CN101163478B - 用于炎症及免疫相关用途之化合物 - Google Patents
用于炎症及免疫相关用途之化合物 Download PDFInfo
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- CN101163478B CN101163478B CN2006800031821A CN200680003182A CN101163478B CN 101163478 B CN101163478 B CN 101163478B CN 2006800031821 A CN2006800031821 A CN 2006800031821A CN 200680003182 A CN200680003182 A CN 200680003182A CN 101163478 B CN101163478 B CN 101163478B
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- Prior art keywords
- optionally substituted
- phenyl
- compound
- pyrazin
- methyl
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- 0 CC1NCC(N(*)C2OC2*)N(C)C1 Chemical compound CC1NCC(N(*)C2OC2*)N(C)C1 0.000 description 5
- MQONHNQFXMKXET-UHFFFAOYSA-N Bc1cnc(N)nc1 Chemical compound Bc1cnc(N)nc1 MQONHNQFXMKXET-UHFFFAOYSA-N 0.000 description 1
- XGKQDCMTIUYHED-UHFFFAOYSA-N O=C(c(c(F)ccc1)c1F)Nc(nc1)ncc1-c1cc(C(F)(F)F)ccc1Cl Chemical compound O=C(c(c(F)ccc1)c1F)Nc(nc1)ncc1-c1cc(C(F)(F)F)ccc1Cl XGKQDCMTIUYHED-UHFFFAOYSA-N 0.000 description 1
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64668305P | 2005-01-25 | 2005-01-25 | |
| US60/646,683 | 2005-01-25 | ||
| PCT/US2006/002874 WO2006081391A2 (en) | 2005-01-25 | 2006-01-25 | Compounds for inflammation and immune-related uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101163478A CN101163478A (zh) | 2008-04-16 |
| CN101163478B true CN101163478B (zh) | 2013-11-27 |
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ID=36741062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800031821A Expired - Fee Related CN101163478B (zh) | 2005-01-25 | 2006-01-25 | 用于炎症及免疫相关用途之化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8518950B2 (enExample) |
| EP (1) | EP1848435B1 (enExample) |
| JP (3) | JP5307402B2 (enExample) |
| KR (1) | KR101436161B1 (enExample) |
| CN (1) | CN101163478B (enExample) |
| AU (1) | AU2006208045B2 (enExample) |
| BR (1) | BRPI0607308A2 (enExample) |
| CA (1) | CA2595855C (enExample) |
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Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2567853T3 (es) | 2005-01-25 | 2016-04-26 | Synta Pharmaceuticals Corporation | Compuestos contra la inflamación y utilizaciones relacionadas con el sistema inmunitario |
| AU2006208043B2 (en) * | 2005-01-25 | 2012-09-20 | Synta Pharmaceuticals Corp. | Thiophene compounds for inflammation and immune-related uses |
| TW200806641A (en) * | 2006-01-25 | 2008-02-01 | Synta Pharmaceuticals Corp | Substituted aromatic compounds for inflammation and immune-related uses |
| EP1984337B1 (en) * | 2006-01-25 | 2014-04-30 | Synta Pharmaceuticals Corp. | Vinyl-phenyl derivatives for inflammation and immune-related uses |
| EP1998612A4 (en) * | 2006-01-25 | 2010-11-24 | Synta Pharmaceuticals Corp | SUBSTITUTED BIARYL COMPOUNDS FOR USE AGAINST INFLAMMATION AND IMMUNE DISORDERS |
| US8119643B2 (en) * | 2006-03-20 | 2012-02-21 | Synta Pharmaceuticals Corp. | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses |
| US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| WO2008063504A2 (en) * | 2006-11-13 | 2008-05-29 | Synta Pharmaceuticals Corp. | Cyclohexenyl-aryl compounds for inflammation and immune-related uses |
| US8435996B2 (en) * | 2007-08-01 | 2013-05-07 | Synta Pharmaceuticals Corp. | Heterocycle-aryl compounds for inflammation and immune-related uses |
| WO2009017831A1 (en) | 2007-08-01 | 2009-02-05 | Synta Pharmaceuticals Corp. | Vinyl-aryl derivatives for inflammation and immune-related uses |
| CA2696349A1 (en) * | 2007-08-15 | 2009-02-19 | President And Fellows Of Harvard College | Heterocyclic inhibitors of necroptosis |
| US8263641B2 (en) | 2007-09-10 | 2012-09-11 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US8389567B2 (en) | 2007-12-12 | 2013-03-05 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| CA2734500A1 (en) | 2008-08-27 | 2010-03-11 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
| US8524763B2 (en) | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| CA2739303A1 (en) * | 2008-10-01 | 2010-04-08 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| US8143269B2 (en) | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| RU2012109233A (ru) * | 2009-09-03 | 2013-10-10 | Аллерган, Инк. | Соединения как модуляторы тирозинкиназы |
| US9340555B2 (en) | 2009-09-03 | 2016-05-17 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
| WO2011034962A2 (en) | 2009-09-16 | 2011-03-24 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
| WO2011041433A1 (en) * | 2009-09-29 | 2011-04-07 | The Trustees Of The University Of Pennsylvania | Methods for diagnosing and treating encephalitis or epilepsy |
| US8993612B2 (en) | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US8754219B2 (en) | 2010-04-27 | 2014-06-17 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| HUE029570T2 (en) | 2010-04-27 | 2017-03-28 | Calcimedica Inc | Intracellular calcium modifying compounds |
| CN114591311A (zh) | 2010-08-27 | 2022-06-07 | 钙医学公司 | 调节细胞内钙的化合物 |
| EP2632906B1 (en) | 2010-10-30 | 2016-04-06 | Lupin Limited | Oxazoline and isoxazoline derivatives as crac modulators |
| AR086113A1 (es) * | 2011-04-30 | 2013-11-20 | Abbott Lab | Isoxazolinas como agentes terapeuticos |
| JP5985611B2 (ja) * | 2011-05-03 | 2016-09-06 | シンタ ファーマシューティカルズ コーポレーション | 炎症および免疫関連用途のための化合物 |
| WO2012170931A2 (en) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US9856240B2 (en) | 2011-10-19 | 2018-01-02 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| AU2013247671A1 (en) * | 2012-04-13 | 2014-10-23 | Mitsubishi Tanabe Pharma Corporation | Amidopyridine derivative, and use thereof |
| AU2013255441B2 (en) | 2012-05-02 | 2017-11-09 | Lupin Limited | Substituted pyrazole compounds as CRAC modulators |
| US9399638B2 (en) | 2012-05-02 | 2016-07-26 | Lupin Limited | Substituted pyridine compounds as CRAC modulators |
| WO2014031755A1 (en) * | 2012-08-21 | 2014-02-27 | The Board Of Regents Of The University Of Texas System | Fendiline derivatives and methods of use thereof |
| US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| EP2968276A4 (en) | 2013-03-15 | 2017-02-15 | President and Fellows of Harvard College | Hybrid necroptosis inhibitors |
| EP3010586A1 (en) | 2013-06-21 | 2016-04-27 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
| US9790231B2 (en) | 2013-06-24 | 2017-10-17 | Lupin Limited | Chromane and chromene derivatives and their use as CRAC modulators |
| WO2016057338A1 (en) | 2014-10-06 | 2016-04-14 | Takeda Pharmaceutical Company Limited | Heteroarylamide inhibitors of tbk1 |
| CN114712513A (zh) | 2015-02-27 | 2022-07-08 | 钙医学公司 | 胰腺炎治疗 |
| CA2995094A1 (en) | 2015-08-07 | 2017-02-16 | Calcimedica, Inc. | Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury |
| BR112021004893A2 (pt) | 2018-09-14 | 2021-06-01 | Rhizen Pharmaceuticals A G | composições compreendendo um inibidor de crac e um corticosteroide e métodos de uso dos mesmos |
| CA3139291A1 (en) * | 2019-07-18 | 2021-01-21 | Jacky Vonderscher | Method for decreasing adverse-effects of interferon |
| EP4043450A4 (en) * | 2019-09-25 | 2023-10-25 | Medshine Discovery Inc. | 2H-BENZOPYRAN DERIVATIVES USABLE AS CRAC INHIBITORS |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| AU2021207804A1 (en) | 2020-01-13 | 2022-09-01 | Verge Analytics, Inc. | Substituted pyrazolo-pyrimidines and uses thereof |
| US20240043403A1 (en) * | 2020-11-30 | 2024-02-08 | Astellas Pharma Inc. | Heteroaryl carboxamide compound |
| WO2022179577A1 (zh) * | 2021-02-25 | 2022-09-01 | 南京明德新药研发有限公司 | 一种环丙基取代的苯并呋喃类化合物的晶型及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6803372B2 (en) * | 1999-08-20 | 2004-10-12 | Banyu Pharmaceutical Co., Ltd. | Spiro compounds |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US6274171B1 (en) | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
| JP4385414B2 (ja) | 1997-10-13 | 2009-12-16 | アステラス製薬株式会社 | アミド若しくはアミン誘導体 |
| TWI279402B (en) * | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
| JP3553560B2 (ja) | 1999-08-20 | 2004-08-11 | 萬有製薬株式会社 | 新規スピロ化合物 |
| US6462053B1 (en) * | 1999-08-20 | 2002-10-08 | Banyu Pharmaceutical Co., Ltd. | Spiro compounds |
| NZ519070A (en) * | 1999-11-26 | 2005-08-26 | Shionogi & Co | NPY Y5 antagonists |
| JP4083422B2 (ja) | 2000-12-22 | 2008-04-30 | 石原産業株式会社 | アニリン誘導体またはその塩ならびにそれらを含有するサイトカイン産生抑制剤 |
| US6924291B2 (en) | 2001-01-23 | 2005-08-02 | Merck & Co., Inc. | Process for making spiro isobenzofuranone compounds |
| GB0124932D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124928D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| EP1458715B1 (en) | 2001-12-18 | 2005-12-07 | AstraZeneca AB | Novel compounds |
| AU2003213266A1 (en) * | 2002-03-06 | 2003-09-22 | Smithkline Beecham Corporation | Condensed heterocyclic compounds as calcitonin agonists |
| AU2003253925A1 (en) | 2002-07-18 | 2004-02-09 | Banyu Pharmaceutical Co., Ltd. | Combination therapy for the treatment of obesity |
| US7541477B2 (en) | 2002-07-30 | 2009-06-02 | Banyu Pharmaceutical Co., Ltd. | Antagonists to melanin-concentrating hormone receptor comprising benzimidazole derivative as active ingredient |
| US20040110802A1 (en) | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
| US6657024B1 (en) | 2002-09-03 | 2003-12-02 | Fina Technology, Inc. | Polymerization catalyst system using n-butylmethyldimethoxysilane for preparation of polypropylene film grade resins |
| CA2510471A1 (en) * | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| WO2004089919A1 (ja) | 2003-04-02 | 2004-10-21 | Banyu Pharmaceutical Co., Ltd. | シクロヘキサンカルボキサミド誘導体 |
| US20060148721A1 (en) | 2003-06-06 | 2006-07-06 | Erondu Ngozi E | Combination therapy for the treatment of dyslipidemia |
| US20070099884A1 (en) * | 2003-06-06 | 2007-05-03 | Erondu Ngozi E | Combination therapy for the treatment of diabetes |
| EP1644365A2 (en) * | 2003-07-02 | 2006-04-12 | Biofocus Discovery Ltd | Pyrazine and pyridine derivatives as rho kinase inhibitors |
| DE602004030689D1 (de) | 2003-07-23 | 2011-02-03 | Synta Pharmaceuticals Corp | Verbindungen gegen entzündungen und immun-relevante verwendungen |
| JP2007503393A (ja) | 2003-08-22 | 2007-02-22 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | Copd及び肺高血圧の治療方法 |
| WO2005090340A1 (ja) * | 2004-03-22 | 2005-09-29 | Banyu Pharmaceutical Co., Ltd. | ピペリジン-1-カルボキサミド誘導体 |
| KR20070057965A (ko) | 2004-09-21 | 2007-06-07 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| DE602005009021D1 (de) | 2004-12-17 | 2008-09-25 | Lilly Co Eli | Neue mch-rezeptorantagonisten |
| KR20070107022A (ko) | 2005-01-07 | 2007-11-06 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| ES2567853T3 (es) | 2005-01-25 | 2016-04-26 | Synta Pharmaceuticals Corporation | Compuestos contra la inflamación y utilizaciones relacionadas con el sistema inmunitario |
| AU2006208043B2 (en) | 2005-01-25 | 2012-09-20 | Synta Pharmaceuticals Corp. | Thiophene compounds for inflammation and immune-related uses |
| ES2270715B1 (es) * | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| CN102775396B (zh) | 2005-11-08 | 2014-10-08 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的杂环调控剂 |
| EP1960367A2 (en) * | 2005-12-05 | 2008-08-27 | Boehringer Ingelheim International GmbH | Substituted pyrazole compounds useful as soluble epoxide hydrolase inhibitors |
| ZA200805192B (en) * | 2005-12-29 | 2009-11-25 | Lexicon Pharmaceuticals Inc | Multicyclic amino acid derivatives and methods of their use |
| US7957808B2 (en) | 2006-01-13 | 2011-06-07 | Vanderbilt University | System and methods of deep brain stimulation for post-operation patients |
| PE20071241A1 (es) * | 2006-01-17 | 2008-01-14 | Schering Corp | Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios |
| US8119643B2 (en) | 2006-03-20 | 2012-02-21 | Synta Pharmaceuticals Corp. | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6803372B2 (en) * | 1999-08-20 | 2004-10-12 | Banyu Pharmaceutical Co., Ltd. | Spiro compounds |
Non-Patent Citations (4)
| Title |
|---|
| Donald J. P. Pinto et al.Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423),a HighlyPotent,Selective,and Orally Bioavailable Inhibitor ofBlood Coagulation Factor Xa.Journal of Medicinal Chemistry44 4.2001,44(4),566-578. |
| Donald J. P. Pinto et al.Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423),a HighlyPotent,Selective,and Orally Bioavailable Inhibitor ofBlood Coagulation Factor Xa.Journal of Medicinal Chemistry44 4.2001,44(4),566-578. * |
| Urska Bratusek et al.Transformations of (Z)-2-benzoylamino-4-dimethylamino-2-oxo-3-butene and (E)-3-benzoylamino-4-cyano-2-oxo-3-buteneinto pyrimidine, pyrazole and isoxazole derivatives.ARKIVOCV.2003,V77-86. * |
| UrskaBratuseketal.Transformationsof(Z)-2-benzoylamino-4-dimethylamino-2-oxo-3-buteneand(E)-3-benzoylamino-4-cyano-2-oxo-3-buteneintopyrimidine pyrazole and isoxazole derivatives.ARKIVOCV.2003 |
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| NZ556732A (en) | 2011-11-25 |
| PL1848435T3 (pl) | 2016-08-31 |
| CA2595855A1 (en) | 2006-08-03 |
| US8518950B2 (en) | 2013-08-27 |
| WO2006081391A3 (en) | 2007-08-02 |
| EP1848435A2 (en) | 2007-10-31 |
| ZA200707125B (en) | 2008-11-26 |
| CA2595855C (en) | 2017-07-04 |
| US9493427B2 (en) | 2016-11-15 |
| MX2007008957A (es) | 2007-12-06 |
| NZ590359A (en) | 2012-08-31 |
| JP5307402B2 (ja) | 2013-10-02 |
| BRPI0607308A2 (pt) | 2009-08-25 |
| US20150266829A1 (en) | 2015-09-24 |
| US20060173021A1 (en) | 2006-08-03 |
| AU2006208045B2 (en) | 2012-08-30 |
| CN101163478A (zh) | 2008-04-16 |
| JP2013047247A (ja) | 2013-03-07 |
| HK1110240A1 (zh) | 2008-07-11 |
| EP1848435B1 (en) | 2016-01-20 |
| IL184756A0 (en) | 2008-08-07 |
| AU2006208045A1 (en) | 2006-08-03 |
| ES2567853T3 (es) | 2016-04-26 |
| TW200638933A (en) | 2006-11-16 |
| US20130309272A1 (en) | 2013-11-21 |
| KR20070110303A (ko) | 2007-11-16 |
| EP1848435A4 (en) | 2010-09-29 |
| TWI422376B (zh) | 2014-01-11 |
| WO2006081391A2 (en) | 2006-08-03 |
| US9090570B2 (en) | 2015-07-28 |
| JP2014221840A (ja) | 2014-11-27 |
| JP2008528520A (ja) | 2008-07-31 |
| KR101436161B1 (ko) | 2014-09-01 |
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