CN101204412A - 治疗骨质疏松症的复方中药 - Google Patents
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Abstract
本发明公开了一种治疗骨质疏松症的复方中药，属于中成药；旨在提供一种治疗骨质疏松症，而且药味较少、疗效与同类传统中药相当的中成药。它是由下列比例的原料按常规的工艺方法制成的固体制剂：淫羊藿3250克∶续断250克∶牡蛎50克。本发明配方简单、成本低，具有与同类传统中药等同的功效。
Description
技术领域：本发明涉及一种中药，尤其涉及一种治疗骨质疏松症的中成药。
背景技术：骨质疏松是老年妇女的常见病、多发病；目前，用于治疗骨质疏松症的药物有很多。西药以激素类药物为主，其副作用较大，不宜长期服用；而中药主要以滋肝补肾、温阳补阴、行气活血的复方制剂为主，如：公开号为“CN1552360A”、公开日为“2004年12月8日”、发明创造名称为“骨松宝丸及制备方法”的中国专利文献中公开了一种治疗骨质疏松症的中成药，它由淫羊藿、续断、莪术、三棱、知母、川芎、赤芍、生地、牡蛎共九味中药制成，其缺点是配方药味繁多、制备工艺复杂、服用量大、服药次数多、成本高等。
发明内容：为了克服现有技术中存在的不足，本发明旨在提供一种药味较少、疗效与同类传统中药相当的治疗骨质疏松症的复方中药。
本发明的技术方案是由下列比例的原料按常规的工艺方法制成的固体制剂：淫羊藿3250克：续断250克：牡蛎50克。
在上述技术方案中，本发明可以是胶囊剂，也可以是片剂。
上述淫羊藿可以为小蘖科植物粗毛淫羊藿Epimedim acuminatumFranch.、黔岭淫羊藿Epimedium leptorrhizum Stearn、毡毛淫羊藿Epimedium coactum H.R.Liang et W.M.Yan、箭叶淫羊藿Epimediumsagittatum(Sieb.et Zucc.)Maxim.、及巫山淫羊藿Epimedium wushanenseT.S.Ying的干燥全草或地上部分；续断为川续断科植物川续断Dipsacusasperoides C.Y.Cheng et T.M.Ai的干燥根；牡蛎为牡蛎科动物长牡蛎Ostrea gigas Thunberg、大连湾牡蛎Ostrea talienwhanensis Crosse或近江牡蛎Ostrea rivularis Could的贝壳。
其中，淫羊藿对性机能有影响，具有催淫作用；它有补肾壮阳，祛风除湿的功效；主治阳痿不举，小便淋泥，筋骨孪急，半身不遂，腰膝无力，风湿痹痛，四肢不仁，老年昏耄，中年健忘等症。续断具有补肝肾，续筋骨，调血脉等功效；主治腰背酸痛，足膝无力，胎漏，崩漏，遗精，跌打损伤等症。牡蛎含有80-95％的碳酸钙、磷酸钙及硫酸钙，并含有镁、铝、硅及氧化铁等，煅烧后碳酸盐分解可产生氧化钙等；具有敛阴，止汗，涩精，化痰，软监等功效；主治惊痫，眩晕，自汗，盗汗，遗精，淋虫，崩漏，带下等症，对怀孕妇女及小儿钙质缺乏与结核等有疗效。
与现有技术比较，本发明具有治疗骨质疏松症的作用；在保持传统同类中药原有功效的前提下，大大减少了药味配方、简化了制备工艺、降低了成本。以下是以SD大鼠为实验对象，观察本发明与同类传统中药——“骨松宝胶囊”对SD大鼠骨密度影响所做的对比实验。其方法为：
用剂量为40mg/kg的戊巴比妥钠对SD大鼠作腹腔注射(ip)麻醉，无菌操作，切除双侧卵巢，将10只SD大鼠切除双侧卵巢旁各一块脂肪组织作为对照组(假手术组)，术后45天将去卵巢SD大鼠60只随机分为五组：本发明高剂量组(0.6g/kg)、本发明中剂量组(0.3g/kg)、本发明低剂量组(0.15g/kg)、骨松宝胶囊组(0.8g/kg)、模型组(等容积生理盐水)，加上对照组(等容积生理盐水)共六个组。分组当日，各组SD大鼠按各自药物和剂量灌胃给药(ig)，每日一次，连续90天。末次给药后的次日以剂量为40mg/kg的戊巴比妥钠作腹腔注射(ip)麻醉，用双能X线骨密度仪测骨密度。测量数据见下表：
| 组别 | 剂量(g/Kg) | 数量(只) | 骨密度(g/cm2) | |||
| 大腿 | 骨盆 | 脊柱 | 全身 | |||
| 对照组 | - | 10 | 128.30±9.23** | 138.60±15.96 | 114.90±13.46 | 140.70±9.74* |
| 模型组 | - | 11 | 117.36±6.50 | 128.54±8.87 | 109.36±9.32 | 130.27±7.32 |
| 骨松宝胶囊组 | 0.8 | 12 | 125.58±10.26* | 129.67±12.02 | 117.83±14.92 | 136.42±8.00 |
| 本发明高剂量组 | 0.6 | 11 | 129.00±8.76** | 137.91±13.63 | 125.55±12.97** | 1443.00±8.07** |
| 本发明中剂量组 | 0.3 | 11 | 122.73±8.21 | 133.36±12.40 | 116.09±7.45 | 137.45±8.55* |
| 本发明低剂量组 | 0.15 | 11 | 119.18±9.81 | 127.91±14.51 | 115.18±12.29 | 134.64±8.81 |
与模型组比*p＜0.05，**p＜0.01。
从上表中可以看出：相对于对照组，模型组SD大鼠的大腿、骨盆、脊柱和全身骨密度均有不同程度的下降，其中以大腿和全身骨密度降低程度最为明显(P＜0.01，P＜0.05)，表现出明显的骨质疏松改变。与模型组对比，本发明各剂量组均能不同程度地改善去势大鼠的上述骨质疏松指征。其中，本发明高剂量组对大腿、脊柱和全身骨骼以及本发明中剂量组对全身骨骼的骨密度改善尤为明显，差异显著(P＜0.01，P＜0.05)，因此本发明具有与同类传统中药“骨松宝”等同的功效。
具体实施方式：下面结合具体的实施例对本发明作进一步说明：
实施例1，取淫羊藿3250克、续断250克、牡蛎(煅)50克，按常规的工艺方法配以辅料即可制成胶囊剂、片剂等常规固体制剂。
Claims (3)
1.一种治疗骨质疏松症的复方中药，其特征在于它是由下列比例的原料按常规的工艺方法制成的固体制剂：淫羊藿3250克：续断250克：牡蛎50克。
2.根据权利要求1所述的治疗骨质疏松症的复方中药，其特征在于：它是胶囊剂。
3.根据权利要求1所述的治疗骨质疏松症的复方中药，其特征在于：它是片剂。
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552386A (zh) * | 2012-02-14 | 2012-07-11 | 山东省中医药研究院 | 一种抗骨质疏松的中药制剂及其制备方法 |
| CN105726979A (zh) * | 2016-04-19 | 2016-07-06 | 元和药业股份有限公司 | 蒙药复方制剂参竹精新用途及其药物制剂和制备方法 |
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| CN101036722A (zh) * | 2006-03-15 | 2007-09-19 | 张丽英 | 一种缓解疲劳、改善男性更年期综合征的保健食品及制备 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552386A (zh) * | 2012-02-14 | 2012-07-11 | 山东省中医药研究院 | 一种抗骨质疏松的中药制剂及其制备方法 |
| CN102552386B (zh) * | 2012-02-14 | 2014-09-10 | 山东省中医药研究院 | 一种抗骨质疏松的中药制剂及其制备方法 |
| CN105726979A (zh) * | 2016-04-19 | 2016-07-06 | 元和药业股份有限公司 | 蒙药复方制剂参竹精新用途及其药物制剂和制备方法 |
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Effective date of registration: 20211129 Address after: 1610, 16th floor, 101-2-16th floor, building 21, Rongda Road, Chaoyang District, Beijing 100012 Patentee after: Zhongguancun Technology Leasing Co.,Ltd. Address before: 551200 Guizhou Longli County, Gujiao industrial city Patentee before: GUIZHOU FUHUA PHARMACEUTICAL Co.,Ltd. |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240117 Address after: 551206 pharmaceutical industry city, Yanhou village, Gujiao Town, Longli County, Qiannan Buyei and Miao Autonomous Prefecture, Guizhou Province Patentee after: GUIZHOU FUHUA PHARMACEUTICAL Co.,Ltd. Address before: 1610, 16th floor, 101-2-16th floor, building 21, Rongda Road, Chaoyang District, Beijing 100012 Patentee before: Zhongguancun Technology Leasing Co.,Ltd. |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Compound Chinese Medicine for the Treatment of Osteoporosis Granted publication date: 20100526 Pledgee: Qiannan Buyei and Miao Autonomous Prefecture Branch of Postal Savings Bank of China Ltd. Pledgor: GUIZHOU FUHUA PHARMACEUTICAL Co.,Ltd. Registration number: Y2024980009161 |