CN101193698A - 用于固相萃取的极性官能化聚合物改性的多孔基质 - Google Patents
用于固相萃取的极性官能化聚合物改性的多孔基质 Download PDFInfo
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- CN101193698A CN101193698A CNA2006800201625A CN200680020162A CN101193698A CN 101193698 A CN101193698 A CN 101193698A CN A2006800201625 A CNA2006800201625 A CN A2006800201625A CN 200680020162 A CN200680020162 A CN 200680020162A CN 101193698 A CN101193698 A CN 101193698A
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229940093633 tricaprin Drugs 0.000 description 1
- QQQSFSZALRVCSZ-UHFFFAOYSA-N triethoxysilane Chemical compound CCO[SiH](OCC)OCC QQQSFSZALRVCSZ-UHFFFAOYSA-N 0.000 description 1
- 229960000834 vinyl ether Drugs 0.000 description 1
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/264—Synthetic macromolecular compounds derived from different types of monomers, e.g. linear or branched copolymers, block copolymers, graft copolymers
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28042—Shaped bodies; Monolithic structures
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
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- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
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- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/328—Polymers on the carrier being further modified
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- B01J2220/00—Aspects relating to sorbent materials
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- B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Surface Treatment Of Glass Fibres Or Filaments (AREA)
- Nonwoven Fabrics (AREA)
Abstract
Description
聚合物改性的玻璃纤维单块 | 碳% | 氢% | 氮% |
NVA-DVB低 | 57.5 | 5 | 0.42 |
NVA-DVB高 | 50.15 | 5.38 | 2.14 |
PSDVB-NHCOCH3 | 48.37 | 4.02 | 2.55 |
分析物 | log P |
苯异丙胺 | 1.76 |
麻黄碱 | 1.61 |
去甲替林 | 4.74 |
米安色林 | 3.85 |
马来酸氯苯那敏 | 3.38 |
诺氟西汀 | 3.75 |
溴苯那敏 | 3.89 |
奎尼丁 | 2.62 |
时间 | 甲醇% | 甲酸% | 流速(μL/min) |
0:00 | 15 | 85 | 300 |
0:30 | 15 | 85 | 300 |
2:00 | 85 | 15 | 300 |
2:30 | 85 | 15 | 300 |
2:31 | 15 | 85 | 300 |
3:30 | 15 | 85 | 300 |
分析物 | log P |
阿替洛尔 | 0.16 |
盐酸雷尼替丁 | 0.27 |
沙丁胺醇 | 0.97 |
半硫酸巴美生 | 1.29 |
马来酸噻吗洛尔 | 1.83 |
卡立普多 | 1.96 |
分析物 | log P | PSDVB | PSDVB-NHCOCH3 | NVA-DVB“高” | NVA-DVB“低” |
阿替洛尔 | 0.16 | 0 | 0 | 7 | 12.5 |
雷尼替丁 | 0.27 | 0 | 1.1 | 44 | 81 |
沙丁胺醇 | 0.97 | 0 | 0 | 4 | 7.9 |
巴美生 | 1.29 | 0 | 2.0 | 14 | 16.9 |
噻吗洛尔 | 1.83 | 0 | 1.2 | 65 | 80 |
卡立普多 | 1.96 | 0 | 1.2 | 57 | 82 |
DVBmL | STmL | NVAgm | 癸醇mL | 十二烷醇mL | THFmL | 流速mL/min |
低NVA | ||||||
17.14 | - | 3.4 | 26 | - | 4 | 229 |
17.14 | - | 3.4 | 36 | - | 4 | 659 |
17.14 | - | 3.4 | - | 26 | 4 | 488 |
高NVA | ||||||
10 | - | 7.7 | 46 | - | 4 | 409 |
10 | - | 7.7 | 56 | - | 4 | 882 |
PSDVB | ||||||
15 | 5 | - | 26 | - | 4 | 229 |
10 | 10 | - | 26 | - | 4 | 414 |
5 | 15 | - | 26 | - | 4 | 444 |
EmporeTM High Performance Extraction Disks,SDB-XC | ||||||
- | - | - | - | - | - | 28 |
Claims (22)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US11/119,840 | 2005-05-02 | ||
US11/119,840 US20060247361A1 (en) | 2005-05-02 | 2005-05-02 | Polar functionalized polymer modified porous substrate for solid phase extraction |
PCT/US2006/015718 WO2006118887A2 (en) | 2005-05-02 | 2006-04-25 | Polar functionized polymer modified porous substrate for solid phase extraction |
Publications (2)
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CN101193698A true CN101193698A (zh) | 2008-06-04 |
CN101193698B CN101193698B (zh) | 2012-06-13 |
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CN2006800201625A Expired - Fee Related CN101193698B (zh) | 2005-05-02 | 2006-04-25 | 用于固相萃取的极性官能化聚合物改性的多孔基质 |
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US (1) | US20060247361A1 (zh) |
EP (1) | EP1899050A2 (zh) |
JP (1) | JP2008540084A (zh) |
CN (1) | CN101193698B (zh) |
AU (1) | AU2006242643B2 (zh) |
CA (1) | CA2606660A1 (zh) |
WO (1) | WO2006118887A2 (zh) |
Cited By (4)
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CN107923882A (zh) * | 2015-07-31 | 2018-04-17 | 株式会社大赛璐 | 超临界流体色谱法用的固定相 |
CN109806852A (zh) * | 2019-03-04 | 2019-05-28 | 北京理工大学 | 一种腺嘌呤功能化聚丙二醇的应用 |
CN113735999A (zh) * | 2021-09-03 | 2021-12-03 | 浙江理工大学龙港研究院有限公司 | 一种具有高稳定性和柔韧性的多孔聚合物及其应用 |
CN115627009A (zh) * | 2022-08-05 | 2023-01-20 | 上海组波智能仪器科技有限公司 | 一种改性多孔柔性材料及其制备方法和萃取应用 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US7311825B2 (en) * | 2005-05-02 | 2007-12-25 | Varian, Inc. | Polymer modified porous substrate for solid phase extraction |
WO2008144301A1 (en) * | 2007-05-15 | 2008-11-27 | Waters Investments Limited | Apparatus and methods for the detection of plasma metanephrines |
EP2233206B1 (en) * | 2009-03-24 | 2015-07-29 | Symrise AG | Flavor extracting device for isolation or analysis of volatile compounds |
CN102711978B (zh) | 2010-01-08 | 2015-11-25 | 塔斯马尼亚大学 | 多孔聚合物整料、其制备方法及其用途 |
CA2836812C (en) | 2011-07-12 | 2018-07-10 | University Of Tasmania | Use of porous polymer materials for storage of biological samples |
EP2570184A1 (en) * | 2011-09-15 | 2013-03-20 | InstrAction GmbH | Sorbent comprising on its surface an aromatic ring system having an anionic or deprotonizable group for the purification of organic molecules |
US11454578B2 (en) | 2016-04-07 | 2022-09-27 | North Carolina State University | Passive sampler and methods of making |
US11596876B2 (en) | 2018-02-05 | 2023-03-07 | Clemson University Research Foundation | Channeled fibers in separation of biologically active nanoparticles |
US11879043B2 (en) * | 2021-04-05 | 2024-01-23 | Dionex Corporation | Coated poly-olefins |
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DE2357184A1 (de) * | 1973-11-16 | 1975-05-22 | Merck Patent Gmbh | Verfahren zur herstellung von organisch modifizierten siliciumdioxiden |
US4512897A (en) * | 1981-07-28 | 1985-04-23 | Amf Incorporated | Molecular separation column and use thereof |
US5035803A (en) * | 1989-02-14 | 1991-07-30 | The Regents Of The University Of California | High yield water-soluble polymer silica separation resins |
US5328758A (en) * | 1991-10-11 | 1994-07-12 | Minnesota Mining And Manufacturing Company | Particle-loaded nonwoven fibrous article for separations and purifications |
EP0758261B1 (en) * | 1994-05-05 | 1998-08-26 | Minnesota Mining And Manufacturing Company | Chemically modified solid phase extraction particles and articles containing same |
US5529686A (en) * | 1994-07-15 | 1996-06-25 | Minnesota Mining And Manufacturing Company | Composite membranes for solid phase extractions and reactions |
US5882521A (en) * | 1996-04-18 | 1999-03-16 | Waters Investment Ltd. | Water-wettable chromatographic media for solid phase extraction |
US5906796A (en) * | 1997-08-04 | 1999-05-25 | Ansys, Inc. | Solid phase extraction plate |
JP4883837B2 (ja) * | 1998-06-12 | 2012-02-22 | ウォーターズ・テクノロジーズ・コーポレーション | 固相抽出及びクロマトグラフィー用の新規なイオン交換多孔質樹脂 |
JP2001343378A (ja) * | 2000-06-02 | 2001-12-14 | Showa Denko Kk | 固相抽出用充填剤及び固相抽出方法 |
US6759442B2 (en) * | 2000-06-02 | 2004-07-06 | Showa Denko Kabushiki Kaisha | Packing material for solid phase extraction and solid phase extraction method |
EP1179732B2 (en) * | 2000-08-11 | 2012-02-29 | Rohm And Haas Company | Polymeric adsorbent and method of preparation |
WO2002045848A1 (fr) * | 2000-12-07 | 2002-06-13 | Sun Plastics Co., Ltd. | Materiau de capture d'une substance chimique, procede de production de ce dernier et tube de capture de substance chimique |
JP2002361082A (ja) * | 2001-06-08 | 2002-12-17 | Sekisui Chem Co Ltd | 疎水性物質吸着剤 |
US6926823B2 (en) * | 2002-06-03 | 2005-08-09 | Varian, Inc. | Polymer with superior polar retention for sample pretreatment |
US6749749B2 (en) * | 2002-06-26 | 2004-06-15 | Isco, Inc. | Separation system, components of a separation system and methods of making and using them |
DE602004024190D1 (de) * | 2003-02-19 | 2009-12-31 | Natrix Separations Inc | Geträgerte poröse gele umfassende verbundmaterialien |
CA2523982C (en) * | 2003-05-29 | 2012-01-10 | Varian, Inc. | Solid phase extraction pipette |
-
2005
- 2005-05-02 US US11/119,840 patent/US20060247361A1/en not_active Abandoned
-
2006
- 2006-04-25 JP JP2008510045A patent/JP2008540084A/ja active Pending
- 2006-04-25 WO PCT/US2006/015718 patent/WO2006118887A2/en active Application Filing
- 2006-04-25 EP EP06751420A patent/EP1899050A2/en not_active Withdrawn
- 2006-04-25 CN CN2006800201625A patent/CN101193698B/zh not_active Expired - Fee Related
- 2006-04-25 CA CA002606660A patent/CA2606660A1/en not_active Abandoned
- 2006-04-25 AU AU2006242643A patent/AU2006242643B2/en not_active Ceased
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107923882A (zh) * | 2015-07-31 | 2018-04-17 | 株式会社大赛璐 | 超临界流体色谱法用的固定相 |
CN107923882B (zh) * | 2015-07-31 | 2021-10-15 | 株式会社大赛璐 | 超临界流体色谱法用的固定相 |
CN109806852A (zh) * | 2019-03-04 | 2019-05-28 | 北京理工大学 | 一种腺嘌呤功能化聚丙二醇的应用 |
CN113735999A (zh) * | 2021-09-03 | 2021-12-03 | 浙江理工大学龙港研究院有限公司 | 一种具有高稳定性和柔韧性的多孔聚合物及其应用 |
CN113735999B (zh) * | 2021-09-03 | 2023-02-21 | 浙江理工大学龙港研究院有限公司 | 一种具有高稳定性和柔韧性的多孔聚合物及其应用 |
CN115627009A (zh) * | 2022-08-05 | 2023-01-20 | 上海组波智能仪器科技有限公司 | 一种改性多孔柔性材料及其制备方法和萃取应用 |
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CN101193698B (zh) | 2012-06-13 |
JP2008540084A (ja) | 2008-11-20 |
AU2006242643A1 (en) | 2006-11-09 |
US20060247361A1 (en) | 2006-11-02 |
WO2006118887A2 (en) | 2006-11-09 |
AU2006242643B2 (en) | 2012-03-15 |
EP1899050A2 (en) | 2008-03-19 |
CA2606660A1 (en) | 2006-11-09 |
WO2006118887A3 (en) | 2007-06-14 |
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