CN101199470B - Calcite medical dental cream and process for preparing same - Google Patents
Calcite medical dental cream and process for preparing same Download PDFInfo
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- CN101199470B CN101199470B CN2007101992521A CN200710199252A CN101199470B CN 101199470 B CN101199470 B CN 101199470B CN 2007101992521 A CN2007101992521 A CN 2007101992521A CN 200710199252 A CN200710199252 A CN 200710199252A CN 101199470 B CN101199470 B CN 101199470B
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Abstract
The invention provides a gypsum rubrum medical toothpaste. The toothpaste is made with processed calcite as the main active medical material and commonly used toothpaste base material through common technique. The gypsum rubrum medical toothpaste integrates the functions of diminishing inflammation, stopping bleeding, easing pain and detumescence and has good effects in curing gingival bleeding and teethridge abscess and can care the mouth well and keep the foul breath fresh.
Description
Technical field
The invention belongs to the daily-use chemical industry technical field, relate to a kind of medicated toothpaste, particularly a kind of have a treatment gingival hemorrhage, the gingiva detumescence, and the toothpaste of relieve inflammation or internal heat antiinflammatory and tooth-whitening---Mirabilitum crystallina toothpaste the invention still further relates to the preparation technology of Mirabilitum crystallina toothpaste.
Background technology
Mirabilitum crystallina is Sulfates mineral gypsum and carbonate calcite family mineral calcite.Be national folk resolving heat and reducing pathogenic fire mineral drugs such as Tibetan, illiteracy, Nahsi, be stated from " WU Pu Bencao " i.e. having another name called of " herbal classic " Mirabilitum crystallina the earliest.Be divided into south, calcite again; Acrid in the mouth, salty, cold in nature, GUIXIN, stomach, kidney channel have resolving heat and reducing pathogenic fire, sharp key, the repercussive effect, have concurrently antibiotic, anti-infectious function.Cold in nature the falling of Mirabilitum crystallina let out, and the merit of resolving heat and reducing pathogenic fire is arranged, and is used for warm febrile disease at edema caused by disorder of QI, and the high fever excessive thirst has good clearing heat and anti-inflammatory functions, grinds external into powder to conjunctival congestion and swelling pain, laryngopharynx swelling and pain, and aphtha of the mouth and tongue, burn due to hot liquid or fires etc. have better curative effect.
Toothpaste is articles for daily use indispensable during people live, and the quality of tooth also directly affects health; Medicated toothpaste in the market is of a great variety, differs from one another.According to investigations, also be not the medicated toothpaste of active component preparation in the market with the Mirabilitum crystallina.
Summary of the invention
The invention provides a kind of inhibition gingival hemorrhage that has, gingiva detumescence, the Mirabilitum crystallina medicated toothpaste of the antiinflammatory of relieving inflammation or internal heat.
Another object of the present invention provides a kind of preparation technology of Mirabilitum crystallina medicated toothpaste.
Mirabilitum crystallina medicated toothpaste of the present invention is to be main active constituents of medicine with Mirabilitum crystallina, is equipped with the substrate commonly used of preparation toothpaste, and prepared forms routinely.
Because Mirabilitum crystallina is cold in nature, fall and let out, have resolving heat and reducing pathogenic fire, sharp key, the effect of detumescence, have concurrently antibiotic, anti-infectious function.With the Mirabilitum crystallina is the medicated toothpaste of pharmaceutically active feedstock production, and gingivitis, gingival swelling and pain, periodontitis, gingival hemorrhage, dental caries, tooth macula lutea etc. are had better curative effect.
The present invention can also select Margarita powder, trona, Cacumen Myricariae Germanicae extract, Herba Oxytropis Kansuensis extract etc. for use, with the Mirabilitum crystallina medicine jointly as pharmaceutically active substance, make various efficacy of drugs produce synergism, thereby more effectively prevent and treat gingivitis, gingival swelling and pain, periodontitis, gingival hemorrhage, dental caries, tooth macula lutea etc.
Margarita powder has removing toxic substances and promoting granulation, looks improving and the skin nourishing, the removing nebula that makes eye bright, tranquillizing the mind by relieving convulsion, and can antiinflammatory, sterilization, antipruritic effect; Trona has removing toxic substances and promoting pus discharge, eliminates indigestion and phlegm the effect of anthelmintic relieving constipation; Cacumen Myricariae Germanicae has the effect of dispelling wind to relieve the exterior syndrome, dispelling wind and removing obstruction in the collateral; Herba Oxytropis Kansuensis has heat-clearing and toxic substances removing, the granulation promoting skin ulcer that heals, hesitant pulse hemostasis, the effect of relieving constipation, this four flavor helps altogether that Mirabilitum crystallina is invigorated blood circulation, blood stasis expelling, detumescence, hemostasis, analgesic effect, makes the control treatment gingival hemorrhage of Mirabilitum crystallina medicated toothpaste of the present invention, the gingiva detumescence, the effect of the antiinflammatory of relieving inflammation or internal heat is more remarkable.
In order to make medicated toothpaste have better treatment, health care and preventive effect, active constituents of medicine and adjuvant are prepared burden with 5%～25%, 95%～75% weight percent.Wherein the amount of Mirabilitum crystallina is 5%～25% of a raw material total amount; The amount of Margarita powder is a raw material total amount 0～5%; The amount of trona is 0～5% of a raw material total amount; The amount of Cacumen Myricariae Germanicae extract is 0～5% of a raw material total amount; The amount of Herba Oxytropis Kansuensis is 0～5% of a raw material total amount.
The active constituents of medicine Mirabilitum crystallina that the present invention adopts is the Mirabilitum crystallina through concocting, and its concocting method has following 12 kinds:
One, gets the Mirabilitum crystallina crude drug, remove impurity, clean, be broken into fritter or be ground into fine powder and use.
Two, get clean Mirabilitum crystallina, put in the refractory container, forge with high heat to being popular in, taking-up cools, and grinds or is ground into fine powder and use.
Three, get Rhizoma Zingiberis Recens and clean, smash extracting juice to pieces, clear water slightly adds Mirabilitum crystallina again and goes into to boil altogether in the pot to juice and do, and takes out, and dries porphyrize.The every 100kg of Mirabilitum crystallina uses Rhizoma Zingiberis Recens 10kg.
Four, get clean Mirabilitum crystallina, put and forge on the intense fire to being popular in, take out, in the vinegar of quenching, take out cold back, dries, and porphyrize sieves.The every 100kg of Mirabilitum crystallina uses vinegar 10kg.
Five, get clean Mirabilitum crystallina, be ground into the Semen Viciae fabae size, add Natrii Sulfas, boiled 3 hours, discard nitre liquid,, till the washing liquid clarification, the Mirabilitum crystallina dried and crushed is become fine powder with clear water rinsing 10-15 time.
Six, get clean Mirabilitum crystallina, pound into fritter, put in the refractory container, forge, drop into the shortcake of quenching in " Da La " (skim milk), take out pulverizing and make to white.
Seven, get clean Mirabilitum crystallina 1kg, smash, it is an amount of to add Sal Nitri 10g and water, boils 3h, and the liquid that anhydrates inclines, water cyclic washing 10～15 times till the washing liquid clarification, dries, and is ground into fine powder, and is with milk an amount of, stir into the dough shape, make the about 10cm of diameter, the cake that thick 3cm is following dries in the shade.
Eight, take the Mirabilitum crystallina of the Semen Viciae fabae size that Natrii Sulfas boiled, be ground into Semen avenae nudae grain size, put into iron pan and stir-fry, fry, add a juice barley wine, make the Mirabilitum crystallina submergence to hot with equivalent Sal, airtight, after cooling, take out Mirabilitum crystallina and dry promptly.
Nine, be broken into the granule of Semen Glycines size after Mirabilitum crystallina is cleaned, pour into to heat in the iron pan again and stir-fry, its color becomes little when yellow, spray a little Chinese liquor add a cover cool cold after, become the soft standard that promptly reached.
Ten, Mirabilitum crystallina cleaned sorted out impurity, smash to pieces grind into powder after, pour into to heat in the iron pan and stir-fry for several times, a little Calculus Bovis water or white sugar water of spirt again adds a cover that to be placed on shady and cool place standby.
11, the Mirabilitum crystallina of smashing to pieces is poured in the iron pan, in wine, pulled out then and dry in the shade with the strong fiery back bubble of frying.
12, earlier Mirabilitum crystallina is smashed in the crock of packing into together with making up a prescription to pieces 2/3, reserved 1/3 space, the good seal openning after waiting to do, is uninterruptedly burnt and was opened openning in 10 days later on, becomes white with the full color of jar, has promptly obtained required medicine material.
Annotate: wherein one, three, four, five, six come from " science of Chinese drug processing dictionary ", the chief editor of Shanghai science tech publishing house: leaf decide Jiang Yuansi and is led to June in 2005 the 1st edition
Two. 11. 12 come from " concocting method commonly used and the effect thereof of Chinese national folk medical magazine total the 55th phase＜Mirabilitum crystallina in 2002〉" crust figure, Na Ren and spend the 101st page
Seven, eight, nine, ten come from " Tibetan medicine standard ", and the Qinghai People's Press publishes Tibet, Qinghai, Sichuan, Gansu, Yunnan, Xinjiang health bureau and compiles December in 1979 the 1st edition
The preparation method of Mirabilitum crystallina medicated toothpaste of the present invention, finish by following processing step:
1. with selected Mirabilitum crystallina medical material routinely technology concoct;
2. the trona medical material is removed impurity, washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 200～500 mesh sieves;
3. after selected Cacumen Myricariae Germanicae, Herba Oxytropis Kansuensis medical material being removed impurity, pulverize separately, water are carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
4. extract the substrate amount commonly used that extractum, Herba Oxytropis Kansuensis extract extractum and preparation toothpaste by the Mirabilitum crystallina after the process of preparing Chinese medicine of above-mentioned formula ratio, Margarita powder, trona powder, Cacumen Myricariae Germanicae, place the vacuum Manufacturing medicine extract machine to carry out after homogenizing handles, promptly canned.
Mirabilitum crystallina medicated toothpaste of the present invention can be confirmed by following clinical observation to the therapeutical effect of gingivitis, gingival swelling and pain, periodontitis, gingival hemorrhage, dental caries, tooth macula lutea etc.Following table is the clinical observation statistical table of Mirabilitum crystallina medicated toothpaste of the present invention.
| Disease | The observation number | Produce effects | Effectively | Effective percentage (%) |
| Gingivitis | 36? | 26? | 7? | 91.7? |
| Gingival swelling and pain | 38? | 26? | 8? | 89.5? |
| Periodontitis | 38? | 25? | 10? | 92.1? |
| Gingival hemorrhage | 29? | 18? | 6? | 82.8? |
| Dental caries | 31? | 14? | 8? | 77.4? |
| The tooth macula lutea | 26? | 16? | 7? | 88.5? |
[0034]Toothpaste of the present invention, use every day sooner or later, and toothpaste should more need be grown than ordinary toothpaste stops longer slightly time, especially cacodontia in the oral cavity the periodontal time of staying.As can be seen from the above table, toothpaste of the present invention has the antiinflammatory of relieving inflammation or internal heat, reducing swelling and alleviating pain, and effects such as tooth-whitening can be used for effectively preventing: gingivitis, periodontitis, gingival swelling and pain, oral ulcer and dental caries etc., and can tooth-whitening.
Mirabilitum crystallina medicated toothpaste of the present invention has the better curative effect gingivitis, gingival swelling and pain, periodontitis, gingival hemorrhage, dental caries, tooth macula lutea etc. except having, and also has following characteristics:
1, medicated toothpaste of the present invention has analgesia, and anastalsis is obvious to gingival hemorrhage, dental bed abscess curative effect;
2, medicated toothpaste collection of the present invention antiinflammatory, hemostasis, the detumescence effect can be nursed the oral cavity well, makes implication keep pure and fresh.
3, cost is low, cheap.
The specific embodiment
The preparation of embodiment 1, Mirabilitum crystallina medicated toothpaste
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 4.5g, Cacumen Myricariae Germanicae extract 0.5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 10g, Macrogol 4000 .5g, deionized water 19.92g.
Preparation technology:
1. with selected Mirabilitum crystallina medical material washing, air-dry, after the calcining, pulverize; Add an amount of Sal Nitri and water, boil 3h, the liquid that anhydrates that inclines, water cyclic washing 10～15 times till the washing liquid clarification, dries.
2. above-mentioned Mirabilitum crystallina is ground to form smalls, add milk during grinding, the addition of milk is: 10KG milk/100～200KG Mirabilitum crystallina; Grind and finish, the milk that inclines, pulverize air-dry back, crosses 400 mesh sieves, gets Mirabilitum crystallina pharmaceutically active raw material;
3. after selected Cacumen Myricariae Germanicae medical material being removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
4. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, the former abrasive lapping of Cacumen Myricariae Germanicae pharmaceutically active is even;
5. the 4. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, after crossing 400 mesh sieves, join system cream in the vacuum Manufacturing medicine extract machine (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect the reuse ultraviolet radiation disinfection earlier in alcohol), just make the Mirabilitum crystallina lotion of toothpaste;
6. go out cream, chemical examination;
7. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 2:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 7.5g, Margarita powder 2.5g, calcium phosphate dibasic dihydrate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 10g, Macrogol 4000 .5g, deionized water 14.92g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, remove impurity, clean, pulverize, cross 200 mesh sieves, get Mirabilitum crystallina pharmaceutically active raw material;
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, the former abrasive lapping of Margarita powder pharmaceutically active is even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 200 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 3:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 10g, Margarita powder 2.5g, trona pharmaceutically active raw material 2.5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring 9 (white) 0.08g, xylitol 0.5g, precipitated silica 10g, Macrogol 600 0.5g, deionized water 9.92g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, put in the refractory container, forge with high heat to being popular in, taking-up cools, and is ground into fine powder, crosses 300 mesh sieves, gets Mirabilitum crystallina pharmaceutically active raw material; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 300 mesh sieves.
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, Margarita powder, the former abrasive lapping of trona pharmaceutically active are even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 300 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 4:
Raw material is equipped with: Mirabilitum crystallina medicine material 10g, Margarita powder 2.5g, Cacumen Myricariae Germanicae extract 2.5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 10g, cetomacrogol 1000 0.5g, deionized water 9.92g.
Preparation technology:
1. get Rhizoma Zingiberis Recens and clean, smash extracting juice to pieces, add small amount of deionized water, add Mirabilitum crystallina again and go into to boil altogether in the pot to juice and do, the addition of Rhizoma Zingiberis Recens is: 10KG Rhizoma Zingiberis Recens/100KG Mirabilitum crystallina.Take out, dry, porphyrize is crossed 400 mesh sieves, promptly gets Mirabilitum crystallina pharmaceutically active raw material; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, Margarita powder, the former abrasive lapping of Cacumen Myricariae Germanicae pharmaceutically active are even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 5:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 5g, Margarita powder 5g, Cacumen Myricariae Germanicae extract 5g, trona pharmaceutically active raw material 2.5g, Herba Oxytropis Kansuensis extract 2.5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.8g, precipitated silica 8g, Macrogol 600 0.5g, deionized water 6.62g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, put and forge on the intense fire to being popular in, take out, in the vinegar of quenching, the addition of vinegar is: 10KG vinegar/100KG Mirabilitum crystallina.Take out cold back, dries, and porphyrize is crossed 400 mesh sieves, gets Mirabilitum crystallina pharmaceutically active raw material; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.20 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 400 mesh sieves.After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, the other drug activated feedstock grinds evenly;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 6:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 13g, Margarita powder 5g, Herba Oxytropis Kansuensis extract 2g, trona pharmaceutically active raw material 2g, Cacumen Myricariae Germanicae extract 3g, calcium phosphate dibasic dihydrate 30g, glycerol 15g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.8g, precipitated silica 8g, PEG400 0.5g, deionized water 6.62g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, be ground into the Semen Viciae fabae size, add Natrii Sulfas, the addition of Natrii Sulfas is: 1KG Natrii Sulfas/1000KG Mirabilitum crystallina.Boiled 3 hours, and discarded nitre liquid,, till the washing liquid clarification,, cross 400 mesh sieves the Mirabilitum crystallina dried and crushed with clear water rinsing 10-15 time.Get Mirabilitum crystallina pharmaceutically active raw material; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.20 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 400 mesh sieves.After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, the other drug activated feedstock grinds evenly;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 7:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 10g, Cacumen Myricariae Germanicae extract 5g, trona pharmaceutically active raw material 5g, calcium carbonate 30g, glycerol 15g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, glucide 0.5g, precipitated silica 10g, PEG400 0.5g, deionized water 9.92g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, pound into fritter, put in the refractory container, forge to white, drop into the shortcake of quenching in " Da La, " (skim milk), the addition of " Da La " is: 10KG " Da La "/100KG Mirabilitum crystallina, take out pulverizing and make.Cross 200 mesh sieves, get Mirabilitum crystallina pharmaceutically active raw material; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.10 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 200 mesh sieves.
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, Cacumen Myricariae Germanicae, the former abrasive lapping of trona pharmaceutically active are even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 200 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 8:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 15g, trona pharmaceutically active raw material 5g, calcium hydrogen phosphate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 8g, Macrogol 4000 .5g, deionized water 6.92g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, get clean Mirabilitum crystallina 1kg, smash, it is an amount of to add Sal Nitri 10g and water, boils 3h, the liquid that anhydrates that inclines, water cyclic washing 10～15 times is till the washing liquid clarification, dry, be ground into fine powder, with milk an amount of, stir into the dough shape, make the about 10cm of diameter, the cake that thick 3cm is following dries in the shade.Cross 300 mesh sieves, get Mirabilitum crystallina pharmaceutically active raw material; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 300 mesh sieves.
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, the former abrasive lapping of trona pharmaceutically active is even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 300 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 9:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 15g, trona pharmaceutically active raw material 3g, Herba Oxytropis Kansuensis extract 2g, Cacumen Myricariae Germanicae extract 2g, calcium phosphate dibasic dihydrate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, glucide 0.5g, precipitated silica 8g, Macrogol 2000 0.5g, deionized water 4.92g.
Preparation technology:
1. take the Mirabilitum crystallina of the Semen Viciae fabae size that Natrii Sulfas boiled, be ground into Semen avenae nudae grain size, put into iron pan and stir-fry with equivalent Sal, fry to hot, add a juice barley wine, the addition of barley wine is: 10KG barley wine/100KG Mirabilitum crystallina makes the Mirabilitum crystallina submergence, airtight, after cooling, take out Mirabilitum crystallina and dry, pulverize, cross 400 mesh sieves, get Mirabilitum crystallina pharmaceutically active raw material; Selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 400 mesh sieves, promptly gets trona pharmaceutically active raw material; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.25 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.25 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, the other drug activated feedstock grinds evenly;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 10:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 10g, Cacumen Myricariae Germanicae extract 5g, Margarita powder 5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 9g, PEG400 0.5g, deionized water 5.92g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, be broken into the granule of Semen Glycines size, pour into again to heat in the iron pan and stir-fry, its color becomes little when yellow, spray a little Chinese liquor add a cover cool cold after, become the soft standard that promptly reached, pulverize, cross 300 mesh sieves, promptly get Mirabilitum crystallina pharmaceutically active raw material; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.25 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, Cacumen Myricariae Germanicae, the former abrasive lapping of Margarita powder pharmaceutically active are even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 300 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 11:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 10g, Herba Oxytropis Kansuensis extract 5g, Margarita powder 5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 9g, PEG400 0.5g, deionized water 5.92g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, smash to pieces, pour the iron pan turning in into and fry for several times, a little white sugar water of spirt is again added a cover and is placed on shady and cool place and dries in the shade, and pulverizes, and crosses 500 mesh sieves, promptly gets Mirabilitum crystallina pharmaceutically active raw material; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, Herba Oxytropis Kansuensis, the former abrasive lapping of Margarita powder pharmaceutically active are even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 500 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 12:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 10g, Cacumen Myricariae Germanicae extract 2g, Herba Oxytropis Kansuensis extract 2g, Margarita powder 5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 9g, PEG400 0.5g, deionized water 5.92g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, pulverize, the Mirabilitum crystallina of pulverizing is poured in the iron pan, in wine, pull out then and dry in the shade, pulverize, cross 400 mesh sieves, promptly get Mirabilitum crystallina pharmaceutically active raw material with the strong fiery back bubble of frying; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.10 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing; After selected Herba Oxytropis Kansuensis medical material removed impurity, pulverize, water is carried, and it is 1.15 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, Cacumen Myricariae Germanicae, Herba Oxytropis Kansuensis, the former abrasive lapping of Margarita powder pharmaceutically active are even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 400 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 13:
Raw material is equipped with: Mirabilitum crystallina pharmaceutically active raw material 10g, Cacumen Myricariae Germanicae extract 5g, Margarita powder 5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 9g, PEG400 0.5g, deionized water 5.92g.
Preparation technology:
1. get the Mirabilitum crystallina crude drug, after the clean system, pulverize, get the same crock interior 2/3 of packing into together that makes up a prescription of Mirabilitum crystallina after will pulverizing, reserve 1/3 space, sealing is after waiting to do, the uninterrupted baked wheaten cake opened openning in 10 days later on, become white with the full color of jar, promptly obtained required medicine material, go out jar after, cross 300 mesh sieves, promptly get Mirabilitum crystallina pharmaceutically active raw material; After selected Cacumen Myricariae Germanicae medical material removed impurity, pulverize, water is carried, and it is 1.10 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
2. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, Cacumen Myricariae Germanicae, the former abrasive lapping of Margarita powder pharmaceutically active are even;
3. the 2. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 300 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
4. go out cream, chemical examination;
5. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 14:
Raw material is equipped with: Mirabilitum crystallina medicine material 15g, Margarita powder 5g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 9g, Macrogol 600 0.5g, deionized water 5.92g.
Preparation technology:
1. selected Mirabilitum crystallina medical material is made only, air-dry, after the calcining, pulverizing and obtaining diameter is the following granule of 1mm; Get Mirabilitum crystallina granule 1KG, it is an amount of to add Sal Nitri 10g and water, boils 3h, the liquid that anhydrates that inclines, and water cyclic washing 10～15 times till the washing liquid clarification, dries.
2. above-mentioned granule is ground to form smalls, add milk during grinding, the addition of milk is: 10KG milk/100KG Mirabilitum crystallina; Grind and finish, the milk that inclines, pulverize air-dry back, crosses 200 mesh sieves, gets Mirabilitum crystallina pharmaceutically active raw material;
3. with food coloring with deionized water furnishing toner, and with the Mirabilitum crystallina pharmaceutically active raw material of the above-mentioned process of preparing Chinese medicine, the former abrasive lapping of Margarita powder pharmaceutically active is even;
4. the 3. synthetic pharmaceutically active raw material blending of substrate in will filling a prescription and step, cross and join the vacuum Manufacturing medicine extract machine behind 200 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
5. go out cream, chemical examination;
6. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Embodiment 15:
Raw material is equipped with: Mirabilitum crystallina medicine material 20g, calcium carbonate 30g, glycerol 20g, sodium carboxymethyl cellulose 1g, sodium lauryl sulphate 2g, sorbitol 10g, Oleum menthae 1g, food coloring (white) 0.08g, xylitol 0.5g, precipitated silica 9g, PEG400 0.5g, deionized water 5.92g.
Preparation technology:
1. selected Mirabilitum crystallina medical material is made only, air-dry, after the calcining, pulverizing and obtaining diameter is the following granule of 1mm; Get Mirabilitum crystallina granule 1KG, it is an amount of to add Sal Nitri 10g and water, boils 3h, the liquid that anhydrates that inclines, and water cyclic washing 10～15 times till the washing liquid clarification, dries.
2. above-mentioned granule is ground to form smalls, add milk during grinding, the addition of milk is: 10KG milk/200KG Mirabilitum crystallina; Grind and finish, the milk that inclines, pulverize air-dry back, crosses 500 mesh sieves, gets Mirabilitum crystallina pharmaceutically active raw material;
3. food coloring is used deionized water furnishing toner, and even with the former abrasive lapping of Mirabilitum crystallina pharmaceutically active of the above-mentioned process of preparing Chinese medicine;
4. substrate in will filling a prescription and the 3. synthetic Mirabilitum crystallina pharmaceutically active of step raw material blending, cross and join the vacuum Manufacturing medicine extract machine behind 500 mesh sieves and (must carry out disinfection to the vacuum Manufacturing medicine extract machine in advance: disinfect in alcohol earlier, the reuse ultraviolet radiation disinfection) system cream just makes the Mirabilitum crystallina lotion of toothpaste in;
5. go out cream, chemical examination;
6. aseptic canning goes in flexible pipe or the box to seal, and just makes Mirabilitum crystallina toothpaste finished product.
Claims (6)
1. Mirabilitum crystallina medicated toothpaste, be by the substrate commonly used of the pharmaceutically active raw material of following percentage by weight and preparation toothpaste routinely prepared form:
Mirabilitum crystallina 1%～25% Margarita powder of concocting 0～5%, trona 0～5%
Cacumen Myricariae Germanicae extract 0～5% Herba Oxytropis Kansuensis extract 0～5% substrate 75～95%
Described Mirabilitum crystallina is concocted by the common process of any process of preparing Chinese medicine Mirabilitum crystallina in the prior art and is formed;
Described trona is concocted and got by following technology: selected trona medical material is removed impurity, and washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 200～500 mesh sieves;
Described Cacumen Myricariae Germanicae extract is made by following technology: after selected Cacumen Myricariae Germanicae medical material is removed impurity, pulverize, water is carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
Described Herba Oxytropis Kansuensis extract is made by following technology: after selected Herba Oxytropis Kansuensis medical material is removed impurity, pulverize, water is carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing.
2. Mirabilitum crystallina medicated toothpaste as claimed in claim 1 is characterized in that: described substrate comprises:
Abrasivus 8%～60%, sweeting agent 0%～1%, foaming agent 1%～5%, adhesive 0.5%～3%,
Wetting agent 5%～30%, spice 0%～2%, antiseptic 0%～0.5%, deionized water 1%～40%,
Brightening agent 0%～1.5%, food coloring 0%～1.5%.
3. the Mirabilitum crystallina medicated toothpaste of stating as claim 2 is characterized in that: described abrasivus is any in calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, aluminium hydroxide, Alumina hydrate, calcite in powder, the leuchtenbergite; Foaming agent is any in sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, the acyl glutamic acid sodium; Sweeting agent has any in sucrose, glucide, cyclamate, xylitol, the dipeptide sodium; Adhesive has any in sodium alginate, carboxymethyl cellulose, hydroxyethyl-cellulose, yellow gummy powder, the hydroxypropyl guar gum; Wetting agent is any in glycerol, sorbitol, propylene glycol, the Polyethylene Glycol; Spice is any in Oleum menthae, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, mandarin oil, wintergreen oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Mentholum, Borneolum Syntheticum, citral, lauryl aldehyde, vanillin, the pentyl acetate; Antiseptic is at least a in p-Hydroxybenzoate, sodium benzoate, potassium sorbate, the sorbitol; Described brightening agent is titanium dioxide or Margarita powder.
4. the preparation method of Mirabilitum crystallina medicated toothpaste according to claim 1, finish by following processing step:
1. with selected Mirabilitum crystallina medical material routinely technology concoct; Cross 200～500 mesh sieves;
2. the trona medical material is removed impurity, washing after drying in the shade, is put the interior little fire of iron pan and is stir-fried, and after drying, pulverizes, and crosses 200～500 mesh sieves;
3. after selected Cacumen Myricariae Germanicae, Herba Oxytropis Kansuensis medical material being removed impurity, pulverize separately, water are carried, and it is 1.10～1.30 extractum that concentrated solution is condensed into relative density after with activated carbon decolorizing;
4. extract the substrate amount commonly used that extractum, Herba Oxytropis Kansuensis extract extractum and preparation toothpaste by the Mirabilitum crystallina after the process of preparing Chinese medicine of above-mentioned formula ratio, Margarita powder, trona powder, Cacumen Myricariae Germanicae, place the vacuum Manufacturing medicine extract machine to carry out after homogenizing handles, promptly canned.
5. as the preparation method of Mirabilitum crystallina medicated toothpaste as described in the claim 4, it is characterized in that: described substrate comprises:
Abrasivus 8%～60%, sweeting agent 0%～1%, foaming agent 1%～5%, adhesive 0.5%～3%,
Wetting agent 5%～30%, spice 0%～2%, antiseptic 0%～0.5%, deionized water 1%～40%,
Brightening agent 0%～1.5%, food coloring 0%～1.5%.
6. as the preparation method of Mirabilitum crystallina medicated toothpaste as described in the claim 4, it is characterized in that: described wherein abrasivus is any in calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, aluminium hydroxide, Alumina hydrate, calcite in powder, the leuchtenbergite; Foaming agent is any in sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, the acyl glutamic acid sodium; Sweeting agent has any in sucrose, glucide, cyclamate, xylitol, the dipeptide sodium; Adhesive is any in sodium alginate, carboxymethyl cellulose, hydroxyethyl-cellulose, yellow gummy powder, the hydroxypropyl guar gum; Wetting agent is any in glycerol, sorbitol, propylene glycol, the Polyethylene Glycol; Spice is any in Oleum menthae, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, mandarin oil, wintergreen oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Mentholum, Borneolum Syntheticum, citral, lauryl aldehyde, vanillin, the pentyl acetate; Antiseptic is at least a in p-Hydroxybenzoate, sodium benzoate, potassium sorbate, the sorbitol; Described brightening agent is titanium dioxide or Margarita powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2007101992521A CN101199470B (en) | 2007-11-24 | 2007-11-24 | Calcite medical dental cream and process for preparing same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101992521A CN101199470B (en) | 2007-11-24 | 2007-11-24 | Calcite medical dental cream and process for preparing same |
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| CN101199470A CN101199470A (en) | 2008-06-18 |
| CN101199470B true CN101199470B (en) | 2010-12-08 |
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| CN102114038B (en) * | 2011-01-27 | 2012-08-22 | 中国科学院西北高原生物研究所 | Cold-system preparation method of south calcite as a Tibetan medicine |
| CN106265126A (en) * | 2016-08-17 | 2017-01-04 | 林少英 | A kind of whitening toothpaste |
| CN107823051A (en) * | 2017-11-28 | 2018-03-23 | 李妍 | A kind of preparation method for the toothpaste for preventing and treating pregnant women's oulitis |
| CN108478449A (en) * | 2018-05-16 | 2018-09-04 | 丁国华 | Gypsum rubrum toothpaste preparation method |
| CN112415157A (en) * | 2020-11-24 | 2021-02-26 | 内蒙古祈蒙药业股份有限公司 | Quality control method of Anxiao six-ingredient granules |
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