CN101176745A - Method for making chinese medicine radix astragali - Google Patents
Method for making chinese medicine radix astragali Download PDFInfo
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- CN101176745A CN101176745A CNA2006101316026A CN200610131602A CN101176745A CN 101176745 A CN101176745 A CN 101176745A CN A2006101316026 A CNA2006101316026 A CN A2006101316026A CN 200610131602 A CN200610131602 A CN 200610131602A CN 101176745 A CN101176745 A CN 101176745A
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Abstract
The invention relates to a processing method of the Chinese herbal medicine astragalus, which is characterized in that: the Chinese herbal medicine astragalus is put into the refine honey under normal temperature and evenly mixed; the astragalus is then covered closely until the refine honey is fully absorbed by the Chinese herbal medicine astragalus; then the astragalus is put in an oven for drying and is taken out when dried; thus, the processed honey-made astragalus is obtained. With the method of putting the astragalus into the refine honey and mixing the two, covering the astragalus closely until the refine honey is fully absorbed by the Chinese herbal medicine astragalus, the invention has the advantages that: the function of invigorating spleen to replenish qi of the Chinese herbal medicine astragalus is reinforced; the astragaloside IV content is 48.8% to 752.5% higher than the prior art, proving than the invention can significantly reduce the loss of the astragaloside IV after the Chinese herbal medicine astragalus is processed; with the invention adopting drying method, the processing conditions such as processing temperature can be well controlled, and the unification and quality controllability of honey-made astragalus can be reinforced.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to the concocting method of Chinese medicine astragalus.
Technical background
Chinese medicine astragalus is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongho-licus (Bge.) Hsiao or Radix Astragali Astragalusmembranaceus (Fisch.) Bge..Chinese medicine astragalus has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.It is one of tonic Chinese medicine of being most widely used of China.Modern scientific research proves, contains number of chemical compositions such as saponin, flavone, polysaccharide and alkaloid in the Chinese medicine astragalus.Saponin component wherein is a triterpene saponin componds, is one of effective ingredient in the universally recognized Chinese medicine astragalus.
Chinese medicine astragalus beginning is stated from Shennong's Herbal, classifies as top gradely, has another name called Radix astragali.Beginning Song dynasty adopts methods such as processed with honey, processed with salt, processed with wine to concoct the Radix Astragali; Period of Ming and Qing increase concocting methods such as stir-frying with ginger juice, milk system, and wherein except that the processed with honey Radix Astragali was widely passed on later age, several now nothings of other concocting method were continued to use.The processing action of the Radix Astragali, purpose and theoretical beginning see the period of Ming and Qing, as " giving birth to controlling carbuncle, the processed with honey tonifying deficiency ", " control carbuncle and give birth to usefulness, control insufficiency of lung-QI processed with honey usefulness, control the inferior empty saline or steaming or stir-fry with ", " mulse is coated with it, processs usefulness, invigorating the spleen and replenishing QI " etc.The at present domestic concocting method that generally adopts clinically is a processed with honey.Modern process of preparing Chinese medicine experience is thought the sweet temperature of the processed with honey Radix Astragali and is moistened partially, is longer than invigorating the spleen and replenishing QI, has the effect of moisturizing concurrently.Pharmacopoeia of the People's Republic of China version in 2005 has been recorded the Radix Astragali and two kinds of decoction pieces specifications of Radix Astragali Preparata.The concocting method of regulation Radix Astragali Preparata is to get the clean Radix Astragali, fries to pale brown color and tack-free according to the processed with honey method.Use this kind concocting method when estimating the processed product quality, many color, feel, outward appearances with processed product are index, and experience is too relied on, and are difficult for formulating unified standard.
Summary of the invention
The concocting method that the purpose of this invention is to provide a kind of Chinese medicine astragalus, this method adopts the processed with honey method.At normal temperatures, water dilutes refined honey, and after fully stirring with the Chinese medicine astragalus product of giving birth to, moistening to refined honey is given birth to the abundant absorption of product by Chinese medicine astragalus, after the Radix Astragali sprawled in pallet put into baking oven.Take out the oven dry back, promptly gets processed with honey Radix Astragali processed product.
Contain a large amount of saponin constituents in the Chinese medicine astragalus, as Radix Astragali saponin (astragaloside) I～VIII etc., wherein astragaloside (Radix Astragali saponin IV) is one of main component in the Chinese medicine astragalus, have set upright, effects such as strong, antiinflammatory, analgesia, blood pressure lowering, and be the content inspection item that the Chinese medicine astragalus of Pharmacopoeia of the People's Republic of China version regulation in 2005 is given birth to product and processed product.In the Chinese medicine astragalus processed with honey process, saponin component wherein can be affected and lose.Therefore, the processed with honey process will guarantee the content of astragaloside, makes Chinese medicine astragalus through after concocting, and its invigorating the spleen and replenishing QI effect is enhanced to guarantee that simultaneously original effect do not suffer a loss.
It is as follows to implement technical scheme of the present invention:
At normal temperatures, water dilutes refined honey, after fully stirring with the Chinese medicine astragalus product of giving birth to again, and moistening 1～2h, sprawl in pallet, toast drying, baking drying time is 2～4h, the baking baking temperature is 75～105 ℃, and take out the oven dry back, promptly gets processed with honey Radix Astragali processed product; Wherein, refining close mass ratio with the living product of Chinese medicine astragalus is 15: 100～35: 100, and the mass ratio of refined honey and water is 1: 2～2: 1.
Detection method:
(1), the preparation of test liquid: get the Chinese medicine astragalus of concocting without this method and give birth to product and concoct each 4g of powder (crossing sieve No. four) of the processed with honey Radix Astragali processed product of gained through this method, the accurate title, decide, and puts in the cable type extractor according, add methanol 25ml, merceration spends the night, and adds methanol 75ml again, reflux 4h, the extracting solution recovery is concentrated into dried, and residue adds water 10ml, slight fever makes dissolving, uses water saturation n-butanol extraction 4 times, each 40ml, merge n-butyl alcohol liquid, the n-butyl alcohol liquid after reuse ammonia solution thorough washing merges 2 times, each 40ml, discard ammonia solution, with n-butyl alcohol liquid evaporate to dryness, residue adds water 5ml makes dissolving, puts cold, by the D101 macroporous resin column, (internal diameter 1.5cm, long 12cm) is with water 50ml eluting, discard water liquid, reuse 40% ethanol 30ml eluting discards eluent, uses 70% ethanol 80ml eluting at last, collect eluent, evaporate to dryness with dissolve with methanol and be transferred in the 5ml measuring bottle, adds methanol to scale, shake up, promptly get need testing solution.
(2), chromatographic condition: chromatographic column: Diamonsil C
18Analytical column (5 μ, 250 * 4.6mm); Mobile phase: acetonitrile-water (32: 68); Flow velocity: 0.6mlmin
-1Column temperature: 35 ℃; Flow rate of carrier gas: 2.7mlmin
-1ELSD detector drift tube temperature: 100 ℃; Sample size 20 μ l.
(3), detect figure (high-efficient liquid phase chromatogram) and see accompanying drawing.
Beneficial effect of the present invention can show by the active constituent content contrast:
Method of the present invention is carried out processed product to Chinese medicine astragalus, the method drawing standard curve of stipulating in the version in 2005 according to the Pharmacopoeia of the People's Republic of China, the detection method that provides in the present patent application file is provided is recorded astragaloside peak area integrated value, it is 0.9599mgg that the substitution standard curve calculates Astragaloside content
-1Using additive method concocts Chinese medicine astragalus, the method drawing standard curve of stipulating in the version in 2005 according to the Pharmacopoeia of the People's Republic of China, the detection method of using in the present patent application records astragaloside peak area integrated value, and the substitution standard curve calculates Astragaloside content and is up to 0.6452mgg
-1, minimum is 0.1126mgg
-1And the Astragaloside content of giving birth in the product with the same batch Chinese medicine astragalus that same detection method is measured is 1.0150mgg
-1Therefore use method of the present invention Chinese medicine astragalus is concocted, want high by 48.8%～752.5%, prove that the present invention is obvious through the effect of the loss of process of preparing Chinese medicine back astragaloside for reducing Chinese medicine astragalus with respect to other concocting method Astragaloside contents.Method of the present invention adopts roast method, is evaluation index with the Astragaloside content, can well control process of preparing Chinese medicine conditions such as concocting temperature, helps strengthening the unification and the quality controllability of processed with honey Radix Astragali quality.
Description of drawings
Fig. 1 is the high-efficient liquid phase chromatogram of astragaloside reference substance.
Fig. 2 is the high-efficient liquid phase chromatogram of processed with honey Radix Astragali processed product.
Fig. 3 is the high-efficient liquid phase chromatogram that Chinese medicine astragalus is given birth to product.
The specific embodiment
Embodiment 1:
At normal temperatures, after the 125g refined honey adds the dilution of 250g water, give birth to product 500g with Chinese medicine astragalus and mix, mix moistening 1h thoroughly, sprawl in pallet, sprawl thickness 1.5cm, put into baking oven and take out behind the baking 3h down for 90 ℃, obtain the processed with honey processed product of Chinese medicine astragalus.The main saponin constituent Astragaloside content of this processed with honey processed product is 0.9599mgg
-1
Embodiment 2:
At normal temperatures, after the 75g refined honey adds the dilution of 75g water, give birth to product 500g with Chinese medicine astragalus and mix, mix moistening 1.5h thoroughly, sprawl in pallet, sprawl thickness 1.5cm, put into baking oven and take out behind the baking 3h down for 105 ℃, obtain the processed with honey processed product of Chinese medicine astragalus.The main saponin constituent Astragaloside content of this processed with honey processed product is 0.9003mgg
-1
Embodiment 3:
At normal temperatures, after the 125g refined honey adds the dilution of 250g water, give birth to product 500g with Chinese medicine astragalus and mix, mix moistening 1.5h thoroughly, sprawl in pallet, sprawl thickness 2cm, put into baking oven and take out behind the baking 4h down for 75 ℃, obtain the processed with honey processed product of Chinese medicine astragalus.The main saponin constituent Astragaloside content of this processed with honey processed product is 0.6539mgg
-1
Embodiment 4:
At normal temperatures, after the 175g refined honey adds the dilution of 350g water, give birth to product 500g with Chinese medicine astragalus and mix, mix moistening 2h thoroughly, sprawl in pallet, sprawl thickness 1.5cm, put into baking oven and take out behind the baking 2h down for 90 ℃, obtain the processed with honey processed product of Chinese medicine astragalus.The main saponin constituent Astragaloside content of this processed with honey processed product is 0.6936mgg
-1
Embodiment 5:
At normal temperatures, after the 75g refined honey adds the dilution of 75g water, give birth to product 500g with Chinese medicine astragalus and mix, mix moistening 1.5h thoroughly, sprawl in pallet, sprawl thickness 2cm, put into baking oven and take out behind the baking 3h down for 105 ℃, obtain the processed with honey processed product of Chinese medicine astragalus.The main saponin constituent Astragaloside content of this processed with honey processed product is 0.8900mgg
-1
Claims (1)
1. the concocting method of a Chinese medicine astragalus, it is characterized in that: at normal temperatures, water dilutes refined honey, after fully stirring with the Chinese medicine astragalus product of giving birth to again, and moistening 1～2h, sprawl in pallet, toast drying, baking drying time is 2～4h, and the baking baking temperature is 75～105 ℃, take out the oven dry back, promptly gets processed with honey Radix Astragali processed product; Wherein, refining close mass ratio with the living product of Chinese medicine astragalus is 15: 100～35: 100, and the mass ratio of refined honey and water is 1: 2～2: 1.
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| CNA2006101316026A CN101176745A (en) | 2006-11-03 | 2006-11-03 | Method for making chinese medicine radix astragali |
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| CNA2006101316026A CN101176745A (en) | 2006-11-03 | 2006-11-03 | Method for making chinese medicine radix astragali |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301183A (en) * | 2013-06-18 | 2013-09-18 | 山东省中医药研究院 | Processing method of milkvetch root fried with honey |
| CN104257735A (en) * | 2014-09-23 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Method for preparing milkvetch root fried with honey |
| CN105949815A (en) * | 2016-05-07 | 2016-09-21 | 浙江农林大学 | Ultrasonic-Soxhlet combined extraction device and traditional Chinese medicine dreg pigment extraction method based on same |
| CN110794080A (en) * | 2019-11-20 | 2020-02-14 | 刘圣梅 | Method for detecting quality of medicine for treating colitis |
| CN112190606A (en) * | 2020-10-27 | 2021-01-08 | 河南华夏药材有限公司 | Processing method of honey-fried astragalus membranaceus |
-
2006
- 2006-11-03 CN CNA2006101316026A patent/CN101176745A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301183A (en) * | 2013-06-18 | 2013-09-18 | 山东省中医药研究院 | Processing method of milkvetch root fried with honey |
| CN103301183B (en) * | 2013-06-18 | 2015-02-18 | 山东省中医药研究院 | Processing method of milkvetch root fried with honey |
| CN104257735A (en) * | 2014-09-23 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Method for preparing milkvetch root fried with honey |
| CN105949815A (en) * | 2016-05-07 | 2016-09-21 | 浙江农林大学 | Ultrasonic-Soxhlet combined extraction device and traditional Chinese medicine dreg pigment extraction method based on same |
| CN110794080A (en) * | 2019-11-20 | 2020-02-14 | 刘圣梅 | Method for detecting quality of medicine for treating colitis |
| CN112190606A (en) * | 2020-10-27 | 2021-01-08 | 河南华夏药材有限公司 | Processing method of honey-fried astragalus membranaceus |
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Open date: 20080514 |