CN101133030B - 具有清凉性质的薄荷烷甲酰胺衍生物 - Google Patents

具有清凉性质的薄荷烷甲酰胺衍生物 Download PDF

Info

Publication number
CN101133030B
CN101133030B CN200680006684XA CN200680006684A CN101133030B CN 101133030 B CN101133030 B CN 101133030B CN 200680006684X A CN200680006684X A CN 200680006684XA CN 200680006684 A CN200680006684 A CN 200680006684A CN 101133030 B CN101133030 B CN 101133030B
Authority
CN
China
Prior art keywords
compound
refrigerant
oral cavity
menthane
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200680006684XA
Other languages
English (en)
Chinese (zh)
Other versions
CN101133030A (zh
Inventor
L·科尔
S·M·弗尔勒
C·加洛宾
P·V·克拉维克
A·马苏尔
J·P·斯莱克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Givaudan SA
Original Assignee
Givaudan SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Givaudan SA filed Critical Givaudan SA
Publication of CN101133030A publication Critical patent/CN101133030A/zh
Application granted granted Critical
Publication of CN101133030B publication Critical patent/CN101133030B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/244—Endothermic; Cooling; Cooling sensation
CN200680006684XA 2005-03-01 2006-02-23 具有清凉性质的薄荷烷甲酰胺衍生物 Expired - Fee Related CN101133030B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65756205P 2005-03-01 2005-03-01
US60/657,562 2005-03-01
PCT/CH2006/000116 WO2006092074A1 (en) 2005-03-01 2006-02-23 Menthane carboxamide derivatives having cooling properties

Publications (2)

Publication Number Publication Date
CN101133030A CN101133030A (zh) 2008-02-27
CN101133030B true CN101133030B (zh) 2010-07-28

Family

ID=36127379

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200680006684XA Expired - Fee Related CN101133030B (zh) 2005-03-01 2006-02-23 具有清凉性质的薄荷烷甲酰胺衍生物

Country Status (12)

Country Link
US (1) US7868004B2 (US07868004-20110111-C00007.png)
EP (1) EP1853565B1 (US07868004-20110111-C00007.png)
JP (1) JP2008531606A (US07868004-20110111-C00007.png)
KR (1) KR20070107083A (US07868004-20110111-C00007.png)
CN (1) CN101133030B (US07868004-20110111-C00007.png)
AT (1) ATE482199T1 (US07868004-20110111-C00007.png)
BR (1) BRPI0607407A2 (US07868004-20110111-C00007.png)
CA (1) CA2597415A1 (US07868004-20110111-C00007.png)
DE (1) DE602006017038D1 (US07868004-20110111-C00007.png)
ES (1) ES2352563T3 (US07868004-20110111-C00007.png)
MX (1) MX2007010040A (US07868004-20110111-C00007.png)
WO (1) WO2006092074A1 (US07868004-20110111-C00007.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4786544B2 (ja) 2003-11-21 2011-10-05 ジボダン エス エー Ｎ置換ｐ−メンタンカルボキサミド類
US8263046B2 (en) 2005-10-25 2012-09-11 Givaudan S.A. N-phenyl-N-pyridinyl-benzamides and benzenesulfonomides having cooling properties
BRPI0721140A2 (pt) * 2006-12-20 2014-04-01 Givaudan Nederland Services Bv P-mentano-3-carboxamida n-substituída e usos da mesma.
WO2009076792A1 (en) * 2007-12-19 2009-06-25 Givaudan Sa Cooling compounds
WO2009089641A1 (en) * 2008-01-17 2009-07-23 Givaudan Sa Benzimidazole derivatives and their use as cooling agents
GB0902849D0 (en) * 2009-02-19 2009-04-08 Givaudan Sa Organic compounds
GB201103103D0 (en) 2011-02-23 2011-04-06 Givaudan Sa Organic compounds
EP2497458A1 (en) * 2011-03-08 2012-09-12 B.R.A.I.N. Biotechnology Research And Information Network AG Small molecule modulators of the cold and menthol receptor TRPM8
US20150307447A1 (en) 2014-04-23 2015-10-29 The Procter & Gamble Company Compositions for deposition on biological surfaces

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351761A (en) * 1971-02-04 1974-05-01 Wilkinson Sword Ltd Substituted p-menthane carboxamides and compositions containing them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5918309A (en) * 1997-10-14 1999-07-06 Second Chance Body Armor, Inc. Blunt force resistant structure for a protective garment
CN1300095C (zh) 2002-10-28 2007-02-14 吉万奥丹股份有限公司 清凉剂溶液及含有其的组合物
JP5105873B2 (ja) * 2003-07-02 2012-12-26 ジェネンテック， インコーポレイテッド Ｔｒｐ−ｐ８活性化合物と治療的処置方法
JP5335191B2 (ja) 2003-08-22 2013-11-06 デンドレオン コーポレイション Ｔｒｐ−ｐ８発現に関連する疾患の処置をするための組成物および方法
JP4786544B2 (ja) 2003-11-21 2011-10-05 ジボダン エス エー Ｎ置換ｐ−メンタンカルボキサミド類
GB0425661D0 (en) 2004-11-23 2004-12-22 Givaudan Sa Organic compounds
US8673198B2 (en) * 2006-02-18 2014-03-18 Honeywell International Inc Method of making improved ballistic products

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351761A (en) * 1971-02-04 1974-05-01 Wilkinson Sword Ltd Substituted p-menthane carboxamides and compositions containing them

Also Published As

Publication number Publication date
DE602006017038D1 (de) 2010-11-04
BRPI0607407A2 (pt) 2009-09-01
US20080305051A1 (en) 2008-12-11
MX2007010040A (es) 2007-09-21
ES2352563T3 (es) 2011-02-21
CA2597415A1 (en) 2006-09-08
US7868004B2 (en) 2011-01-11
WO2006092074A1 (en) 2006-09-08
ATE482199T1 (de) 2010-10-15
JP2008531606A (ja) 2008-08-14
KR20070107083A (ko) 2007-11-06
CN101133030A (zh) 2008-02-27
EP1853565A1 (en) 2007-11-14
EP1853565B1 (en) 2010-09-22

Similar Documents

Publication Publication Date Title
CN101133030B (zh) 具有清凉性质的薄荷烷甲酰胺衍生物
EP0641187B1 (en) Coolant compositions
JP2978043B2 (ja) （２ｓ）−３−｛（１ｒ，２ｓ，５ｒ）−［ ５−メチル−２−（１−メチルエチル）シクロヘキシル ］オキシ｝−１，２−プロパンジオール，その製造方法および用途
US7893110B2 (en) Carboxylic acid amides provoking a cooling sensation
CN101184470A (zh) 清凉化合物
JP2008115181A (ja) Ｎα−（メンタンカルボニル）アミノ酸アミド及びその生理的冷却作用成分としての使用
US8377422B2 (en) Carboxamide derivatives having cooling properties
JP5031160B2 (ja) チタン誘導化合物、その製造法およびその使用
US7935848B2 (en) Butone derivatives useful as cooling agents
JPH09217083A (ja) 清涼感改善剤
CA2214108A1 (en) Coolant compositions
US20100297038A1 (en) Benzimidazole Derivatives And Their Use As Cooling Agents
JP2009529545A (ja) パラ置換２−アルコキシフェノール化合物
FR2569981A1 (fr) Dentifrice antiplaque stable et son procede de preparation
CN111479553B (zh) 口腔用组合物
JP7058093B2 (ja) 粘膜刺激・苦味抑制剤及び口腔用組成物
WO2007138031A2 (en) Menthane carboxylic acid n-(alkylthioalkyl)amides and use thereof as physiologically active cooling active ingredients
AU704226B2 (en) Coolant compositions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100728

Termination date: 20110223