CN101103044B - 抗α9整联蛋白抗体及其用途 - Google Patents

抗α9整联蛋白抗体及其用途 Download PDF

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CN101103044B
CN101103044B CN2006800022521A CN200680002252A CN101103044B CN 101103044 B CN101103044 B CN 101103044B CN 2006800022521 A CN2006800022521 A CN 2006800022521A CN 200680002252 A CN200680002252 A CN 200680002252A CN 101103044 B CN101103044 B CN 101103044B
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integrin
antibody
leu
gly
val
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CN101103044A (zh
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黑泷大翼
金山刚士
今重之
上出利光
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Kidswell Bio Corp
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    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
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CN2006800022521A 2005-01-13 2006-01-12 抗α9整联蛋白抗体及其用途 Expired - Fee Related CN101103044B (zh)

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Application Number Priority Date Filing Date Title
JP2005006348 2005-01-13
JP006348/2005 2005-01-13
PCT/JP2006/300676 WO2006075784A1 (ja) 2005-01-13 2006-01-12 抗α9インテグリン抗体とその用途

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CN101103044A CN101103044A (zh) 2008-01-09
CN101103044B true CN101103044B (zh) 2013-01-02

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US (1) US7595045B2 (https=)
EP (1) EP1840135B1 (https=)
JP (1) JP4871740B2 (https=)
KR (1) KR101316990B1 (https=)
CN (1) CN101103044B (https=)
CA (1) CA2593777C (https=)
IN (1) IN266863B (https=)
TW (1) TWI375565B (https=)
WO (1) WO2006075784A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101429783B1 (ko) * 2006-07-12 2014-08-18 가부시키가이샤 진 테크노 사이언스 항 인간 α9 인테그린 항체와 그 용도
WO2008075045A1 (en) * 2006-12-18 2008-06-26 Cartela R & D Ab Binding agents to the integrin alpha-11 subunit, and uses thereof
ES2582277T3 (es) 2007-12-28 2016-09-12 The Chemo-Sero-Therapeutic Research Institute Anticuerpo anti-integrina alfa 9 de ser humano
KR101597842B1 (ko) * 2008-01-11 2016-02-25 가부시키가이샤 진 테크노 사이언스 인간화된 항-알파9 인테그린 항체 및 그의 용도
CA2711882C (en) * 2008-01-11 2016-07-19 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Improved humanized anti-human .alpha.9-integrin antibody
JP5306659B2 (ja) * 2008-01-11 2013-10-02 株式会社ジーンテクノサイエンス 抗ヒトα9インテグリン抗体とその用途
KR101599096B1 (ko) * 2009-02-23 2016-03-02 가부시키가이샤 진 테크노 사이언스 항인간 α9 인테그린 항체와 그 용도
EP2406285B1 (en) * 2009-03-10 2016-03-09 Gene Techno Science Co., Ltd. Generation, expression and characterization of the humanized k33n monoclonal antibody
WO2011004847A1 (ja) * 2009-07-07 2011-01-13 一般財団法人化学及血清療法研究所 新規ヒト化抗ヒトα9インテグリン抗体
CN103619874A (zh) * 2011-06-30 2014-03-05 株式会社免疫生物研究所 可溶性整联蛋白α4突变体
JP5687305B2 (ja) * 2013-05-07 2015-03-18 株式会社ジーンテクノサイエンス 抗ヒトα9インテグリン抗体とその用途
AU2014413901B2 (en) * 2014-12-12 2021-04-01 Commonwealth Scientific And Industrial Research Organisation Dislodgement and release of HSC from the bone marrow stem cell niche using alpha9 integrin antagonists
US11806382B2 (en) 2019-11-18 2023-11-07 University Of Iowa Research Foundation Methods of inhibiting integrin α9β1 activity
CN113234161B (zh) * 2021-06-24 2022-06-07 福州迈新生物技术开发有限公司 抗cd3蛋白单克隆抗体及其细胞株、制备方法和应用
US20250289894A1 (en) * 2024-03-15 2025-09-18 Morphic Therapeutic, Inc. Integrin alpha-7 beta-1 antibodies and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037914A1 (en) * 1997-02-26 1998-09-03 Toray Industries, Inc. Remedies for hepatitis
AR016133A1 (es) 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
US6939855B2 (en) * 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
US20040234524A1 (en) 2001-04-05 2004-11-25 Toshimitsu Uede Anti-osteopontin antibody and use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PALMER EL.SEQUENCE AND TISSUE DISTRIBUTION OF THEINTEGRIN-ALPHA-9 SUBUNIT, A NOVEL PARTNER OFBETA-1 THAT IS WIDELY DISTRIBUTED IN EPITHELIAAND MUSCLE.The Journal of Cell Biology123 5.1993,123(5),1289-1297. *
PALMEREL.SEQUENCEANDTISSUEDISTRIBUTIONOFTHEINTEGRIN-ALPHA-9SUBUNIT A NOVEL PARTNER OFBETA-1 THAT IS WIDELY DISTRIBUTED IN EPITHELIAAND MUSCLE.The Journal of Cell Biology123 5.1993
Protopopov,A.等.序列号Q91YD5.UniProtKB/TrEMBL.2001, *

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Publication number Publication date
CN101103044A (zh) 2008-01-09
US7595045B2 (en) 2009-09-29
WO2006075784A1 (ja) 2006-07-20
CA2593777A1 (en) 2006-07-20
EP1840135A1 (en) 2007-10-03
CA2593777C (en) 2014-12-02
EP1840135B1 (en) 2013-03-27
KR20070115884A (ko) 2007-12-06
TWI375565B (en) 2012-11-01
US20080152653A1 (en) 2008-06-26
TW200637575A (en) 2006-11-01
JPWO2006075784A1 (ja) 2008-06-12
EP1840135A4 (en) 2009-11-11
KR101316990B1 (ko) 2013-10-11
JP4871740B2 (ja) 2012-02-08
IN266863B (https=) 2015-06-10

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