CN101203740B - 用碳纳米管控制的分子鉴定 - Google Patents

用碳纳米管控制的分子鉴定 Download PDF

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CN101203740B
CN101203740B CN2006800201574A CN200680020157A CN101203740B CN 101203740 B CN101203740 B CN 101203740B CN 2006800201574 A CN2006800201574 A CN 2006800201574A CN 200680020157 A CN200680020157 A CN 200680020157A CN 101203740 B CN101203740 B CN 101203740B
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molecule
nanotube
carbon nano
tube
identification device
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CN101203740A (zh
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J·戈洛夫琴科
D·布兰顿
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Harvard University
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44791Microapparatus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44743Introducing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/48707Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721Investigating individual macromolecules, e.g. by translocation through nanopores
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/762Nanowire or quantum wire, i.e. axially elongated structure having two dimensions of 100 nm or less

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  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Organic Chemistry (AREA)
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  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
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  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2006800201574A 2005-04-06 2006-04-06 用碳纳米管控制的分子鉴定 Active CN101203740B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US66863205P 2005-04-06 2005-04-06
US60/668,632 2005-04-06
US68879905P 2005-06-09 2005-06-09
US60/688,799 2005-06-09
US72760305P 2005-10-18 2005-10-18
US60/727,603 2005-10-18
PCT/US2006/012800 WO2007084163A2 (en) 2005-04-06 2006-04-06 Molecular characterization with carbon nanotube control

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CN101203740B true CN101203740B (zh) 2011-03-23

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CN2011100264059A Pending CN102183630A (zh) 2005-04-06 2006-04-06 用碳纳米管控制的分子鉴定

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US (5) US7468271B2 (enExample)
EP (2) EP2348300A3 (enExample)
JP (2) JP4891313B2 (enExample)
CN (2) CN101203740B (enExample)
AT (1) ATE529734T1 (enExample)
AU (1) AU2006336262B2 (enExample)
CA (1) CA2603352C (enExample)
WO (1) WO2007084163A2 (enExample)

Families Citing this family (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362002B1 (en) * 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US20120160687A1 (en) 1995-03-17 2012-06-28 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US8206568B2 (en) * 1999-06-22 2012-06-26 President And Fellows Of Harvard College Material deposition techniques for control of solid state aperture surface properties
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
WO2005017025A2 (en) 2003-08-15 2005-02-24 The President And Fellows Of Harvard College Study of polymer molecules and conformations with a nanopore
WO2006028508A2 (en) 2004-03-23 2006-03-16 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7435353B2 (en) * 2004-12-09 2008-10-14 President And Fellows Of Harvard College Patterning by energetically-stimulated local removal of solid-condensed-gas layers and solid state chemical reactions produced with such layers
CA2603352C (en) * 2005-04-06 2013-10-01 Jene Golovchenko Molecular characterization with carbon nanotube control
KR100691806B1 (ko) * 2005-08-04 2007-03-12 삼성전자주식회사 비드 및 나노포어를 이용한 핵산 검출방법 및 검출장치
KR100730350B1 (ko) * 2005-10-17 2007-06-19 삼성전자주식회사 표면처리된 나노포어를 이용한 dna 검출방법 및검출장치
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US8119032B2 (en) 2006-02-07 2012-02-21 President And Fellows Of Harvard College Gas-phase functionalization of surfaces including carbon-based surfaces
EP1999067B1 (en) * 2006-02-07 2014-04-09 President and Fellows of Harvard College Gas-phase functionalization of carbon nanotubes
WO2007133710A2 (en) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
US8003319B2 (en) * 2007-02-02 2011-08-23 International Business Machines Corporation Systems and methods for controlling position of charged polymer inside nanopore
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
EP3798317B1 (en) 2007-04-04 2024-01-03 The Regents of the University of California Compositions, devices, systems, and methods for using a nanopore
US9395352B2 (en) 2007-04-06 2016-07-19 Arizona Board Of Regents On Behalf Of Arizona State University Devices and methods for target molecule characterization
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
EP3543357A1 (en) 2007-05-08 2019-09-25 Trustees of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
US7709298B2 (en) * 2007-07-18 2010-05-04 Hewlett-Packard Development Company, L.P. Selectively altering a predetermined portion or an external member in contact with the predetermined portion
WO2009035647A1 (en) * 2007-09-12 2009-03-19 President And Fellows Of Harvard College High-resolution molecular graphene sensor comprising an aperture in the graphene layer
WO2009046094A1 (en) 2007-10-01 2009-04-09 Nabsys, Inc. Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment
EP2205522B1 (en) * 2007-10-02 2019-03-13 President and Fellows of Harvard College Carbon nanotube synthesis for nanopore devices
WO2009045472A1 (en) * 2007-10-02 2009-04-09 President And Fellows Of Harvard College Capture, recapture, and trapping of molecules with a nanopore
WO2009052214A2 (en) * 2007-10-15 2009-04-23 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
GB0724736D0 (en) * 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
US8183648B2 (en) * 2008-01-25 2012-05-22 Ut-Battelle, Llc Nanoscopic electrode molecular probes
WO2009117522A2 (en) * 2008-03-18 2009-09-24 Reinhart, Kevin Nanopore and carbon nanotube based dna sequencer and a serial recognition sequencer
WO2009117517A2 (en) * 2008-03-18 2009-09-24 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Nanopore and carbon nanotube based dna sequencer
WO2009120327A1 (en) * 2008-03-24 2009-10-01 The Board Of Trustees Of The Leland Stanford Junior University Apparatus for atomic force microscope-assisted deposition of nanostructures
CN102150037B (zh) * 2008-07-11 2014-06-04 康奈尔大学 集成电荷传感器的纳米流体通道及基于该纳米流体通道的方法
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP2342362B1 (en) 2008-09-03 2017-03-01 Nabsys 2.0 LLC Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
IT1393996B1 (it) * 2008-09-18 2012-05-17 Univ Degli Studi Genova Dispositivo di fuga di riferimento per la calibrazione delle perdite
US9851378B2 (en) * 2008-09-29 2017-12-26 Wentworth Laboratories Inc. Methods of fabricating probe cards including nanotubes
WO2010042514A1 (en) * 2008-10-06 2010-04-15 Arizona Board Of Regents Nanopore and carbon nanotube based dna sequencer and a serial recognition elements
KR101118461B1 (ko) * 2008-10-10 2012-03-06 나노칩스 (주) 초고속 고감도 dna 염기서열 분석 시스템
WO2013154750A1 (en) 2012-04-10 2013-10-17 The Trustees Of Columbia Unversity In The City Of New York Systems and methods for biological ion channel interfaces
WO2010062903A2 (en) * 2008-11-26 2010-06-03 Board Of Regents, The University Of Texas System Genomic sequencing using modified protein pores and ionic liquids
KR101797773B1 (ko) 2009-01-30 2017-11-15 옥스포드 나노포어 테크놀로지즈 리미티드 막횡단 시퀀싱에서 핵산 구축물용 어댑터
CN102482330A (zh) 2009-01-30 2012-05-30 牛津纳米孔技术有限公司 酶突变体
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
WO2010111605A2 (en) * 2009-03-27 2010-09-30 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US8455260B2 (en) * 2009-03-27 2013-06-04 Massachusetts Institute Of Technology Tagged-fragment map assembly
US9810680B2 (en) * 2009-04-16 2017-11-07 Nanonex Corporation Nanogap electronic detector for measuring properties of a biomolecule stretched in a nanochannel, and method thereof
US8926904B2 (en) 2009-05-12 2015-01-06 Daniel Wai-Cheong So Method and apparatus for the analysis and identification of molecules
US8246799B2 (en) * 2009-05-28 2012-08-21 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
WO2011032040A1 (en) 2009-09-10 2011-03-17 Centrillion Technology Holding Corporation Methods of targeted sequencing
KR101732207B1 (ko) 2009-09-18 2017-05-02 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 고감도 분자 탐지 및 분석을 가능하게 하는 나노공극을 가지는 베어, 단일층 그래핀 멤브레인
AU2010301128B2 (en) 2009-09-30 2014-09-18 Quantapore, Inc. Ultrafast sequencing of biological polymers using a labeled nanopore
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
BR112012013074B1 (pt) 2009-12-01 2018-09-18 Oxford Nanopore Technologies Limited instrumento de análise e módulo para realizar análise bioquímica, e, método para operar um instrumento de análise para realizar análise bioquímica
WO2011067961A1 (ja) * 2009-12-02 2011-06-09 独立行政法人科学技術振興機構 流路デバイス及びそれを含むサンプル処理装置
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
WO2011097171A1 (en) 2010-02-02 2011-08-11 Arizona Board Of Regents Controlled tunnel gap device for sequencing polymers
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US20110192723A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
US20120052188A1 (en) 2010-02-08 2012-03-01 Genia Technologies, Inc. Systems and methods for assembling a lipid bilayer on a substantially planar solid surface
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US9605307B2 (en) * 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US8084319B2 (en) * 2010-02-12 2011-12-27 International Business Machines Corporation Precisely tuning feature sizes on hard masks via plasma treatment
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2534267B1 (en) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
WO2011108540A1 (ja) 2010-03-03 2011-09-09 国立大学法人大阪大学 ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置
US8603303B2 (en) 2010-03-15 2013-12-10 International Business Machines Corporation Nanopore based device for cutting long DNA molecules into fragments
US8039250B2 (en) * 2010-03-15 2011-10-18 International Business Machines Corporation Piezoelectric-based nanopore device for the active control of the motion of polymers through the same
US8557529B2 (en) 2010-04-09 2013-10-15 International Business Machines Corporation Nanopore capture system
KR101648417B1 (ko) * 2010-05-14 2016-08-16 서울대학교산학협력단 절연된 박막 전극의 전위 측정을 통한 나노포어 입자 검출기
US8828138B2 (en) 2010-05-17 2014-09-09 International Business Machines Corporation FET nanopore sensor
US8828211B2 (en) 2010-06-08 2014-09-09 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
US8940148B2 (en) 2010-06-22 2015-01-27 International Business Machines Corporation Nano-fluidic field effective device to control DNA transport through the same
US8598018B2 (en) 2010-06-22 2013-12-03 International Business Machines Corporation Forming an electrode having reduced corrosion and water decomposition on surface using a custom oxide layer
US8354336B2 (en) * 2010-06-22 2013-01-15 International Business Machines Corporation Forming an electrode having reduced corrosion and water decomposition on surface using an organic protective layer
JP5427722B2 (ja) * 2010-07-28 2014-02-26 株式会社日立ハイテクノロジーズ ナノポア式分析装置及び試料分析用チャンバ
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
WO2012043109A1 (ja) * 2010-09-30 2012-04-05 Jsr株式会社 マイクロアレイ用等の細孔板の製造方法、前記方法に用いられる感光性組成物、マイクロアレイ用等の細孔板およびマイクロアレイ用基板
WO2012044857A2 (en) * 2010-09-30 2012-04-05 California Institute Of Technology Devices and methods for sequencing nucleic acids
US9593370B2 (en) 2010-10-01 2017-03-14 Oxford Nanopore Technologies Ltd. Biochemical analysis apparatus and rotary valve
US8859201B2 (en) 2010-11-16 2014-10-14 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
CN102169105A (zh) * 2010-12-22 2011-08-31 东南大学 一种基于石墨烯的纳米孔单分子传感器及其介质辨识方法
CN103620403B (zh) 2011-01-11 2016-08-10 纽约市哥伦比亚大学理事会 使用纳米管监测单分子的系统和方法
US8962242B2 (en) * 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US20120193231A1 (en) 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases
US8852407B2 (en) 2011-01-28 2014-10-07 International Business Machines Corporation Electron beam sculpting of tunneling junction for nanopore DNA sequencing
US8986524B2 (en) 2011-01-28 2015-03-24 International Business Machines Corporation DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
WO2012109574A2 (en) 2011-02-11 2012-08-16 Nabsys, Inc. Assay methods using dna binding proteins
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
CN103380369B (zh) 2011-02-23 2016-12-28 纽约市哥伦比亚大学理事会 使用纳米孔进行单分子检测的系统和方法
US20140162247A1 (en) * 2011-03-09 2014-06-12 Stuart Lindsay Molecular transistor
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
EP4109094A1 (en) 2011-04-04 2022-12-28 President and Fellows of Harvard College Nanopore sensing by local electrical potential measurement
US8558326B2 (en) 2011-04-06 2013-10-15 International Business Machines Corporation Semiconductor devices having nanochannels confined by nanometer-spaced electrodes
US8518829B2 (en) * 2011-04-22 2013-08-27 International Business Machines Corporation Self-sealed fluidic channels for nanopore array
US9040311B2 (en) * 2011-05-03 2015-05-26 International Business Machines Corporation Calibration assembly for aide in detection of analytes with electromagnetic read-write heads
US8855957B2 (en) 2011-05-03 2014-10-07 International Business Machines Corporation Method for calibrating read sensors of electromagnetic read-write heads
KR101410127B1 (ko) * 2011-05-04 2014-06-25 충북대학교 산학협력단 나노채널을 이용한 실시간 분자서열 분석시스템 및 방법
EP4273092A3 (en) 2011-05-27 2024-01-17 Oxford Nanopore Technologies plc Method and apparatus for determining the presence, absence or characteristics of an analyte
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
US8546080B2 (en) 2011-06-17 2013-10-01 International Business Machines Corporation Molecular dispensers
KR101910978B1 (ko) * 2011-06-22 2018-10-24 삼성전자주식회사 나노 센서 및 그의 제조 방법
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
KR102023754B1 (ko) 2011-07-27 2019-09-20 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 생체분자 특성규명용 나노포어 센서
JP5670278B2 (ja) * 2011-08-09 2015-02-18 株式会社日立ハイテクノロジーズ ナノポア式分析装置
EP2562135A1 (de) * 2011-08-22 2013-02-27 ETH Zurich Verfahren zur Herstellung und Ausrichtung von Nanowires und Anwendungen eines solchen Verfahrens
US8557097B2 (en) 2011-09-09 2013-10-15 International Business Machines Corporation Embedding a nanotube inside a nanopore for DNA translocation
WO2013043545A1 (en) * 2011-09-19 2013-03-28 California Institute Of Technology Using a field effect device for identifying translocating charge-tagged molecules in a nanopore sequencing device
EP2574923A1 (en) * 2011-09-28 2013-04-03 Koninklijke Philips Electronics N.V. Apparatus for the processing of single molecules
WO2013056182A1 (en) * 2011-10-12 2013-04-18 Devernoe David Piezoelectric devices and methods
KR101933619B1 (ko) 2011-12-26 2018-12-31 삼성전자주식회사 나노포어 소자 및 그 제조 방법, 나노포어 소자를 포함하는 핵산 검출 장치
JP2013156167A (ja) * 2012-01-30 2013-08-15 Osaka Univ 物質の移動速度の制御方法および制御装置、並びに、これらの利用
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
US20130256139A1 (en) * 2012-03-30 2013-10-03 International Business Machines Corporation Functionalized graphene or graphene oxide nanopore for bio-molecular sensing and dna sequencing
WO2013151532A1 (en) * 2012-04-02 2013-10-10 Lux Bio Group, Inc. Apparatus and method for molecular separation, purification, and sensing
US10029915B2 (en) 2012-04-04 2018-07-24 International Business Machines Corporation Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores
KR20130114435A (ko) 2012-04-09 2013-10-17 삼성전자주식회사 다수의 전극을 갖는 생분자 검출 장치
WO2013158280A1 (en) 2012-04-20 2013-10-24 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule nucleic-acid assay platforms
CN103424457B (zh) * 2012-05-18 2016-02-10 中国科学院微电子研究所 生物传感器及其dna测序方法
KR101882865B1 (ko) 2012-07-03 2018-07-27 삼성전자주식회사 핵산의 염기 서열을 결정하는 방법
KR20140012506A (ko) * 2012-07-20 2014-02-03 삼성전자주식회사 비대칭 전해질 농도를 이용하여 생물분자를 분석하는 방법
US8765609B2 (en) 2012-07-25 2014-07-01 Power Integrations, Inc. Deposit/etch for tapered oxide
US8702940B2 (en) 2012-07-27 2014-04-22 International Business Machines Corporation Increased molecule capture rate into a nanopore
JP6033602B2 (ja) * 2012-08-08 2016-11-30 株式会社日立ハイテクノロジーズ 生体分子検出方法、生体分子検出装置、および分析用デバイス
KR20150041146A (ko) * 2012-08-17 2015-04-15 오사카 유니버시티 시료의 분석 방법
US10876157B2 (en) * 2012-09-27 2020-12-29 The Trustees Of The University Of Pennsylvania Insulated nanoelectrode-nanopore devices and related methods
JP6063693B2 (ja) * 2012-10-03 2017-01-18 株式会社日立ハイテクノロジーズ 分析装置及び分析方法
WO2014105246A2 (en) 2012-10-05 2014-07-03 Massachusetts Institute Of Technology Nanofluidic sorting system for gene synthesis and pcr reaction products
WO2014059144A1 (en) 2012-10-10 2014-04-17 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Systems and devices for molecule sensing and method of manufacturing thereof
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
US8968582B2 (en) 2012-11-12 2015-03-03 International Business Machines Corporation Device for electrical characterization of molecules using CNT-nanoparticle-molecule-nanoparticle-CNT structure
US8963215B2 (en) 2012-11-30 2015-02-24 International Business Machines Corporation Integrated carbon nanotube field effect transistor and nanochannel for sequencing
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
JP6282036B2 (ja) 2012-12-27 2018-02-21 クオンタムバイオシステムズ株式会社 物質の移動速度の制御方法および制御装置
WO2014113557A1 (en) 2013-01-18 2014-07-24 Nabsys, Inc. Enhanced probe binding
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
CN103193189B (zh) * 2013-02-21 2015-08-26 东南大学 一种用于dna检测的多电极纳米孔装置及其制造方法
JP5904958B2 (ja) * 2013-03-07 2016-04-20 株式会社東芝 半導体マイクロ分析チップ及びその製造方法
AU2014228529B8 (en) * 2013-03-15 2018-06-14 President And Fellows Of Harvard College Fabrication of nanopores in atomically-thin membranes by ultra-short electrical pulsing
US9046511B2 (en) 2013-04-18 2015-06-02 International Business Machines Corporation Fabrication of tunneling junction for nanopore DNA sequencing
US9541541B2 (en) * 2013-04-30 2017-01-10 Globalfoundries Inc. Nanopore device for drug-like molecule screening or lead optimization to a targeted protein
US9372171B2 (en) 2013-04-30 2016-06-21 International Business Machines Corporation Nanopore sensor for detecting molecular interactions
US8890121B1 (en) 2013-05-06 2014-11-18 International Business Machines Corporation Integrated nanowire/nanosheet nanogap and nanopore for DNA and RNA sequencing
AU2014268322B2 (en) 2013-05-24 2019-01-24 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed FRET detection
US9182369B2 (en) 2013-06-19 2015-11-10 Globalfoundries Inc. Manufacturable sub-3 nanometer palladium gap devices for fixed electrode tunneling recognition
US9188578B2 (en) 2013-06-19 2015-11-17 Globalfoundries Inc. Nanogap device with capped nanowire structures
US10041930B2 (en) * 2013-06-28 2018-08-07 Globalfoundries Inc. Tunneling junction to distinguish targeted DNA segment
EP3042187A4 (en) * 2013-08-27 2017-09-13 Quantum Biosystems Inc. Nano-gap electrode and methods for manufacturing same
US9371561B2 (en) 2013-08-30 2016-06-21 Globalfoundries Inc. DNA sequencing using a suspended carbon nanotube
CN105531379A (zh) * 2013-09-13 2016-04-27 科罗拉多州立大学董事会法人团体 量子分子测序(qm-seq):dna、rna和单核苷酸修饰的独特纳米电子隧穿光谱学指纹的鉴定
CN106104274B (zh) 2013-09-18 2018-05-22 量子生物有限公司 生物分子测序装置、系统和方法
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
JP2015077652A (ja) 2013-10-16 2015-04-23 クオンタムバイオシステムズ株式会社 ナノギャップ電極およびその製造方法
US9551697B2 (en) * 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
GB201406155D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
WO2015131073A1 (en) 2014-02-27 2015-09-03 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Triazole-based reader molecules and methods for synthesizing and use thereof
US10344324B2 (en) * 2014-03-26 2019-07-09 International Business Machines Corporation Electrical trapping and stretching of charged biomolecules by single electrode gating structure
US10337060B2 (en) 2014-04-04 2019-07-02 Oxford Nanopore Technologies Ltd. Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid
US10438811B1 (en) 2014-04-15 2019-10-08 Quantum Biosystems Inc. Methods for forming nano-gap electrodes for use in nanosensors
CN106471359A (zh) * 2014-04-28 2017-03-01 量子生物有限公司 纳米间隙电极装置和系统及其形成方法
WO2015170782A1 (en) 2014-05-08 2015-11-12 Osaka University Devices, systems and methods for linearization of polymers
AU2015330841B2 (en) 2014-10-10 2019-08-15 Quantapore, Inc. Nanopore-based polymer analysis with mutually-quenching fluorescent labels
GB201418469D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Method
CA2964790C (en) 2014-10-24 2023-02-21 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
CN107207246B (zh) 2014-12-01 2019-12-20 康奈尔大学 具有对齐的纳米级电子元件的含纳米孔的基板及其制备和使用方法
KR102369770B1 (ko) * 2014-12-08 2022-03-02 버클리 라잇츠, 인크. 측방향/수직 트랜지스터 구조들을 포함하는 미세유체 디바이스 및 그 제조 및 사용 프로세스
US10364461B2 (en) 2014-12-08 2019-07-30 The Regents Of The University Of Colorado Quantum molecular sequencing (QM-SEQ): identification of unique nanoelectronic tunneling spectroscopy fingerprints for DNA, RNA, and single nucleotide modifications
EP3254103B1 (en) 2015-02-05 2023-08-16 President and Fellows of Harvard College Nanopore sensor including fluidic passage
DE102015205435B4 (de) * 2015-03-25 2023-02-16 Robert Bosch Gmbh Sequenziervorrichtung und Verfahren zum Betreiben einer Sequenziervorrichtung
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN108521782A (zh) * 2015-10-21 2018-09-11 豪夫迈·罗氏有限公司 含氟聚合物作为疏水层以支持用于纳米孔的脂质双层形成的用途
ES2877193T3 (es) 2016-04-27 2021-11-16 Quantum Biosystems Inc Sistemas y métodos para la medición y secuenciación de biomoléculas
GB201610190D0 (en) * 2016-06-10 2016-07-27 Univ Leiden Structure
CN106092409A (zh) * 2016-06-13 2016-11-09 常州大学 利用光学快速测量dna分子间作用力的方法
US10823721B2 (en) 2016-07-05 2020-11-03 Quantapore, Inc. Optically based nanopore sequencing
US10507053B2 (en) * 2016-07-15 2019-12-17 I.C. Medical, Inc. Ultrapolar electrosurgery blade assembly and ultrapolar electrosurgery pencil with argon beam capability
WO2018067457A1 (en) 2016-10-03 2018-04-12 So Daniel Wai Cheong Method and apparatus for the analysis and identification of molecules
JP2017123838A (ja) * 2016-12-14 2017-07-20 クオンタムバイオシステムズ株式会社 物質の移動速度の制御方法および制御装置、並びに、これらの利用
US10889857B2 (en) 2017-02-01 2021-01-12 Seagate Technology Llc Method to fabricate a nanochannel for DNA sequencing based on narrow trench patterning process
US10731210B2 (en) 2017-02-01 2020-08-04 Seagate Technology Llc Fabrication of nanochannel with integrated electrodes for DNA sequencing using tunneling current
US10641726B2 (en) 2017-02-01 2020-05-05 Seagate Technology Llc Fabrication of a nanochannel for DNA sequencing using electrical plating to achieve tunneling electrode gap
US10640827B2 (en) 2017-02-01 2020-05-05 Seagate Technology Llc Fabrication of wedge shaped electrode for enhanced DNA sequencing using tunneling current
US10752947B2 (en) 2017-03-09 2020-08-25 Seagate Technology Llc Method to amplify transverse tunneling current discrimination of DNA nucleotides via nucleotide site specific attachment of dye-peptide
US10830721B2 (en) * 2017-04-28 2020-11-10 Palo Alto Research Center Incorporated Metal nanoparticle-decorated nanotubes for gas sensing
KR102885764B1 (ko) 2017-06-29 2025-11-13 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 나노포어를 통한 폴리머의 결정적 스텝핑
GB201801768D0 (en) 2018-02-02 2018-03-21 Oxford Nanopore Tech Ltd Synthesis method
WO2020013256A1 (ja) * 2018-07-11 2020-01-16 国立大学法人大阪大学 流路、流路の製造方法、電極構造体、および、電極構造体の製造方法
GB201811623D0 (en) 2018-07-16 2018-08-29 Univ Oxford Innovation Ltd Molecular hopper
CN109455662B (zh) * 2018-11-26 2020-07-03 广东工业大学 一种固态纳米孔结构
GB201821155D0 (en) 2018-12-21 2019-02-06 Oxford Nanopore Tech Ltd Method
CN109852678B (zh) * 2019-03-01 2024-11-12 天津大学 基于碳纳米管和单链dna缠绕结构的dna测序方法
EP3835755A4 (en) * 2019-03-12 2022-05-04 Tohoku University Endotoxin detection device and endotoxin detection method
EP3962746B1 (en) * 2019-05-02 2025-01-15 The Board Of Trustees Of The University Of Illinois Atomic-to-nanoscale matter emission/flow regulation devices and methods
US20200393407A1 (en) * 2019-06-13 2020-12-17 University Of Kentucky Research Foundation Cross-gap-nanopore heterostructure device and method for identifying chemical substance
US12222346B2 (en) 2020-04-01 2025-02-11 The Trustees Of The University Of Pennsylvania Stable nanopores and nanopore arrays for ionic and other measurements
CN111398137B (zh) * 2020-04-02 2022-07-05 武汉生之源生物科技股份有限公司 一种基于电阻微米孔颗粒计数器的检测方法及其应用
US12487229B2 (en) 2021-12-08 2025-12-02 Western Digital Technologies, Inc. Devices, systems, and methods of using smart fluids to control molecule speeds
US11892445B2 (en) * 2021-12-08 2024-02-06 Western Digital Technologies, Inc. Devices, systems, and methods of using smart fluids to control translocation speed through a nanopore
US11946894B2 (en) * 2022-02-16 2024-04-02 Western Digital Technologies, Inc. Low noise amplifiers with feedback for nanopore applications
US11940404B2 (en) 2022-02-16 2024-03-26 Western Digital Technologies, Inc. Low noise amplifiers with shields for nanopore Applications
US12259353B2 (en) 2022-04-19 2025-03-25 Western Digital Technologies, Inc. Amplifiers for biological sensing applications
EP4662489A1 (en) 2023-02-07 2025-12-17 Oxford University Innovation Limited Method of characterising a peptide, polypeptide or protein using a nanopore
CN116399927B (zh) * 2023-03-27 2025-10-28 东南大学 复合纳米孔生物传感器及其制备方法与应用
US12461064B2 (en) 2023-06-23 2025-11-04 Western Digital Technologies, Inc. Magnetic control of molecule translocation speed through a nanopore
GB202312709D0 (en) 2023-08-18 2023-10-04 Univ Oxford Innovation Ltd Nanopore

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57182449A (en) 1981-05-07 1982-11-10 Fuji Xerox Co Ltd Forming method of ink jet multinozzle
US4728591A (en) 1986-03-07 1988-03-01 Trustees Of Boston University Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-device structures
EP0244496B1 (de) 1986-05-06 1991-01-16 Ibm Deutschland Gmbh Maske für die Ionen-, Elektronen- oder Röntgenstrahllithographie und Verfahren zur ihrer Herstellung
JP2753306B2 (ja) 1988-03-18 1998-05-20 株式会社日立製作所 イオンビーム加工方法及び集束イオンビーム装置
US5420067A (en) 1990-09-28 1995-05-30 The United States Of America As Represented By The Secretary Of The Navy Method of fabricatring sub-half-micron trenches and holes
US5683547A (en) 1990-11-21 1997-11-04 Hitachi, Ltd. Processing method and apparatus using focused energy beam
US5242537A (en) 1991-04-30 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Ion beam etching of metal oxide ceramics
TW284911B (enExample) 1992-08-18 1996-09-01 At & T Corp
NL9401260A (nl) 1993-11-12 1995-06-01 Cornelis Johannes Maria Van Ri Membraan voor microfiltratie, ultrafiltratie, gasscheiding en katalyse, werkwijze ter vervaardiging van een dergelijk membraan, mal ter vervaardiging van een dergelijk membraan, alsmede diverse scheidingssystemen omvattende een dergelijk membraan.
US5798042A (en) * 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US5893974A (en) * 1994-03-07 1999-04-13 Regents Of University Of California Microfabricated capsules for immunological isolation of cell transplants
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6362002B1 (en) * 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
SE9502258D0 (sv) 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US5888591A (en) 1996-05-06 1999-03-30 Massachusetts Institute Of Technology Chemical vapor deposition of fluorocarbon polymer thin films
GB9609815D0 (en) 1996-05-10 1996-07-17 Scient Generics Ltd Denaturation of double-stranded nucleic acids
US6346189B1 (en) 1998-08-14 2002-02-12 The Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube structures made using catalyst islands
US6200893B1 (en) 1999-03-11 2001-03-13 Genus, Inc Radical-assisted sequential CVD
US6333016B1 (en) 1999-06-02 2001-12-25 The Board Of Regents Of The University Of Oklahoma Method of producing carbon nanotubes
EP1059266A3 (en) 1999-06-11 2000-12-20 Iljin Nanotech Co., Ltd. Mass synthesis method of high purity carbon nanotubes vertically aligned over large-size substrate using thermal chemical vapor deposition
US6361861B2 (en) 1999-06-14 2002-03-26 Battelle Memorial Institute Carbon nanotubes on a substrate
US7582490B2 (en) * 1999-06-22 2009-09-01 President And Fellows Of Harvard College Controlled fabrication of gaps in electrically conducting structures
US7118657B2 (en) 1999-06-22 2006-10-10 President And Fellows Of Harvard College Pulsed ion beam control of solid state features
EP1192103A1 (en) * 1999-06-22 2002-04-03 President And Fellows of Harvard College Control of solid state dimensional features
US6783643B2 (en) * 1999-06-22 2004-08-31 President And Fellows Of Harvard College Control of solid state dimensional features
US8206568B2 (en) 1999-06-22 2012-06-26 President And Fellows Of Harvard College Material deposition techniques for control of solid state aperture surface properties
US6464842B1 (en) * 1999-06-22 2002-10-15 President And Fellows Of Harvard College Control of solid state dimensional features
US6544463B1 (en) * 1999-07-26 2003-04-08 The Trustees Of The University Of Pennsylvania Hybrid materials and methods for producing the same
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6297063B1 (en) 1999-10-25 2001-10-02 Agere Systems Guardian Corp. In-situ nano-interconnected circuit devices and method for making the same
AU3970401A (en) 1999-11-29 2001-06-04 Trustees Of The University Of Pennsylvania, The Fabrication of nanometer size gaps on an electrode
DE60039632D1 (de) 1999-12-15 2008-09-04 Univ R Kohlenstoff-nano-röhrchen-vorrichtung
EP1149932A3 (en) 2000-01-26 2003-09-10 Iljin Nanotech Co., Ltd. Thermal chemical vapor deposition apparatus and method of synthesizing carbon nanotubes using the same
AU2001241474A1 (en) 2000-02-11 2001-08-20 The Texas A And M University System Biosensor compositions and methods of use
IT1317842B1 (it) 2000-02-18 2003-07-15 Attilio Citterio Procedimenti di modifica superficiale della silice per elettroforesicapillare e cromatografia.
US7001792B2 (en) * 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6413792B1 (en) * 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
EP1285252A1 (en) * 2000-04-24 2003-02-26 Eagle Research & Development, LLC An ultra-fast nucleic acid sequencing device and a method for making and using the same
KR100360476B1 (ko) * 2000-06-27 2002-11-08 삼성전자 주식회사 탄소나노튜브를 이용한 나노 크기 수직 트랜지스터 및 그제조방법
GB2364933B (en) * 2000-07-18 2002-12-31 Lg Electronics Inc Method of horizontally growing carbon nanotubes
US20020048632A1 (en) 2000-08-24 2002-04-25 Smalley Richard E. Polymer-wrapped single wall carbon nanotubes
US6566983B2 (en) 2000-09-02 2003-05-20 Lg Electronics Inc. Saw filter using a carbon nanotube and method for manufacturing the same
US6743408B2 (en) 2000-09-29 2004-06-01 President And Fellows Of Harvard College Direct growth of nanotubes, and their use in nanotweezers
US6355561B1 (en) 2000-11-21 2002-03-12 Micron Technology, Inc. ALD method to improve surface coverage
KR100362377B1 (ko) 2000-12-05 2002-11-23 한국전자통신연구원 탄소 나노 튜브를 이용한 전계 방출 소자 및 그 제조 방법
US6423583B1 (en) 2001-01-03 2002-07-23 International Business Machines Corporation Methodology for electrically induced selective breakdown of nanotubes
US6958216B2 (en) * 2001-01-10 2005-10-25 The Trustees Of Boston College DNA-bridged carbon nanotube arrays
US6939579B2 (en) 2001-03-07 2005-09-06 Asm International N.V. ALD reactor and method with controlled wall temperature
US6803840B2 (en) 2001-03-30 2004-10-12 California Institute Of Technology Pattern-aligned carbon nanotube growth and tunable resonator apparatus
US20020172767A1 (en) 2001-04-05 2002-11-21 Leonid Grigorian Chemical vapor deposition growth of single-wall carbon nanotubes
JP2002340538A (ja) * 2001-05-14 2002-11-27 Matsushita Electric Ind Co Ltd 薄板材の平坦度測定装置および方法
DE10123876A1 (de) 2001-05-16 2002-11-28 Infineon Technologies Ag Nanoröhren-Anordnung und Verfahren zum Herstellen einer Nanoröhren-Anordnung
JP3948223B2 (ja) * 2001-05-30 2007-07-25 株式会社日立製作所 遺伝子配列の読み取り装置
US6706402B2 (en) 2001-07-25 2004-03-16 Nantero, Inc. Nanotube films and articles
US6643165B2 (en) 2001-07-25 2003-11-04 Nantero, Inc. Electromechanical memory having cell selection circuitry constructed with nanotube technology
US6919592B2 (en) 2001-07-25 2005-07-19 Nantero, Inc. Electromechanical memory array using nanotube ribbons and method for making same
US6982165B2 (en) * 2001-09-24 2006-01-03 Intel Corporation Nucleic acid sequencing by raman monitoring of molecular deconstruction
WO2003060209A1 (en) 2002-01-11 2003-07-24 The Trustees Of Boston College Reinforced carbon nanotubes
US20040132070A1 (en) 2002-01-16 2004-07-08 Nanomix, Inc. Nonotube-based electronic detection of biological molecules
US6894359B2 (en) 2002-09-04 2005-05-17 Nanomix, Inc. Sensitivity control for nanotube sensors
US20030148289A1 (en) * 2002-02-04 2003-08-07 Intel Corporation Modified carbon nanotubes as molecular labels with application to DNA sequencing
US6891227B2 (en) 2002-03-20 2005-05-10 International Business Machines Corporation Self-aligned nanotube field effect transistor and method of fabricating same
US7476501B2 (en) * 2002-03-26 2009-01-13 Intel Corporation Methods and device for DNA sequencing using surface enhanced raman scattering (SERS)
US20040038260A1 (en) 2002-04-18 2004-02-26 Imedd, Inc. Nanopump device for analyzing DNA sequences
US7744816B2 (en) * 2002-05-01 2010-06-29 Intel Corporation Methods and device for biomolecule characterization
US6689674B2 (en) 2002-05-07 2004-02-10 Motorola, Inc. Method for selective chemical vapor deposition of nanotubes
US6919002B2 (en) 2002-05-17 2005-07-19 Agilent Technologies, Inc. Nanopore system using nanotubes and C60 molecules
US7005264B2 (en) * 2002-05-20 2006-02-28 Intel Corporation Method and apparatus for nucleic acid sequencing and identification
JP4974263B2 (ja) 2002-05-20 2012-07-11 富士通株式会社 半導体装置の製造方法
AU2002951274A0 (en) 2002-08-30 2002-09-19 Commonwealth Scientific And Industrial Research Organisation Methods for the chemical and physical modification of nanotubes, methods for linking the nanotubes, methods for the directed positioning of nanotubes, and uses thereof
ATE340017T1 (de) * 2002-09-25 2006-10-15 Schwerionenforsch Gmbh Verfahren zur herstellung einer nanovorrichtung für eine kontrollierte strömung geladener teilchen
US7135728B2 (en) 2002-09-30 2006-11-14 Nanosys, Inc. Large-area nanoenabled macroelectronic substrates and uses therefor
US20040144972A1 (en) 2002-10-04 2004-07-29 Hongjie Dai Carbon nanotube circuits with high-kappa dielectrics
WO2004035211A1 (en) * 2002-10-15 2004-04-29 Advanced Research Corporation Solid state membrane channel device for the measurement and characterization of atomic and molecular sized samples
DE10250984A1 (de) 2002-10-29 2004-05-19 Hahn-Meitner-Institut Berlin Gmbh Feldeffekttransistor sowie Verfahren zu seiner Herstellung
US7253434B2 (en) * 2002-10-29 2007-08-07 President And Fellows Of Harvard College Suspended carbon nanotube field effect transistor
AU2003304248A1 (en) * 2002-10-29 2005-01-13 President And Fellows Of Harvard College Carbon nanotube device fabrication
DE10250829B4 (de) 2002-10-31 2006-11-02 Infineon Technologies Ag Nichtflüchtige Speicherzelle, Speicherzellen-Anordnung und Verfahren zum Herstellen einer nichtflüchtigen Speicherzelle
US7374649B2 (en) 2002-11-21 2008-05-20 E. I. Du Pont De Nemours And Company Dispersion of carbon nanotubes by nucleic acids
EP1426470A1 (en) * 2002-12-03 2004-06-09 Motorola, Inc. Linkage of nanomorphic carbon to a nucleic acid
US7898005B2 (en) * 2002-12-09 2011-03-01 The Regents Of The University Of California Inorganic nanotubes and electro-fluidic devices fabricated therefrom
US20040200734A1 (en) 2002-12-19 2004-10-14 Co Man Sung Nanotube-based sensors for biomolecules
US6870361B2 (en) 2002-12-21 2005-03-22 Agilent Technologies, Inc. System with nano-scale conductor and nano-opening
US7410564B2 (en) * 2003-01-27 2008-08-12 Agilent Technologies, Inc. Apparatus and method for biopolymer identification during translocation through a nanopore
US7282130B2 (en) 2003-01-31 2007-10-16 Agilent Technologies, Inc. Apparatus and method for control of biopolymer translocation through a nanopore
JP2006523144A (ja) 2003-02-03 2006-10-12 プレジデント アンド フェロウズ オブ ハーバード カレッジ 制御された導電性構造体のギャップの製造法
NL1022855C2 (nl) 2003-03-05 2004-09-07 Univ Delft Tech Werkwijze en inrichting voor het gecontroleerd vervaardigen van openingen op nanometerschaal.
ITTO20030425A1 (it) 2003-06-06 2004-12-07 St Microelectronics Srl Dispositivo interruttore elettrico a comando ottico basato su nanotubi di carbonio e sistema interruttore elettrico utilizzante tale dispositivo interruttore.
JP4130385B2 (ja) * 2003-07-23 2008-08-06 独立行政法人科学技術振興機構 ゲスト分子を内包した単層カーボンナノチューブの製造方法
US7625840B2 (en) 2003-09-17 2009-12-01 Uchicago Argonne, Llc. Catalytic nanoporous membranes
US20050164211A1 (en) * 2004-01-22 2005-07-28 Hannah Eric C. Carbon nanotube molecular labels
WO2006028508A2 (en) * 2004-03-23 2006-03-16 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
JP2008505044A (ja) 2004-03-26 2008-02-21 フォスター−ミラー,インコーポレーテッド 電解析出によって製造されたカーボンナノチューブに基づく電子デバイス及びその応用
US7312155B2 (en) 2004-04-07 2007-12-25 Intel Corporation Forming self-aligned nano-electrodes
US20060073489A1 (en) 2004-10-05 2006-04-06 Gangqiang Li Nanopore separation devices and methods of using same
US7473943B2 (en) 2004-10-15 2009-01-06 Nanosys, Inc. Gate configuration for nanowire electronic devices
US7435353B2 (en) 2004-12-09 2008-10-14 President And Fellows Of Harvard College Patterning by energetically-stimulated local removal of solid-condensed-gas layers and solid state chemical reactions produced with such layers
US7524431B2 (en) 2004-12-09 2009-04-28 President And Fellows Of Harvard College Lift-off patterning processing employing energetically-stimulated local removal of solid-condensed-gas layers
CA2603352C (en) * 2005-04-06 2013-10-01 Jene Golovchenko Molecular characterization with carbon nanotube control
US7625702B2 (en) * 2005-12-20 2009-12-01 International Business Machines Corporation Helical wrapping of single-walled carbon nanotubes by genomic DNA
EP1999067B1 (en) 2006-02-07 2014-04-09 President and Fellows of Harvard College Gas-phase functionalization of carbon nanotubes
US20070275396A1 (en) * 2006-03-17 2007-11-29 Ming Zheng Detection of DNA hybridization with a carbon nanotube label
WO2009045472A1 (en) 2007-10-02 2009-04-09 President And Fellows Of Harvard College Capture, recapture, and trapping of molecules with a nanopore
EP2205522B1 (en) * 2007-10-02 2019-03-13 President and Fellows of Harvard College Carbon nanotube synthesis for nanopore devices
US8986928B2 (en) * 2009-04-10 2015-03-24 Pacific Biosciences Of California, Inc. Nanopore sequencing devices and methods
US8864969B2 (en) * 2009-06-25 2014-10-21 The Board Of Trustees Of The Leland Stanford Junior University Electro-diffusion enhanced bio-molecule charge detection using electrostatic interaction
WO2013074546A1 (en) * 2011-11-14 2013-05-23 The Regents Of The University Of California Two- chamber dual-pore device

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