CN101111490A - 4-(1h-吲哚-3-基)-嘧啶-2-基胺衍生物及其治疗用途 - Google Patents

4-(1h-吲哚-3-基)-嘧啶-2-基胺衍生物及其治疗用途 Download PDF

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Publication number
CN101111490A
CN101111490A CNA2006800037688A CN200680003768A CN101111490A CN 101111490 A CN101111490 A CN 101111490A CN A2006800037688 A CNA2006800037688 A CN A2006800037688A CN 200680003768 A CN200680003768 A CN 200680003768A CN 101111490 A CN101111490 A CN 101111490A
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compound
indol
amine
pyrimidin
formula
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Chinese (zh)
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彼得·M·费希尔
王淑东
克里斯托弗·K·米德斯
马丁·J·I·安德鲁斯
达伦·吉布森
肯尼思·邓肯
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Cyclacel Ltd
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Cyclacel Ltd
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CNA2006800037688A 2005-01-11 2006-01-11 4-(1h-吲哚-3-基)-嘧啶-2-基胺衍生物及其治疗用途 Pending CN101111490A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB200500492.4 2005-01-11
GBGB0500492.4A GB0500492D0 (en) 2005-01-11 2005-01-11 Compound

Publications (1)

Publication Number Publication Date
CN101111490A true CN101111490A (zh) 2008-01-23

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US (1) US20090318446A1 (https=)
EP (1) EP1836194A1 (https=)
JP (1) JP2008526824A (https=)
CN (1) CN101111490A (https=)
AU (1) AU2006205710A1 (https=)
BR (1) BRPI0606313A2 (https=)
CA (1) CA2592723A1 (https=)
GB (1) GB0500492D0 (https=)
IL (1) IL184313A0 (https=)
MX (1) MX2007008373A (https=)
WO (1) WO2006075152A1 (https=)

Cited By (9)

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Publication number Priority date Publication date Assignee Title
CN101723936B (zh) * 2008-10-27 2014-01-15 上海睿星基因技术有限公司 激酶抑制剂及其在药学中的用途
CN104876914A (zh) * 2014-02-28 2015-09-02 山东轩竹医药科技有限公司 嘧啶衍生物类间变性淋巴瘤激酶抑制剂
CN104892585A (zh) * 2014-03-06 2015-09-09 山东轩竹医药科技有限公司 嘧啶衍生物类间变性淋巴瘤激酶抑制剂
CN107987054A (zh) * 2017-11-28 2018-05-04 四川大学 一种新型cdk2抑制剂及其抗乳腺癌的应用
WO2019154177A1 (zh) * 2018-02-12 2019-08-15 恩瑞生物医药科技（上海）有限公司 嘧啶类化合物、其制备方法及其医药用途
CN110214138A (zh) * 2017-01-26 2019-09-06 韩美药品株式会社 嘧啶化合物及其药物用途
CN116693506A (zh) * 2018-07-25 2023-09-05 韩美药品株式会社 嘧啶化合物及包括它的用于预防或治疗癌症的药物组合物
US12350265B2 (en) 2019-06-27 2025-07-08 Hanmi Pharm. Co., Ltd. Pharmaceutical composition for treating acute myeloid leukemia, containing FLT3 inhibitor and chemotherapeutic agents
US12433867B2 (en) 2019-02-22 2025-10-07 Hanmi Pharm. Co., Ltd. Pharmaceutical composition comprising FLT3 inhibitor and hypomethylating agent for treating acute myeloid leukemia

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KR101283895B1 (ko) * 2011-08-04 2013-07-16 한국해양과학기술원 5-하이드록시인돌 화합물 또는 해면동물 스칼라리스폰지아 추출물을 유효성분으로 함유하는 암 질환의 예방 및 치료를 위한 조성물
CN108685922A (zh) 2011-09-30 2018-10-23 沃泰克斯药物股份有限公司 用atr抑制剂治疗胰腺癌和非小细胞肺癌
CN106496173A (zh) 2011-09-30 2017-03-15 沃泰克斯药物股份有限公司 用于制备可用作atr激酶抑制剂的化合物的方法
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US9498471B2 (en) 2011-10-20 2016-11-22 The Regents Of The University Of California Use of CDK9 inhibitors to reduce cartilage degradation
US8841450B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
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US8841337B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
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CN108478577A (zh) 2012-04-05 2018-09-04 沃泰克斯药物股份有限公司 可用作atr激酶抑制剂的化合物及其组合疗法
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