CN104257735A - Method for preparing milkvetch root fried with honey - Google Patents
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to a method for preparing milkvetch root fried with honey. The method comprises the following steps: moistening raw milkvetch root and honey until the honey water is totally absorbed by the raw milkvetch root, frying the moistened milkvetch root at the temperature of 220-240 DEG C, thereby obtaining the milkvetch root fried with honey. According to the preparation method provided by the invention, the milkvetch root is moistened and fried at a high temperature, so that the heating temperature and time of the milkvetch root can be controlled, and the preparation process is controllable. According to the milkvetch root fried with honey prepared by the method, the content of astragaloside is 6.56-11.21mg/g, the content of calycosin-7-glucoside is 3.95-8.15mg/g, and the content of the components is far higher than that in the prior art.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs processing technique field, be specifically related to a kind of concocting method of Radix Astragali (processed with Mel).
Background technology
The prepared slices of Chinese crude drugs are elements that TCM examines prescription, are also the base stocks of Chinese patent medicine, and the quality of its quality will directly have influence on the embodiment of tcm clinical curative effect, thus concerns the healthy of the people.Although the prepared slices of Chinese crude drugs have very long processing in China and use history, systematic perspective and globality are often lacked to comprehensive research of Chinese medicine, be unfavorable for the prepared slices of Chinese crude drugs and the announcement of concocting inherent law.The low-level of About The Quality of Sliced Herbal Medicine research has influence on production and the application of the prepared slices of Chinese crude drugs.The current ubiquity of Manufacture of medicinal slices of TCM enterprise that production form is extensive, processing technique is simple; Quality control method is poor, quality index is coarse and crude and single; The problem such as the uneven and production and marketing level of the prepared slice quality caused because production equipment is backward, automaticity is low, production scale is little is low.The existence of these problems has badly influenced TCM and has examined stabilizing and increasing of prescription and Chinese patent medicine clinical efficacy, also seriously constrains and excavates further motherland's medicine and pharmacology treasure-house.
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus.membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..The Radix Astragali has tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promote the production of body fluid nourish blood, the effect such as row stagnant blood stasis dispelling, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Can be used for the deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, and arthralgia pain is numb, and carbuncle difficulty is burst, and bursts for a long time and the disease such as not to hold back.
The Radix Astragali, medicinal with a long history of China, is widely used clinically.And in concrete practice, the Radix Astragali has to pass through and follows an example to do, the decoction pieces making different size can be applied.Chinese medicine astragalus has multiple concocting method in ancient times, the concocting method recorded of successive dynasties comprise steam, processed with honey, processed with wine, salt system, parch, stir-frying with ginger juice etc., but wherein majority now eliminated need not, use till today and be most widely used be only processed with honey method.The Pharmacopoeia of the People's Republic of China 2010 editions has recorded the Radix Astragali and Radix Astragali Preparata two kinds of decoction pieces specifications, and the concocting method States Pharmacopoeia specifications of Radix Astragali Preparata is: get astragalus mongholicus tablet, fries to tack-free according to processed with honey method (appendix II D).The processing procedure of Radix Astragali Preparata, though pharmacopeia has regulation, without design parameter, therefore affect comparatively large by subjective factors on the judgement of concocting process and the degree of process of preparing Chinese medicine, between different batches Radix Astragali Preparata decoction pieces, quality often has larger difference, and clinical efficacy is difficult to ensure.
Application number is 201310240956.4 concocting methods that patent document discloses a kind of Radix Astragali (processed with Mel), the method comprises the steps:, and (1) gets the refined honey of Radix Astragali prepared slice quality 15 ~ 30%, add water, mixing, wherein, the mass ratio of refined honey and water is 1:(0.5 ~ 1.5); (2) Radix Astragali decoction pieces is placed in the above-mentioned refined honey added water, mixes thoroughly, moistening 40min-2h, fully exhausted by Radix Astragali decoction pieces to refined honey; (3) Radix Astragali decoction pieces good for above-mentioned moistening is placed in microwave container, HIGH-POWERED MICROWAVES heating 3-5min, stirred once every 2 minutes during microwave heating, smoke 30-50min for 80-100 DEG C in rearmounted baking oven, to decoction pieces surface buff to sundown, take out, dry in the air to room temperature, sieve removes chip, and sealing, namely obtains Chinese medicine honey Radix Astragali Preparata decoction pieces.The method adopts warming over fire after applying ointment and microwave method to prepare Radix Astragali Preparata decoction pieces.Warming over fire after applying ointment concocting process is more easy to control, but concocted time is long, and the microwave processing time is short, obtains processed product effective component extraction rate high, but but there is the problem concocting inequality.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and the concocting method that improves a kind of Radix Astragali (processed with Mel), this concocting method is by the moistening Radix Astragali, and then high temperature parch, makes the acid extraction of the Radix Astragali controlled, thus makes concocting process controlled.
The concocting method of Radix Astragali (processed with Mel), comprises the following steps: at room temperature, by Radix Astragali and hydromel moistening, after all being absorbed to hydromel by Radix Astragali, by the Radix Astragali of moistening 220 DEG C ~ 240 DEG C parches, obtains Radix Astragali (processed with Mel).
In said method:
The weight ratio of described Radix Astragali and hydromel is 100:10 ~ 30.
Described hydromel is made up of for 50:50 ~ 100 by weight pure water and refined honey.
Described refined honey is middle honey, is heated to 116 ~ 118 DEG C by Mel, and water content is 10 ~ 13%.
The parch time of the Radix Astragali is 30 ~ 40min.
As the further improvement of foregoing invention, in hydromel, add the kieselguhr of 2 ~ 4% of Radix Astragali weight.
As the further improvement of foregoing invention, after parch completes, by the mode of sieving, kieselguhr is separated with the Radix Astragali.
As the further improvement of foregoing invention, the concocting method of described Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:50 ~ 100 are prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts moistening in hydromel by Radix Astragali, the weight ratio of Radix Astragali and hydromel is 100:10 ~ 30, and the moistening time is 1 ~ 5h;
Step 3, by the Radix Astragali of moistening 220 DEG C ~ 240 DEG C parches, the parch time is 30 ~ 40min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
As the further improvement of foregoing invention, the concocting method of described Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:50 ~ 100 are prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts Radix Astragali and adds moistening in diatomaceous hydromel in advance, and in hydromel, kieselguhr weight is made a living 2 ~ 4% of astragalus weight, and the weight ratio of Radix Astragali and hydromel is 100:10 ~ 30, and the moistening time is 1 ~ 5h;
Step 3, by the Radix Astragali of moistening 220 DEG C ~ 240 DEG C parches, the parch time is 30 ~ 40min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
As the further improvement of foregoing invention, the concocting method of described Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:80 is prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts Radix Astragali and adds moistening in diatomaceous hydromel in advance, and in hydromel, kieselguhr weight is made a living 3% of astragalus weight, and the weight ratio of Radix Astragali and hydromel is 100:20, and the moistening time is 3h;
Step 3, by the Radix Astragali of moistening 230 DEG C of parches, the parch time is 35min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
Compared with prior art, its remarkable advantage is: the first in the present invention, reduce operating procedure and the time of traditional concocting method, and concocting method of the present invention is more efficient than traditional method; Second, according to main active (astragaloside and calycosin glucoside) the assay condition of the Pharmacopoeia of the People's Republic of China (2010 editions) Radix Astragali Preparata, the content adopting traditional method to concoct processed with honey money Astragaloside IV in Radix Astragali and the calycosin glucoside obtained is 0.96 ~ 1.53mg/g, 1.78 ~ 3.45mg/g; And in the Radix Astragali (processed with Mel) adopting method of the present invention to prepare, the content of astragaloside and calycosin glucoside can up to being 11.21mg/g, 8.15mg/g; 3rd, concocting method of the present invention is by the moistening Radix Astragali, and then high temperature parch, makes the acid extraction of the Radix Astragali controlled, thus make concocting process controlled.
Detailed description of the invention
Honey during refined honey required for the present invention is preferably, can commercially availablely buy, as commercially available Flos cercis chinensis Mel.Also prepare by following methods: Mel is heated to 116 ~ 118 DEG C, water content is about 10 ~ 13%, faint yellow, have stickiness, method is more specifically: put by Mel in pot and be heated to boiling slowly rear (temperature is about 116 ~ 118 DEG C), uses slow fire instead and keeps micro-boiling, be 10 ~ 13% to water content, drag for supernatant foam and waxiness, then with sieve sieve or gauze elimination impurity, to obtain final product.The explanation of said method just to the present invention's refined honey used, but should not be construed as limiting the invention.
Embodiment 1
The concocting method of Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:50 is prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts moistening in hydromel by Radix Astragali, the weight ratio of Radix Astragali and hydromel is 100:10, and the moistening time is 1h;
Step 3, by the Radix Astragali of moistening 220 DEG C of parches, the parch time is 30min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
Embodiment 2
The concocting method of Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:100 is prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts moistening in hydromel by Radix Astragali, the weight ratio of Radix Astragali and hydromel is 100:30, and the moistening time is 5h;
Step 3, by the Radix Astragali of moistening 240 DEG C of parches, the parch time is 40min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
Embodiment 3
The concocting method of Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:70 is prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts moistening in hydromel by Radix Astragali, the weight ratio of Radix Astragali and hydromel is 100:20, and the moistening time is 3h;
Step 3, by the Radix Astragali of moistening 230 DEG C of parches, the parch time is 35min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
Embodiment 4
The concocting method of Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:50 is prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts Radix Astragali and adds moistening in diatomaceous hydromel in advance, and in hydromel, kieselguhr weight is made a living 2% of astragalus weight, and the weight ratio of Radix Astragali and hydromel is 100:10, and the moistening time is 1h;
Step 3, by the Radix Astragali of moistening 220 DEG C of parches, the parch time is 30min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
Embodiment 5
The concocting method of Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:100 is prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts Radix Astragali and adds moistening in diatomaceous hydromel in advance, and in hydromel, kieselguhr weight is made a living 4% of astragalus weight, and the weight ratio of Radix Astragali and hydromel is 100:30, and the moistening time is 5h;
Step 3, by the Radix Astragali of moistening 240 DEG C of parches, the parch time is 40min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
Embodiment 6
The concocting method of Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:80 is prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts Radix Astragali and adds moistening in diatomaceous hydromel in advance, and in hydromel, kieselguhr weight is made a living 3% of astragalus weight, and the weight ratio of Radix Astragali and hydromel is 100:20, and the moistening time is 3h;
Step 3, by the Radix Astragali of moistening 230 DEG C of parches, the parch time is 35min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
Reference examples 1
With reference to Pharmacopoeia of People's Republic of China 2010 first, under Radix Astragali Preparata item, get the Radix Astragali, according to processed with honey method, after first refined honey being added proper amount of boiling water dilution, add and treat that big gun is processed in product and mix thoroughly, vexed, put in parch container, fry to tack-free with slow fire, take out, cool.
Reference examples 2
With reference to publication number be 103301183A, name is called the patent documentation of " a kind of concocting method of Radix Astragali (processed with Mel) ", concrete steps are:
(1) get the refined honey of Radix Astragali prepared slice quality 15 ~ 30%, add water, mixing, wherein, the mass ratio of refined honey and water is 1:(0.5 ~ 1.5);
(2) Radix Astragali decoction pieces is placed in the above-mentioned refined honey added water, mixes thoroughly, moistening 40min ~ 2h, fully exhausted by Radix Astragali decoction pieces to refined honey;
(3) Radix Astragali decoction pieces good for above-mentioned moistening is placed in microwave container, HIGH-POWERED MICROWAVES heating 3 ~ 5min, stirred once every 2 minutes during microwave heating, smoke 30 ~ 50min for 80 ~ 100 DEG C in rearmounted baking oven, to decoction pieces surface buff to sundown, take out, dry in the air to room temperature, sieve removes chip, and sealing, namely obtains Chinese medicine honey Radix Astragali Preparata decoction pieces.
Concocting method compares:
The method (comparative example 1) provide the embodiment of the present invention 1 and pharmacopeia and the method (comparative example 2) of existing report compare, and result is as follows:
As can be known from the above table, the method for comparative example 1 and 2 is uncontrollable, and index composition is all low than embodiment 1, and step is complicated, and acid extraction completely quantitatively, is not unfavorable for suitability for industrialized production.Embodiment 1 step is easy, and quantitatively omnidistance, consuming time short, is conducive to suitability for industrialized production.
Comparision contents:
(1) astragaloside
With reference to the assay of astragaloside under the Pharmacopoeia of the People's Republic of China (2010 editions) Radix Astragali Preparata catalogue, detect the astragaloside in embodiment and comparative example, concrete grammar is:
Chromatographic condition and system suitability take octadecylsilane chemically bonded silica as filler; With acetonitrile-water (32:68) for mobile phase; Evaporative light scattering detector detects.Number of theoretical plate calculates should be not less than 4000 by astragaloside peak.
The preparation of reference substance solution gets astragaloside reference substance in right amount, accurately weighed, adds methanol and makes the solution of every 1mL containing 0.5mg, to obtain final product.
The preparation of need testing solution is got powder in this product and is about 4g, accurately weighed, put in apparatus,Soxhlet's, add methanol 40mL, merceration spends the night, add methanol more appropriate, reflux 4 hours, extracting solution recycling design is also concentrated into dry, residue adds water 10mL, slight fever makes dissolving, 4 times are extracted with water saturated n-butyl alcohol jolting, each 40mL, merge n-butyl alcohol liquid, 2 times are fully washed with ammonia solution, each 40mL, discard ammoniacal liquor, n-butyl alcohol liquid evaporate to dryness, the residue 5mL that adds water makes dissolving, let cool, by D101 type macroporous adsorptive resins, with water 50mL eluting, discard water liquid, use 40% ethanol 30mL eluting again, discard eluent, continue with 70% ethanol 80mL eluting, collect eluent, evaporate to dryness, residue adds dissolve with methanol, be transferred in 5mL measuring bottle, add methanol to scale, shake up, obtain.
Algoscopy is accurate respectively draws reference substance solution 10 μ L, 20 μ L, need testing solution 20 μ L, injection liquid chromatography, measures, calculates with external standard two-point method logarithmic equation.
(2) calycosin glucoside
Chromatographic condition and system suitability take octadecylsilane chemically bonded silica as filler; Take acetonitrile as mobile phase A, with 0.2% formic acid solution for Mobile phase B, the regulation according to the form below carries out gradient elution; Determined wavelength is 260nm.Number of theoretical plate calculates should be not less than 3000 by calycosin glucoside peak.
| Time (minute) | Mobile phase A (%) | Mobile phase B (%) |
| 0～20 | 20→40 | 80→60 |
| 20～30 | 40 | 60 |
The preparation of reference substance solution gets Calycosin-7-O-BETA-D-glucoside reference substance in right amount, adds methanol and makes the solution of every 1mL containing 50 μ g, to obtain final product.
This product powder (crossing No. four sieves) 1g is got in the preparation of need testing solution, accurately weighed, puts in round-bottomed flask, precision adds methanol 50mL, weighed weight, heating and refluxing extraction 4 hours, let cool, more weighed weight, the weight of less loss is supplied with methanol, shake up, filter, precision measures subsequent filtrate 25mL, recycling design is to dry, and residue adds dissolve with methanol, is transferred in 5mL measuring bottle, add methanol to scale, shake up, to obtain final product.
Algoscopy precision draws reference substance solution and each 10 μ L of need testing solution, injection liquid chromatography, measures, to obtain final product.
Embodiment 1 to 6 gained sample and comparative example 1 and comparative example 2 gained sample are carried out content detection as stated above, and result is as follows:
As can be known from the above table, in the Radix Astragali (processed with Mel) that comparative example 1,2 provides, the content of astragaloside is 0.96 ~ 1.53mg/g, the content of calycosin glucoside is 1.78 ~ 3.45mg/g, and in the Radix Astragali (processed with Mel) that embodiments of the invention provide, the content of astragaloside is 6.56 ~ 11.21mg/g, and calycosin glucoside is 3.95 ~ 8.15mg/g.Result shows: Radix Astragali (processed with Mel) active constituent content provided by the invention is high, is better than prior art.In embodiment 4 ~ 6, the content of effective ingredient is higher than embodiment 1 ~ 3, and this may be the impurity that can adsorb due to kieselguhr in hydromel, and active constituent content is improved.
Claims (10)
1. the concocting method of Radix Astragali (processed with Mel), is characterized in that: comprise the following steps: at room temperature, by Radix Astragali and hydromel moistening, after all being absorbed to hydromel by Radix Astragali, by the Radix Astragali of moistening 220 DEG C ~ 240 DEG C parches, obtains Radix Astragali (processed with Mel).
2. the concocting method of Radix Astragali (processed with Mel) according to claim 1, is characterized in that: the weight ratio of described Radix Astragali and hydromel is 100:10 ~ 30.
3. the concocting method of Radix Astragali (processed with Mel) according to claim 1, is characterized in that: described hydromel is made up of for 50:50 ~ 100 by weight pure water and refined honey.
4. the concocting method of Radix Astragali (processed with Mel) according to claim 3, is characterized in that: described refined honey is middle honey, is heated to 116 ~ 118 DEG C by Mel, and water content is 10 ~ 13%.
5. the concocting method of Radix Astragali (processed with Mel) according to claim 1, is characterized in that: the parch time of the Radix Astragali is 30 ~ 40 minutes.
6. the concocting method of Radix Astragali (processed with Mel) according to claim 1, is characterized in that: the kieselguhr adding 2 ~ 4% of Radix Astragali weight in hydromel.
7. the concocting method of Radix Astragali (processed with Mel) according to claim 6, is characterized in that: after parch completes, and by the mode of sieving, kieselguhr is separated with the Radix Astragali.
8. the concocting method of Radix Astragali (processed with Mel) according to claim 1, is characterized in that: comprise the following steps:
Step 1 is that 50:50 ~ 100 are prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts moistening in hydromel by Radix Astragali, the weight ratio of Radix Astragali and hydromel is 100:10 ~ 30, and the moistening time is 1 ~ 5h;
Step 3, by the Radix Astragali of moistening 220 DEG C ~ 240 DEG C parches, the parch time is 30 ~ 40min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
9. the concocting method of Radix Astragali (processed with Mel) according to claim 1, is characterized in that: comprise the following steps:
Step 1 is that 50:50 ~ 100 are prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts Radix Astragali and adds moistening in diatomaceous hydromel in advance, and in hydromel, kieselguhr weight is made a living 2 ~ 4% of astragalus weight, and the weight ratio of Radix Astragali and hydromel is 100:10 ~ 30, and the moistening time is 1 ~ 5h;
Step 3, by the Radix Astragali of moistening 220 DEG C ~ 240 DEG C parches, the parch time is 30 ~ 40min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
10. the concocting method of Radix Astragali (processed with Mel) according to claim 1, is characterized in that: the concocting method of described Radix Astragali (processed with Mel), comprises the following steps:
Step 1 is that 50:80 is prepared into hydromel according to the weight ratio of pure water and refined honey, for subsequent use;
Step 2, at room temperature, puts Radix Astragali and adds moistening in diatomaceous hydromel in advance, and in hydromel, kieselguhr weight is made a living 3% of astragalus weight, and the weight ratio of Radix Astragali and hydromel is 100:20, and the moistening time is 3h;
Step 3, by the Radix Astragali of moistening 230 DEG C of parches, the parch time is 35min, after parch terminates, lets cool to room temperature, obtains Radix Astragali (processed with Mel).
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| CN105193907A (en) * | 2015-10-09 | 2015-12-30 | 江苏健生源中药材有限公司 | Method for preparing astragalus membranaceus decoction pieces |
| CN109078044A (en) * | 2018-09-28 | 2018-12-25 | 安徽汇中州中药饮片有限公司 | Baikal skullcap root decoction pieces processing procedure |
| CN112190606A (en) * | 2020-10-27 | 2021-01-08 | 河南华夏药材有限公司 | Processing method of honey-fried astragalus membranaceus |
| CN113181233A (en) * | 2021-05-17 | 2021-07-30 | 辽宁中医药大学 | Processing method for improving content of glycoside and aglycone in astragalus membranaceus |
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| CN109078044A (en) * | 2018-09-28 | 2018-12-25 | 安徽汇中州中药饮片有限公司 | Baikal skullcap root decoction pieces processing procedure |
| CN112190606A (en) * | 2020-10-27 | 2021-01-08 | 河南华夏药材有限公司 | Processing method of honey-fried astragalus membranaceus |
| CN113181233A (en) * | 2021-05-17 | 2021-07-30 | 辽宁中医药大学 | Processing method for improving content of glycoside and aglycone in astragalus membranaceus |
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