CN101175730B - 制备取代嘧啶的方法 - Google Patents

制备取代嘧啶的方法 Download PDF

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Publication number
CN101175730B
CN101175730B CN2006800169422A CN200680016942A CN101175730B CN 101175730 B CN101175730 B CN 101175730B CN 2006800169422 A CN2006800169422 A CN 2006800169422A CN 200680016942 A CN200680016942 A CN 200680016942A CN 101175730 B CN101175730 B CN 101175730B
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CN
China
Prior art keywords
compound
formula
alkyl
prc
solvent
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2006800169422A
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English (en)
Chinese (zh)
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CN101175730A (zh
Inventor
G·D·安尼斯
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EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
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Publication of CN101175730A publication Critical patent/CN101175730A/zh
Application granted granted Critical
Publication of CN101175730B publication Critical patent/CN101175730B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2006800169422A 2005-05-16 2006-05-12 制备取代嘧啶的方法 Expired - Fee Related CN101175730B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68129805P 2005-05-16 2005-05-16
US60/681,298 2005-05-16
PCT/US2006/018522 WO2006124657A1 (en) 2005-05-16 2006-05-12 Method for preparing substituted pyrimidines

Publications (2)

Publication Number Publication Date
CN101175730A CN101175730A (zh) 2008-05-07
CN101175730B true CN101175730B (zh) 2011-05-25

Family

ID=36867439

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800169422A Expired - Fee Related CN101175730B (zh) 2005-05-16 2006-05-12 制备取代嘧啶的方法

Country Status (13)

Country Link
US (1) US8013155B2 (enExample)
EP (1) EP1888536B1 (enExample)
JP (1) JP5069677B2 (enExample)
KR (1) KR101348458B1 (enExample)
CN (1) CN101175730B (enExample)
AT (1) ATE465999T1 (enExample)
AU (1) AU2006247581B2 (enExample)
BR (1) BRPI0612414A2 (enExample)
DE (1) DE602006013970D1 (enExample)
IL (1) IL185884A (enExample)
PL (1) PL1888536T3 (enExample)
WO (1) WO2006124657A1 (enExample)
ZA (1) ZA200707974B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1877384T3 (pl) * 2005-05-06 2011-09-30 Du Pont Sposób wytwarzania opcjonalnie 2-podstawionych kwasów 1,6-dihydro-6-okso-4-pirymidynokarboksylowych
CA2646143A1 (en) * 2006-04-10 2007-10-25 E. I. Du Pont De Nemours And Company Herbicidal mixtures
WO2013124246A1 (de) 2012-02-22 2013-08-29 Bayer Intellectual Property Gmbh Herbizid wirksame 4-dialkoxymethyl-2-phenylpyrimidine
CN102977050B (zh) * 2012-11-20 2015-04-22 浙江工业大学 一种2-苯并噻唑二甲缩醛和2-苯并噻唑甲醛的合成方法
CN116063179A (zh) * 2023-02-20 2023-05-05 南京杰运医药科技有限公司 一种4-甲氧基乙酰乙酸甲酯的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095240A (en) * 1981-03-05 1982-09-29 Fujisawa Pharmaceutical Co Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
CN1071049A (zh) * 1991-10-09 1993-04-21 纳幕尔杜邦公司 用于稻中杂草防治的除草剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA207185A (en) 1921-01-04 C. Wagner Virgil Warming plate
JPS57158779A (en) * 1981-03-05 1982-09-30 Fujisawa Pharmaceut Co Ltd Dihydropyrimidine derivative and its salt, their preparation and antiallergic containing the same
DE3935277A1 (de) 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
CA2321153A1 (en) 1998-02-17 1999-08-19 Timothy D. Cushing Anti-viral pyrimidine derivatives
SK285728B6 (sk) 1999-04-15 2007-07-06 Basf Aktiengesellschaft Spôsob prípravy substituovaných pyrimidínov
US20030130264A1 (en) 2001-02-16 2003-07-10 Tularik Inc. Methods of using pyrimidine-based antiviral agents
ATE440825T1 (de) 2003-06-06 2009-09-15 Vertex Pharma Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
PL1877384T3 (pl) 2005-05-06 2011-09-30 Du Pont Sposób wytwarzania opcjonalnie 2-podstawionych kwasów 1,6-dihydro-6-okso-4-pirymidynokarboksylowych

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095240A (en) * 1981-03-05 1982-09-29 Fujisawa Pharmaceutical Co Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
CN1071049A (zh) * 1991-10-09 1993-04-21 纳幕尔杜邦公司 用于稻中杂草防治的除草剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chidambaram N. et al.A highly selective methodology for the direct conversion ofacetals to esters.J. Org. Chem.57 18.1992,57(18),5013-5015.
Chidambaram N. et al.A highly selective methodology for the direct conversion ofacetals to esters.J. Org. Chem.57 18.1992,57(18),5013-5015. *
Karimi et al.Efficient aerobic oxidation of acetals to esters catalysed by N-hydroxyphthalimide and Co(Ⅱ) under mild conditions.Synthesis15.2003,152373-2377. *

Also Published As

Publication number Publication date
BRPI0612414A2 (pt) 2010-11-09
EP1888536B1 (en) 2010-04-28
ATE465999T1 (de) 2010-05-15
EP1888536A1 (en) 2008-02-20
IL185884A0 (en) 2008-01-06
CN101175730A (zh) 2008-05-07
US8013155B2 (en) 2011-09-06
KR101348458B1 (ko) 2014-01-07
AU2006247581B2 (en) 2011-10-20
US20090054647A1 (en) 2009-02-26
DE602006013970D1 (de) 2010-06-10
KR20080016640A (ko) 2008-02-21
JP2008540655A (ja) 2008-11-20
JP5069677B2 (ja) 2012-11-07
AU2006247581A1 (en) 2006-11-23
PL1888536T3 (pl) 2010-09-30
ZA200707974B (en) 2008-11-26
WO2006124657A1 (en) 2006-11-23
IL185884A (en) 2012-03-29

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110525

Termination date: 20170512