CN101111490A - 4-(1h-吲哚-3-基)-嘧啶-2-基胺衍生物及其治疗用途 - Google Patents

4-(1h-吲哚-3-基)-嘧啶-2-基胺衍生物及其治疗用途 Download PDF

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Publication number
CN101111490A
CN101111490A CNA2006800037688A CN200680003768A CN101111490A CN 101111490 A CN101111490 A CN 101111490A CN A2006800037688 A CNA2006800037688 A CN A2006800037688A CN 200680003768 A CN200680003768 A CN 200680003768A CN 101111490 A CN101111490 A CN 101111490A
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China
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compound
indol
amine
pyrimidin
formula
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Chinese (zh)
Inventor
彼得·M·费希尔
王淑东
克里斯托弗·K·米德斯
马丁·J·I·安德鲁斯
达伦·吉布森
肯尼思·邓肯
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Cyclacel Ltd
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Cyclacel Ltd
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CNA2006800037688A 2005-01-11 2006-01-11 4-(1h-吲哚-3-基)-嘧啶-2-基胺衍生物及其治疗用途 Pending CN101111490A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0500492.4A GB0500492D0 (en) 2005-01-11 2005-01-11 Compound
GB200500492.4 2005-01-11

Publications (1)

Publication Number Publication Date
CN101111490A true CN101111490A (zh) 2008-01-23

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CNA2006800037688A Pending CN101111490A (zh) 2005-01-11 2006-01-11 4-(1h-吲哚-3-基)-嘧啶-2-基胺衍生物及其治疗用途

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US (1) US20090318446A1 (https=)
EP (1) EP1836194A1 (https=)
JP (1) JP2008526824A (https=)
CN (1) CN101111490A (https=)
AU (1) AU2006205710A1 (https=)
BR (1) BRPI0606313A2 (https=)
CA (1) CA2592723A1 (https=)
GB (1) GB0500492D0 (https=)
IL (1) IL184313A0 (https=)
MX (1) MX2007008373A (https=)
WO (1) WO2006075152A1 (https=)

Cited By (9)

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Publication number Priority date Publication date Assignee Title
CN101723936B (zh) * 2008-10-27 2014-01-15 上海睿星基因技术有限公司 激酶抑制剂及其在药学中的用途
CN104876914A (zh) * 2014-02-28 2015-09-02 山东轩竹医药科技有限公司 嘧啶衍生物类间变性淋巴瘤激酶抑制剂
CN104892585A (zh) * 2014-03-06 2015-09-09 山东轩竹医药科技有限公司 嘧啶衍生物类间变性淋巴瘤激酶抑制剂
CN107987054A (zh) * 2017-11-28 2018-05-04 四川大学 一种新型cdk2抑制剂及其抗乳腺癌的应用
WO2019154177A1 (zh) * 2018-02-12 2019-08-15 恩瑞生物医药科技（上海）有限公司 嘧啶类化合物、其制备方法及其医药用途
CN110214138A (zh) * 2017-01-26 2019-09-06 韩美药品株式会社 嘧啶化合物及其药物用途
CN116693506A (zh) * 2018-07-25 2023-09-05 韩美药品株式会社 嘧啶化合物及包括它的用于预防或治疗癌症的药物组合物
US12350265B2 (en) 2019-06-27 2025-07-08 Hanmi Pharm. Co., Ltd. Pharmaceutical composition for treating acute myeloid leukemia, containing FLT3 inhibitor and chemotherapeutic agents
US12433867B2 (en) 2019-02-22 2025-10-07 Hanmi Pharm. Co., Ltd. Pharmaceutical composition comprising FLT3 inhibitor and hypomethylating agent for treating acute myeloid leukemia

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JP2013526540A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
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CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
EP2688886A1 (en) 2011-03-22 2014-01-29 Amgen Inc. Azole compounds as pim inhibitors
JP2014510151A (ja) 2011-04-05 2014-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ（ｔｒａｋｉｎａｓｅ）阻害剤として有用なアミノピラジン化合物
DK2707101T3 (da) 2011-05-12 2019-05-13 Proteostasis Therapeutics Inc Proteostaseregulatorer
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WO2012178124A1 (en) 2011-06-22 2012-12-27 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
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CN103702990B (zh) 2011-07-27 2015-09-09 阿斯利康(瑞典)有限公司 2-(2,4,5-取代苯胺)嘧啶衍生物作为egfr调谐子用于治疗癌症
KR101283895B1 (ko) * 2011-08-04 2013-07-16 한국해양과학기술원 5-하이드록시인돌 화합물 또는 해면동물 스칼라리스폰지아 추출물을 유효성분으로 함유하는 암 질환의 예방 및 치료를 위한 조성물
KR20140084112A (ko) 2011-09-30 2014-07-04 버텍스 파마슈티칼스 인코포레이티드 Ａｔｒ 키나제의 억제제로서 유용한 화합물
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WO2013059634A1 (en) 2011-10-20 2013-04-25 The Regents Of The University Of California Use of cdk9 inhibitors to reduce cartilage degradation
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US8841450B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
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CA2869309C (en) 2012-04-05 2021-02-09 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase and combination therapies thereof
US8999632B2 (en) 2012-10-04 2015-04-07 Vertex Pharmaceuticals Incorporated Method for measuring ATR inhibition mediated increases in DNA damage
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