CN101163703B - 用作肽脱甲酰基酶（pdf）抑制剂的咪唑并[1,2-a]吡啶衍生物 - Google Patents

用作肽脱甲酰基酶（pdf）抑制剂的咪唑并[1,2-a]吡啶衍生物 Download PDF

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Publication number
CN101163703B
CN101163703B CN2006800139164A CN200680013916A CN101163703B CN 101163703 B CN101163703 B CN 101163703B CN 2006800139164 A CN2006800139164 A CN 2006800139164A CN 200680013916 A CN200680013916 A CN 200680013916A CN 101163703 B CN101163703 B CN 101163703B
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CN
China
Prior art keywords
imidazo
hydroxy
ylamino
acetamide
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800139164A
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English (en)
Chinese (zh)
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CN101163703A (zh
Inventor
M·托尔曼
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Novartis AG
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Novartis AG
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Publication date
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Publication of CN101163703A publication Critical patent/CN101163703A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2006800139164A 2005-04-25 2006-04-24 用作肽脱甲酰基酶（pdf）抑制剂的咪唑并[1,2-a]吡啶衍生物 Expired - Fee Related CN101163703B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005019181A DE102005019181A1 (de) 2005-04-25 2005-04-25 Peptid-Deformylase (PDF) Inhibitoren 1
DE102005019181.9 2005-04-25
PCT/EP2006/003767 WO2006114263A1 (en) 2005-04-25 2006-04-24 Imidazo [1, 2-a] pyridine derivatives useful as peptide deformylase (pdf) inhibitors

Publications (2)

Publication Number Publication Date
CN101163703A CN101163703A (zh) 2008-04-16
CN101163703B true CN101163703B (zh) 2010-12-15

Family

ID=36692610

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800139164A Expired - Fee Related CN101163703B (zh) 2005-04-25 2006-04-24 用作肽脱甲酰基酶（pdf）抑制剂的咪唑并[1,2-a]吡啶衍生物

Country Status (12)

Country Link
US (2) US7662833B2 (enExample)
EP (1) EP1877408A1 (enExample)
JP (1) JP2008538778A (enExample)
KR (1) KR20080002867A (enExample)
CN (1) CN101163703B (enExample)
AU (1) AU2006239548B8 (enExample)
BR (1) BRPI0609946A2 (enExample)
CA (1) CA2605925A1 (enExample)
DE (1) DE102005019181A1 (enExample)
MX (1) MX2007013225A (enExample)
RU (1) RU2420526C2 (enExample)
WO (1) WO2006114263A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008068392A1 (fr) * 2006-12-07 2008-06-12 Commissariat A L'energie Atomique Nouveaux derives fluorophores imidazo [1,2-a] pyridin-3-yl-amine et leur procede de preparation
WO2008141239A1 (en) * 2007-05-10 2008-11-20 Acadia Pharmaceuticals Inc. Imidazol [1,2-a] pyridines and related compounds with activity at cannabinoid cb2 receptors
DE102007040336A1 (de) 2007-08-27 2009-03-05 Johann Wolfgang Goethe-Universität Frankfurt am Main Neue Inhibitoren der 5-Lipoxygenase und deren Verwendungen
FR2925903B1 (fr) * 2008-01-02 2011-01-21 Sanofi Aventis DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
WO2010032195A1 (en) * 2008-09-16 2010-03-25 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
CN101729939B (zh) * 2008-10-31 2012-12-05 中兴通讯股份有限公司 无源光网络带宽分配方法及系统
WO2011041713A2 (en) * 2009-10-02 2011-04-07 Glaxosmithkline Llc Piperazinyl antiviral agents
EP2601194B1 (en) * 2010-08-03 2016-05-25 Merck Sharp & Dohme Corp. Fused-imidazoyl compounds useful as antimicrobial agents
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
SG11201400988SA (en) * 2011-10-21 2014-07-30 Glaxosmithkline Llc Compounds and methods for enhancing innate immune responses
KR101650539B1 (ko) 2014-10-15 2016-08-26 장준구 다각도로 발광하는 led패키지
CN107245050B (zh) * 2016-12-05 2019-10-25 徐州医科大学 香草醛异羟肟酸类衍生物及其应用
EP3750878B1 (en) 2019-06-14 2025-05-14 Vivoryon Therapeutics N.V. Heteroaromatic inhibitors of astacin proteinases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632040A1 (en) * 1993-07-02 1995-01-04 Takeda Chemical Industries, Ltd. Antibacterial imidazole derivatives
WO2001085170A1 (en) * 2000-05-05 2001-11-15 Smithkline Beecham Corporation Peptide deformylase inhibitors
WO2003101442A1 (en) * 2002-05-31 2003-12-11 Smithkline Beecham Corporation Peptide deformylase inhibitors
WO2004052919A2 (en) * 2002-12-11 2004-06-24 Smithkline Beecham Corporation Peptide deformylase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU176214B (en) * 1977-05-18 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 5,6-dihydro-imidazo-square bracket-5,1-a-square bracket closed-isoquinolin derivatives
CA1164459A (en) * 1980-11-11 1984-03-27 Yung-Hsiung Yang Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives
JPS61218589A (ja) * 1985-03-26 1986-09-29 Eisai Co Ltd ５―（６―イミダゾ〔１，２―ａ〕ピリジニル）ピリジン誘導体
CZ297278B6 (cs) * 1996-08-07 2006-10-11 Darwin Discovery Limited Deriváty hydroxamové a karboxylové kyseliny a jejich pouzití
DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
TWI312347B (en) * 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
DE10150172A1 (de) * 2001-10-11 2003-04-30 Morphochem Ag Neue Verbindungen, die Protein Tyrosin Phosphatase 1B (PTP-1B) inhibieren
US20040127719A1 (en) * 2002-03-08 2004-07-01 Kexin Yang Alpha-isocyanocarboxylate solid support templates, method of preparation and for using the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632040A1 (en) * 1993-07-02 1995-01-04 Takeda Chemical Industries, Ltd. Antibacterial imidazole derivatives
WO2001085170A1 (en) * 2000-05-05 2001-11-15 Smithkline Beecham Corporation Peptide deformylase inhibitors
WO2003101442A1 (en) * 2002-05-31 2003-12-11 Smithkline Beecham Corporation Peptide deformylase inhibitors
WO2004052919A2 (en) * 2002-12-11 2004-06-24 Smithkline Beecham Corporation Peptide deformylase inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chen, Jack J. et al..Multi-Component Synthesis of Imidazo[1,2-a] AnnulatedHeterocycles on α-Isocyano Resin Esters.Synlett 8.2001,(8),1263-1265.
Chen, Jack J. et al..Multi-Component Synthesis of Imidazo[1,2-a] AnnulatedHeterocycles on α-Isocyano Resin Esters.Synlett 8.2001,(8),1263-1265. *
EP 0632040 A1,全文.

Also Published As

Publication number Publication date
EP1877408A1 (en) 2008-01-16
AU2006239548B2 (en) 2010-04-29
MX2007013225A (es) 2007-12-12
JP2008538778A (ja) 2008-11-06
AU2006239548B8 (en) 2010-08-26
CN101163703A (zh) 2008-04-16
KR20080002867A (ko) 2008-01-04
BRPI0609946A2 (pt) 2010-05-11
CA2605925A1 (en) 2006-11-02
WO2006114263A1 (en) 2006-11-02
US20090215816A1 (en) 2009-08-27
DE102005019181A1 (de) 2006-10-26
RU2420526C2 (ru) 2011-06-10
RU2007143512A (ru) 2009-06-10
US20080188515A1 (en) 2008-08-07
US7662833B2 (en) 2010-02-16
AU2006239548A1 (en) 2006-11-02

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Granted publication date: 20101215

Termination date: 20120424