CN101856084A - Chinese herbal medicine preparation against chicken heat shock - Google Patents

Chinese herbal medicine preparation against chicken heat shock Download PDF

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Publication number
CN101856084A
CN101856084A CN201010193956A CN201010193956A CN101856084A CN 101856084 A CN101856084 A CN 101856084A CN 201010193956 A CN201010193956 A CN 201010193956A CN 201010193956 A CN201010193956 A CN 201010193956A CN 101856084 A CN101856084 A CN 101856084A
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chinese herbal
heat shock
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crude drugs
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CN101856084B (en
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史秋梅
高桂生
高光平
沈萍
汤生玲
张艳英
杨宗泽
贺英
杨彩然
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Hebei Normal University of Science and Technology
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Hebei Normal University of Science and Technology
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Abstract

The invention relates to a Chinese herbal medicine preparation against chicken heat shock, which is an oral liquid comprising the following components in parts by weight: 2-4 parts of plaster, 2-4 parts of ageratum, 1-3 parts of rhizoma atractylodis, 2-4 parts of hawthorn, 2-4 parts of pine needle, 0.5-1.5 parts of gynostemma pentaphylla and 0.5-1.5 parts of liquorice. The raw materials are crushed, mixed, boiled with water, extracted, concentrated and packaged to obtain the Chinese herbal medicine preparation against chicken heat shock. The invention has sound effect against chicken heat shock.

Description

The Chinese herbal and crude drugs preparations of anti-chicken heat shock
Technical field
The present invention relates to raise chickens and use Chinese herbal and crude drugs preparations, be specifically related to a kind of Chinese herbal and crude drugs preparations of anti-chicken heat shock.
Background technology
High temperature is one of stress factor that in numerous environmental factors in summer chicken is had the greatest impact.Feed intake, daily gain and feed that high temperature can reduce chicken digest and absorb rate.From medical science and biology angle, essence of stress be body under the stressor effect of super thresholding intensity, the process of rebuilding body homeostasis.The metabolism of animal body changes along with the change of environment temperature, so preferred ambient temperature can make animal metabolism intensity and quantity of heat production remain on the physiology floor level.When environment temperature surpass laying hen etc. during the hot-zone higher limit, responsing reaction can take place in body, this phenomenon is called the heat stress of chicken.Heat stress causes animal body neuroendocrine system, respiratory system, digestive system function disorder, tissue damage.Tracing it to its cause, mainly is because under the condition of high temperature, body quickens because of heat radiation need make peripheral blood circulation, causes body tissue organ severe depletion of oxygen ischemic, brings out various diseases and takes place.At present, the heat stress of control chicken mainly relies on the people to improve breeding environment for creating conditions, or adds sodium acid carbonate and replenishing vitamins C in daily ration, adds amino acid in right amount, and with the extent of reaction of reduction heat stress, but practical application effect is unsatisfactory.
Summary of the invention
The objective of the invention is at the problems referred to above, providing a kind of can increase feed intake, the daily gain of chicken season and improve the Chinese herbal and crude drugs preparations that feed digests and absorbs the anti-chicken heat shock of rate at summer high temperature.
Technical scheme of the present invention is: a kind of Chinese herbal and crude drugs preparations of anti-chicken heat shock, and it is the oral liquid of being made by the following weight proportion raw material: gypsum 2-4 part, ageratum 2-4 part, rhizoma atractylodis 1-3 part, hawthorn 2-4 part, pine needle 2-4 part, gynostemma pentaphylla 0.5-1.5 part, Radix Glycyrrhizae 0.5-1.5 part.
The preferred feedstock weight proportion of the Chinese herbal and crude drugs preparations of the anti-chicken heat shock of the present invention is: 3 parts in gypsum, 3 parts of ageratums, 2 parts of rhizoma atractylodis, 3 parts of hawthorn, 3 parts in pine needle, 1 part of gynostemma pentaphylla, 1 part in Radix Glycyrrhizae.
Each component pharmacological effect is as follows in the prescription of the present invention:
1, gypsum effect: gypsum is mainly hydrous calcium sulfate, and clay, organic matter, trace element etc. are often arranged in addition, has clearing heat-fire, relieving restlessness effect such as quench the thirst.Gypsum does not have cooling effect to normal body temperature, and the animal used as test rabbit of artificial fever is had tangible antipyretic effect.
2, wrinkled giant hyssop effect: wrinkled giant hyssop contains volatile oil 0.28%, and main component is an estragole, anethole, anisaldehyde, citrene, methoxy cinnamaldehyde; Contain flavone compound, maslinic acid, oleanolic acid etc. in addition.Test tube experiment wrinkled giant hyssop decoction (8~15%) has inhibitory action to multiple pathogenic funguses such as trichophytons; Fragrant ether leachate (3%) of flower bud and alcohol extract (1%) also can suppress multiple pathogenic fungus.The bright juice of wrinkled giant hyssop can suppress the growth of staphylococcus aureus, staphylococcus albus and hay bacillus.Herba Agastaches Rugosae volatile oil can stimulate stomach lining, promotes gastric secretion, strengthens digestion power.
3, rhizoma atractylodis effect: mainly contain atractylol in the volatile oil of rhizoma atractylodis, contain materials such as atractylone, vitamin A sample material, Cobastab and synanthrin in addition, be used for the treatment of wet the Sheng and be stranded spleen, burnout is had a liking for for sleeping in, gastral cavity ruffian abdominal distension, poor appetite, dysentery is had loose bowels in vomiting, malaria, phlegm and retained fluid, oedema, the time gas flu, wind-cold-dampness arthralgia, sufficient impotence, yctalopia.Rhzoma Atractylodis Lanceae volatile oil animal used as test is had be good for the stomach, calmness, hypoglycemic, row's potassium, row's sodium and bacteriostasis, the gastritis and the gastric ulcer that simultaneously can anti-hydrochloric acid cause promote gastrointestinal peristalsis.Vitamin A sample material can be treated yctalopia and the keratomalacia that causes because of VAD.
4, hawthorn effect: hawthorn mainly contains flavone compound, secondly be crataegolic acid, oleanolic acid, ursolic acid, chlorogenic acid, caffeic acid, endoplasm glucoside, lipase, carbohydrate, vitamin C, riboflavin and calcium, phosphorus, iron etc., be used for carnivorous stagnant, gastral cavilty turgor, rush down that dysentery is suffered from abdominal pain, hemostasis through close, stasis of blood resistance in postpartum, trusted subordinate's shouting pain, hernia pain, hyperlipemia.Recent studies proves that hawthorn can increase secretion, the promotion digestion of digestive ferment in the stomach, and contains lipase, can strengthen gastric lipase, protease activities.Hawthorn has stronger antibacterial action to bacillus ceylonensis A, and Pseudomonas aeruginosa, staphylococcus aureus, Escherichia coli, proteus, second streptococcus, corynebacterium diphtheriae, typhoid bacillus etc. are all had antibacterial action.Living hawthorn and charred FRUCTUS CRATAEGI do not have significant difference to shigella flexneri, bacillus ceylonensis A, proteus, colibacillary antibacterial action.
5, pine needle effect: 65 kinds of components are arranged in the fresh pine needle, and its main component is alkane, olefin(e) acid, ketenes, sterols; The component of withered pine needle has 44 kinds, and its main component is alkanoic acid, ketone, ester class and sterols material, and extract from pine needles can be used for the expansion artery blood vessel, increases the red blood cell oxygen carrying capacity, stimulates circulation, and improves the function of capillary, improves immunity.Contain several amino acids, trace element in the pine needle meal, can stimulate the ovulation function of laying hen effectively, improve laying rate, add 3%~5% pine needle meal in laying ration, egg production can improve 6.1%~13.8%; Efficiency of feed utilization improves 15.1%, and the weight of laying eggs improves 2.9%, and rate of fertilization improves 1.0%, and yolk color is darker, adds 3%~5% pine needle meal in daily ration of broiler, and daily gain can improve 8.1%~12.0%, and the feed return rate improves 8.4%.Simultaneously, contain phytocide and vitamin in the pine needle meal, have the effect of disease resistance, can effectively resist the generation of laying hen disease.
6, gynostemma pentaphylla effect: gynostemma pentaphylla contains multiple gynosaponin, and contains glycosides displayed, carbohydrate, 9 kinds of trace elements such as selenium, copper, manganese, zinc, iron and 18 seed amino acids.Gynostemma pentaphylla and gynosaponin have anti-stress effect preferably, and the adaptogen of genseng sample is arranged; Can strengthen specificity and nospecific immunity effect, and have immunoregulation effect; Have effects such as anti-inflammatory, anti-gastroenteritic ulcer and early stage of pyogenic infection of skin.
7, Radix Glycyrrhizae effect: Radix Glycyrrhizae mainly contains compositions such as glycyrrhizic acid, glycyrrhizin, 24-hydroxyl enoxolone, licoflavone, glycyrrhizin, isoliquiritigenin, licorice polysaccharide, has antiulcer, promotes pancreatic secretion, protects the liver, the effects such as phagocytic function of lipopenicillinase, adjusting macrophage.Glycyrrhizic acid is natural antidote, can be used for body anti-ageing, strengthen immunity, keep water-electrolyte metabolism balance etc.; Licorice polysaccharide has anti-adenovirus type III, herpes simplex virus I-type activity.
Prescription foundation of the present invention: high temperature has become one of stress factor that in numerous environmental factors in summer laying hen is had the greatest impact, when environment temperature surpass laying hen etc. during the hot-zone higher limit, can cause body neuroendocrine system, respiratory system, digestive system function disorder, tissue damage, feed intake, daily gain and the feed that can reduce chicken digest and absorb rate, cause chicken egg productivity to descend, egg diminishes, eggshell thinning and of poor quality, the resistance of chicken reduces, M ﹠ M increases, and seriously restricts the safety of poultry husbandry production and the raising of economic benefit.Therefore aspect preventing and treating with clearing heat and promoting fluid, invigorating the spleen, beneficial stomach yin-nourishing, strengthening chicken anti-heat stress ability is principle.With the gypsum clearing heat-fire, relieving restlessness is quenched the thirst in the side; Wrinkled giant hyssop, rhizoma atractylodis, gynostemma pentaphylla have drying damp and strengthening spleen, remove dampness by means of aromatics, and deliver relieving summer-heat, ward off the turbid and middle preventing or arresting vomiting of dirtyization; Hawthorn has food digesting stomach fortifying, and promoting the circulation of qi disappears stagnant, the promoting blood circulation and stopping pain effect; The pine needle expelling wind and activating blood flow makes eye bright, calms the nerves, and detoxifcation, antipruritic; Sweet Wen Yiqi of Radix Glycyrrhizae and middle invigorating the spleen, current twelve channels and collaterals, coordinating the drug actions of a prescription.In the side all medicines mutually and, play clearing heat and promoting fluid altogether, invigorating the spleen, beneficial stomach yin-nourishing strengthen the effect of chicken anti-heat stress ability.Be applicable to the airframe systems dysfunction that the control heat stress causes, situations such as tissue damage; Can increase the laying hen daily gain, improve efficiency of feed utilization.For convenient application in the sick control of chicken, make oral liquid.
The present invention is on the basis of having carried out a large amount of practical applications, according to the traditional medicine ancient prescription, learns in conjunction with modern popular is sick, and aetology and immunologic theoretical screening form, and are used for the anti-heat stress of chicken, have good effect.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment:
1, takes by weighing raw material (medicine materical crude slice) respectively, be total to 1000g, wherein: gypsum 188g, ageratum 188g, rhizoma atractylodis 125g, hawthorn 188g, pine needle 188g, gynostemma pentaphylla 62g, Radix Glycyrrhizae 61g;
2, ageratum, rhizoma atractylodis, hawthorn, pine needle, gynostemma pentaphylla, Radix Glycyrrhizae are ground into the Chinese medicine meal respectively, land plaster is broken into the Chinese medicine fine powder;
3, get ageratum meal 188g, put in the distil container, use steam distillation, volatile oil is extracted in heating, collects the volatile oil that distills out; Other gets gypsum 188g, rhizoma atractylodis 125g, and hawthorn 188g, pine needle 188g, gynostemma pentaphylla 62g, Radix Glycyrrhizae 61g is the Six-element Chinese herbal medicine altogether, and add water 7000ml and soak after 1 hour, the dregs of a decoction after the ageratum distillation, water is opened back slow fire boiling 30 minutes; Filter, add water 5000ml more at every turn and decoct secondary, each 20 minutes, filter; Merge three times filtrate, be concentrated into about 900ml;
4, above-mentioned distillate, concentrate are merged, add 0.05% Sodium Benzoate as anticorrisive agent, add water to 1000ml, stir evenly, filter, can is sterilized, and promptly gets the Chinese herbal and crude drugs preparations of the anti-chicken heat shock of the present invention.
Some test situation of utilizing the present invention to carry out are as follows:
1, Chinese herbal and crude drugs preparations anti-heat stress mechanism of the present invention research
120 brown 88 age in days laying hens of Yi Sha are equally divided into 4 groups, 30 every group at random: be respectively high temperature group and normal temperature group, the high temperature group is divided into high temperature again with preparation group of the present invention, with Western medicine Vc group and high temperature control group, tests grouping and sees Table 1; The normal temperature group is at 22 ℃, and the high temperature group is raised under 26 ℃~30 ℃ environment.The omnidistance 10d altogether of test, at test 1d, 4d, 8d, 10d, every group each cut open at random and kill 5, observes the influence of this Chinese herbal and crude drugs preparations to indexs such as heat stress laying hen intestinal villus intraepithelial lymphocyte and goblet cell quantity, duodenum mucous membrane structure and ileal mucous membrane structure, spleen tissue morphology, blood total protein and inorganic ions.
Table 1 test grouping and processing
Figure BSA00000132271000041
(1) to the influence of heat stress laying hen intestinal villus intraepithelial lymphocyte and goblet cell quantity
Under the condition of high temperature between chicken intestinal mucosa epithelium the quantity of lymphocyte and goblet cell be downward trend gradually; Use this Chinese herbal and crude drugs preparations can promote lymphocyte and goblet cell to generate.
(2) to the morphologic influence of heat stress laying hen spleen tissue
The white pulp area of the spleen of test group enlarges markedly, and periarterial lymphatic sheath thickens, and the splenic corpuscle volume is big and obvious.Test shows that hot environment has produced certain damage to laying hen immune organ spleen, adds this Chinese herbal and crude drugs preparations and can alleviate its damage significantly, promotes growing of histoorgan.
(3) to the influence of heat stress laying hen duodenum mucous membrane structure
Under the condition of high temperature, this Chinese herbal and crude drugs preparations alleviates the intestinal mucosa pathological change, promotes villus growth.Remarkable to the DM protective effect.
(4) to the influence of heat stress laying hen ileal mucous membrane structure
The effect of the anti-heat stress in this Chinese herbal and crude drugs preparations group is better than the Vc group; Under the elevated temperature heat stress situation, along with the increase of test fate, the ileal mucous membrane thickness and the villus length of this Chinese herbal and crude drugs preparations group and Vc group are the trend that raises gradually, but mucosal thickness, villus length all are lower than the normal temperature control group always, simultaneously, it is sparse that fine hair becomes, and obscission is arranged; The villus length of this Chinese herbal and crude drugs preparations group and enteraden degree of depth ratio are higher than other medication groups, and is in rising trend, the most approaching with the normal temperature control group, and the ratio of all the other each groups is on a declining curve.By test as can be seen, the chicken ileum fine hair of 4d normal temperature control group is intensive, and high temperature control group ileum intestinal villus is then more sparse, also has the part villus shedding, phenomenon of rupture.Chinese herbal and crude drugs preparations group 4d ileum enteraden has certain growth, and high temperature control group mucosal structure sustains damage seriously, shows as the mucous epithelium sex change, large tracts of land comes off, and lamina propria is exposed.
(5) to the influence of indexs such as heat stress laying hen blood total protein and inorganic ions
Heat stress has reduced the content of high temperature control group total protein, blood sodium, blood potassium, blood chlorine, and this Chinese herbal and crude drugs preparations group, its total protein downward trend slows down, and the reduction trend of sodium ion is slowed down to some extent, and rise to some extent to a certain extent; The content of blood potassium, blood chlorine all has rise.This Chinese herbal medicine anti-heat stress preparation has certain effect to the biochemical indicator of alleviating the heat stress laying hen.
2, Chinese herbal and crude drugs preparations anti-heat stress prevention effect of the present invention research
Qinhuangdao, Hebei province plant uses the Chinese herbal and crude drugs preparations of the anti-chicken heat shock of the present invention, according to anti-heat stress Chinese herbal and crude drugs preparations group 1.5ml/ only, and Western medicine V CGroup 0.4%Vc solution 1.5ml/ only adds anti-heat stress Chinese herbal and crude drugs preparations and Vc in the drinking-water of laying hen to.Found that this Chinese herbal and crude drugs preparations group, Western medicine V under normal temperature and high temperature CThe trend that group all has the laying rate of making, egg size to increase.Compare with control group, this Chinese herbal and crude drugs preparations group laying rate increases by 18.78%, 18.46% respectively in aliquot and megathermal period.Western medicine V CGroup laying rate, egg size have been compared increase trend with control group (not medication group), but difference is not remarkable.Western medicine V CGroup is having certain anti-heat stress effect aspect laying rate, the egg size, but it is obvious to be not so good as this Chinese herbal and crude drugs preparations group effect.This Chinese herbal and crude drugs preparations group thyroxine T3/T4 ratio minimum illustrates that its thyroxinic functional activity is the highest.In entire test, this Chinese herbal and crude drugs preparations group feedstuff-meat ratio is minimum, and no laying hen death shows that the production performance of this group is best.

Claims (2)

1. the Chinese herbal and crude drugs preparations of an anti-chicken heat shock is characterized in that it is the oral liquid of being made by the following weight proportion raw material: gypsum 2-4 part, ageratum 2-4 part, rhizoma atractylodis 1-3 part, hawthorn 2-4 part, pine needle 2-4 part, gynostemma pentaphylla 0.5-1.5 part, Radix Glycyrrhizae 0.5-1.5 part.
2. the Chinese herbal and crude drugs preparations of anti-chicken heat shock according to claim 1 is characterized in that it is the oral liquid of being made by the following weight proportion raw material: 3 parts in gypsum, 3 parts of ageratums, 2 parts of rhizoma atractylodis, 3 parts of hawthorn, 3 parts in pine needle, 1 part of gynostemma pentaphylla, 1 part in Radix Glycyrrhizae.
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101961462A (en) * 2010-10-20 2011-02-02 江苏经贸职业技术学院 Chinese medicinal composition for resisting heat stress of pigeons and application thereof
CN102217742A (en) * 2011-08-04 2011-10-19 戴加阳 Chicken feed
CN103330740A (en) * 2013-05-24 2013-10-02 镇江天和生物技术有限公司 Chinese herbal medicine preparation for preventing and treating heat stress of laying hen
CN104719641A (en) * 2015-03-15 2015-06-24 湖南农业大学 Preparation method of livestock and poultry anti-stress feed additive
CN104095145B (en) * 2014-07-16 2016-08-24 宾阳县王灵镇良骏养鹅场 A kind of Chinese prescription is as the application of feed additive
CN106177559A (en) * 2016-08-22 2016-12-07 牛金鹏 A kind of herbal medicine preventing and treating chicken heat shock reaction

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Publication number Priority date Publication date Assignee Title
CN101156917A (en) * 2007-10-09 2008-04-09 北京农学院 A medicine for preventing and treating livestock birds heat irritability syndrome

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CN101156917A (en) * 2007-10-09 2008-04-09 北京农学院 A medicine for preventing and treating livestock birds heat irritability syndrome

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101961462A (en) * 2010-10-20 2011-02-02 江苏经贸职业技术学院 Chinese medicinal composition for resisting heat stress of pigeons and application thereof
CN101961462B (en) * 2010-10-20 2011-11-30 江苏经贸职业技术学院 Chinese medicinal composition for resisting heat stress of pigeons and application thereof
CN102217742A (en) * 2011-08-04 2011-10-19 戴加阳 Chicken feed
CN103330740A (en) * 2013-05-24 2013-10-02 镇江天和生物技术有限公司 Chinese herbal medicine preparation for preventing and treating heat stress of laying hen
CN104095145B (en) * 2014-07-16 2016-08-24 宾阳县王灵镇良骏养鹅场 A kind of Chinese prescription is as the application of feed additive
CN104719641A (en) * 2015-03-15 2015-06-24 湖南农业大学 Preparation method of livestock and poultry anti-stress feed additive
CN104719641B (en) * 2015-03-15 2018-05-22 湖南农业大学 A kind of preparation method of livestock and poultry anti-stress feed addictive
CN106177559A (en) * 2016-08-22 2016-12-07 牛金鹏 A kind of herbal medicine preventing and treating chicken heat shock reaction

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