CN101156917A - A medicine for preventing and treating livestock birds heat irritability syndrome - Google Patents
A medicine for preventing and treating livestock birds heat irritability syndrome Download PDFInfo
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Abstract
The invention provides a medicine used for preventing and treating heat stress syndrome of livestocks. The drug efficacy component is produced by the raw materials in the following parts by weight: atractylodes rhizome is 100 to 200 parts, yellow corktree bark is 50 to 150 parts, plaster stone is 50 to 150 parts, wrinkled giant hyssop is 50 to 150 parts, auckandia root is 50 to 150 parts, and licorice is 30 to 80 parts. Together with a pharmaceutically acceptable carrier, the medicine can be produced into various dosage forms, such as powder, mixture, tablets, capsules as well as granules, etc. The medicine can resist heat stress and normal stress of the livestock, clear away heat and toxic materials, invigorate the spleen for eliminating dampness, supply body fluid and reinforce vital energy, eliminate evil factors and support healthy energy, and harmonize yin-yang, and is used for the stress of chickens and pigs, especially listlessness, inappetence, low immunologic function, and producibility reduction, etc. which are caused by damp and heat environment. Clinical trials prove that the medicine has good heat stress resistance effect for brood sows, fattening pigs, layer chicken, and meat chicken, and the products conform to demands on the nuisanceless animal products.
Description
Technical field
The present invention relates to a kind of medicine that is used to prevent and treat livestock and poultry heat stress, be applied to nuisanceless aquaculture, is to be that the herbal medicine of feedstock production is used for preventing and treating livestock birds heat irritability syndrome with Chinese medicine specifically.Invention also relates to the preparation method of this medicine.
Background technology
Along with global climate warms, high temperature is the key factor that influences poultry production in summer as one of stress factor.Poultry are dispelled the heat in high temperature difficult, thermal balance imbalance causing heat stress, fertility performance decline.Birds fever, metabolism are vigorous, skin does not have sweat gland and by characteristics such as plumage is abundant, heat radiation difficulty, thermal balance imbalance cause heat stress in hot environment, thereby make its laying rate descend 10～30%, efficiency of feed utilization descends 10～20%, and mortality rate rises 5～10%.Swine Production is lost bigger in high temperature.Have data to show, nearly all large-scale pig farm all causes sow just before giving birth phase, perinatal death and piglet death in hot environment; The oestrus of sow rate reduces by 20～30%, returns the feelings rate and improves 20～30%.Nest litter size, piglet birth weight, survival rate also are subjected to influence in various degree.Sow and piglet also reach more than 20% because of a series of economic losses that feed intake decline causes.Because stress middle 17-hydroxy-11-dehydrocorticosterone secretion increase, immunity of organisms is suppressed, and very easily brings out the popular of various typical cases or atypical infectious disease, particularly some immunosuppressant disease M ﹠ Ms increase, and cause bigger economic loss.
For this reason, herding produces that to continue to use for a long time with chemical medicine, antibiotic be that main body cooperates the veterinary of the vaccine immunity technology of preventing epidemic always.Issuing and implementation along with the nuisanceless veterinary drug usage criteria of country, both at home and abroad to chemical medicine, more and more strictness of antibiotic interpolation restriction, and chemicals, hormone, antibiotic remains problem not only have influence on China people's health in the animal products, and are the biggest obstacles of products export.Show according to interrelated data: along with increasing of international Livestock Product Trade technology barriers, some animal products of China are because technical specifications such as cause of disease, residue of veterinary drug surpass the controlling index of European Union and main body entrance state, and quilt is rejected, detains and termination of the contract even Feng Guan etc. occur repeatedly.European Union is also developing natural plant energetically simultaneously, and environmental type natural plants such as immunomodulator are product as an alternative, promotes in breeding production.
Summary of the invention
The object of the present invention is to provide a kind of medicine that can prevent and treat livestock birds heat irritability syndrome effectively.The present invention also aims to provide the preparation method of this medicine.
The scheme of technical solution problem of the present invention is based on China's medical science starts with from regulating aspects such as immunity of organism, fertility performance and heat radiation, focuses on the drug mechanism of aspect further investigation anti-heat stress such as cellular immunization, mucosal immunity, specific immunity and peripheral circulation heat radiation, respiratory tract evaporative heat loss, drainage heat radiation.The result has shown the regulation and control of above-mentioned various aspects very effective at present, this product is started with from keeping body stable state, body health state under extreme conditions, coordinate the physiological function of poultry, improving the adaptability of poultry to stressor---long-term interpolation is not only favourable to regulating immunity of organism, promote that simultaneously body dispels the heat by all kinds of means, promoted the maximum performance of growth performance.
The active ingredient of medicine of the present invention is made by the raw material of following weight portion:
Rhizoma Atractylodis 100～200, Cortex Phellodendri 50～150, Gypsum Fibrosum 50～150, Herba Pogostemonis 50～150, the Radix Aucklandiae 50～150, Radix Glycyrrhizae 30～80.
Be preferably: Rhizoma Atractylodis 150g Cortex Phellodendri 100g Gypsum Fibrosum 100g Herba Pogostemonis 100g Radix Aucklandiae 100g Radix Glycyrrhizae 50g
The present invention is applicable to damp and hot laying equal stress on, or weight in wet base is in heat, the descender of searching for food.
Rhizoma Atractylodis, Cortex Phellodendri, Gypsum Fibrosum are principal agent among the present invention, the arduous temperature of Rhizoma Atractylodis, and dampness is good for the stomach, Cortex Phellodendri clearing up internal heat by using drugs of bitter in taste and cold in nature dampness, Gypsum Fibrosum is sweet cold, clearing away heat-fire, relieving restlessness is promoted the production of body fluid, and directly rolls over pathogenic summer-heat.Three medicines are harmonious, and suffering can be loose, but hardship can be clearly can dry consolidating YIN, sweet diarrhea due to cold pathogen fire Bao Jin makes heat of wetting clear, deposit cloudy end sharp.
The hot tepor of Herba Pogostemonis, eliminating turbid pathogen with aromatics is separated in the harmony in the exterior, matches clearing away heat and expelling pathogen in the exterior, clearing stomach regulating the spleen and stomach with Gypsum Fibrosum.The Radix Aucklandiae tepor of working hard, the merit of profit is strengthened and ended to circulation of qi promoting reason spleen with the Cortex Phellodendri pungent drugs can disperse and bitter drugs can descend that matches; Match with Herba Pogostemonis, circulation of qi promoting removing dampness appetizing is accessory drugs altogether.
Radix Glycyrrhizae is sweet flat, QI invigorating and middle heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Be messenger drug.
This medicine can be made dosage forms such as powder, mixture, tablet, capsule, granule with pharmaceutically acceptable carrier.
Oral liquid usage, consumption: pig, chicken: treatment 0.3mL/kg, 7 days one courses of treatment, every day 1 time, drinking-water administration; Preventive dose reduces by half.
Granule usage and dosage: pig, chicken: treatment 0.2g/kg, 7 days one courses of treatment, every day 1 time, drinking-water or spice administration; Preventive dose reduces by half.
This medicine can resist livestock and poultry heat stress and generally stress, heat-clearing and toxic substances removing, invigorating the spleen for eliminating dampness, supplementing QI for promoting the production of body fluid, eliminating pathogenic factor for supporting vital QI, YIN and YANG balance regulating.Be used for the particularly lethargy that causes of hygrothermal environment of chicken, pig, inappetence, immunologic hypofunction, degradation under the fertility performance.
Show through clinical experiment: still be that laying hen, broiler all demonstrate good anti-heat stress effect no matter, and product meets the publicly harmless animal product requirement brood sow, growing and fattening pigs.
The specific embodiment:
Following embodiment is used to further specify the present invention, but can not limit the scope of the invention.
The preparation of embodiment 1 oral liquid
Pharmacodynamic raw materials: Rhizoma Atractylodis 150g Cortex Phellodendri 100g Gypsum Fibrosum 100g Herba Pogostemonis 100g Radix Aucklandiae 100g Radix Glycyrrhizae 50g
Above Six-element is got Rhizoma Atractylodis, Herba Pogostemonis adds 8 times of amounts of water, extracts volatile oil 8 hours, collects volatile oil, and is standby, the medicinal liquid after the extraction, and device is stored in addition.Medicinal residues and all the other 4 flavor medical materials add 10 times of amounts of water and decoct three times, and each 1 hour, merge decoction liquor, filter, merge with above-mentioned medicinal liquid, be evaporated to relative density 1.05 (40 ℃), cold preservation 24 hours, high speed centrifugation.Stir the mixed liquor that adds polyoxyethylene sorbitan monoleate 3025mL and volatile oil down, add the 2g potassium sorbate, add water to be adjusted to 100000mL, filter, fill, sterilization, promptly.
The preparation of embodiment 2 oral liquids
Pharmacodynamic raw materials: Rhizoma Atractylodis 100 Cortex Phellodendris 150 Gypsum Fibrosum 50 Herba Pogostemoniss 150 Radix Aucklandiae 50 Radix Glycyrrhizaes 80
Above Six-element is got Rhizoma Atractylodis, Herba Pogostemonis adds 8 times of amounts of water, extracts volatile oil 8 hours, collects volatile oil, and is standby, the medicinal liquid after the extraction, and device is stored in addition.Medicinal residues and all the other 4 flavor medical materials add 10 times of amounts of water and decoct three times, and each 1 hour, merge decoction liquor, filter, merge with above-mentioned medicinal liquid, be evaporated to relative density 1.05 (40 ℃), cold preservation 24 hours, high speed centrifugation.Stir the mixed liquor that adds polyoxyethylene sorbitan monoleate 3025 mL and volatile oil down, add the 2g potassium sorbate, add water to be adjusted to 100000mL, filter, fill, sterilization, promptly.
The preparation of embodiment 3 oral liquids
Pharmacodynamic raw materials: Rhizoma Atractylodis 200 Cortex Phellodendris 50 Gypsum Fibrosum 150 Herba Pogostemoniss 50 Radix Aucklandiae 150 Radix Glycyrrhizaes 30
Above Six-element is got Rhizoma Atractylodis, Herba Pogostemonis adds 8 times of amounts of water, extracts volatile oil 8 hours, collects volatile oil, and is standby, the medicinal liquid after the extraction, and device is stored in addition.Medicinal residues and all the other 4 flavor medical materials add 10 times of amounts of water and decoct three times, and each 1 hour, merge decoction liquor, filter, merge with above-mentioned medicinal liquid, be evaporated to relative density 1.05 (40 ℃), cold preservation 24 hours, high speed centrifugation.Stir the mixed liquor that adds polyoxyethylene sorbitan monoleate 3025mL and volatile oil down, add the 2g potassium sorbate, add water to be adjusted to 100000mL, filter, fill, sterilization, promptly.
The preparation of embodiment 4 granules
Pharmacodynamic raw materials: Rhizoma Atractylodis 150g Cortex Phellodendri 100g Gypsum Fibrosum 100g Herba Pogostemonis 100g Radix Aucklandiae 100g Radix Glycyrrhizae 50g
Above Six-element is got Rhizoma Atractylodis, Herba Pogostemonis and is added 8 times of water gagings and extracted volatile oil 8 hours, collects volatile oil, beta cyclodextrin enclose, 40 ℃ of dryings; Medicinal liquid after the extraction, device is stored in addition; Medicinal residues and all the other 4 flavor medical materials add 10 times of water gagings and decoct three times, and each 2 hours, merge decoction liquor, filter, merge with above-mentioned medicinal liquid, standing over night, leaching supernatant are evaporated to relative density 1.21～1.27 (50 ℃), are dried to dried cream.Dried cream powder is broken into fine powder, with the volatile oil beta cyclodextrin inclusion complex mixing, adds an amount of dextrin, wet granulation, and 500 grams are made in cold drying, and packing is promptly.
The preparation of embodiment 5 granules
Pharmacodynamic raw materials: Rhizoma Atractylodis 150g Cortex Phellodendri 80g Gypsum Fibrosum 100g Herba Pogostemonis 120g Radix Aucklandiae 80g Radix Glycyrrhizae 50g
Above Six-element is got Rhizoma Atractylodis, Herba Pogostemonis and is added 8 times of water gagings and extracted volatile oil 8 hours, collects volatile oil, beta cyclodextrin enclose, 40 ℃ of dryings; Medicinal liquid after the extraction, device is stored in addition; Medicinal residues and all the other 4 flavor medical materials add 10 times of water gagings and decoct three times, and each 2 hours, merge decoction liquor, filter, merge with above-mentioned medicinal liquid, standing over night, leaching supernatant are evaporated to relative density 1.21～1.27 (50 ℃), are dried to dried cream.Dried cream powder is broken into fine powder, with the volatile oil beta cyclodextrin inclusion complex mixing, adds an amount of dextrin, wet granulation, and 500 grams are made in cold drying, and packing is promptly.
The preparation of embodiment 6 granules
Pharmacodynamic raw materials: Rhizoma Atractylodis 180g Cortex Phellodendri 100g Gypsum Fibrosum 120g Herba Pogostemonis 120g Radix Aucklandiae 80g Radix Glycyrrhizae 50g
Get Rhizoma Atractylodis, Herba Pogostemonis and add 8 times of water gagings and extracted volatile oil 8 hours, collect volatile oil, beta cyclodextrin enclose, 40 ℃ of dryings; Medicinal liquid after the extraction, device is stored in addition; Medicinal residues and all the other 4 flavor medical materials add 10 times of water gagings and decoct three times, and each 2 hours, merge decoction liquor, filter, merge with above-mentioned medicinal liquid, standing over night, leaching supernatant are evaporated to relative density 1.21～1.27 (50 ℃), are dried to dried cream.Dried cream powder is broken into fine powder, with the volatile oil beta cyclodextrin inclusion complex mixing, adds an amount of dextrin, wet granulation, and 500 grams are made in cold drying, and packing is promptly.
The clinical prevention effect:
1. anti-heat stress Chinese medicine is to the experimental result of growing and fattening pigs under the high temperature:
Laboratory animal: age in days is that 120 days DABAI is hybridized 120 of growing and fattening pigs, is divided into 3 groups,
Every group of counterpoise 64 ± 0.5kg, the grouping situation sees Table 1.Diets of different nutrition level (percentage by weight): digestible energy 15.65MJ/kg, crude protein 14%, crude fibre 5%, calcium 0.9%, phosphorus 0.5% are the result of use that example illustrates this drug invention with embodiment 1 liquid preparation oral liquid.Oral liquid usage, consumption: pig, chicken: treatment 0.3mL/kg, 7 days one courses of treatment, every day 1 time, drinking-water administration; Preventive dose reduces by half.(down together)
Experimental condition: 26～40 ℃ of high temperature groups, 23 ℃ of room temperature groups.
Table 1 anti-heat stress Chinese medicine is to the influence of fertility performance under the growing and fattening pigs high temperature
| Grouping | A test number | Head is weightening finish (kg) all | Daily gain (g) | Omnidistance head is feed consumption (kg) all | Feedstuff-meat ratio |
| High temperature matched group anti-heat stress Chinese drug-treated group room temperature matched group | 40 40 40 | 10.25±0.85 11.60±1.26 12.56±1.78 a | 512.12±22.81 580.47±32.57 a 598.47±32.57 a | 25.93±2.11 24.83±2.17 26.78±2.73 | 2.53∶1 2.14∶1 a 2.13∶1 a |
As can be seen from Table 1, adopt medicine of the present invention, under hot conditions, also can obtain and the similar feeding effect of room temperature matched group.
Anti-heat stress Chinese medicine under the high temperature to the experimental result of sow reproductive performance in puerperal
Test pig selects for use 3 to 5 tires, age 50 of the Large White of the childbirth between 2.5 to 3.5 years old about 18 days.Adding anti-heat stress Chinese medicine in drinking-water, is contrast with the breeding parameter in the early stage thermophilic, and the basal diet of feeding is identical.Began the Chinese medicine of feeding in preceding 8 days from weaning, drink water continuously a week.The digestible energy of diet is 3.0 thermies, and crude protein 14.0% can digest aminoacid 0.71%, and wherein methionine+cystine is 0.31%, and lysine is 0.50%; Ca0.64%, P0.46% (all by weight percentage).The duration of test mean temperature reaches 31.07 ℃, and on average every day, the highest temperature reached 33.43 ℃.
Table 2 anti-heat stress Chinese medicine is to the influence of sow postweaning estrus under the high temperature
| Group | A test sow number | A number of oestrusing in one week | The breeding rate of once oestrusing (%) | Return feelings rate (%) |
| High temperature matched group anti-heat stress Chinese drug-treated group | 10 10 | 9 10 | 90 100 | 10 0 |
By the breeding of all oestrusing in a week of the visible test group of table 2, the non-estrus sow has appearred in matched group, and exists and return the feelings phenomenon, needs to breed for the second time.The feelings rate of returning of test group is zero, and it is 20% that matched group returns the feelings rate.
Table 3 anti-heat stress Chinese medicine is to the extremely influence of estrus time again of sow wean under the high temperature
| Group | A test sow number | Wean extremely again estrus time (my god) |
| High temperature matched group anti-heat stress Chinese drug-treated group | 10 10 | 5.1 3.5 |
By table 3 as seen, test group is compared with matched group, and all there were significant differences to the time of oestrusing again in wean.
Table 4 anti-heat stress Chinese medicine under the high temperature to the influence of sows farrowing head number
| Group | A test sow number | A total farrowing number | The young number of average every nest |
| High temperature matched group anti-heat stress Chinese drug-treated group | 10 10 | 98 120 | 9.8±1.34 12±1.89 A |
As can be seen from Table 4, used the young number of the average every nest of medicine group of the present invention to improve 22.4%.
3. anti-heat stress Chinese medicine is to the result of the test of laying hen egg laying performance under the high temperature
34 age in week 3600 of egg-laying peak Luo Man laying hens, hen house ground, tank cleaning and sterilizing are carried out in conventional feeding and management every day, air-atomizing sterilization, conventional feeding and management and immunity.The experimental basis daily ration consists of (percentage by weight): corn 62.05%, wheat bran 2%, bean cake 17.7%, rapeseed cake 5%, cottonseed meal 2%, calcium hydrogen phosphate 0.75%, stone powder 9.2%, Sal 0.3%, additive (compound vitamin and mine trace element) 1%.The experimental basis diets of different nutrition level is (percentage by weight): metabolizable energy 2561KJ/kg, crude protein 15.7%, calcium 3.49%, total phosphorus 0.49%, available phosphorus 0.28%, lysine 0.691%, methionine 0.256%, methionine+cystine 0.549%.Feed intake 120g/ is the sky only.Experimental period 33.4 ℃～39.0 ℃ of environment maximum temperatures.
Table 5 anti-heat stress Chinese medicine is to the influence of laying hen egg laying performance under the high temperature
| Group | Laying rate (%) | Egg size (g) | Hatching egg mortality (%) |
| High temperature matched group anti-heat stress Chinese drug-treated group | 82.43±0.025 85.18±0.015 * | 56.94±0.72 57.46±0.51 | 3.899±0.122 2.499±0.545 * |
As can be seen from Table 5, medicine group of the present invention all increases on laying rate, egg size, and the hatching egg mortality significantly is lower than matched group.
Summer anti-heat stress Chinese herb prevention chick heat stress result of the test
Selecting for use 1～51 age in days to like to pull out the man healthy commodity chickling of benefit tests.The raising condition is the flat house of supporting of all-in and all-out system ground hassock material, keeps clean, notes ventilating, and carries out record.Free choice feeding is freely drunk water.Feedstuff by China all broiler company feed factory No. 101 material, No. 102 material and No. 103 material are provided.Hen house duration of test in summer ambient temperature: 26～39 ℃
Table 6 newcastle epidemic disease antibody level monitoring is unit: log2 as a result
| Grouping | 25 ages in days | 35 ages in days | 42 ages in days |
| Anti-heat stress Chinese drug-treated group high temperature matched group | 4.9±0.8 4.3±1.1 | 6.1±0.6 * 4.75±0.8 | 5.7±1.1 4.8±0.8 |
As can be seen from Table 6, medicine group antibody horizontal of the present invention is significantly higher than matched group, illustrates that medicine of the present invention can improve its immunocompetence to newcastle.
Table 7 anti-heat stress Chinese medicine is to the influence of meat chicken production performance under the high temperature
| Grouping | Test chicken quantity | Rate of animals delivered to the slaughter-house % | Average weight Kg | Feedstuff-meat ratio |
| Anti-heat stress Chinese drug-treated group high temperature matched group | 6000 6126 | 94.9 93.5 | 2.69 * 2.50 * | 2.25∶1 2.28∶1 |
As can be seen from Table 7, used the chicken rate of animals delivered to the slaughter-house height of medicine group of the present invention, illustrated that its growth is fast, chicken group turnaround speed is fast, and is good in economic efficiency.And, using the chicken average weight height of medicine group of the present invention, feedstuff-meat ratio is low.
Claims (3)
1. medicine of preventing and treating livestock birds heat irritability syndrome, its active ingredient is made by the raw material of following weight portion: Rhizoma Atractylodis 100～200, Cortex Phellodendri 50～150, Gypsum Fibrosum 50～150, Herba Pogostemonis 50～150, the Radix Aucklandiae 50～150, Radix Glycyrrhizae 30～80.
2. medicine as claimed in claim 1, its active ingredient is made by the raw material of following weight portion: Rhizoma Atractylodis 150g, Cortex Phellodendri 100g, Gypsum Fibrosum 100g, Herba Pogostemonis 100g, Radix Aucklandiae 100g, Radix Glycyrrhizae 50g.
3. powder, oral liquid, tablet, capsule or the granule that becomes with pharmaceutically acceptable preparing carriers with claim 1 or 2 described medicines.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101856084A (en) * | 2010-06-03 | 2010-10-13 | 河北科技师范学院 | Chinese herbal medicine preparation against chicken heat shock |
| CN102119983A (en) * | 2010-12-17 | 2011-07-13 | 河南省农业科学院 | Traditional Chinese medicine composition for preventing and treating heat stress of livestock and poultry |
| CN101744923B (en) * | 2008-12-12 | 2011-12-21 | 北京大北农科技集团股份有限公司 | Traditional Chinese medicine compound pharmaceutical composition used for laying fowls and preparation method and application thereof |
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| CN1939339A (en) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | Chinese-medicinal composition for treating fowl and animal thermal stress |
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| CN101744923B (en) * | 2008-12-12 | 2011-12-21 | 北京大北农科技集团股份有限公司 | Traditional Chinese medicine compound pharmaceutical composition used for laying fowls and preparation method and application thereof |
| CN101856084A (en) * | 2010-06-03 | 2010-10-13 | 河北科技师范学院 | Chinese herbal medicine preparation against chicken heat shock |
| CN102119983A (en) * | 2010-12-17 | 2011-07-13 | 河南省农业科学院 | Traditional Chinese medicine composition for preventing and treating heat stress of livestock and poultry |
| CN102119983B (en) * | 2010-12-17 | 2012-06-13 | 河南省农业科学院 | Traditional Chinese medicine composition for preventing and treating heat stress of livestock and poultry |
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| CN103417688A (en) * | 2013-08-07 | 2013-12-04 | 江西农业大学 | Compound preparation for preventing and treating heat stress syndrome of beef cattle, and preparation method and use method of compound preparation |
| CN104324133A (en) * | 2014-10-21 | 2015-02-04 | 广西辉澎农牧有限公司 | Veterinary drug for clearing heat and removing toxicity and preparation method of veterinary drug |
| CN104324133B (en) * | 2014-10-21 | 2017-12-12 | 安徽浩翔农牧有限公司 | A kind of clearing heat and detoxicating veterinary drug and preparation method thereof |
| CN109221758A (en) * | 2018-09-21 | 2019-01-18 | 荆州市和美华生物科技有限公司 | A kind of functional nutrient additive and its preparation method and application improving heat stress of layer |
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