CN101146905A - 抗腐蚀清洁剂组合物及其在清洗牙科器械和医疗器械中的应用 - Google Patents
抗腐蚀清洁剂组合物及其在清洗牙科器械和医疗器械中的应用 Download PDFInfo
- Publication number
- CN101146905A CN101146905A CN200680005032.4A CN200680005032A CN101146905A CN 101146905 A CN101146905 A CN 101146905A CN 200680005032 A CN200680005032 A CN 200680005032A CN 101146905 A CN101146905 A CN 101146905A
- Authority
- CN
- China
- Prior art keywords
- acid
- corrosion
- detergent compositions
- agent
- washing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005260 corrosion Methods 0.000 title claims abstract description 57
- 238000004140 cleaning Methods 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title claims description 42
- 239000003599 detergent Substances 0.000 title claims description 30
- -1 alkyl pyrrolidones Chemical class 0.000 claims abstract description 35
- 230000007797 corrosion Effects 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 21
- 239000003112 inhibitor Substances 0.000 claims abstract description 11
- 239000000243 solution Substances 0.000 claims abstract description 11
- 150000003973 alkyl amines Chemical class 0.000 claims abstract description 8
- 239000007864 aqueous solution Substances 0.000 claims abstract description 8
- 230000007935 neutral effect Effects 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 56
- 238000005406 washing Methods 0.000 claims description 31
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 14
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 10
- 239000006260 foam Substances 0.000 claims description 10
- 230000003165 hydrotropic effect Effects 0.000 claims description 10
- 229920001451 polypropylene glycol Polymers 0.000 claims description 10
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims description 9
- 239000013543 active substance Substances 0.000 claims description 9
- 230000005764 inhibitory process Effects 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 229940048842 sodium xylenesulfonate Drugs 0.000 claims description 6
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- JJJOZVFVARQUJV-UHFFFAOYSA-N 2-ethylhexylphosphonic acid Chemical compound CCCCC(CC)CP(O)(O)=O JJJOZVFVARQUJV-UHFFFAOYSA-N 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 4
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 4
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 claims description 3
- GXGJIOMUZAGVEH-UHFFFAOYSA-N Chamazulene Chemical group CCC1=CC=C(C)C2=CC=C(C)C2=C1 GXGJIOMUZAGVEH-UHFFFAOYSA-N 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 3
- JYXGIOKAKDAARW-UHFFFAOYSA-N N-(2-hydroxyethyl)iminodiacetic acid Chemical compound OCCN(CC(O)=O)CC(O)=O JYXGIOKAKDAARW-UHFFFAOYSA-N 0.000 claims description 3
- NJMVHBQEIKOPIT-UHFFFAOYSA-N acetic acid 2-(2-aminoethylamino)ethanol Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.NCCNCCO NJMVHBQEIKOPIT-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229920001400 block copolymer Polymers 0.000 claims description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- NSFKBZXCXCJZDQ-UHFFFAOYSA-N cumene;sodium Chemical compound [Na].CC(C)C1=CC=CC=C1 NSFKBZXCXCJZDQ-UHFFFAOYSA-N 0.000 claims description 3
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 3
- TVHALOSDPLTTSR-UHFFFAOYSA-H hexasodium;[oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O TVHALOSDPLTTSR-UHFFFAOYSA-H 0.000 claims description 3
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims description 3
- 229960003330 pentetic acid Drugs 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 3
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 2
- 229940050410 gluconate Drugs 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 150000003852 triazoles Chemical class 0.000 claims description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 2
- 235000015165 citric acid Nutrition 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 229910000404 tripotassium phosphate Inorganic materials 0.000 claims 2
- 235000019798 tripotassium phosphate Nutrition 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 238000010936 aqueous wash Methods 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- VLAPMBHFAWRUQP-UHFFFAOYSA-L molybdic acid Chemical compound O[Mo](O)(=O)=O VLAPMBHFAWRUQP-UHFFFAOYSA-L 0.000 claims 1
- 238000013022 venting Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 abstract description 7
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 abstract description 2
- 238000005187 foaming Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000011010 flushing procedure Methods 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
- 238000005536 corrosion prevention Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 239000006174 pH buffer Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000013530 defoamer Substances 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 150000002191 fatty alcohols Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000013556 antirust agent Substances 0.000 description 2
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 238000005530 etching Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 102220123883 rs886043541 Human genes 0.000 description 2
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- 238000012369 In process control Methods 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229910000754 Wrought iron Inorganic materials 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 125000005619 boric acid group Chemical group 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000010965 in-process control Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical group [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 238000004506 ultrasonic cleaning Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/40—Monoamines or polyamines; Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/58—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/835—Mixtures of non-ionic with cationic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0073—Anticorrosion compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/28—Heterocyclic compounds containing nitrogen in the ring
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/30—Amines; Substituted amines ; Quaternized amines
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/34—Organic compounds containing sulfur
- C11D3/3418—Toluene -, xylene -, cumene -, benzene - or naphthalene sulfonates or sulfates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
- C11D3/361—Phosphonates, phosphinates or phosphonites
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
- C11D3/364—Organic compounds containing phosphorus containing nitrogen
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Abstract
公开了一种清洗牙科器械和医疗器械的新方法，其中不仅在清洗周期的洗涤阶段而且在至少一个后续的冲洗周期使用含有低残留腐蚀抑制剂的清洗溶液，以使清洗和腐蚀防护最优化。特别适用于该方法的新型清洗溶液的pH为中性至碱性，并且在水溶液中含有低泡沫表面活性剂和选自C4－C16烷基吡咯烷酮及C1－C18烷基胺的组中的腐蚀抑制剂。
Description
技术领域
本发明一般涉及牙科器械和医疗器械的清洗方法。更具体地，根据一个方面，本发明涉及一种对牙科器械和外科器械进行清洗以使腐蚀防护和清洗效率最优化的新方法。
根据另一方面，本发明涉及一种用于内科和外科器械的新的抗腐蚀清洁剂组合物，该组合物特别适用于本发明的清洗方法。
背景技术
牙科器械和医疗器械尽管是由不锈钢制成的，但是在维护周期中(洗涤、消毒、杀菌)仍然受到腐蚀。牙科器械由于含碳量更高而一般更容易受到腐蚀。为了实现想要的器械特性如表面硬度和持久性，器械制造者经常采取诸如热处理的加工方法，这样的加工方法也具有损害器械的耐腐蚀性的不良影响。为了降低腐蚀过程的等级和速率，或者甚至完全避免发生腐蚀，必须采取一些有效的腐蚀防护措施。
已知在某些情况下即使仅仅长时间暴露于清水中，器械表面也会开始腐蚀。已开发的一些用于清洗医疗器械的清洁剂含有防锈剂。通常仅在清洗周期的洗涤阶段使用该清洁剂，这些防锈剂的作用限于该洗涤阶段。这一般排除了清洗周期的冲洗阶段和最终的空气干燥阶段。为了也覆盖这些阶段，通常使用不同系列的化学药品。已知这些化学药品作为具有防锈剂的冲洗助剂。冲洗助剂起到了双重作用，(i)改变冲洗水性质以有助于器械干燥，和(ii)提高对生锈的防护。润滑防锈剂产品(surgical milk product)也可以用于防止器械表面在冲洗阶段后的腐蚀。
这样的方法需要用于洗涤周期的许多不同的化学药品。单独化学药品、操作和化学药品剂量分配系统的成本使该清洗方法花费大而且复杂。
医疗器械的清洗周期一般由多个连续的阶段组成：预洗涤、洗涤、冲洗(一般有两次)和干燥。预洗涤阶段用于溶解器械上的血液，使用冷水以防止血液凝固。该周期的洗涤部分使用热水/温水和清洁剂。根据需要来匹配洗涤时间、水温和清洁剂。使用许多次冲洗来除去在洗涤阶段溶解的污垢以及残留的清洁剂。
已经开发了许多专门用于超声洗涤器的由防锈剂增强的清洁剂，其中不推荐对器械进行冲洗以使清洁剂存在于器械表面。提供一个例子是由HealthSonics Corporation生产的超声溶液(Ultrasonic Solution)。清洗周期结束后，防锈剂保留在器械表面。这样的防锈具有时限效应(time-limited action)，在常规的高温灭菌过程中将从表面蒸发或被烧掉，因此当器械接着用于患者时其表面基本上没有任何残留。
不幸的是，通过省去冲洗阶段以获得防锈剂的最大防护作用，器械的清洁度会受到损害。冲洗阶段的真正目的是冲掉在洗涤阶段松动并溶解的污垢，并且将污垢与所使用的清洁剂一起冲洗掉。
发明内容
措辞“非冲洗抗腐蚀清洁剂”将用于指由防锈剂增强的清洁剂，所述防锈剂在清洗周期结束后保留在器械表面，其中，防锈具有时限效应，在高温灭菌过程中将从表面蒸发或被烧掉，因此当器械用于患者时其表面基本上没有任何残留。
我们发现许多这样的非冲洗抗腐蚀清洁剂实际上能够有效地用于包括洗涤、冲洗和干燥阶段的洗涤周期(如在过程控制的喷淋洗涤器中)，以防止腐蚀，而无损于清洗效率。清洁剂用于清洗周期的洗涤阶段以清洗并防止腐蚀(如用于超声洗涤器时)，但是也以较低浓度加到随后的冲洗阶段，特别是最后的冲洗阶段。这保持了高水平的腐蚀防护，而没有进行前述的为了适当清洗而必须的冲洗。这种新的清洗器械的方法至少最后的冲洗含有清洁剂，不需要多种化学药品(清洗剂、冲洗助剂、润滑防锈剂)。
我们还开发了一系列专门配制的抗腐蚀清洁剂组合物，该组合物含有低泡沫表面活性剂和烷基吡咯烷酮或特定的烷基胺，该组合物在具有编程的洗涤和冲洗阶段的自动洗涤系统中对医疗器械进行洗涤/消毒时提供了腐蚀控制。
具体实施方式
如上所述，我们已经发现了合适的由防锈剂(主要地，这些防锈剂的生锈防护具有时限效应，在随后的加热灭菌过程中将从表面蒸发或被烧掉)增强的清洁剂可以用于过程控制的喷淋洗涤器，不仅可以在洗涤阶段使用，而且可以在一个或多个冲洗阶段使用，以使清洗和腐蚀防护最优化。这样的器械洗涤器的例子有SciCan制造的HYDRIM(商标)器械洗涤器。
表1表示在SciCan制造的HYDRIM C51W器械洗涤器的清洗周期中，预洗涤、洗涤和第二冲洗阶段的一般清洁剂用量列表。对于该机器，整个清洗周期的水的总体积为3L。分配到预洗涤、洗涤和第二冲洗阶段的清洁剂的总体积分别为5.7ml、37ml和11.37 mL。
表1
清洁剂用量(ml)
Hydrim C51W
| 周期 | 预洗涤 | 洗涤 | 第二冲洗 | |
| 预洗涤阶段开始 | 洗涤阶段开始 | 45℃下 | 第二冲洗开始 | |
| P1(正常) | 5.7 | 18.5 | 18.5 | 11.37 |
| P2(强化) | 5.7 | 18.5 | 18.5 | 11.37 |
使用者可以选择两种清洗程序(周期)中的任一种。指定的P1(正常)从预洗涤到第二冲洗大约运行5分钟，而P2(强化)周期耗时大约9分钟。在各情况下，均在预洗涤阶段开始时加入低浓度(例如全部强度的30％)的抗腐蚀清洁剂组合物。
在洗涤阶段开始时加入较高浓度(全部清洁剂浓度)的清洁组合物并且当洗涤水加热至45℃时再加入较高浓度的清洁组合物，以提供清洗特性和腐蚀防护。HYDRIM机器操作的温度范围为室温至约70℃。该清洁剂也可以用于温度达到93℃的洗涤器/消毒器。
第一冲洗不使用任何清洁剂。第一冲洗阶段很短，洗涤阶段残留的清洁剂仍然可以保护器械。
第二(以及任何随后的)冲洗使用浓度降低的清洁剂(例如全部强度的30％)。在此，清洁剂用于腐蚀防护并用作冲洗助剂。清洁剂改变冲洗水表面张力以增强除去(排掉)表面的水。来自清洁剂的化学药品在湿的时候和干燥周期中也保护器械不受腐蚀。留下的干燥表面目视是干净的，没有任何有害残留物。检测器械表面的残留物水平低于23×10-3μg/mm2，这个结果相当于通常使用任何其它冲洗助剂时获得的结果。残留物看不到并且对器械表面、性能、使用寿命或维护周期没有不利影响。
根据本发明，可以方便地使用许多商购的用于超声清洗机的非冲洗抗腐蚀清洁剂。即，它们也可以在清洗周期的洗涤阶段后的阶段加入。然而，我们已经开发了提供优良的清洗性质和腐蚀抑制性质的、特别配方的低泡沫腐蚀防护清洗浓缩溶液，该浓缩溶液含有低泡沫表面活性剂和烷基吡咯烷酮或烷基胺。
发现本发明的清洗浓度以及含有至少0.005％低泡沫表面活性剂和至少0.005％C4-C16烷基吡咯烷酮或C1-C18烷基胺的稀释溶液令人惊讶地展示出良好的清洗性质/腐蚀抑制性质，特别是在清洗金属牙科器械时。某些这样的器械经常在清洗和冲洗后变得生锈，但是本发明的制剂能够防止生锈和腐蚀。
本发明的清洗浓缩溶液的pH为中性至碱性，优选为7-12。在整个说明书中，含水清洗组合物中成分的浓度以重量百分含量表示。本发明的低泡沫腐蚀防护清洗溶液的有效成分如下：
(a)约0.005-10％的低泡沫表面活性剂，该表面活性剂为选自聚氧乙烯/聚氧丙烯嵌段共聚物的制剂，该嵌段共聚物的聚氧丙烯分子量为1500-8500，聚氧丙烯分子量占总分子量的约30％以下；
(b)约0.005-10％的腐蚀抑制成分，该腐蚀抑制成分为选自C4-C16烷基吡咯烷酮或C1-C18烷基胺的化合物；
(c)约0.01-15％的至少一种助洗剂，该助洗剂为选自膦酸，如1-羟基亚乙基-1，1-二膦酸、氨基三(亚甲基膦酸)、二亚甲基三胺五(亚甲基膦酸)、二羟乙基亚氨基双(亚甲基膦酸)、乙二胺四(亚甲基膦酸)，EDTA(乙二胺四乙酸)，DTPA(二亚乙基三胺五乙酸)，HEDTA(N-(羟乙基)-乙二胺四乙酸)，NTA(氨三乙酸)，2-羟乙基亚氨基二乙酸，三磷酸钠或三磷酸钠钾，柠檬酸，四磷酸钠，六偏磷酸钠，及它们的混合物的组中的配方；和
(d)约0-20％的至少一种水溶助长剂，该水溶助长剂选自二甲苯磺酸钠、异丙基苯磺酸钠、C6-C18烷基磺酸及其盐、C6-C20烷基多苷、及C6-C16二苯醚二磺酸酯的组中的配方。
术语“助洗剂”通常用于清洁剂制剂领域，是指一种能够捕获多价阳离子如钙和镁并将其从水中除去的分子。这样的阳离子往往使表面活性剂沉淀，形成不需要的浮渣或水垢。
“水溶助长剂”为用于提高表面活性剂在水溶液中的溶解度的化合物。它们的用途在本领域的教科书和文献中有描述，例如Milton所著的The Bookof Surfactants and Interfacial Phenomena。
尽管许多烷基吡咯烷酮已经用作表面活性剂，但是它们作为腐蚀抑制剂的有效作用是新的并且是令人意外的。据推测，这可能源于C4-C16烷基吡咯烷酮在溶液中变为两性离子的能力，所述两性离子具有吸收到带正电荷或负电荷的金属表面的能力，从而提供均一的腐蚀防护。
对于C1-C18烷基胺，这些化合物在中性或弱碱性pH下电离为季铵盐形式，该阳离子能够吸收到带负电荷的金属表面，再一次促进腐蚀抑制。
本发明的组合物可以选择性地含有以下附加成分：
一约0.001-20％的至少一种溶剂，该溶剂为选自二元醇、二元醇醚、C1-C6直链或支链醇和芳香醇的组中的配方；
—约0.001-10％的至少一种pH缓冲剂，该pH缓冲剂为选自硼酸、柠檬酸、磷酸、及它们的盐的配方；
—0.01-10％％的至少一种其它表面活性剂，该其它表面活性剂选自非离子型、阴离子型、两性及阳离子型；和
一约0.001-10％的至少一种腐蚀抑制剂，该腐蚀抑制剂为选自钼酸盐(例如钼酸钠)、亚硝酸盐(例如亚硝酸钠)、三唑(例如1，2，3-苯并三唑)、葡糖酸盐和羧酸的组中的配方。
在高含碳量(最低0.15％)的不锈钢金属棒上进行了一系列洗涤测试。该材料已经进行过热处理以降低耐腐蚀性。检查这些棒表面的“生锈”外观。
常规的非冲洗抗腐蚀清洁剂表明超过25％的表面由锈/腐蚀覆盖，而表2的申请人的制剂都表现出低于5％的腐蚀覆盖率；表3中给出的本发明抗腐蚀清洁剂组合物的最优选实施方式没有在测试钢棒表面产生可目测的生锈或腐蚀。
表2
| 4472 | 4473 | 4474 | 4475 | 4608 | 4673 | 4677 | 4679 | 4680 | 4690 | |
| 原料 | 重量％ | 重量％ | 重量％ | 重量％ | 重量％ | 重量％ | 重量％ | 重量％ | 重量％ | 重量％ |
| 去离子水1 | 适量至100 | 50.60 | 45.60 | 47.30 | 58.30 | 62.30 | 33.24 | |||
| Dequest 20102 | 8.00 | 8.00 | 8.00 | 8.00 | 8.00 | 8.00 | 12.80 | |||
| KOH(45％)3 | 11.50 | 11.50 | 11.50 | 11.50 | 10 50 | 9.00 | 16.80 | |||
| 丙二醇4 | 7.00 | 8.00 | 12.00 | 12.00 | 10.00 | 9.50 | 16.00 | |||
| 二甲苯磺酸钠5 | 8.40 | |||||||||
| Pluronic 17R26 | 0.05 | 0.50 | 0.70 | 0.50 | 0.50 | 0.80 | ||||
| Bioterge PAS-8S7 | 1.40 | 1.40 | 1.40 | |||||||
| Cobratec 35G8 | 3.50 | |||||||||
| 钼酸钠9 | 1.50 | 1.50 | 1.50 | 1.50 | ||||||
| 硼酸10 | 2 | 2.00 | 2.00 | 2.00 | 0.20 | 0.20 | 0.20 | |||
| 辛胺11 | 1 | 0 | 0 | 0 | ||||||
| Surfadone LP-10012 | 0 | 2 | 0 | 0 | 2.00 | 4.00 | 2.00 | 2.00 | 2.00 | 3.20 |
| 三乙醇胺13 | 0 | 0 | 5 | 0 | ||||||
| SXS14 | 14.50 | 14.00 | 14.00 | 10.00 | 8.00 | 16.00 | ||||
| Ethox 240015 | 1.00 | 0.50 | 0.50 | 0.96 | ||||||
| 总量 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
注释：
1、载体
2、1-羟基亚乙基-1，1-二膦酸(助洗剂)
3、氢氧化钾(pH调节剂)
4、溶剂
5、水溶助长剂
6、BASF的聚氧乙烯/聚氧丙烯共聚物的注册商标(消泡剂)
7、Stepan的辛基磺酸酯的注册商标(阴离子表面活性剂)
8、1，2，3-苯并三唑(用于铜的抗腐蚀剂)
9、腐蚀抑制剂
10、无毒pH缓冲剂
11、腐蚀抑制剂
12、ISP的N-辛基-2-吡咯烷酮的注册商标(腐蚀抑制剂)
13、腐蚀抑制剂和pH调节剂
14、Stepan的二甲苯磺酸钠的商标(水溶助长剂)
15、Ethox的环氧乙烷/环氧丙烷共聚物的注册商标(非离子型表面活性剂)
表3
| 原料 | 化学药品名称 | 来源/供应者 | 重量％ |
| 去离子水 | 载体 | 50.14 | |
| Dequest 2010(60％) | 1-羟基亚乙基-1，1-二膦酸(助洗剂) | Solutia | 10.50 |
| 丙二醇 | 溶剂 | 5.00 | |
| 硼酸 | pH缓冲剂 | Borax | 0.20 |
| SXS(40％) | 二甲苯磺酸钠(水溶助长剂) | Stepan | 16.00 |
| KOH(45％) | 氢氧化钾(pH调节剂) | 12.80 | |
| Ethox 2400 | 脂肪醇乙氧基化物(非离子型表面活性剂) | Ethox公司 | 0.96 |
| Surfodone LP 100 | N-辛基-2-吡咯烷酮(阳离子表面活性剂) | ISP公司 | 3.20 |
| Dehypon LS 36 | 脂肪醇C12-C14 EO/PO(非离子型表面活性剂消泡剂) | Cognis | 0.60 |
| Dehypon LS 54 | 脂肪醇C12-C14 EO/PO(非离子型表面活性剂消泡剂) | Cognis | 0.60 |
| 总量 | 100 |
本领域技术人员可以理解的是，在不脱离本发明的主旨和范围情况下，可以对如上所述的方法和组合物作出各种改变。因此，应当理解在此所描述的具体实施方式仅是为了说明，本发明只通过随附的权利要求书来限定。
Claims (13)
1.一种用于清洗牙科器械和医疗器械的抗腐蚀清洁剂组合物，水溶液形式的该抗腐蚀清洁剂组合物含有：
(a)0.005-10％的低泡沫表面活性剂；
(b)0.005-10％的腐蚀抑制化合物，该腐蚀抑制化合物选自C4-C16烷基吡咯烷酮及C1-C18烷基胺；
(c)0.01-15％的助洗剂化合物，该助洗剂化合物防止通过水溶液中的金属离子与所述表面活性剂反应而生成沉淀；和
(d)0-20％的水溶助长剂，
其中，所述抗腐蚀清洁剂组合物的pH为中性至碱性。
2.根据权利要求1所述的抗腐蚀清洁剂组合物，其中，该抗腐蚀清洁剂组合物的pH为7至12。
3.根据权利要求1或2所述的抗腐蚀清洁剂组合物，其中，所述低泡沫表面活性剂选自由聚氧乙烯/聚氧丙烯嵌段共聚物所组成的组中，该嵌段共聚物的聚氧丙烯分子量为1500-8500，聚氧丙烯分子量占总分子量的约30％以下。
4.根据权利要求2或3所述的抗腐蚀清洁剂组合物，其中，所述助洗剂化合物选自由1-羟基亚乙基-1，1-二膦酸、氨基三(亚甲基膦酸)、二亚甲基三胺五(亚甲基膦酸)、二羟乙基亚氨基双(亚甲基膦酸)、乙二胺四(亚甲基膦酸)、EDTA(乙二胺四乙酸)、DTPA(二亚乙基三胺五乙酸)、HEDTA(N-(羟乙基)-乙二胺四乙酸)、NTA(氨三乙酸)、2-羟乙基亚氨基二乙酸、三磷酸钠或三磷酸钾、柠檬酸、四磷酸钠、六偏磷酸钠、及它们的混合物所组成的组中。
5.根据权利要求2-4中任意一项所述的抗腐蚀清洁剂组合物，其中，所述水溶助长剂选自由二甲苯磺酸钠、异丙基苯磺酸钠、C6-C18烷基磺酸及其盐、C6-C20烷基多苷、及C6-C16二苯醚二磺酸酯所组成的组中。
6.一种用于清洗牙科器械和医疗器械的抗腐蚀清洁剂组合物，水溶液形式的该抗腐蚀清洁剂组合物含有：
(a)0.005-10％的低泡沫表面活性剂，该低泡沫表面活性剂选自由聚氧乙烯/聚氧丙烯嵌段共聚物所组成的组中，该嵌段共聚物的聚氧丙烯分子量为1500-8500，聚氧丙烯分子量占总分子量的约30％以下；
(b)0.005-10％的腐蚀抑制化合物，该腐蚀抑制化合物选自C4-C16烷基吡咯烷酮及C1-C18烷基胺；
(c)助洗剂化合物，该助洗剂化合物防止通过水溶液中的金属与所述表面活性剂反应而生成沉淀，该助洗剂化合物选自由1-羟基亚乙基-1，1-二膦酸、氨基三(亚甲基膦酸)、二亚甲基三胺五(亚甲基膦酸)、二羟乙基亚氨基双(亚甲基膦酸)、乙二胺四(亚甲基膦酸)、EDTA(乙二胺四乙酸)、DTPA(二亚乙基三胺五乙酸)、HEDTA(N-(羟乙基)-乙二胺四乙酸)、NTA(氨三乙酸)、2-羟乙基亚氨基二乙酸、三磷酸钠或三磷酸钾、柠檬酸、四磷酸钠、六偏磷酸钠、及它们的混合物所组成的组中；和
(d)0-20％的水溶助长剂，该水溶助长剂选自由二甲苯磺酸钠、异丙基苯磺酸钠、C6-C18烷基磺酸及其盐、C6-C20烷基多苷、及C6-C16二苯醚二磺酸酯所组成的组中，
其中，所述水溶液的pH为7至12。
7.根据权利要求6所述的抗腐蚀清洁剂组合物，其中，该抗腐蚀清洁剂组合物还含有0.001-20％的溶剂，该溶剂选自由二元醇、二元醇醚、C1-C6直链或支链醇、及芳香醇所组成的组中。
8.根据权利要求6或7所述的抗腐蚀清洁剂组合物，其中，该抗腐蚀清洁剂组合物还含有0.001-10％的缓冲剂，该缓冲剂选自由硼酸、柠檬酸、磷酸、及它们的盐所组成的组中。
9.根据权利要求6-8中任意一项所述的抗腐蚀清洁剂组合物，其中，所述抗腐蚀清洁剂组合物还含有0.01-10％％的其它表面活性剂，该其它表面活性剂选自非离子型、阴离子型、阳离子型、及两性表面活性剂。
10.根据权利要求6-9中任意一项所述的抗腐蚀清洁剂组合物，其中，所述抗腐蚀清洁剂组合物还含有0.01-10％的其它抗腐蚀化合物，该其它抗腐蚀化合物选自由钼酸碱金属盐、亚硝酸碱金属盐、三唑、葡糖酸盐和羧酸所组成的组中。
11.一种清洗金属的医疗和牙科器械以除去污染物并抑制腐蚀的方法，该方法包括：
(a)在洗涤阶段，在含有清洁剂组合物的水溶液中洗涤所述器械，然后从器械上排去液体，所述清洁剂组合物含有低残留的腐蚀抑制剂；
(b)使所述器械经过至少一个使用含水冲洗液进行冲洗和排液的阶段，至少在最后的冲洗阶段中所述含水冲洗液含有选择浓度的所述清洁剂。
12.根据权利要求11所述的方法，该方法还包括预洗涤阶段，该预洗涤阶段使用含有所述清洁剂的水溶液，所述清洁剂的浓度低于所述洗涤阶段。
13.根据权利要求11或12所述的方法，其中，所述清洁剂组合物为权利要求1或6的清洁剂组合物。
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102294056A (zh) * | 2011-09-02 | 2011-12-28 | 山东新华医疗器械股份有限公司 | 手术器械保湿剂及其制备方法 |
| CN102294056B (zh) * | 2011-09-02 | 2013-12-04 | 山东新华医疗器械股份有限公司 | 手术器械保湿剂及其制备方法 |
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| CN111088120A (zh) * | 2019-12-30 | 2020-05-01 | 深圳金泽万长石化有限公司 | 一种强力去污清洗液及其制备方法 |
| CN111088120B (zh) * | 2019-12-30 | 2021-05-07 | 深圳金泽万长石化有限公司 | 一种强力去污清洗液及其制备方法 |
| CN115595034A (zh) * | 2022-10-25 | 2023-01-13 | 广东润和新材料科技有限公司（Cn） | 一种机舱用抗病毒抗菌纳米涂料及其制备方法与应用 |
| CN115595034B (zh) * | 2022-10-25 | 2023-08-08 | 广东润和新材料科技有限公司 | 一种机舱用抗病毒抗菌纳米涂料及其制备方法与应用 |
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| US20060194706A1 (en) | 2006-08-31 |
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| CA2597230C (en) | 2012-03-06 |
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| EP1851297B1 (en) | 2010-11-03 |
| US7462586B2 (en) | 2008-12-09 |
| KR20070103761A (ko) | 2007-10-24 |
| EP1851297A4 (en) | 2008-05-28 |
| ATE486923T1 (de) | 2010-11-15 |
| CA2768903C (en) | 2014-03-25 |
| EP1851297A1 (en) | 2007-11-07 |
| CA2597230A1 (en) | 2006-08-24 |
| DE602006017971D1 (de) | 2010-12-16 |
| HK1118572A1 (en) | 2009-02-13 |
| CA2768903A1 (en) | 2006-08-24 |
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