CN112891412A - Anti-alcoholism medicine and preparation method thereof - Google Patents

Anti-alcoholism medicine and preparation method thereof Download PDF

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Publication number
CN112891412A
CN112891412A CN202110187800.9A CN202110187800A CN112891412A CN 112891412 A CN112891412 A CN 112891412A CN 202110187800 A CN202110187800 A CN 202110187800A CN 112891412 A CN112891412 A CN 112891412A
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parts
alcoholism
raw materials
medicine
angelica
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王和天
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/41Crassulaceae (Stonecrop family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/17Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting

Abstract

The invention discloses an anti-alcoholism medicine and a preparation method thereof, relating to the technical field of traditional Chinese medicine, wherein the anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 10-20 parts of flower of kudzuvine, 10-20 parts of hovenia dulcis thunb, 2-8 parts of Chinese rhubarb, 8-16 parts of rhodiola rosea, 8-16 parts of salvia miltiorrhiza, 5-15 parts of angelica and 8-15 parts of scutellaria baicalensis. The anti-alcoholism medicine provided by the invention has an obvious anti-alcoholism effect through the synergistic effect of seven Chinese herbal medicines of pueraria flower, hovenia dulcis thunb, rheum officinale, rhodiola rosea, salvia miltiorrhiza, angelica sinensis and scutellaria baicalensis, has an anti-alcoholism effect of 94%, particularly has a good effect on light and medium (excitation stage and ataxia stage) people, and has a good effect on relieving flushing or pallor of the face, congestion of eyes, accelerated heart rate, dizziness, headache and the like in the states, and dizziness, headache, fatigue and chest distress discomfort in the next day.

Description

Anti-alcoholism medicine and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine, in particular to an anti-alcoholism medicine and a preparation method thereof.
Background
Simple intoxication is also called general intoxication and refers to acute alcoholism caused by a large amount of drinking at one time. The severity of the intoxication is related to the drinking speed, the drinking amount, the alcohol concentration in blood and the individual tolerance of the patient. Clinically, the disease is usually divided into an excitation phase, an ataxia phase and a lethargy phase, wherein the excitation phase is also called mild intoxication, the ataxia phase is also called moderate intoxication, and the lethargy phase is also called high intoxication. Mild (symptomatic) patients develop abnormal mental states after drinking, such as excessive speech, irritability, flush or pale complexion, congestion of eyes, accelerated heart rate, dizziness, headache and the like. With the progress of the disease, the patients have unstable gait, clumsy movements, ambiguous speech, allophasis, blurred vision and double images, and may have nausea, vomiting, etc. Patients with severe (symptomatic) poisoning are in a state of lethargy, pale complexion, purple lips, wet and cold skin, low body temperature, shallow breathing and dilated pupils. Severe patients are deeply unconscious, blood pressure is reduced, respiration is slow, heart rate is accelerated until death due to failure.
At present, various sobering-up products are available in the market, but the effects are very slight, the effects are not good enough, and toxic and side effects exist.
Disclosure of Invention
Therefore, the invention provides an anti-alcoholism medicine and a preparation method thereof, which are used for solving the problems of slight efficacy, toxic and side effects and the like of the existing anti-alcoholism product.
In order to achieve the above purpose, the invention provides the following technical scheme:
according to the first aspect of the invention, the anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 10-20 parts of flower of kudzuvine, 10-20 parts of hovenia dulcis thunb, 2-8 parts of Chinese rhubarb, 8-16 parts of rhodiola rosea, 8-16 parts of salvia miltiorrhiza, 5-15 parts of angelica and 8-15 parts of scutellaria baicalensis.
Further, the anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 12-18 parts of flower of kudzuvine, 12-18 parts of hovenia dulcis thunb, 4-6 parts of Chinese rhubarb, 10-14 parts of rhodiola root, 10-14 parts of salvia miltiorrhiza, 8-12 parts of angelica and 10-14 parts of scutellaria baicalensis.
Further, the anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 15 parts of flower of kudzuvine, 15 parts of hovenia dulcis thunb, 5 parts of Chinese rhubarb, 12 parts of rhodiola root, 12 parts of salvia miltiorrhiza, 10 parts of angelica and 12 parts of scutellaria baicalensis.
The raw materials adopted by the invention have the following effects:
kudzuvine flower, sweet in flavor, cool in nature. Has effects of relieving alcoholic intoxication, activating spleen, and stopping bleeding, and can be used for treating alcoholic intoxication, dysphoria, thirst, headache, dizziness, abdominal distention, vomiting, acid regurgitation, anorexia, hematemesis, and intestinal wind with hemoptysis.
Hovenia dulcis Thunb, sweet in flavor and mild in nature. Has the effects of relieving alcoholism, quenching thirst, relieving restlessness, stopping vomit and facilitating urination and defecation. It can be used for treating alcoholic intoxication, polydipsia, emesis, and constipation.
The Xining rhubarb refers to root and rhizome of Rheum palmatum L.and Rheum tanguticum Maxim. of Polygonaceae, which are produced mainly in Qinghai province, and is one of famous and famous genuine medicinal materials in Qinghai province, in terms of excellent quality, bright color, high oiliness, high content of main effective components such as anthraquinone, pure nature, no pollution, unique processing method and famous and abroad, and the Guangxin terms of "Xining rhubarb". Bitter and cold. Can purge, purge fire, promote blood circulation, and invigorate stomach; xining rhubarb has the effect of quickly purging the lower energizer, can accelerate the discharge of toxins such as alcohol and the like in the gastrointestinal tract, is used for removing food retention and stagnation, purging intense heat and cooling blood, promoting blood circulation and removing blood stasis, and is used for treating abdominal pain, constipation, jaundice, fullness in chest and abdomen, typhoid fever, swelling toxin and the like in the traditional Chinese medicine. Recent scientific researches prove that the rhubarb has stronger antibacterial action and has antibacterial action on staphylococcus aureus, dysentery bacillus, typhoid bacillus, escherichia coli and pseudomonas aeruginosa. In addition, it also has blood pressure lowering and diuretic effects.
Rhodiola rosea is the dry root and rhizome of rhodiola crenulata of Crassulaceae, and has sweet taste and cold property. Has the effects of benefiting qi, activating blood circulation, dredging collaterals, relieving asthma, removing blood stasis and reducing swelling. Can be used for treating cardiovascular and cerebrovascular oxygen supply deficiency, digestive tract congestion, and injury after drinking. It is used clinically in treating qi deficiency, blood stasis, chest pain, apoplexy, hemiplegia, listlessness and asthma.
Dan Shen is bitter in taste and slightly cold in nature. Enters heart and liver meridians, and has the effects of promoting blood circulation, removing blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood and resolving carbuncle. Can be used for relieving symptoms of alcoholic intoxication, such as stagnation of qi and blood stasis, and discomfort of liver region. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
Dang Gui is sweet and pungent in flavor and warm in nature. Has the functions of enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening intestine and relaxing bowels. Liver yin is yang-activating, and angelica has the functions of nourishing blood, promoting blood circulation, tonifying liver blood and nourishing liver yin, and is used together with rhodiola rosea and salvia miltiorrhiza to relieve alcoholism, nourish heart and liver and remove stasis and toxin. Dang Gui is commonly used for blood deficiency and chlorosis, vertigo, palpitation, irregular menstruation, amenorrhea, dysmenorrhea, deficiency cold, abdominal pain, rheumatic arthralgia, traumatic injury, carbuncle, ulcer, intestinal dryness and constipation. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Baikal skullcap root, bitter and cold. The meridian entered is entered into the lung, gallbladder, spleen, large intestine and small intestine meridians. The functions are mainly used for clearing heat and drying dampness, purging fire and removing toxin, stopping bleeding and preventing miscarriage. Can clear away the stagnated heat and alcohol toxicity in the digestive tract after relieving the alcoholic intoxication.
According to a second aspect of the present invention, the above-mentioned method for preparing an anti-hangover drug comprises the steps of:
selecting the following raw materials with high quality: 10-20 parts of flower of kudzuvine, 10-20 parts of hovenia dulcis thunb, 2-8 parts of Chinese rhubarb, 8-16 parts of rhodiola rosea, 8-16 parts of salvia miltiorrhiza, 5-15 parts of angelica and 8-15 parts of scutellaria baicalensis, and drying for later use;
pulverizing the dried raw materials respectively, and sieving; uniformly mixing the crushed raw materials; sterilizing, and packaging.
Further, the mesh number of the sieving is 120-150 meshes.
Further, the sterilization and disinfection adopts a dry heat sterilization and disinfection method.
The invention has the following advantages:
the anti-alcoholism medicine disclosed by the invention has an obvious anti-alcoholism effect through the synergistic effect of seven Chinese herbal medicines, namely the flower of kudzuvine, the hovenia dulcis thunb, the rheum officinale, the rhodiola rosea, the salvia miltiorrhiza, the angelica sinensis and the scutellaria baicalensis, has a good anti-alcoholism effect with an anti-alcoholism efficiency of 94%, particularly has a good effect on light and moderate (excitation stage and ataxia stage) people, and has a good effect on relieving flushing or pallor of the face, congestion of eyes, accelerated heart rate, dizziness, headache and the like in the states, and dizziness, headache, fatigue and chest distress discomfort in the next day, wherein the relieving flushing of the face and congestion of the eyes are generally 50-80 minutes, and the relieving dizziness and headache are generally 2-3 hours. The time for relieving the drowsiness after drinking by the anti-alcoholic drug is generally 2-4 hours. The long-term clinical experiments prove that the anti-alcoholism medicine has no toxic or side effect and is safe to use.
The preparation method of the medicine for relieving alcoholism and protecting liver is simple, easy to realize and suitable for industrial popularization and application.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 15 parts of flower of kudzuvine, 15 parts of hovenia dulcis thunb, 5 parts of Chinese rhubarb, 12 parts of rhodiola root, 12 parts of salvia miltiorrhiza, 10 parts of angelica and 12 parts of scutellaria baicalensis.
The preparation method of the anti-alcoholism medicine comprises the following steps:
selecting high-quality flos Puerariae Lobatae, semen Hoveniae, radix et rhizoma Rhei, radix Rhodiolae, Saviae Miltiorrhizae radix, radix Angelicae sinensis, and Scutellariae radix, and drying;
crushing the dried raw materials respectively, and sieving the crushed raw materials with a sieve of 120-150 meshes; uniformly mixing the crushed raw materials; then, the dry heat sterilization method is adopted for sterilization and disinfection, and finally the mixture is subpackaged into 5 g and one bag.
Example 2
The anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 10 parts of flower of kudzuvine, 10 parts of hovenia dulcis thunb, 2 parts of Chinese rhubarb, 8 parts of rhodiola root, 8 parts of salvia miltiorrhiza, 5 parts of angelica and 8 parts of scutellaria baicalensis.
The preparation method of the anti-alcoholism drug is the same as that of example 1.
Example 3
The anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 20 parts of kudzuvine flower, 20 parts of hovenia dulcis thunb, 8 parts of Chinese rhubarb, 16 parts of rhodiola root, 16 parts of salvia miltiorrhiza, 15 parts of angelica and 15 parts of scutellaria baicalensis.
The preparation method of the anti-alcoholism drug is the same as that of example 1.
Example 4
The anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 12 parts of kudzuvine flower, 12 parts of hovenia dulcis thunb, 4 parts of Chinese rhubarb, 10 parts of rhodiola root, 10 parts of salvia miltiorrhiza, 8 parts of angelica and 10 parts of scutellaria baicalensis.
The preparation method of the anti-alcoholism drug is the same as that of example 1.
Example 5
The anti-alcoholism medicine is prepared from the following raw materials in parts by weight: 18 parts of kudzuvine flower, 18 parts of hovenia dulcis thunb, 6 parts of Chinese rhubarb, 14 parts of rhodiola root, 14 parts of salvia miltiorrhiza, 12 parts of angelica and 14 parts of scutellaria baicalensis.
The preparation method of the anti-alcoholism drug is the same as that of example 1.
The anti-alcoholism medicine has the characteristics of short anti-alcoholism time and good anti-alcoholism effect, and is explained by the following clinical experiments.
1. General data
100 drunken patients or volunteers were selected.
2. Application method
When the anti-alcoholic drug of example 1 is taken, before drinking or when uncomfortable symptoms occur, 50-100 ml of white water or beverage (tea, fruit juice) is taken with water for 1-2 bags. For preventing discomfort symptom after drinking, 1 bag can be taken after drinking.
3. Standard of therapeutic effect
Cure-the drunk symptoms are completely disappeared;
improvement-partial disappearance and alleviation of drunkenness symptoms;
ineffectiveness-no disappearance of intoxication symptoms.
4. Effect
The experimental results show that 60 cases are cured, 34 cases are improved, 6 cases are invalid, and the effective rate reaches 94% when the anti-alcoholism medicine is used for relieving alcoholism, and the anti-alcoholism effect is obvious through the synergistic effect of seven Chinese herbal medicines, namely kudzuvine flower, hovenia dulcis thunb, corning rhubarb, rhodiola rosea, salvia miltiorrhiza, angelica and scutellaria baicalensis. In the clinical experiment process, the anti-alcoholism medicine disclosed by the invention is also found to have a non-toxic effect, particularly has a good effect on light and moderate (excitation stage and ataxia stage) people, and has a good effect on relieving the flushing or pallor of the face, the congestion of eyes, the heart rate acceleration, the dizziness, the headache and the like in the states, and the dizziness, the headache, the fatigue and the chest distress discomfort in the next day, wherein the effects of relieving the flushing of the face and the congestion of the eyes are generally 50-80 minutes, and the effects of relieving the dizziness and the headache are generally 2-3 hours. The time for relieving the drowsiness after drinking by the anti-alcoholic drug is generally 2-4 hours.
Typical cases are as follows:
duzi, age 56 years, occupation: manager, the previous drinking amount is small, after the anti-alcoholism medicine is taken for a plurality of times, the drinking amount is increased, and the uncomfortable symptoms disappear after 30-45 minutes of drinking.
Yellow certain, age: age 58, occupation: the drunkenness symptom is eliminated after the surgeon takes the anti-alcoholism medicine, and the operation can be performed on the next day (the operation can not be performed on the next day after drinking the medicine).
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (6)

1. The anti-alcoholism medicine is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of flower of kudzuvine, 10-20 parts of hovenia dulcis thunb, 2-8 parts of Chinese rhubarb, 8-16 parts of rhodiola rosea, 8-16 parts of salvia miltiorrhiza, 5-15 parts of angelica and 8-15 parts of scutellaria baicalensis.
2. The anti-alcoholism drug according to claim 1, which is prepared from the following raw materials in parts by weight: 12-18 parts of flower of kudzuvine, 12-18 parts of hovenia dulcis thunb, 4-6 parts of Chinese rhubarb, 10-14 parts of rhodiola root, 10-14 parts of salvia miltiorrhiza, 8-12 parts of angelica and 10-14 parts of scutellaria baicalensis.
3. The anti-alcoholism drug according to claim 2, which is prepared from the following raw materials in parts by weight: 15 parts of flower of kudzuvine, 15 parts of hovenia dulcis thunb, 5 parts of Chinese rhubarb, 12 parts of rhodiola root, 12 parts of salvia miltiorrhiza, 10 parts of angelica and 12 parts of scutellaria baicalensis.
4. A process for the preparation of an anti-hangover drug according to any of claims 1 to 3, which comprises the steps of:
selecting the following raw materials with high quality: 10-20 parts of flower of kudzuvine, 10-20 parts of hovenia dulcis thunb, 2-8 parts of Chinese rhubarb, 8-16 parts of rhodiola rosea, 8-16 parts of salvia miltiorrhiza, 5-15 parts of angelica and 8-15 parts of scutellaria baicalensis, and drying for later use;
pulverizing the dried raw materials respectively, and sieving; uniformly mixing the crushed raw materials; sterilizing, and packaging.
5. The method for preparing an anti-hangover drug as claimed in claim 4, wherein the mesh number of the sieve is 120-150 meshes.
6. The method for producing an anti-alcoholic agent according to claim 4, wherein the sterilization is performed by dry heat sterilization.
CN202110187800.9A 2021-02-18 2021-02-18 Anti-alcoholism medicine and preparation method thereof Pending CN112891412A (en)

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Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
本草岐黄: "过年了,做点准备防止假期病", 《HTTPS://MP.WEIXIN.QQ.COM/S?SRC=11&TIMESTAMP=1639450164&VER=3495&SIGNATURE=EC7M4EIH-0HVX*VBQBE3JPU0QRLGTIAAIZGY8OG5SMJ1DYIGR7VM-E7JXRZBGKINBTLPZEVFA7FIDWV4NTBU-INMMBCPJXLS36SENB-XSQXTKO8LN6AVNEMEDURYY2XS&NEW=1》 *
民间养生: "其实男人更需要当归的关怀(马悦凌)", 《HTTPS://MP.WEIXIN.QQ.COM/S?SRC=11&TIMESTAMP=1639542608&VER=3497&SIGNATURE=1T7ITALHKPGC0DQXUWLNQJOF3KUP6BFNHDNAZ690TLO*PUYWI-KTHPFBRYRF2GXEID66RUUEZZ3Z4CCEJ*TE47W1FNFSL8YO48WWP*GDAKEPLD-WLPST3T9BT58B1NAQ&NEW=1》 *

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Application publication date: 20210604