JP5069677B2 - 置換ピリミジンの製造方法 - Google Patents

置換ピリミジンの製造方法 Download PDF

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Publication number
JP5069677B2
JP5069677B2 JP2008512374A JP2008512374A JP5069677B2 JP 5069677 B2 JP5069677 B2 JP 5069677B2 JP 2008512374 A JP2008512374 A JP 2008512374A JP 2008512374 A JP2008512374 A JP 2008512374A JP 5069677 B2 JP5069677 B2 JP 5069677B2
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JP
Japan
Prior art keywords
compound
formula
acid
solvent
cyclopropyl
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Expired - Fee Related
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JP2008512374A
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English (en)
Japanese (ja)
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JP2008540655A5 (enExample
JP2008540655A (ja
Inventor
アニス，ゲイリー・デイビツド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
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Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of JP2008540655A publication Critical patent/JP2008540655A/ja
Publication of JP2008540655A5 publication Critical patent/JP2008540655A5/ja
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2008512374A 2005-05-16 2006-05-12 置換ピリミジンの製造方法 Expired - Fee Related JP5069677B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68129805P 2005-05-16 2005-05-16
US60/681,298 2005-05-16
PCT/US2006/018522 WO2006124657A1 (en) 2005-05-16 2006-05-12 Method for preparing substituted pyrimidines

Publications (3)

Publication Number Publication Date
JP2008540655A JP2008540655A (ja) 2008-11-20
JP2008540655A5 JP2008540655A5 (enExample) 2009-07-02
JP5069677B2 true JP5069677B2 (ja) 2012-11-07

Family

ID=36867439

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008512374A Expired - Fee Related JP5069677B2 (ja) 2005-05-16 2006-05-12 置換ピリミジンの製造方法

Country Status (13)

Country Link
US (1) US8013155B2 (enExample)
EP (1) EP1888536B1 (enExample)
JP (1) JP5069677B2 (enExample)
KR (1) KR101348458B1 (enExample)
CN (1) CN101175730B (enExample)
AT (1) ATE465999T1 (enExample)
AU (1) AU2006247581B2 (enExample)
BR (1) BRPI0612414A2 (enExample)
DE (1) DE602006013970D1 (enExample)
IL (1) IL185884A (enExample)
PL (1) PL1888536T3 (enExample)
WO (1) WO2006124657A1 (enExample)
ZA (1) ZA200707974B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1877384T3 (pl) * 2005-05-06 2011-09-30 Du Pont Sposób wytwarzania opcjonalnie 2-podstawionych kwasów 1,6-dihydro-6-okso-4-pirymidynokarboksylowych
CA2646143A1 (en) * 2006-04-10 2007-10-25 E. I. Du Pont De Nemours And Company Herbicidal mixtures
WO2013124246A1 (de) 2012-02-22 2013-08-29 Bayer Intellectual Property Gmbh Herbizid wirksame 4-dialkoxymethyl-2-phenylpyrimidine
CN102977050B (zh) * 2012-11-20 2015-04-22 浙江工业大学 一种2-苯并噻唑二甲缩醛和2-苯并噻唑甲醛的合成方法
CN116063179A (zh) * 2023-02-20 2023-05-05 南京杰运医药科技有限公司 一种4-甲氧基乙酰乙酸甲酯的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA207185A (en) 1921-01-04 C. Wagner Virgil Warming plate
GB2095240A (en) * 1981-03-05 1982-09-29 Fujisawa Pharmaceutical Co Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
JPS57158779A (en) * 1981-03-05 1982-09-30 Fujisawa Pharmaceut Co Ltd Dihydropyrimidine derivative and its salt, their preparation and antiallergic containing the same
DE3935277A1 (de) 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
CN1071049A (zh) * 1991-10-09 1993-04-21 纳幕尔杜邦公司 用于稻中杂草防治的除草剂
CA2321153A1 (en) 1998-02-17 1999-08-19 Timothy D. Cushing Anti-viral pyrimidine derivatives
SK285728B6 (sk) 1999-04-15 2007-07-06 Basf Aktiengesellschaft Spôsob prípravy substituovaných pyrimidínov
US20030130264A1 (en) 2001-02-16 2003-07-10 Tularik Inc. Methods of using pyrimidine-based antiviral agents
ATE440825T1 (de) 2003-06-06 2009-09-15 Vertex Pharma Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
PL1877384T3 (pl) 2005-05-06 2011-09-30 Du Pont Sposób wytwarzania opcjonalnie 2-podstawionych kwasów 1,6-dihydro-6-okso-4-pirymidynokarboksylowych

Also Published As

Publication number Publication date
BRPI0612414A2 (pt) 2010-11-09
EP1888536B1 (en) 2010-04-28
ATE465999T1 (de) 2010-05-15
EP1888536A1 (en) 2008-02-20
IL185884A0 (en) 2008-01-06
CN101175730A (zh) 2008-05-07
US8013155B2 (en) 2011-09-06
KR101348458B1 (ko) 2014-01-07
CN101175730B (zh) 2011-05-25
AU2006247581B2 (en) 2011-10-20
US20090054647A1 (en) 2009-02-26
DE602006013970D1 (de) 2010-06-10
KR20080016640A (ko) 2008-02-21
JP2008540655A (ja) 2008-11-20
AU2006247581A1 (en) 2006-11-23
PL1888536T3 (pl) 2010-09-30
ZA200707974B (en) 2008-11-26
WO2006124657A1 (en) 2006-11-23
IL185884A (en) 2012-03-29

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