CN101129524A - 鸡屎藤提取物及其医药用途 - Google Patents
鸡屎藤提取物及其医药用途 Download PDFInfo
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- CN101129524A CN101129524A CNA2007101521631A CN200710152163A CN101129524A CN 101129524 A CN101129524 A CN 101129524A CN A2007101521631 A CNA2007101521631 A CN A2007101521631A CN 200710152163 A CN200710152163 A CN 200710152163A CN 101129524 A CN101129524 A CN 101129524A
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- Medicines Containing Plant Substances (AREA)
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Abstract
Description
组别 | 剂量 | 扭体次数 |
空白阿司匹林提取物I | 0.2ml/只200mg/kg200mg/kg400mg/kg | 44.222±4.736923.9±5.0671**24.132±5.725*23.876±3.762** |
600mg/kg | 22.168±2.490** | |
提取物II | 200mg/kg | 23.345±5.612* |
400mg/kg | 22.123±3.456** | |
600mg/kg | 21.033±2.489** | |
提取物III | 200mg/kg | 23.653±5.234* |
400mg/kg | 22.475±3.832** | |
600mg/kg | 20.122±2.765** |
组别 | 剂量 | 耐受时间(秒) |
空白吗啡 | 0.2ml/只10mg/kg | 12.915±1.47344.403±3.499** |
本发明提取物I本发明提取物II本发明提取物III | 150mg/kg300mg/kg600mg/kg150mg/kg300mg/kg600mg/kg150mg/kg300mg/kg | 19.970±1.532**24.102±1.148***36.162±3.432***18.870±1.432**26.212±1.120***38.354±3.324***20.170±1.234**29.302±1.223*** |
600mg/kg | 40.122±3.312*** |
组别 | 剂量 | 耐受时间(秒) |
空白吗啡本发明提取物I本发明提取物II本发明提取物III | 0.2ml/只10mg/kg150mg/kg300mg/kg600mg/kg150mg/kg300mg/kg600mg/kg150mg/kg | 1.518±0.1514.95±0.347***2.345±0.235*2.630±0.123**2.730±0.255**2.732±0.221*2.935±0.125**3.011±0.215**2.626±0.225* |
300mg/kg | 2.940±0.122** | |
600mg/kg | 3.132±0.245** |
组别 | 剂量 | 小鼠舔足次数 | |||
钠络酮 | 格林本脲 | 尼莫地平 | |||
空白吗啡 | 0.3ml/只10mg/kg | 83.833±13.5516.667±1.256*** | 85.833±9.16374.333±11.011 | 89.333±18.81410.833±1.939*** | 80.833±8.4676.333±3.844*** |
提取物I | 600mg/kg | 25.712±6.320** | 34.523±4.668** | 39.534±5.532* | 56.250±6.535 |
提取物II | 600mg/kg | 24.452±5.98** | 35.456±4.776** | 40.754±6.012* | 57.156±6.787 |
提取物III | 600mg/kg | 23.998±6.587** | 35.912±4.445** | 39.879±5.879* | 57.034±6.665 |
组别 | 剂量 | 小鼠舔足次数 | |||
钠络酮 | 格林本脲 | 尼莫地平 | |||
空白吗啡 | 0.3ml/只10mg/kg | 45.167±12.8640.167±0.167** | 47.5±6.57147±8.246 | 46.5±8.0610.833±0.477** | 40.833±6.1940±0** |
提取物I | 600mg/kg | 1.165±1.158** | 2.02±1.324** | 3.792±1.128** | 38.450±9.232 |
提取物II | 600mg/kg | 1.046±1.096** | 1.98±1.325** | 3.425±1.001** | 39.687±8.765 |
提取物III | 600mg/kg | 1.035±1.122** | 2.01±1.112** | 3.546±1.231** | 38.780±8.451 |
组别 | 剂量 | 重量差(mg) |
空白地塞米松提取物I | 0.3ml/只0.5mg/kg150mg/kg300mg/kg | 4.75±1.0566.958±1.662**8.742±1.598**8.120±0.815*** |
600mg/kg | 6.249±1.082** | |
提取物II | 150mg/kg | 8.005±1.467** |
300mg/kg | 7.625±0.901*** | |
600mg/kg | 6.023±1.112** | |
提取物III | 150mg/kg | 8.002±1.456** |
300mg/kg | 7.570±0.798*** | |
600mg/kg | 5.989±1.034** |
Claims (6)
Priority Applications (1)
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CN2007101521631A CN101129524B (zh) | 2007-09-18 | 2007-09-18 | 鸡屎藤提取物及其医药用途 |
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CN2007101521631A CN101129524B (zh) | 2007-09-18 | 2007-09-18 | 鸡屎藤提取物及其医药用途 |
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Publication Number | Publication Date |
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CN101129524A true CN101129524A (zh) | 2008-02-27 |
CN101129524B CN101129524B (zh) | 2010-04-21 |
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CN2007101521631A Expired - Fee Related CN101129524B (zh) | 2007-09-18 | 2007-09-18 | 鸡屎藤提取物及其医药用途 |
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CN (1) | CN101129524B (zh) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009152724A1 (zh) * | 2008-06-20 | 2009-12-23 | Jiang Yi | 鸡屎藤苷酸甲酯用于制备止痛和/或抗炎药物的应用 |
CN101890033A (zh) * | 2009-05-20 | 2010-11-24 | 苏州颐华生物医药技术有限公司 | 鸡屎藤苷酸用于制备止痛和/或抗炎药物的应用 |
CN101637475B (zh) * | 2008-07-29 | 2011-06-01 | 上海医药工业研究院 | 鸡矢藤苷酸或含其的植物提取物的应用 |
CN102344474A (zh) * | 2011-07-26 | 2012-02-08 | 苏州宝泽堂医药科技有限公司 | 一种鸡屎藤苷的制备方法 |
CN102727616A (zh) * | 2012-06-19 | 2012-10-17 | 中国医学科学院药用植物研究所 | 一种鸡屎藤的乙酸乙酯提取物及其应用 |
CN104398619A (zh) * | 2014-11-06 | 2015-03-11 | 宁波大昌药业有限公司 | 鸡矢藤提取物及其用途 |
CN104435226A (zh) * | 2014-11-06 | 2015-03-25 | 宁波大昌药业有限公司 | 鸡矢藤提取物及其用途 |
CN104474068A (zh) * | 2014-11-06 | 2015-04-01 | 宁波大昌药业有限公司 | 鸡矢藤提取物及其用途 |
CN105713056A (zh) * | 2016-02-25 | 2016-06-29 | 湖南中医药大学 | 一种水线草中鸡矢藤苷甲酯的提取分离方法 |
CN108503678A (zh) * | 2017-02-24 | 2018-09-07 | 深圳曜曦生命科技有限公司 | 一种环烯醚萜类化合物及其制备方法和应用 |
CN112047988A (zh) * | 2019-06-05 | 2020-12-08 | 宁波大昌药业有限公司 | 鸡矢藤苷单体化合物、其制备方法和用途 |
CN112047989A (zh) * | 2019-06-05 | 2020-12-08 | 宁波大昌药业有限公司 | 鸡矢藤苷酸甲酯单体化合物、其制备方法和用途 |
CN115137676A (zh) * | 2021-03-30 | 2022-10-04 | 海南师范大学 | 一种鸡屎藤提取物及其在制备牙膏中的应用 |
-
2007
- 2007-09-18 CN CN2007101521631A patent/CN101129524B/zh not_active Expired - Fee Related
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009152724A1 (zh) * | 2008-06-20 | 2009-12-23 | Jiang Yi | 鸡屎藤苷酸甲酯用于制备止痛和/或抗炎药物的应用 |
CN101637475B (zh) * | 2008-07-29 | 2011-06-01 | 上海医药工业研究院 | 鸡矢藤苷酸或含其的植物提取物的应用 |
CN101890033A (zh) * | 2009-05-20 | 2010-11-24 | 苏州颐华生物医药技术有限公司 | 鸡屎藤苷酸用于制备止痛和/或抗炎药物的应用 |
WO2010133166A1 (zh) * | 2009-05-20 | 2010-11-25 | 苏州颐华生物医药技术有限公司 | 鸡屎藤苷酸用于制备止痛和/或抗炎药物的应用 |
CN102344474A (zh) * | 2011-07-26 | 2012-02-08 | 苏州宝泽堂医药科技有限公司 | 一种鸡屎藤苷的制备方法 |
CN102727616A (zh) * | 2012-06-19 | 2012-10-17 | 中国医学科学院药用植物研究所 | 一种鸡屎藤的乙酸乙酯提取物及其应用 |
CN102727616B (zh) * | 2012-06-19 | 2014-07-23 | 中国医学科学院药用植物研究所 | 一种鸡屎藤的乙酸乙酯提取物及其应用 |
CN104435226B (zh) * | 2014-11-06 | 2018-03-30 | 宁波大昌药业有限公司 | 鸡矢藤提取物及其用途 |
CN104398619A (zh) * | 2014-11-06 | 2015-03-11 | 宁波大昌药业有限公司 | 鸡矢藤提取物及其用途 |
CN104435226A (zh) * | 2014-11-06 | 2015-03-25 | 宁波大昌药业有限公司 | 鸡矢藤提取物及其用途 |
CN104474068A (zh) * | 2014-11-06 | 2015-04-01 | 宁波大昌药业有限公司 | 鸡矢藤提取物及其用途 |
CN104398619B (zh) * | 2014-11-06 | 2017-11-28 | 宁波大昌药业有限公司 | 鸡矢藤提取物及其用途 |
CN105713056A (zh) * | 2016-02-25 | 2016-06-29 | 湖南中医药大学 | 一种水线草中鸡矢藤苷甲酯的提取分离方法 |
CN108503678A (zh) * | 2017-02-24 | 2018-09-07 | 深圳曜曦生命科技有限公司 | 一种环烯醚萜类化合物及其制备方法和应用 |
CN112047988A (zh) * | 2019-06-05 | 2020-12-08 | 宁波大昌药业有限公司 | 鸡矢藤苷单体化合物、其制备方法和用途 |
CN112047989A (zh) * | 2019-06-05 | 2020-12-08 | 宁波大昌药业有限公司 | 鸡矢藤苷酸甲酯单体化合物、其制备方法和用途 |
CN112047988B (zh) * | 2019-06-05 | 2023-02-03 | 宁波大昌药业有限公司 | 鸡矢藤苷单体化合物、其制备方法和用途 |
CN112047989B (zh) * | 2019-06-05 | 2023-02-03 | 宁波大昌药业有限公司 | 鸡矢藤苷酸甲酯单体化合物、其制备方法和用途 |
CN115137676A (zh) * | 2021-03-30 | 2022-10-04 | 海南师范大学 | 一种鸡屎藤提取物及其在制备牙膏中的应用 |
CN115137676B (zh) * | 2021-03-30 | 2024-03-26 | 海南师范大学 | 一种鸡屎藤提取物及其在制备牙膏中的应用 |
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