethanol adds the injection water and stirs evenly filtration to 100ml, fill, sterilization, promptly.
Have heat-clearing and toxic substances removing, declare the effect of wind heat clearly.Be applicable to virus and bacterial infection.Intramuscular injection.Once measure per 1 kg body weight 0.05-0.1 milliliter, 1 time on the one, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 3: 5 parts of Flos Loniceraes, 4 parts of Rhizoma Cimicifugaes, 8 parts of Radix Scutellariaes.Extracting honeysuckle, Radix Scutellariae, Rhizoma Cimicifugae add 5～6 times of water gagings, decoct 1 hour, filter, and collect filtrate.Residue adds 2 times of water gagings again and decocts 1 time, filters, and merges twice filtrate and be concentrated into syrupy shape in water-bath, adds 3 times of amount 95% ethanol, stir, placed 24 hours, filter, filtrate recycling ethanol is concentrated into syrupy shape, adds 3 times of amount 95% ethanol again, stir, place a night, filter, filtrate recycling ethanol adds the injection water and stirs evenly filtration to 100ml, fill, sterilization, promptly.
Have heat-clearing and toxic substances removing, declare the effect of wind heat clearly.Be applicable to virus and bacterial infection.Intramuscular injection.Once measure per 1 kg body weight 0.05-0.1 milliliter, 1 time on the one, logotype 3-5 days; The serious symptom doubled amount is used.
Claims (3)
1. one kind has heat-clearing and toxic substances removing, declares the Chinese medicine preparation for animals of wind heat effect clearly, it is characterized in that: Flos Lonicerae 2-5 part, Rhizoma Cimicifugae 2-4 part, Radix Scutellariae 4-8 part.
2. according to claim 1ly a kind ofly have heat-clearing and toxic substances removing, declare the Chinese medicine preparation for animals of wind heat effect clearly, it is characterized in that optimizing prescriptions of the present invention is: 3 parts of Flos Loniceraes, 2 parts of Rhizoma Cimicifugaes, 5 parts of Radix Scutellariaes.
3. according to claim 1ly a kind ofly have heat-clearing and toxic substances removing, declare the Chinese medicine preparation for animals of wind heat effect clearly, it is characterized in that: the dosage form of described Chinese medicine preparation for animals is an injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101305445A CN101209291A (en) | 2006-12-25 | 2006-12-25 | Chinese medicine injection for animals with heat-clearing, detoxication wind-heat-removing efficacy |
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| CNA2006101305445A CN101209291A (en) | 2006-12-25 | 2006-12-25 | Chinese medicine injection for animals with heat-clearing, detoxication wind-heat-removing efficacy |
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| CN101209291A true CN101209291A (en) | 2008-07-02 |
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| CNA2006101305445A Pending CN101209291A (en) | 2006-12-25 | 2006-12-25 | Chinese medicine injection for animals with heat-clearing, detoxication wind-heat-removing efficacy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671122A (en) * | 2012-05-07 | 2012-09-19 | 青岛绿曼生物工程有限公司 | Compound pure Chinese medicinal composition for treating livestock gastric-enteritis and preparation method thereof |
-
2006
- 2006-12-25 CN CNA2006101305445A patent/CN101209291A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671122A (en) * | 2012-05-07 | 2012-09-19 | 青岛绿曼生物工程有限公司 | Compound pure Chinese medicinal composition for treating livestock gastric-enteritis and preparation method thereof |
| CN102671122B (en) * | 2012-05-07 | 2014-04-16 | 青岛绿曼生物工程有限公司 | Compound pure Chinese medicinal composition for treating livestock gastric-enteritis and preparation method thereof |
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Open date: 20080702 |