CN101199466B - Lamiophlomis rotata medical dental cream and process for preparing same - Google Patents
Lamiophlomis rotata medical dental cream and process for preparing same Download PDFInfo
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- CN101199466B CN101199466B CN2007101992377A CN200710199237A CN101199466B CN 101199466 B CN101199466 B CN 101199466B CN 2007101992377 A CN2007101992377 A CN 2007101992377A CN 200710199237 A CN200710199237 A CN 200710199237A CN 101199466 B CN101199466 B CN 101199466B
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Abstract
The invention provides a lamioplomis rotata medical toothpaste which is prepared with lamioplomis rotate extract as main medical active material and commonly used auxiliary material through common technique. The medical toothpaste of the invention has the functions of easing pain, stopping bleeding, diminishing inflammation and preventing bacteria and can effectively cure oral diseases such as ngival hemorrhage, ngivitis, periodontitis, gingival atrophy and oral ulcer; meanwhile, the invention can clean the teeth and the mouth, nurse the mouth and keep the foul breath fresh.
Description
Technical field
The invention belongs to filed of daily-use chemical industry, relate to a kind of daily toothpaste, relate in particular to and a kind ofly can effectively prevent and treat gingival hemorrhage, gingivitis, periodontitis, gingival swelling and pain, the medicated toothpaste of gingival atrophy and oral ulcer---Radix Lamiophlomidis Rotatae toothpaste; The present invention also relates to the preparation technology of Radix Lamiophlomidis Rotatae toothpaste simultaneously.
Background technology
Radix Lamiophlomidis Rotatae belongs to the dry herb of labiate Radix Lamiophlomidis Rotatae, be national folk traumatic injury medical herbs such as Tibetan, illiteracy, Nahsi, be stated from Tibetan medicine's masterpiece Four-Volume Medical Code, " month king's medicine is examined " the earliest, be Labiatae Radix Lamiophlomidis Rotatae platymiscium, bitter in the mouth, cold nature, go into Liver Channel, have invigorate blood circulation, blood stasis expelling, detumescence, hemostasis, analgesic effect, have concurrently antibiotic, anti-infectious function.
Radix Lamiophlomidis Rotatae has good pain relieving analgesic activity, Kai Fa Radix Lamiophlomidis Rotatae granule in recent years, capsules etc. are all to gingival swelling and pain, and gingival hemorrhage is better curative effect again, in clinical practice, also show the characteristics of drug safety, determined curative effect, met broad masses of the people's interests.
Toothpaste is articles for daily use indispensable during people live, and the quality of tooth also directly affects health; Medicated toothpaste in the market is of a great variety, differs from one another.According to investigations, also be not the medicated toothpaste of active component preparation in the market with the Radix Lamiophlomidis Rotatae extract.
Summary of the invention
The purpose of this invention is to provide a kind of pain relieving that has, hemostasis, detumescence, antibacterial, the lamiophlomis rotata medical dental cream of antiinflammatory action, this medicated toothpaste can effectively be prevented and treated gingivitis, gingival hemorrhage, periodontitis, gingival swelling and pain, oral diseases such as gingival atrophy and oral ulcer.
Another object of the present invention provides the preparation technology of lamiophlomis rotata medical dental cream.
Lamiophlomis rotata medical dental cream of the present invention is to be main active constituents of medicine with Radix Lamiophlomidis Rotatae extract, and the substrate commonly used and the common process that are equipped with preparation toothpaste are prepared from.
Since the Radix Lamiophlomidis Rotatae medicine have invigorate blood circulation, blood stasis expelling, detumescence, hemostasis, analgesic effect, have concurrently antibiotic, anti-infectious function, with Radix Lamiophlomidis Rotatae extract is the lamiophlomis rotata medical dental cream that main active pharmaceutical ingredient is prepared from, at the control gingival hemorrhage, gingivitis, periodontitis, gingival atrophy and oral ulcer aspect have significant effect.
The present invention can also select Margarita powder, trona, Cacumen Myricariae Germanicae extract, Herba Oxytropis Kansuensis extract etc. for use, with Radix Lamiophlomidis Rotatae extract jointly as pharmaceutically active substance, make various efficacy of drugs produce synergism, thereby more effectively prevent and treat gingival hemorrhage, gingivitis, periodontitis, gingival atrophy and oral ulcer etc.
Margarita powder has removing toxic substances and promoting granulation, looks improving and the skin nourishing, the removing nebula that makes eye bright, tranquillizing the mind by relieving convulsion, and can antiinflammatory, sterilization, antipruritic effect; Trona has removing toxic substances and promoting pus discharge, eliminates indigestion and phlegm the effect of anthelmintic relieving constipation; Cacumen Myricariae Germanicae has the effect of dispelling wind to relieve the exterior syndrome, dispelling wind and removing obstruction in the collateral; Herba Oxytropis Kansuensis raw material Herba Oxytropis Kansuensis has heat-clearing and toxic substances removing, the granulation promoting skin ulcer that heals, the hesitant pulse hemostasis, the effect of relieving constipation, this four flavor helps altogether that Radix Lamiophlomidis Rotatae is invigorated blood circulation, blood stasis expelling, detumescence, hemostasis, analgesic effect, makes the control gingival hemorrhage of lamiophlomis rotata medical dental cream of the present invention, gingivitis, periodontitis, the effect of gingival atrophy and oral ulcer etc. is more remarkable.
In order to make medicated toothpaste of the present invention that good prevention effect be arranged, active constituents of medicine and adjuvant are prepared burden with 12%～25%, 88%～75% weight percent.Wherein the amount of Radix Lamiophlomidis Rotatae is 12%～25% of a raw material total amount; The amount of Margarita powder is a raw material total amount 0～5%; The amount of trona is 0～5% of a raw material total amount; The amount of Cacumen Myricariae Germanicae extract is 0～5% of a raw material total amount; The amount of Herba Oxytropis Kansuensis is 0～5% of a raw material total amount.
Described Radix Lamiophlomidis Rotatae extract is after selected Radix Lamiophlomidis Rotatae medical material is removed impurity, pulverizes, and relative density is put forward, is condensed into to water is 1.10～1.30 extractum.
Described trona is concocted and got by following technology: selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 200～500 mesh sieves.
Described Cacumen Myricariae Germanicae extract is made by following technology: after selected Cacumen Myricariae Germanicae medical material is removed impurity, pulverize, water is carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
Described Herba Oxytropis Kansuensis extract is made by following technology: after selected Herba Oxytropis Kansuensis medical material is removed impurity, pulverize, water is carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
The present invention prepares ointment substrate commonly used and comprises:
Abrasivus 8%～60%, sweeting agent 0%～1%, foaming agent 1%～5%, adhesive 0.5%～3%,
Wetting agent 5%～30%, spice 0%～2%, antiseptic 0%～0.5%, deionized water 1%～40%,
Food coloring 0%～1.5%.
Wherein the general fineness of abrasivus is moderate, pH value is 7.5～9, free from admixture, mainly contain calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, aluminium hydroxide, Alumina hydrate, calcite in powder, leuchtenbergite etc., preferred calcium carbonate or calcium phosphate dibasic dihydrate; Foaming agent has the foaming decontamination, mainly contains sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, acyl glutamic acid sodium etc., preferably sodium dodecyl sulfate; Sweeting agent is mainly selected sucrose, glucide, cyclamate, xylitol, dipeptide sodium etc. for use, and effect is to strengthen sense of taste, eliminates bitterness, and consumption is moderate, preferably sucrose or xylitol; Adhesive is a primary raw material, and pH value is generally 8, and its consumption just becomes with abrasivus, mainly contains sodium alginate, carboxymethyl cellulose, hydroxyethyl-cellulose, yellow gummy powder, hydroxypropyl guar gum etc., preferably carboxymethyl cellulose; Wetting agent has suction antifreeze and guarantee that mastic displays the indeformable effect in back, mainly contains glycerol, sorbitol, propylene glycol, Polyethylene Glycol etc., preferred glycerol; Spice is that Oleum menthae, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, mandarin oil, wintergreen oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Mentholum, Borneolum Syntheticum, citral, lauryl aldehyde, vanillin, pentyl acetate etc. can make people's feeling cool tasty and refreshing, the major ingredient of fragrant odour, preferred Oleum menthae; Described antiseptic is at least a in p-Hydroxybenzoate, sodium benzoate, potassium sorbate, the sorbitol, preferred sorbitol; Described brightening agent is a titanium dioxide, Margarita powder etc., preferred Margarita powder.Deionized water is the one-tenth glue main dispersing medium of toothpaste.
The preparation technology of lamiophlomis rotata medical dental cream of the present invention:
1. after selected Radix Lamiophlomidis Rotatae medical material being removed impurity, pulverize, relative density is put forward, is condensed into to water is 1.10～1.30 extractum;
2. the trona medical material is removed impurity, washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 200～500 mesh sieves;
3. after selected Cacumen Myricariae Germanicae, Herba Oxytropis Kansuensis medical material being removed impurity, pulverize separately, water are carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
4. by above-mentioned formula ratio Radix Lamiophlomidis Rotatae is extracted extractum, Margarita powder, trona powder, Cacumen Myricariae Germanicae and extract the substrate commonly used that extractum, Herba Oxytropis Kansuensis extract extractum and preparation toothpaste, place the vacuum Manufacturing medicine extract machine to carry out after homogenizing handles, promptly canned.
Lamiophlomis rotata medical dental cream of the present invention can be confirmed by following clinical observation to the therapeutical effect of gingival swelling and pain, gingival hemorrhage, gingivitis, periodontitis, gingival atrophy, oral ulcer, halitosis and dental caries etc.Following table is the clinical observation statistical table of Radix Lamiophlomidis Rotatae medicine ointment of the present invention.
| Disease | Number | Produce effects | Effectively | Effective percentage (%) |
| Gingivitis | 24 | 18 | 3 | 87.5 |
| Gingival swelling and pain | 38 | 29 | 7 | 94.7 |
| Periodontitis | 34 | 21 | 6 | 79.4 |
| Oral ulcer | 26 | 15 | 6 | 80.8 |
| Gingival hemorrhage | 33 | 23 | 6 | 87.9 |
| Gingival atrophy | 22 | 13 | 3 | 72.7 |
| Dental caries | 31 | 12 | 7 | 61.3 |
[0026]Lamiophlomis rotata medical dental cream of the present invention, use every day sooner or later, and toothpaste should more need be grown than ordinary toothpaste stops longer slightly time, especially cacodontia in the oral cavity the periodontal time of staying.As can be seen from the above table, toothpaste of the present invention has the pain easing and hemostasis, detumescence, and effects such as anti-inflammation can be used for being used for effective control: gingival swelling and pain, gingival hemorrhage, gingivitis, periodontitis, gingival atrophy, oral ulcer, halitosis and dental caries etc.After using a week, above-mentioned symptom obviously improves, and life-time service is without any side effects, can be used for keeping oral cavity cleaning, and pre-preventing tooth diseases takes place, and impels dental health.
Lamiophlomis rotata medical dental cream of the present invention is except having the control gingival hemorrhage, gingivitis, and periodontitis outside the function of gingival atrophy and oral ulcer, also has following characteristics:
1, can effectively ease pain hemostasis, detumescence; Anti-dental bed abscess, the dental caries effect is obvious;
2, energy antiinflammatory, antibacterial can effectively prevent and treat gingivitis, periodontitis, and gingival hemorrhage, teeth consolidating protects gum.
3, clean the teeth tasty and refreshingly, well the oral cavity is nursed, make implication keep pure and fresh;
4, cost is low, cheap.
The specific embodiment
Embodiment 1:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 12g, Cacumen Myricariae Germanicae extract 3g, calcium phosphate dibasic dihydrate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (fruit green) 0.08g, xylitol 0.5g, precipitated silica 10g, PEG400 0.5g, deionized water 9.92g.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.10 extractum; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.10 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 2:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 15g, Margarita powder 2g, Cacumen Myricariae Germanicae extract 2g, Herba Oxytropis Kansuensis extract 1g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (fruit green) 0.08g, xylitol 0.5g, precipitated silica 10g, Macrogol 600 0.5g, deionized water 4.92g.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.20 extractum; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.10 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 300 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 3:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 18g, Margarita powder 3g, trona 3g, Cacumen Myricariae Germanicae extract 2g, Herba Oxytropis Kansuensis extract 2g, calcium carbonate 30g, glycerol 15g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (fruit green) 0.08g, xylitol 0.5g, precipitated silica 7g, PEG400 0.5g, deionized water 4.92g.
Preparation technology
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.15 extractum; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 300 mesh sieves; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.18 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 300 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 4:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 20g, Margarita powder 5g, trona 5g, Cacumen Myricariae Germanicae extract 3g, Herba Oxytropis Kansuensis extract 2g, calcium hydrogen phosphate 20g, glycerol 15g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (fruit green) 0.08g, glucide 0.5g, precipitated silica 5g, Macrogol 2000 0.5g, deionized water 9.92g.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.20 extractum; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 400 mesh sieves; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.20 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 5:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 20g, Margarita powder 2g, Cacumen Myricariae Germanicae extract 2g, trona 1g, Herba Oxytropis Kansuensis extract 1g, calcium hydrogen phosphate 25g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 5g, Oleum menthae 1g, food coloring (fruit green) 0.08g, glucide 0.5g, precipitated silica 10g, PEG400 0.5g, deionized water 8.92g.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.20 extractum; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 500 mesh sieves; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.20 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 500 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 6:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 23g, Margarita powder 5g, Herba Oxytropis Kansuensis extract 2g, calcium phosphate dibasic dihydrate 25g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 5g, Oleum menthae 1g, food coloring (fruit green) 0.08g, xylitol 0.5g, precipitated silica 8g, Macrogol 2000 0.5g, deionized water 6.92g.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.10 extractum; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.10 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 7:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 15g, Cacumen Myricariae Germanicae extract 5g, trona 5g, calcium hydrogen phosphate 25g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (fruit green) 0.08g, xylitol 0.5g, precipitated silica 10g, PEG400 0.5g, deionized water 4.92g.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.15 extractum; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.10 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 400 mesh sieves.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 8:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 15g, trona 5g, calcium phosphate dibasic dihydrate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (green) 0.08g, xylitol 0.5g, precipitated silica 10g, Liquid Macrogol-4000 0.5g, deionized water 4.92g.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.15 extractum; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 400 mesh sieves.
2. food coloring is used deionized water furnishing toner; All the other pharmaceutically active raw materials mixing behind decolorizing with activated carbon.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 9:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 15g, trona 3g, Herba Oxytropis Kansuensis extract 2g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (fruit green) 0.08g, xylitol 0.5g, precipitated silica 10g, PEG400 0.5g, deionized water 4.92.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.20 extractum; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 300 mesh sieves.After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.10 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 300 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Embodiment 10:
Raw material is equipped with: Radix Lamiophlomidis Rotatae extract 22g, Cacumen Myricariae Germanicae extract 5g, Margarita powder 5g, calcium phosphate dibasic dihydrate 20g, glycerol 18g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (fruit green) 0.08g, xylitol 0.5g, precipitated silica 8g, PEG400 0.5g, deionized water 6.92g.
Preparation technology:
1. the Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, pulverize, the decocting that adds 10 times of medical material volumes boils three times, each 1.5 hours, merge extractive liquid; Filter, and filtrate decompression is concentrated, be condensed into relative density behind the concentrated solution activated carbon decolorizing and be 1.15 extractum; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.20 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. food coloring is standby with deionized water furnishing toner.
3. with behind Radix Lamiophlomidis Rotatae extractum, all the other pharmaceutically active raw materials, the above-mentioned toner mix homogeneously, with the prescription in other substrate mixings after, cross and join the vacuum Manufacturing medicine extract machine behind 500 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Radix Lamiophlomidis Rotatae lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Radix Lamiophlomidis Rotatae toothpaste finished product.
Claims (6)
1. lamiophlomis rotata medical dental cream, be by the substrate commonly used of the pharmaceutically active raw material of following percentage by weight and preparation toothpaste routinely prepared form:
Radix Lamiophlomidis Rotatae extract 12%～25% Margarita powder 0～5%, trona 0～5%
Cacumen Myricariae Germanicae extract 0～5% Herba Oxytropis Kansuensis extract 0～5% substrate 75～88%
Described Radix Lamiophlomidis Rotatae extract is to be made by following technology: after selected Radix Lamiophlomidis Rotatae medical material is removed impurity, pulverize, relative density is put forward, is condensed into to water is 1.10～1.30 extractum;
Described trona is concocted and got by following technology: selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 200～500 mesh sieves;
Described Cacumen Myricariae Germanicae extract is made by following technology: after selected Cacumen Myricariae Germanicae medical material is removed impurity, pulverize, water is carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
Described Herba Oxytropis Kansuensis extract is made by following technology: after selected Herba Oxytropis Kansuensis medical material is removed impurity, pulverize, water is carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. lamiophlomis rotata medical dental cream as claimed in claim 1 is characterized in that: described substrate comprises:
Abrasivus 8%～60%, sweeting agent 0%～1%, foaming agent 1%～5%, adhesive 0.5%～3%,
Wetting agent 5%～30%, spice 0%～2%, antiseptic 0%～0.5%, deionized water 1%～40%,
Brightening agent 0%～1.5%, food coloring 0%～1.5%.
3. lamiophlomis rotata medical dental cream as claimed in claim 2 is characterized in that: described abrasivus is any in calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, aluminium hydroxide, Alumina hydrate, calcite in powder, the leuchtenbergite; Foaming agent is any in sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, the acyl glutamic acid sodium; Sweeting agent has any in sucrose, glucide, cyclamate, xylitol, the dipeptide sodium; Adhesive is any in sodium alginate, carboxymethyl cellulose, hydroxyethyl-cellulose, yellow gummy powder, the hydroxypropyl guar gum; Wetting agent is any in glycerol, sorbitol, propylene glycol, the Polyethylene Glycol; Spice is any in Oleum menthae, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, mandarin oil, wintergreen oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Mentholum, Borneolum Syntheticum, citral, lauryl aldehyde, vanillin, the pentyl acetate; Antiseptic is at least a in p-Hydroxybenzoate, sodium benzoate, potassium sorbate, the sorbitol; Described brightening agent is titanium dioxide or Margarita powder.
4. the preparation method of lamiophlomis rotata medical dental cream according to claim 1, finish by following processing step:
1. after selected Radix Lamiophlomidis Rotatae medical material being removed impurity, pulverize, relative density is put forward, is condensed into to water is 1.10～1.30 extractum;
2. the trona medical material is removed impurity, washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 200～500 mesh sieves;
3. after selected Cacumen Myricariae Germanicae, Herba Oxytropis Kansuensis medical material being removed impurity, pulverize separately, water are carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
4. by above-mentioned formula ratio Radix Lamiophlomidis Rotatae is extracted extractum, Margarita powder, trona powder, Cacumen Myricariae Germanicae and extract the substrate amount commonly used that extractum, Herba Oxytropis Kansuensis extract extractum and preparation toothpaste, place the vacuum Manufacturing medicine extract machine to carry out after homogenizing handles, promptly canned.
5. as the preparation method of lamiophlomis rotata medical dental cream as described in the claim 4, it is characterized in that:
Described substrate comprises:
Abrasivus 8%～60%, sweeting agent 0%～1%, foaming agent 1%～5%, adhesive 0.5%～3%,
Wetting agent 5%～30%, spice 0%～2%, antiseptic 0%～0.5%, deionized water 1%～40%,
Brightening agent 0%～1.5%, food coloring 0%～1.5%.
6. as the preparation method of lamiophlomis rotata medical dental cream as described in the claim 4, it is characterized in that: described abrasivus is any in calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, aluminium hydroxide, Alumina hydrate, calcite in powder, the leuchtenbergite; Foaming agent is any in sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, the acyl glutamic acid sodium; Sweeting agent has any in sucrose, glucide, cyclamate, xylitol, the dipeptide sodium; Adhesive has any in sodium alginate, carboxymethyl cellulose, hydroxyethyl-cellulose, yellow gummy powder, the hydroxypropyl guar gum; Wetting agent is any in glycerol, sorbitol, propylene glycol, the Polyethylene Glycol; Spice is any in Oleum menthae, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, mandarin oil, wintergreen oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Mentholum, Borneolum Syntheticum, citral, lauryl aldehyde, vanillin, the pentyl acetate; Antiseptic is at least a in p-Hydroxybenzoate, sodium benzoate, potassium sorbate, the sorbitol; Described brightening agent is titanium dioxide or Margarita powder.
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| CN2007101992377A CN101199466B (en) | 2007-11-24 | 2007-11-24 | Lamiophlomis rotata medical dental cream and process for preparing same |
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| CN2007101992377A CN101199466B (en) | 2007-11-24 | 2007-11-24 | Lamiophlomis rotata medical dental cream and process for preparing same |
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| CN101199466B true CN101199466B (en) | 2010-11-10 |
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| CN102078375A (en) * | 2009-12-01 | 2011-06-01 | 周广刚 | Externally-used medicine for diminishing inflammation, swelling subsidence and relieving pains on surface of wound |
| RU2457829C2 (en) * | 2010-11-08 | 2012-08-10 | Общество С Ограниченной Ответственностью "Сплат-Косметика" (Ооо "Сплат-Косметика") | Mineral and vitamin complex for strengthening tooth enamel, composition for oral cavity hygiene and toothpaste |
| CN102198069B (en) * | 2011-06-09 | 2013-03-13 | 甘肃独一味生物制药股份有限公司 | Lamiophlomis rotata toothpaste and preparation method thereof |
| CN102579301A (en) * | 2012-03-22 | 2012-07-18 | 珈侬生化科技(中国)有限公司 | Preparation method for myricaria laxiflora extractive and whitening anti-aging cosmetic |
| CN103432018B (en) * | 2013-08-13 | 2015-10-21 | 上海方木精细化工有限公司 | Aluminum oxide type toothpaste |
| CN105078877A (en) * | 2015-09-24 | 2015-11-25 | 福建绿宝食品集团有限公司 | Mushroom type anti-cavity toothpaste and preparing method thereof |
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| CN106265126A (en) * | 2016-08-17 | 2017-01-04 | 林少英 | A kind of whitening toothpaste |
| CN108096109A (en) * | 2018-01-10 | 2018-06-01 | 班戈卓攀健康产业有限责任公司 | A kind of formulation of tooth-paste and preparation method thereof |
| CN110652461A (en) * | 2019-10-28 | 2020-01-07 | 严巧文 | Health-care whitening toothpaste |
| CN110772467A (en) * | 2019-11-28 | 2020-02-11 | 西藏葛如吒生物科技有限公司 | Tibetan medicine toothpaste |
| CN110721194A (en) * | 2019-12-03 | 2020-01-24 | 平措绕吉 | Method for processing Tibetan trona as medicine |
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